3,632 research outputs found
EARLY PREDICTION OF SUBCLINICAL VASCULAR DAMAGE IN RISKY POPULATIONS
No full textBackground. Atherosclerosis is a progressive disease that starts during adoles-cence and exerts its negative effects later in life. High blood pressure is one of the principal risk factors for cardiovascular disease. Central blood pressure is the pressure that directly insists and other major arteries and is linked to target organ damage and cardiovascular events. The aim of the thesis was to assess the role of traditional and novel risk factors (central blood pressure, cBP) on children and adolescents with type I diabetes (T1D; study number 1) and in children and ado-lescents with solitary functional kidney (SFK; study n.2). Methods. Carotid intima-media thickness (cIMT), carotid distensibility coeffi-cient (cDC), and carotid-femoral pulse wave velocity (PWV), were measured in children and adolescents with T1D and SFK. Blood Pressure (BP; both central and peripheral), echocardiographic measurements, biochemical data from blood and urine sample and other cardiovascular risk factors were evaluated in multi-variate linear regressions to assess the association with the measured indices of subclinical vascular damage. Results study 1. One hundred and twenty-six children and adolescents with T1D were included. cIMT was above the 95th percentile for age and height in 61% of the population. Bivariate correlations showed that cBP but not peripheral blood pressure (pBP) were positively associated with cIMT (r = 0.285; p = 0.001). In-dependent determinants of cIMT according to the regression models were only gender, type of glucose monitoring and central systolic BP (cSBP). PWV was as-sociated with age, sex, heart rate, and cSBP; cDC with age and both cSBP, and, alternatively, peripheral BP (pBP). Neither pBP nor any of the tested metabolic parameters, including glycated hemoglobin, were associated with PWV and cIMT. Results study 2. 48 SFK children and adolescents were included. Of them 50% had increased cIMT. cBP was correlated with all vascular indices measured and with the left ventricular mass (r = 0.417; p = 0.005) but not with RWT. pBP cor-related with distensibility, with PWV and with the LVMi. Daytime systolic blood pressure was found to be associated with all vascular indices but not with echo-cardiographic ones. BMI correlated with the variables indicative of organ dam-age and with many pressure variables. No correlation was found between the vas-cular or echocardiographic indices and either estimated glomerulaf filtration rate or urinary albumin to creatinine ratio. In linear regression pBP were not associat-ed with the above-mentioned vascular variables whereas cBP was positively as-sociated with cIMT (even when we consider z-score values). To the contrary, cDC and PWV were not associated with cBP. In binary logistic regression analy-sis, cBP was a predictor for increased cIMT. Conclusions: Taken together, our data show a high prevalence of increased cIMT in children and adolescents with T1D and SFK. cBP more than pBP or other tra-ditional risk factors associates with subclinical organ damage
Subclinical Organ Damage in Children and Adolescents with Hypertension: Current Guidelines and Beyond
No full textHigh blood pressure (BP) is becoming a growing health issue even in children and adolescents. Moreover, BP elevation in youth frequently translates into children and adult hypertension contributing to the development of cardiovascular disease. The detection of early markers of vascular damage, potentially leading to overt cardiovascular disease, is important for clinical decisions about if and how to treat hypertension and can be useful in monitoring the effectiveness of the treatment. The purpose of this review is to summarize the actual knowledge about subclinical organ damage (SOD) in hypertensive children and adolescents and its association with cardiovascular disease in children and young adults. Our focus is especially put on left ventricular mass, pulse wave velocity, carotid intima-media thickness and microalbuminuria. We also want to address the scientific evidence about possible regression of SOD and cardiovascular risk with the use of behavioural and specific anti-hypertensive therapy. Indications from current guidelines are critically discussed
THE INTAKE OF OMEGA-3 PUFA IS NOT ASSOCIATED WITH SUBSTANTIAL CHANGES OF BLOOD PRESSURE EVEN CONSIDERING THE INTERACTION WITH SOME GENE POLYMORPHISMS.
No full textBackground. A higher intake of polyunsaturated fatty acids (PUFA) omega-3 has been associated with lower blood pressure (BP). Their antihypertensive properties could be due to the reduction of the omega-6/omega-3 ratio and consequent competitive effect of omega-3 compared to arachidonic acid (the main omega-6 PUFA). In fact both act as substrate of cytochrome P450 (CYP450), enzymes involved in the production of vasoactive mediators such as 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs). Some polymorphisms (SNPs) in genes that encode for these CYPs were associated with the development of hypertension and ischemic stroke in a Swedish population. The aim of this study was to evaluate if food intake of omega-3 and omega-6 PUFA has a favorable effect on blood pressure, also considering the interaction with different SNPs in genes involved in their metabolism.Methods. We analyzed the change in BP over time (mean follow-up 16.7 ± 1.5 years) in a subset of subjects enrolled in the Malmö Diet and Cancer Study (n = 3632) in relation to PUFA intake, detected by a validated questionnaire, and the their possible interaction with some functional polymorphisms in the CYP4F2, CYP4A11, CYP2J2, CYP2C8 and EPHX2 genes. We repeated the analysis after excluding subjects under antihypertensive therapy (leaving n = 2272 available for the analysis) and in different genders.Results. We did not find any association between the intake of omega-3, omega-6 or their ratio and longitudinal change of BP. After adjustment for the number of statistical tests, we did not observe any effect on blood pressure by the interaction of different assumption of PUFAs and and different genotypes. Neither the exclusion of subjects under chronic antihypertensive therapy or the analysis of males and females separately changed the results.Conclusion. In a Swedish population followed longitudinally, intake of PUFA showed no detectable effect on BP, also after considering a possible interaction with functional SNPs in genes involved in their metabolism. Further studies will be needed to clarify whether and in which individuals PUFA have a beneficial effect on BP
Professor Angela Shannon
No full textAngela Shannon shares her poetry with the Taylor community.
