107 research outputs found
HDAC2-deficient CD4+ T cells in a psoriasis-like mouse model of skin autoimmunity
No full textPsoriasis ist eine Autoimmunerkrankung der Haut, von der 2–4 % der Weltbevölkerung betroffen sind und wogegen derzeit spezifische Medikamente noch fehlen. Die Haut ist ein wichtiges Barrieregewebe des Körpers, in dem Effektor-T-Zellen (Teff) und Foxp3+-regulatorische T-Zellen (Treg) die Immunhomöostase bestimmen. Daher ist das Verständnis der molekularen Mechanismen, die die Differenzierung und Funktion kutaner CD4+ T-Zellen steuern, von entscheidender Bedeutung für die Entwicklung neuartiger T-Zell-basierter Therapien für T-Zell-vermittelte Autoimmunerkrankungen der Haut. Viele Mausmodelle versuchten, menschliche Psoriasis zu reproduzieren, doch das komplexe molekulare Netzwerk, das die Krankheit charakterisiert, macht es schwierig, die Krankheit zu rekapitulieren. Histondeacetylasen (HDACs) haben unterschiedliche Funktionen bei der Regulierung der Biologie und Funktion von T-Zellen. Allerdings ist die Rolle von HDAC2 in kutanen T-Zellen noch immer nicht geklärt. Die Ziele meines Doktoratsprojekts bestehen darin, das Immunmilieu und die Wechselwirkung zwischen Immunzellen und Strukturzellen in einem etablierten Modell der Autoimmunerkrankung der Haut zu charakterisieren und die Auswirkungen des HDAC2-Mangels auf CD4+ T-Zellen bei Autoimmunerkrankungen der Haut zu untersuchen. Zu diesem Zweck verwendeten wir ein Mausmodell einer experimentellen Autoimmunentzündung der Haut (bezeichnet als K5/TGO). In diesem Modell haben wir WT- oder HDAC2-defiziente naive Ova-spezifische OTII CD4+ T-Zellen adoptiv in K5/TGO-Empfängermäuse übertragen, die eine induzierbare Expression von Ova in der Epidermis aufweisen. Adoptiv übertragene T-Zellen reagieren auf in der Haut exprimierte Ova-Antigene und lösen eine Autoimmunerkrankung aus, die hauptsächlich durch Th1- und Th17-Zellen reguliert wird. Wir beobachteten das Immunmilieu der Haut und histologische Merkmale, die Hautläsionen von Psoriasis-Patienten ähnelten. Bei der Untersuchung der Rolle von HDAC2 in CD4+-T-Zellen stellten wir bei K5/TGO-Mäusen, die HDAC2-defiziente T-Zellen erhalten hatten, eine erhöhte Überlebensrate und eine verringerte Hautentzündung fest. Darüber hinaus zeigten unsere Ergebnisse, dass das Fehlen von HDAC2, den Phänotyp (z. B. die Expression von CTLA-4) von Foxp3+ Treg reguliert. Mit unseren Erkenntnissen werden wir ein alternatives Modell der Psoriasis und die molekulare Grundlage für die Entwicklung isoformspezifischer HDAC-Inhibitoren zur Behandlung von Autoimmunerkrankungen liefern.submitted by Alice Emma Taliento, MScLiteraturverzeichnis: Seite 77-88Das + im Titel ist hoch gestelltDissertation University of Salzburg 202
The Dream of Alice. Alice’s Adventures in Wonderland in 150 Years
No full textAlice in Wonderland, published in 1865, is 150 years old and continues to be one of the most popular masterpieces that is appreciated by children and adults. The article explores the polysemy of the text, its fine hermeneutical approaches, the symbolic ramifications of its visual reinterpretations – especially in the illustrations. This novel continues to fuel our imagery and, at same time, it continues to discuss the biographers of Carroll on the complex personality of this author. In particular, the article emphasizes the original and unexpected turn that Alice in Wonderland gave to children's literature, through the storytelling of a point of view – "another look" – that definitely belongs to childhood
Dr. Edwin Wright Letters: Emma Miller
No full textNotes - Ms. Emma Miller discusses her family's travels and early life in Athabasca. She talks of her parent's first jobs (working at Mr. Ike Gagnon's mill) and of living on rabbits and beans in the winter as ""money for meat was scarce. Ms. Miller talks of helping put shingles on Parkhurst school and of being married there to Mr. Peter Miller. Ms. Miller talks of the need and difficulty in recruiting physicians to the far North and how the town finally landed Doctor Meyer (each family agreed to pay twelve dollars per year to the doctor) (2 pages
Il sogno di Alice
No full textAlice in Wonderland, published in 1865, is 150 years old and continues to be one of the most popular masterpieces that is appreciated by children and adults. The article explores the polysemy of the text, its fine hermeneutical approaches, the symbolic ramifications of its visual reinterpretations – especially in the illustra-tions. This novel continues to fuel our imagery and, at same time, it continues to discuss the biographers of Carroll on the complex personality of this author. In particular, the article emphasizes the original and unexpected turn that Alice in Wonderland gave to children’s literature, through the storytelling of a point of view – “another look” – that definitely belongs to childhood
Il sogno di Alice
