117,710 research outputs found
Traduzione e autotraduzione: un percorso attraverso i generi letterari
No full textNel novembre del 2012 si celebrava a Pisa un convegno internazionale, articolato tra la Scuola Normale Normale Superiore e il Dipartimento di Filologia, Letteratura e Linguistica dell'Università. Due intense giornate di dibattito sulla traduzione poetica, narrativa, saggistica, con un occhio al teatro, alla didattica e all’autotraduzione. Questo volume prende avvio proprio da quel proficuo scambio di idee, raccogliendo alcuni degli interventi presentati in quella occasione e dando altresì spazio a nuovi contributi che, per una ragione o per l’altra, non si erano potuti includere nel novero delle comunicazioni dal vivo. Un nuovo percorso, dunque, ricordo di quei giorni di studio, che, sulla falsa riga di quelli, ci conduce attraverso l’intricato e intrigante campo della traduzione.
Con interventi di: Benedetta Campennì, Federica Cappelli, Elena Carpi, Arlindo J. N. Castanho, Daniele Corsi, Giorgio De Marchis, Gian Luigi De Rosa, Sónia Duarte, Joaquim Feio, Giovanna Fiordaliso, Lisa Franchini, Alessandra Ghezzani, Alessandro Ghignoli, Francesca Giannelli, Marco E. L. Guidi, Matteo Lefèvre, Elisa Lupetti, Monica Lupetti, Rebecca Martignoni, Luisa Selvaggini, Stefania Stefanelli, Tommaso Testaverde, Valeria Tocco, Giampaolo Vincenz
Phosphodiesterase specific inhibitors control cell growth of a human neuroepithelioma cell line
No full textThe effects of cyclic nucleotide phosphodiesterase (PDE) inhibitors on cell
proliferation of SK-N-MC human neuroepithelioma cell line was studied. Clonal
density experiments in the presence of 100 microM rolipram and zaprinast showed
respectively 27% and 91% inhibition. The effects of PDE inhibitors were then
investigated on crude cell extracts; the calculated IC50 were 32 microM for
zaprinast and 16 nM for DC-TA-46; the latter inhibitor was used instead of
rolipram for its higher efficacy. Dose-response experiments in clonal density
conditions showed IC50 of 5 microM and 1.8 microM in the presence respectively of
zaprinast and rolipram. These data show that both inhibitors are effective in
reducing cell growth, although the response was quantitatively different
Attachment style and perception of affective touch in patients with anorexia nervosa
No full textreservedIn questo elaborato vorrei esplorare il legame tra lo stile di attaccamento e la percezione tattile affettiva in pazienti con anoressia nervosa, partendo dal modello di Keizer che descrive i fattori transdagnostici che potenzialmente influiscono sulla percezione della piacevolezza del tocco ottimale CT. Keizer illustra la correlazione tra le esperienze tattili esperite durante l’infanzia, la privazione del tocco, lo stile di attaccamento e la percezione di piacevolezza del tocco ottimale CT.
Uno stile di attaccamento disorganizzato si riflette nella percezione alterata del tocco affettivo, per cui in popolazioni psichiatriche possiamo notare una percezione anomala in seguito a una stimolazione tattile affettiva. I pazienti affetti da anoressia nervosa sviluppano solitamente uno stile di attaccamento di tipo disorganizzato e irrisolto, associato a anedonia e una ridotta piacevolezza percepita durante le interazioni sociali, correlata a un sistema afferente CT disfunzionale.
Inoltre in questi pazienti possiamo notare un deficit nell’interocezione che porta a una risposta inferiore durante l anticipazione del tocco associata a una maggiore insoddisfazione del corpo e valutazioni di intensità del tocco percepite più elevate.
Alla luce di ciò, sarebbe utile andare ad esplorare in che maniera interventi di prevenzione durante l’infanzia potrebbero andare a modificare le traiettorie di sviluppo.In this paper I would like to explore the link between the attachment style and the affective tactile perception in patients with anorexia nervosa, starting from Keizer's model that describes the trans-diagnostic factors that potentially influence the perception of the pleasantness of optimal CT touch. Keizer illustrates the correlation between tactile experiences during infancy, touch deprivation, attachment style, and the perception of pleasantness of CT optimal touch.
A disorganized attachment style is reflected in the altered perception of affective touch, so that in psychiatric populations we can notice an abnormal perception following an affective tactile stimulation. Patients with anorexia nervosa usually develop a disorganized and unresolved attachment style associated with anhedonia and a reduced perceived pleasantness during social interactions related to a dysfunctional CT afferent system.
Furthermore, in these patients we can note a deficit in interoception leading to a lower response during touch anticipation associated with higher body dissatisfaction and higher perceived touch intensity ratings.
