1,529 research outputs found
Interação do zinco com antidepressivos no teste de suspensão da cauda e no teste do campo aberto
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O efeito tipo-antidepressivo do zinco vem sendo demonstrado em alguns modelos animais de depressão. No presente estudo, cloreto de zinco (ZnCl2) foi administrado, sozinho ou em combinação com diferentes antidepressivos, por via oral (p.o.), em camundongos, e a resposta comportamental no teste de suspensão da cauda (TSC), teste preditivo de atividade antidepressiva, e no teste do campo aberto foi investigada. ZnCl2 administrado nas doses de 10 e 30 mg/kg, p.o., 60 minutos antes dos testes comportamentais, reduziu o tempo de imobilidade no TSC, sem afetar a atividade locomotora no teste do campo aberto. Além disso, ZnCl2 (30 mg/kg, p.o.) apresentou efeito tipo-antidepressivo quando foi administrado 30' antes do TSC. Os antidepressivos fluoxetina, paroxetina, imipramina, desipramina e bupropiona produziram uma significativa redução no tempo de imobilidade no TSC nas doses de 10; 1; 1;1;10 mg/kg, p.o., respectivamente. O tratamento combinado de doses sub-efetivas de ZnCl2 (1 mg/kg) com doses sub-efetivas de fluoxetina (5 mg/kg), paroxetina (0,1 mg/kg), desipramina (0,1 mg/kg), imipramina (0,1 mg/kg), ou bupropiona (1 mg/kg) gerou uma significativa redução no tempo de imobilidade no TSC, quando comparado com grupos tratados com o veículo, ZnCl2 ou antidepressivos sozinhos. O tratamento com ZnCl2 e antidepressivos sozinhos ou em combinação não afetou a locomoção dos animais submetidos ao teste do campo aberto, exceto a desipramina que administrada sozinha reduziu a locomoção dos animais. O tratamento com desipramina (0,1 mg/kg) ou paroxetina (0,1 mg/kg) sozinhos reduziu o número de respostas de levantamento vertical ("rearings") no teste do campo aberto. O tratamento com bupropiona (1 mg/kg) ou desipramina (0,1 mg/kg) sozinhos reduziu o número de respostas de auto-limpeza dos animais submetidos ao teste do campo aberto. Ainda, a administração combinada de ZnCl2 com bupropiona também diminuiu o número de respostas de auto-limpeza, condizente com um efeito semelhante a de benzodiazepínicos (ansiolíticos). Os resultados indicam, inicialmente, que o ZnCl2 administrado por via oral produz um efeito tipo-antidepressivo no TSC. Além disso, efeitos sinérgicos da administração de ZnCl2 com antidepressivos em diferentes classes foi mostrado no TSC, sugerindo que uma melhora na terapia antidepressiva clássica ocorra quando o zinco é acrescentado ao tratamento realizado com antidepressivos. Ainda, a combinação de ZnCl2 com o inibidor da recaptação de dopamina bupropiona diminuiu o número de auto-limpeza de animais submetidos ao teste do campo aberto, sugerindo que esta combinação seja efetiva no tratamento de pacientes aonde a depressão coexista com a ansiedade
Remnants and Revenants: politics and violence in the work of Agamben and Derrida
No full textThis is the peer reviewed version of the following article: Frazer, Elizabeth, and Kimberly Hutchings. "Remnants and revenants: politics and violence in the work of Agamben and Derrida." The British Journal of Politics & International Relations 13.2 (2011): 127-144, which has been published in final form at http://dx.doi.org/10.1111/j.1467-856X.2010.00428.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Jacques Derrida and Giorgio Agamben both consider the question of whether there can be politics without violence, offering contrasting responses. In the case of Agamben, the remnant (that which remains) is disruptive and destabilising of present institutions; in the case of Derrida the revenant, the spectre, promises a future that is open. This reading of the two theories suggests that Derrida's response to the question of politics and violence is more persuasive than Agamben's. But the abstraction of his argument, like the tensions and contradictions in Agamben's, means that we are not hereby furnished with the resources to think politically about violence
Brisures du romaneque: 'La Malédiction de la Madone', ou d'une pratique ironique du docufiction.
