97 research outputs found
Cognitive System Dynamics
No full textCognitive System Dynamics (CSD) is an original research framework developed by Aryo Kiani to explore how beliefs evolve, persist, and distort under recursive cognitive feedback. It integrates system-level modeling methods with a novel epistemological foundation to address longstanding challenges in the study of bias, misinformation, and rational failure.
This project space is a timestamped, author-verified archive for foundational materials supporting the development of the CSD research program. Select preprints, diagrams, and working papers are made publicly visible for scholarly dialogue and citation. All documents are shared with full attribution requirements under a CC BY-NC-ND 4.0 license.
Collaboration requests and formal inquiries are welcome via the contact information on ParadigmDynamics.or
In Silico Study of Acetogenin Compounds from Soursop (Annona muricata) Leaves as Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: Studi In Silico Senyawa Acetogenin dari Daun Sirsak (Annona muricata) Sebagai Inhibitor Sodium-Glucose Cotransporter-2 (SGLT2)
No full textAcetogenin derived from soursop (Annona muricata) leaves are known to have antidiabetic and anticancer activities. Nevertheless, there has been no study related to the compounds found in A. muricata leaves, such as acetogenin, as SGLT2 inhibitors. This research aims to investigate the activity of acetogenin compounds as SGLT2 inhibitors while maintaining low selectivity against SGLT1 using molecular docking methods using Molegro Virtual Docker (MVD). Based on the Rerank score, five acetogenin compounds, namely muricin H, annonacin A, annopentocin B, murihexocin C, and corossolone, are predicted to be SGLT2 inhibitors with better selectivity compared to empagliflozin. Among these five compounds, muricin H and corossolone exhibit the most similarity in interaction with amino acid residues in the SGLT2 A-chain compared to empagliflozin. In silico ADMET analysis results indicate that both compounds have absorption, distribution, and metabolism capabilities, similar to empagliflozin. However, it should be noted that both compounds are more toxic, with muricin H predicted to have hepatotoxic properties
Potential of Dietary Flavonoids in The Prevention and Therapy of COVID-19 : Focusing in Mast Cell - Calcium Ion Channel Axis
No full textSyndrome Acute Respiratory Syndrome Corona Virus-2 (SARS COV2) is the virus that causes the COVID19 disease and has caused more than 4 million deaths worldwide. This virus infects the host cell through the interaction between the virus’s glycoprotein S molecule with the ACE2 which is the virus receptor, binding, undergoes membrane fusion and enters the cell and replicates in it. Currently, several strategies used in developing anti-viral compounds are targeting compounds that play a role in the process of entering the virus into host cells such as ACE2, S glycoprotein, and TMPRSS2, while some target main proteases such as RNA dependent Polymerase and N proteins. On the other hand, one of the causes for the worsening of COVID-19 cases is hyperinflammation. This condition can also be caused by an increase in calcium consumption activity which is responsible for the process of viral endocytosis, mast cell recruitment, and also the recruitment of surrounding cells to form syncytia. Under these conditions, virions that are trapped and accumulated in the syncytia can initiate the release of virions and pro-inflammatory molecules, leading to hyperinflammation and second week crash. This review will explain the importance of the role of calcium ions and mast cells in mediating inflammation as well as the prospect of inhibiting hyperinflammation in COVID19 using flavonoid compounds contained in daily food ingredients
SEJARAH DAN PERKEMBANGAN JAZZ DI SURABAYA, JAKARTA, BANDUNG 1959-1988
No full textABSTRAK
ARYO SANJAYA : “Sejarah dan Pekembangan Jazz di Surabaya, Jakarta, Bandung 1959-1988”
Skripsi. Program Studi Pendidikan Sejarah Fakultas Ilmu Sosial, Universitas Negeri Jakarta, 2023.
