300 research outputs found
El fundherentismo: la epistemología de Susan Haack
No full textIn this article, the author wishes to present Susan Haack’s epistemological proposal that aims to locate it in the middle between foundationalism and coherentism. The foundationalism asserts the existence of fundamental core beliefs. Instead coherentism believes consistency is enough to justifybeliefs. Haack sees insufficient both proposals and presents a new model to save the best of the other two: the foundherentism. The author explains that this proposal is directed towards two objectives: the problem of the justification of our beliefs and the problem of truth. Since the proposal itself is interesting, but it’s more interesting to see this new epistemology makes by a woman philosopher, with new visions and new perspectives as her contribution.En este artículo, el autor desea presentar la propuesta epistemológica de Susan Haack la misma que pretende ubicarse en el intermedio entre el fundacionalismo y el coherentismo. El fundacionalismo sostiene la existencia de creencias básicas fundamentales. El coherentismo en cambio cree suficiente la coherencia como justificación de las creencias. Haack encuentra insuficientes ambas propuestas y presenta un nuevo modelo que salve lo mejor de los otros dos: el fundherentismo. El autor explica que dicha propuesta se dirige hacia dos objetivos: el problema de la justificación de nuestras creencias y el problema de la verdad. Ya la propuesta misma es interesante, pero es más relevante ver esta nueva mirada para la epistemología cuando consideramos que viene de parte de una filósofa con sus nuevas visiones y nuevas perspectivas como su aporte
Susan Haack on Twardowski’s refutation of the relativity of truth
No full textThis paper comments Susan Haack’s remarks about Twardowski’s criticism of relativism in the theory of truth. The author summarizes Twardowski’s arguments for truth-absolutism and tries to show that that their presentation by Haack is incomplete. The defense of Twardowski’s position in the paper uses ideas developed by Tarski and Kokoszyñska
Expanding the phenotype of <em>DNAJC3 </em>mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration.
No full textIdentification of this additional patient from a distant part of the originally described pedigree (Synofzik et al. 2014) confirms pathogenicity of DNAJC3 mutations. Hypothyroidism is a newly identified feature in addition to the known phenotype (diabetes with multisystemic neurodegeneration)
El símbolo en la obra visual/verbal de Milagro Haack
No full textThe focus of this article is to approach the symbol in the visual / verbal work of Milagro Haack. It is based on the practical precepts of hermeneutics in Gadamer's vision through his work: The actuality of the beautiful: Art as a game, symbol and party (1991) for these purposes, only the symbol is taken for being an experience anthropological art. For correspondences they are used in various collages, drawings, poems and essays by the same author. It was concluded that the symbol responds to visual / verbal correspondences because there are alternatives that cross meanings by causing transpositions in the verbal representation of the images. This leads to a perception that inaugurates the previous Being in a system of equivalences demarcated by an ecphrastic line that draws the existential experience inward and, at the same time, creates a powerful imaginary exterior. But, the meaning is confused by the hermeticism of the word but not of the image. This approach to the category of the symbol due to its complexity still needs to be resolved by other researchers.El centro de interés de este artículo es realizar un acercamiento al símbolo en la obra visual/verbal de Milagro Haack. Se basa en los preceptos prácticos de la hermenéutica en la visión de Gadamer a través de su obra: La actualidad de lo bello: El arte como juego, símbolo y fiesta (1991) para estos fines, solo se toma el símbolo por ser una experiencia antropológica del arte. Para las correspondencias se utilizaron varios collages, dibujos, poemas y ensayos de la misma autora. Se concluyó que el símbolo responde a las correspondencias visuales/verbales porque existen alteridades que cruzan las significaciones al provocar transposiciones en la representación verbal de las imágenes. Esto conduce a una percepción que inaugura al Ser anterior en un sistema de equivalencias demarcadas por una línea ecfrástica que traza la experiencia existencial hacia adentro y, al mismo tiempo, crea un poderoso imaginario exterior. Pero, el sentido se tiende confuso por el hermetismo de la palabra más no de la imagen. Este planteamiento de la categoría del símbolo por su complejidad aún requiere ser resuelta por otros investigadores. Recibido: 07-04-2019 Aceptado: 01-06-201
O Quebra-Cabeça do Método Científico
No full textTranslated by Luiz Henrique de A. Dutra, UFSC. This is a translation of 'The Puzzle of "Scientific Method"', published in Revue Internationale de Philosophie (Issue on Quine), vol. 51 (1997), pp. 495–505. We thank the author and the editors for their kind permission to publish the present translation
México. Serie Cartas Generales
No full textContiene orografía, hidrografía, vías férreas, división política y poblaciones
LINS1-associated neurodevelopmental disorder family with novel mutation expands the phenotypic spectrum.