No full textLa Malédiction de la Madone, pubblicato nel 2022, è il primo romanzo in cui Philippe Vilain, scrittore tra i maggiori rappresentanti dell’autofinzione, ab- bandona la narrazione in prima persona per un “docufiction” in terza persona basato sulla vita della camorrista Pupetta Maresca. questo cambio di rotta, an- cor più sorprendente per un autore come Vilain che aveva sempre vilipeso que- sto genere letterario, è occasione di mettere in questione le sue concezioni del romanzo e della letteratura. Ne vien fuori una narrazione tesa tra l’aspirazione a far corpo unico con la sua precedente produzione letteraria e le condizioni im- poste dalla “docufinzionalizzazione” della storia. La Malédiction de la Madone diventa così un vero e proprio laboratorio letterario dove la sperimentazione più fine e pensosa svela inattese punte d’ironia.La Malédiction de la Madone, published in 2022, is the first novel in which Philippe Vilain, a writer among the greatest representatives of autofiction, abandons the first-person narration for a third-person “docufiction” based on the life of the camorrist Pupetta Maresca. This change of course, even more surprising for an author like Vilain who had always vilified this literary genre, is an opportunity to question his conceptions of the novel and of literature. The result is a narrative tended between the aspiration to merge with his previous literary pro- duction and the conditions imposed by “docufictionalization” of the history. The Malédiction de la Madone thus becomes a real literary laboratory where the finest and most thoughtful experimentation reveals unexpected hints of irony
FP-INJECTIVE SEMIRINGS, SEMIGROUP RINGS AND LEAVITT PATH ALGEBRAS
No full textIn this paper we give characterisations of FP-injective semirings (previously termed “exact” semirings in work of the first author). We provide a basic connection between FP-injective semirings and P-injective semirings, and establish that FP-injectivity of semirings is a Morita invariant property. We show that the analogue of the Faith-Menal conjecture (relating FP-injectivity and self-injectivity for rings satisfying certain chain conditions) does not hold for semirings. We prove that the semigroup ring of a locally finite inverse monoid over an FP-injective ring is FP-injective and give a criterion for the Leavitt path algebra of a finite graph to be FP-injective
Alive-FP: Automated Verification of Floating Point Based Peephole Optimizations in LLVM
No full textPeephole optimizations optimize and canonicalize code to enable other optimizations but are error-prone. Our prior research on Alive, a domain-specific language for specifying LLVM’s peephole optimizations, automatically verifies the correctness of integer-based peephole optimizations and generates C++ code for use within LLVM. This paper proposes Alive-FP, an automated verification and code generation framework for floating point based peephole optimizations in LLVM. Alive-FP handles bit precise floating point optimizations and a class of fast-math optimizations involving signed zeros, not-a-number, and infinities. This paper provides multiple encodings for various floating point operations to account for the various kinds of undefined behavior and under-specification in the LLVM’s language reference manual. We have translated all optimizations that belong to this category into Alive-FP. In this process, we have discovered seven wrong optimizations in LLVM.Technical report DCS-TR-72
Long-term orbital period behaviour of low mass ratio contact binaries GR Vir and FP Boo
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this study, we investigated orbital period variations of two low mass ratio contact binaries GR Vir and FP Boo based on published minima times. From the O-C analysis, it was found that FP Boo indicates orbital period decrease while the period of GR Vir is increasing. Mass transfer process was used to explain increase and decrease in the orbital periods. In the O-C diagrams of both systems periodic variations also exist. Cyclic changes can be explained as being the result of a light-travel time effect via a third component around the eclipsing binaries. In order to interpret of cyclic orbital period changes for GR Vir, which has late-type components, possible magnetic activity cycles of the components have been also considered.Turkish Phys So
[[alternative]]An Efficient Approach for Maintaining Association Rules based on Adjusting FP-tree Structure
No full text[[abstract]]In this thesis, the issue of mining and maintaining association rules in a large database of customer transactions is studied. The maintenance of association rules can be mapped into the problem of maintaining frequent itemsets in the database. Because the mining of association rules is time-consuming, we need an efficient approach to maintain the frequent itemsets when the database is updated. In this study, a general incremental updating technique is proposed for maintaining the frequent itemsets discovered in a database in the cases including insertion, deletion, and modification of transactions in the database. An efficient algorithm, called AFPIM (Adjusting FP-tree for Incremental Mining), is designed based on adjusting FP-tree structures. Our approach uses a FP-tree structure to store the compact information of transactions involving frequent and pre-frequent items in the original database. In most cases, the new FP-tree structure of the updated database can be obtained by adjusting FP-tree of the original database according to the changed transactions without needing to rescan the original database. Experimental results show that AFPIM outperforms the existing algorithms in terms of the execution time.