Penelitian ini bertujuan untuk mendeskripsikan perkembangan musik Jazz di Indonesia dan eksistensi musik Jazz di Indonesia dari tahun 1959 sampai tahun 1988. Metode penelitian yang digunakan adalah metode penelitian sejarah yang langkah-langkahnya terdiri atas pengumpulan sumber (heuristik), kritik sumber (verifikasi), penafsiran (interpretasi), dan penulisan (historiografi). Tahap pertama penulis mengumpulkan sumber primer berupa koran, majalah, dan pelaku sejarah, serta sumber sekunder seperti, buku dan jurnal. Setelah data terkumpul, lalu diverifikasi secara kritik eksternal dan internal. Selanjutnya, menafsirkan makna fakta dan hubungan antara satu fakta dengan fakta lain. Penulis menyajikan fakta yang telah ditafsirkan. Tahap akhir adalah penulisan skripsi.
Penelitian ini menghasilkan informasi bahwa music Jazz dalam sejarahnya pernah dilarang di Indonesia pada masa pemerintahan Soekarno dan pada akhirnya diperbolehkan lagi untuk dikembangkan dimasa pemerintahan Soeharto. 1959 menandai pelarangan music Jazz melalui MANIPOL yang dikeluarkan Soekarno padahal dalam sejarahnya periode ini adalah masa kejayaan music Jazz di Indonesia. Kemudian tahun 1988 adalah tahun terbentuknya Jak Jazz sebagai festival music Jazz Indonesia berskala Internasional terbesar pada saat itu. Jak Jazz menandakan music Jazz kembali diterima dan mulai melebarkan sayapnya terhadap khalayak ramai.
Dapat disimpulkan bahwa Sejarah Jazz di Indonesia sangat Panjang dan dapat terpengaruh dengan kebijakan politik sampai pada akhirnya kita dapat mendengarkan mahakarya para musisi Jazz masa itu di hari ini.
Kata Kunci : Jazz, Jak Jazz, MANIPOL
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ABSTRACT
ARYO SANJAYA : The History and Development of Jazz in Surabaya, Jakarta, Bandung 1959-1988.
Undergradute Thesis. History Education Study Program, Faculty of Social Sciences, Jakarta State University, 2023.
This study aims to describe the development of Jazz music in Indonesia and the existence of Jazz music in Indonesia from 1959 to 1988. The research method used is historical research method whose steps consist of gathering sources (heuristics), source criticism (verification), interpretation (interpretation), and writing (historiography). In the first stage the writer collects primary sources in the form of newspapers, magazines and historical actors, as well as secondary sources such as books and journals. After the data is collected, it is then verified externally and internally. Next, interpret the meaning of facts and the relationship between one fact and another. The author brings together the facts that have been interpreted. The final stage is thesis writing.
This research yields information that historically Jazz music was banned in Indonesia during Soekarno's reign and was finally allowed to be developed again during Suharto's reign. 1959 marked the banning of Jazz music through the MANIPOL issued by Soekarno, even though in its history this period was the heyday of Jazz music in Indonesia. Then 1988 was the year Jak Jazz was formed as the largest international scale Indonesian Jazz music festival at that time. Jak Jazz indicates that Jazz music is being accepted again and is starting to spread its wings to the general public.
It can be concluded that the history of jazz in Indonesia is very long and can be influenced by political policies so that in the end we can listen to the masterpieces of jazz musicians at that time today.