No full textObjective Clinical, neuroimaging, and genetic characterization of 3 patients with LINS1-associated developmental regression, intellectual disability, dysmorphism, and further neurologic deficits. Methods Three affected brothers from a consanguineous family from Afghanistan, their 2 healthy siblings, and both parents were all assessed in the clinic. General and neurologic examination, expert dysmorphology examination, and 3T brain MRI were performed. Whole-exome sequencing was performed for the 3 affected brothers, followed by Sanger sequencing in all available family members. Results The index patient and his 2 affected brothers presented a complex neurologic syndrome with similar features but marked intrafamilial phenotypical variability, including varying degrees of cognitive impairment, speech impairment, dystonia, abnormal eye movements, and dysmorphic features. All 3 affected brothers are homozygous for a novel, pathogenic frameshift mutation in LINS1, c.1672_1679del, and p.Gly558Profs*22, whereas both parents and healthy siblings are heterozygous for the mutation. No major brain malformations were evident in 3T brain MRI of the affected brothers. Conclusion This consanguineous family with a novel mutation expands the spectrum of LINS1-associated disorder to include developmental regression, oculomotor signs, and dystonia, previously not described in the published 9 cases of this rare disorder. The 3T-MRI data from our 3 patients and review of the neuroimaging data in the literature showed unspecific brain MRI changes. LINS1 protein is a known modulating factor of the Wnt signaling pathway, with important roles in organogenesis including of the cerebral cortex. More research is warranted to disentangle the underlying pathophysiologic mechanisms, leading to cognitive impairment and the complex phenotype of LINS1-associated disorder
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A Match Made on Earth: Getting Real About Science and the Law
No full textModern legal systems increasingly depend on scientific testimony; but they also need somehow to ensure, so far as possible, that fact-finders aren\u27t misled by highly speculative, poorly-conducted, or dishonestly-presented science. The Critical Common-sensist understanding of science that the author has developed in Defending Science and elsewhere sheds some light on why these interactions between law and science have proven so problematic. But Ms. Acharya\u27s approach to these difficult issues rests on a flawed conception of the supposed scientificmethod, and an idea of legal legitimacy too weak to bear the weight she places on it; and her claim that the author idealizes science is based on serious misunderstandings
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy
No full textATP synthase or complex V (cV) of the oxidative phosphorylation system is responsible for the production of ATP, dissipating the electrochemical gradient generated by the mitochondrial respiratory chain. In addition to maternally transmitted cV dysfunction caused by mutations in mtDNA genes (MT-ATP6 or MT-ATP8), encoding cV subunits, recessive mutations in the nuclear TMEM70 are the most frequent cause of ATP synthase deficiency.
We report on a cohort of ten Italian patients presenting with neonatal lactic acidosis, respiratory distress, hypotonia, cardiomyopathy and psychomotor delay and harbouring mutations in TMEM70, including the common splice mutation and four novel variants. TMEM70 protein was virtually absent in all tested TMEM70 patients' specimens.
The exact function of TMEM70 is not known, but it is considered to impact on cV assembly since TMEM70 mutations have been associated with isolated cV activity reduction. We detected a clear cV biochemical defect in TMEM70 patients' fibroblasts, whereas the assay was not reliable in frozen muscle. Nevertheless, the evaluation of the amount of holocomplexes in patients with TMEM70 mutations showed a nearly absent cV in muscles and a strong decrease of cV with accumulation of sub-assembly species in fibroblasts. In our cohort we found not only cV deficiencies but also impairment of other OXPHOS complexes. By ultrastructural analysis of muscle tissue from one patient with isolated cV deficiency, we found a severely impaired mitochondrial morphology with loss of the cristae. These findings indicate that cV impairment could indirectly alter other respiratory chain comple
La integridad de la ciencia: significado e importancia
No full textRESUMENSe analiza la integridad de la ciencia, entendida como la firme adhesión a valores epistemoló- gicos. Los valores fundamentales considerados son el respeto por las pruebas y el intercambio de pruebas. Paralelamente se examinan las amenazas actuales a estos valores, en particular en el campo de la investigación biomédica y farmacéutica.PALABRAS CLAVEINVESTIGACIÓN BIOMÉDICA, VALORES EPISTEMOLÓGICOS, INTERCAMBIO DE PRUEBAS, RESPETO POR LAS PRUEBASABSTRACTThe integrity of science understood as the firm adherence to epistemological values is analysed in this paper. Respect for evidence and evidence-sharing are considered to be core values. At the same time, the author examines the current threats to these values, especially in the fields of biomedical and pharmaceutical research.KEYWORDSBIOMEDICAL RESEARCH, EPISTEMOLOGICAL VALUES, EVIDENCE-SHARING, RESPECT FOR EVIDENC
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