Angela Shannon is the author of Singing the Bones Together, a 2004 Minnesota Book Awards Finalist. She teaches English at Bethel University. Her work has been published in journals, textbooks, and anthologies, including TriQuarterly, Ploughshares, Where One Ends Another Begins: 150 Years of Minnesota Poetry, and Beyond the Frontier: African American Poetry for the 21st Century. Her choreopoem Root Woman premiered at the Fleetwood-Jourdain Theater in Evanston, Ill
Angela Shanté : 2022 Irma Black Award Silver Medal Acceptance Speech
No full textAuthor Angela Shanté gives an acceptance speech for When My Cousins Come to Town, illustrated by Keisha Morris (West Margin Press)https://educate.bankstreet.edu/irma_black_awards/1004/thumbnail.jp
Onset of Addison Disease appeared during the first trimester of a twin pregnancy: A case report
No full textKey Clinical MessageAddison Disease is an uncommon, life-threatening condition affecting people at any age, including women during pregnancy. If left untreated, the disease can be rapidly fatal, but the prognosis is good if promptly recognized and hormones are replaced
The Family History of Angela Ruth Weidert
No full textAngela Ruth Weidert authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Spring 2018 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
Snoring in a cohort of obese children: association with palate position and nocturnal desaturations
No full textPurpose of the study: Frequency of habitual snoring is significantly higher in obese than in normal-weight subjects. Obesity and adeno-tonsillar size are risk factors of snoring. Other factors, such as fat distribution and upper airway collapsibility, could explain the relationship between obesity, snoring and obtructive sleep apneas. The aim of the study was to investigate clinical and instrumental significance of snoring in exogenous obese children referred to our department.
Methodology: This preliminary study takes part of a larger prospective respiratory sleep study. In 36 consecutive obese children (18 males), body mass index (BMI), BMI Z score and neck circumference were calculated according to age and sex. Nasal patency, tonsil size, palate position scoring were also recorded. An overnight polygraphy was performed using a portable ambulatory device. Statistical analysis was done using SPSS® Statistics 19.0 software for Windows®.
Main findings: Snoring, objectively measured by polygraphy, was associated with palate position and with oxygen desaturation index (ODI). The correlation between snoring and ODI completely disappeared when adjusting for palate position scoring.
Key conclusions: Low palate position can be identified as an adjunctive, although not unique, factor that can contribute to making snoring and increased desaturation events possibly related to increased risk of upper airway collapsibility during sleep in obese children
Materia-autore = Author-Matter
No full textThe etymology of the word author refers to an act of creation, an act of augmentation, from the Latin verb augere. Author instantiates creation, the expansion of the pre-existing. In 1967 Roland Barthes declared the death of the author in his famous essay to state once more that the crisis is that of the author as a single subjectivity and as a term that condenses prestige, undermined by the de-subjectivation strategies of automatism, fortuity and fragmentation of the historical avant-gardes, as well as by the machinic act and by the reproducibility of the second avant-gardes.
Fifty years after Barthes’ paradigmatic formula, this lack of authorship appears to be a successful brand. The ten- sions between the anomie of matter, the law that establishes authorship and the economy that makes the work pos- sible, invoke discordant perspectives. Artists make the self-destruction of their work the real work, and appeal is made for the demolition of architectures, whether by a recognised author or not, in order to re-design, or better still, re-claim the territory. Artificial intelligence consolidates its logics and its design by progressively shedding human ingenuity. The space of criticism becomes, finally, increasingly ephemeral. However, there is an acceptation of criti- cism that is, rather than an individual ‘signature’, an exploration and explanation of how design makes theory.
The binomial author-matter seeks to mark these tensions and contradictions: the featured term author is main- tained to underline the persistence of that prestigious subjectivity, at the very moment when the rhetoric of “mat- ter as an author” promises other forms of authorship
Giussani Sansoni, Angela
No full textLa scheda ricostruisce la vita e l'apporto della scrittrice Angela Giussani Sansoni alla letteratura per l'infanzia.The headword explains the biography and the contribution of the author Angela Giussani Sansoni to the children's literature
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