Keyword : Jazz, Jak Jazz, MANIPO
Characterization of Adenocarcinoma’s Autofluorescence Properties Using Multiexcitation Analysis Method
No full textGeneral purpose of this research is to get an early cancer detection method based on the properties of optical analysis between normal and adenocarsinoma tissue using the multiexcitation autofluorescence method. Observation of autofluorescence properties was done on the biopsy sample of adenocarcinoma tissues, GR mice transplanted by adenocarsinoma, and cell culture SM 1. Excitation on tissue was done by using the lamp Light Emitting Diode (LED) at some visible light wavelength range. This research obtained that the value of Intensity Auto fluorescence (IAF) at range red wavelength of cells and adenocarsinoma tissues tend to lower compared to the cells normal tissues if its were excited by blue LED. On the contrary, the value of IAF at infra red wavelength from cells and carcinoma tissues tend to higher compared to the cells and normal tissues if its were excited by red LED
In silico Prediction of Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibition Activity by Allium Fistulosum Compound Based on SkelSpheres Molecular Descriptor
No full textThe Sodium-Glucose co-transporter-2 (SGLT2) inhibitor represents a novel agent for the treatment of type 2 diabetes. Drugs of this class function by inhibiting glucose reabsorption in the kidneys, thereby controlling blood glucose levels. It is known that SGLT2 inhibitors activate the AMPK signaling pathway by increasing the expression and activity of AMP-activated protein kinase (AMPK). In vivo tests have demonstrated that ethanolic and aqueous extracts of Welsh onion leaves (Allium fistulosum L) can reduce body weight, liver weight, adipocyte size, and enhance AMP-activated protein kinase (AMPK) expression. In this study, the inhibitory activity (IC50) of compounds within Allium fistulosum against SGLT2 was predicted using the Support Vector Regression (SVR) predictive model and the SkelSpheres descriptor. The results of the predicted IC50 measurements for compounds present in the 70% ethanol extract of Allium fistulosum in silico indicate that 4 tyramine derivatives and 1 decursidate compound exhibit Excellent or Potent inhibitor activity criteria (IC50 \u3c 1 µM). Among these, the four tyramine group compounds are the isomers N-trans-feruloyltyramine and N-cis-feruloyltyramine, as well as the isomers N-trans-feruloyl-3\u27-methoxytyramine and N-cis-feruloyl-3\u27-methoxytyramine. The findings of this study suggest that the ability of Allium fistulosum to enhance AMPK expression is possibly achieved through the inhibition of SGLT2
GENE EXPRESSION PROFILE IN SALMONELLA ENTERITIDIS IN EGG ALBUMEN BASED ON PATHOGENICITY VIA GEO-ANALYSIS
No full textSalmonella enteriditis, a bacterium known for contaminating egg albumen, serves as a significant causative agent of foodborne illnesses in humans. These illnesses manifest with a spectrum of symptoms ranging from mild to severe, contingent upon the varying pathogenicity levels of Salmonella enteritidis. The central objective of this research endeavor was to meticulously analyze the gene expression profile of Salmonella enteritidis in egg albumin, correlating it with the pathogen's varying pathogenicity levels. This analysis was conducted utilizing the Gene Expression Omnibus (GEO) Analysis framework.A comprehensive examination of 18 genomic databases specific to Salmonella enteritidis, extracted from the GEO Dataset (GSE33102), was undertaken. These databases were methodically clustered in accordance with the pathogenicity gradations of the bacteria. Subsequently, an in-depth analysis and visualization of the data were performed using GEO2R. The analytical findings revealed a notable variance in gene expression, with 35-46 genes demonstrating significant differences (Padj<0.05) when comparing groups with High Pathogenicity and High-Medium Pathogenicity against those with Low PathogenicityThe study culminated in the identification of six distinct gene expressions that effectively discriminate between Salmonella enteritidis groups classified as High, High-Medium, and Low Pathogenicity. This discovery propels the hypothesis that these genes could potentially serve as specific markers for the presence of Salmonella enteritidis in contaminated eggs. Such markers would be instrumental in the early detection of foodborne diseases. However, it is imperative to conduct further research to ascertain the viability of these candidate genes as reliable indicators for the early detection of this pathogen in contaminated food sources
Photo electrochemical detection of dengue-related oligonucleotide sequance anthocyanin as an intercalating agent and electrochromic material
No full textChemoprevention Activity of Temu Mangga Extracts
No full textThe chemoprevention activity of temu mangga extracts was investigated by determination of antioxidant activity with a peroxidation number method and gluthatione-S-transferase (GST) activity in Chang medium culture and cell lysate (total GST activity). The results indicated that ethanol extract has a strong antioxidant activity. It is caused by the phenolic group in the ethanol extract. Treatment Chang cell culture with 7th and 4th ethanol fractions increased the GST activity when compared to the control. The total GST activity (cytosolic and microsomal) increased when Chang cell culture was treated with H2O2/Fe+2. The decrease of the total GST activity was observed when 7th and 4th ethanol fractions were supplemented with H2O2/Fe+2 compared to the cell culture receiving H2O2/Fe+2 only
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