La Teste-de-Buch – Lette du Grand Baron, École Gambetta
No full textIdentifiant de l'opération archéologique : 025119 Date de l'opération : 2007 (FP) Il s’agit là de la troisième campagne de fouille programmée menée sur la commune de La Teste. Elle avait un double but : prouver l’existence d’un habitat médiéval en périphérie de la nécropole sondée en 2005 et 2006 et re-qualifier le site de « la lette du Grand Baron » (2 km au sud de l’agglomération actuelle) qui a été, de tout temps et à tort, interprété comme l’emplacement du premier village de La Teste, en..
La Teste-de-Buch – Lette du Grand Baron, École Gambetta
No full textIdentifiant de l'opération archéologique : 025119 Date de l'opération : 2007 (FP) Il s’agit là de la troisième campagne de fouille programmée menée sur la commune de La Teste. Elle avait un double but : prouver l’existence d’un habitat médiéval en périphérie de la nécropole sondée en 2005 et 2006 et re-qualifier le site de « la lette du Grand Baron » (2 km au sud de l’agglomération actuelle) qui a été, de tout temps et à tort, interprété comme l’emplacement du premier village de La Teste, en..
Convolutional neural network based attenuation correction for <sup>123</sup>I-FP-CIT SPECT with focused striatum imaging
No full textSPECT imaging with 123I-FP-CIT is used for diagnosis of neurodegenerative disorders like Parkinson's disease. Attenuation correction (AC) can be useful for quantitative analysis of 123I-FP-CIT SPECT. Ideally, AC would be performed based on attenuation maps (μ-maps) derived from perfectly registered CT scans. Such μ-maps, however, are most times not available and possible errors in image registration can induce quantitative inaccuracies in AC corrected SPECT images. Earlier, we showed that a convolutional neural network (CNN) based approach allows to estimate SPECT-aligned μ-maps for full brain perfusion imaging using only emission data. Here we investigate the feasibility of similar CNN methods for axially focused 123I-FP-CIT scans. We tested our approach on a high-resolution multi-pinhole prototype clinical SPECT system in a Monte Carlo simulation study. Three CNNs that estimate μ-maps in a voxel-wise, patch-wise and image-wise manner were investigated. As the added value of AC on clinical 123I-FP-CIT scans is still debatable, the impact of AC was also reported to check in which cases CNN based AC could be beneficial. AC using the ground truth μ-maps (GT-AC) and CNN estimated μ-maps (CNN-AC) were compared with the case when no AC was done (No-AC). Results show that the effect of using GT-AC versus CNN-AC or No-AC on striatal shape and symmetry is minimal. Specific binding ratios (SBRs) from localized regions show a deviation from GT-AC ≤ 2.5% for all three CNN-ACs while No-AC systematically underestimates SBRs by 13.1%. A strong correlation (r ≥ 0.99) was obtained between GT-AC based SBRs and SBRs from CNN-ACs and No-AC. Absolute quantification (in kBq ml-1) shows a deviation from GT-AC within 2.2% for all three CNN-ACs and of 71.7% for No-AC. To conclude, all three CNNs show comparable performance in accurate μ-map estimation and 123I-FP-CIT quantification. CNN-estimated μ-map can be a promising substitute for CT-based μ-map.RST/Biomedical Imagin
- …