No full textAlice in Wonderland, published in 1865, is 150 years old and continues to be one of the most popular masterpieces that is appreciated by children and adults. The article explores the polysemy of the text, its fine hermeneutical approaches, the symbolic ramifications of its visual reinterpretations – especially in the illustra-tions. This novel continues to fuel our imagery and, at same time, it continues to discuss the biographers of Carroll on the complex personality of this author. In particular, the article emphasizes the original and unexpected turn that Alice in Wonderland gave to children’s literature, through the storytelling of a point of view – “another look” – that definitely belongs to childhood
Aunt Mag - 03
No full textPhotograph - Joe Irwin's Aunt Mag and other standing in front of a plane, likely the Gypsy Moth, [Calgary], Alberta. Left to right: Mrs. Emma Barton, Aunt Mag, Sister Jessie, Mrs. Bob Dingwall and her daughter, Grac
Reading between the blurred lines: A discussion into the representation of rape and rape culture in contemporary fiction
No full textIn this dissertation, the focus will be on the representation of rape and rape culture within contemporary fiction; the aim of this is to discover how prevalent rape and rape culture is within this particular area. The thesis is split into three chapters, the first of which discusses the depictions of male rape and gender shifts in contemporary fiction, focusing on Lisbeth Salander as a rapist in The Girl with the Dragon Tattoo. The second chapter follows on from this, discussing the portrayal of victims of rape within contemporary fiction; and the last chapter debates whether or not a perpetuating rape culture means that women cannot be as sexually experimental as they wish to be. The aim of the dissertation is to focus on how authors depict rape, and whether or not this depiction is perpetuating rape culture, or simply addressing the issue within fiction. The introduction is a larger part of the dissertation, setting up exactly what rape and rape culture is, and how rape myths prevail in modern western society. There are certain areas that the dissertation has not addressed, such as race, because they are such complex issues that merely by giving them a single chapter within the dissertation would not be enough. The dissertation’s main purpose, and main area of focus, is to illustrate the perpetuating rape culture in western societies through gender inequality
Hearing voices : coordinate structures and resurging narrative voices in Alice Munro's Friend of My Youth
No full textInternational audienceThis paper attempts to illustrate how a linguistic analysis of joint and segratory coordinate structures in a literary text enables us to gain access to another level of narrative. It is by working within and without of the grammatical rules that govern this structure that an author like Alice Munro gives us to understand not only the complexity of her text, but also the unassuming complexity of this grammatical structure.Le but de ce papier est de tenter d'illustrer comment l'analyse linguistique de la coordination jointe et distributive d'un texte littéraire nous permet accès à un tout autre niveau de texte. C'est en étendant les frontières des règles grammaticales qui gouvernent ces structures qu'une auteure comme Alice Munro nous permet de saisir, et la complexité de son texte, et la complexité insoupçonnée des structures coordonnées
Letters from American missionaries in China, 1934
No full text1. Letter dated 14 January 1934 from Emma Tucker at Wutingfu Christian Hospital, in Huimin, Shantung, to her children, reporting recent medical cases there; Alan T. Dale (author of "In this light") to marry; upcoming mission synod at Tientsin; 2. Letter date 23 January 1934 from Alice E. Murphy at Lintsing to friends, describing a long oxcart ride following a trip to villages where the missionaries provided training and religious education; village of Fu Jen Chai has a strong Christian community; the church they built; Christmas activities; news of other missionaries; included a photo of Chinese children; 3. Letter dated 11 February 1934 from Emma Boose Tucker to her children, noting death of husband\u27s sister; trip to Tsinan and Tientsin for synod/retreat; news of other missionary families, including health problems, departures, schooling of their children; detailed account of the 11 days at Tientsin; trip home included running out of gas; news of other family friends; Ellises in Farmdale, Ohio; 4. Letter dated 25 February 1934 from Hugh Hubbard at Paotingfu to "home folks," mentioning duck hunting with a Chinese friend; work teaching Chinese women, may lead to a permanent school; further bad financial news from the American Board, may require dismissing several missionaries; 5. Letter dated 4 March 1934 from Altie C. (Mrs. Elmer W.) Galt at Fenchow to Susan Sargent, thanking the "lady doctor" for letter and donation; reference to the Wilburs; financial difficulties of the American Board includes dismissing Chinese workers; Galts will go on furlough, traveling via Kobe, Seattle, San Francisco, and Grinnell; children finishing school in China; Letter dated 18 March 1934 from Mabel Ellis Hubbard at Paotingfu to her mother, written on back of husband Hugh Hubbard\u27s typed family letter, noting that Emery and Minnie Ellis will be at Oberlin, and Hubbards are debating where to send son Wells for colleg
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