In light of this, it would be useful to explore how preventive interventions in childhood could change the developmental trajectories
Brainstem Reflexes in Idiopathic Cervical Dystonia: Does Medullary Dysfunction Play a Role?
No full textBackground: Neurophysiological markers in dystonia have so far not been sistematically applied in clinical practice due to limited reproducibility of results and low correlations with clinical findings. Exceptions might be represented by the blink reflex (BR), including its recovery cycle (BRRC) and the trigemino-cervical reflex (TCR) which, compared to other neurophysiological methods, have shown more consistent alterations in cervical dystonia (CD). However, a comparison between the two techniques, and their possible correlation with disease symptoms, have not been thoroughly investigated. Objectives: To assess the role of BR, BRCC and TCR in the pathophysiology of idiopathic cervical dystonia. Methods: Fourteen patients and 14 age-matched healthy controls (HC) were recruited. Neurophysiological outcome measures included latency of R1 and R2 components of the BR, R2 amplitude, BRRC, latency and amplitude of P19/N31 complex of TCR. Clinical and demographic features of patients were also collected, including age at disease onset, disease duration, presence of tremor, sensory trick and pain. The Toronto Western Spasmodic Torticollis Rating Scale was used to characterize dystonia. Results: Compared to HC, CD patients showed increased latency of the BR R2 and decreased suppression of the BRRC. They also showed increased latency of the P19 and decreased amplitude of P19/N31 complex of TCR. The latency of P19 component of TCR was positively correlated with disease duration. Conclusions: We propose that the increased latency of R2 and P19 observed here might be reflective of brainstem dysfunction, mediated either by local interneuronal excitability changes or by subtle structural damage
Zinc Oxide: a new tool for the solvent free regioselective C-arylsulfonation of Indoles
No full texttrans-Resveratrol is a natural phenolic component of Vitis vinifera L. (Vitaceae). It has shown a number of biological activities, including protection against coronary heart disease, as a result of different effects: significant antioxidant activity, modulation of lipoprotein metabolism, vasodilatatory and platelet antiaggregatory properties. Recently we have reported the synthesis of a series of resveratrolo-coumarine hybrids that showed interesting vasorelaxant and platelet antiaggregatory activities [1,2].
In an attempt to prepare more active heterocyclic derivatives which incorporate the nucleus of the resveratrol, we synthesised a new series of 2-arylbenzofurane derivatives by an intramolecular Wittig reaction starting from the appropriate triphenylphosphonium salt and the corresponding aroyl chloride. The desired Wittig reagent was readily prepared from the conveniently substituted 2-hydroxy-benzyl alcohol and triphenylphosphine hydrobromide (Figure 1) [3].
However, while developing our methodology, we observed, together with the desired 2-arylbenzofurane derivatives with the general stricture 1, the formation of the side products 2 in a ratio ranging from 2:1 to 8:1.
To get insight on the structure and on the mechanism of formation of these side reaction products, we decided to undertake a mass spectrometric study using an ion trap mass spectrometer operating under both EI and CI conditions. In particularly, MS/MS experiments were performed on the molecular ions and on the diagnostic fragment ions generated by the side products 2 as well as by the side product synthesised from labelled starting aroyl chloride. The data so obtained were consistent with the aroyl-benzofurane structure, a scaffold of many pharmaceutical drug candidates [4], thus allowing us to discover and develop a new and convenient approach to the preparation of this class of active compounds
Title: Necrotizing Fasciitis: classification, diagnosis and management
No full textNecrotizing fasciitis (NF), a life-threatening rare infection of the soft tissues, is a medical and surgical emergency. It is characterized by subtle, rapid onset of spreading inflammation and necrosis starting from the fascia, muscles, and subcutaneous fat, with subsequent necrosis of the overlying skin. Once suspected, immediate and extensive radical debridement of necrotic tissues is mandatory. Appropriate antibiotics and intensive general support avoid massive systemic diffusion of the infective process and are the key for successful treatment. However, early diagnosis is missed or delayed in 85% to 100% of cases in large published series: because of the lack of specific clinical features in the initial stage of the disease, it is often underestimated or confused with cellulitis or abscess. Mortality rates are still high and have shown no tendency to decrease in the last 100 years. Unfortunately, the prevalence of the disease is such that physicians rarely become sufficiently confident with NF to be able to proceed with rapid diagnosis and management. This review covers the literature published in MEDLINE in the period 1970 to December 31, 2010. Particular attention is
given to the clinical and laboratory elements to be considered for diagnosis. A wide variety of diagnostic tools have been described to facilitate and hasten the diagnosis of NF, but the most important tool for early diagnosis still remains a high index of clinical suspicion
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Ipotesi di riqualificazione funzionale di una cava di sabbia a Quartu S. Elena (Provincia di Cagliari)
No full text- …
