563 research outputs found
Habitusreflexion und reflexiver Habitus im diskursiven Widerstreit – grundlagentheoretische Überlegungen und empirische Annäherungsversuche
No full textWittek D, te Poel K, Lischka-Schmidt R, Leonhard T. Habitusreflexion und reflexiver Habitus im diskursiven Widerstreit – grundlagentheoretische Überlegungen und empirische Annäherungsversuche. In: Reintjes C, Kunze I, eds. Reflexion und Reflexivität in Unterricht, Schule und Lehrer:innenbildung. Studien zur Professionsforschung und Lehrerbildung. Bad Heilbrunn: Julius Klinkhardt; 2022: 39-57
Hochschuladäquat und berufsfeldbedeutsam? Professionalisierung durch Reflexion in der ersten Phase der Lehrer*innenbildung am Beispiel der Formate rekonstruktive Kasuistik und Lerntagebuch
No full textte Poel K, Schlag S, Lischka-Schmidt R, Hartung-Beck V, Wittek D, Bauer T. Hochschuladäquat und berufsfeldbedeutsam? Professionalisierung durch Reflexion in der ersten Phase der Lehrer*innenbildung am Beispiel der Formate rekonstruktive Kasuistik und Lerntagebuch. In: Reintjes C, Kunze I, eds. Reflexion und Reflexivität in Unterricht, Schule und Lehrer:innenbildung. Studien zur Professionsforschung und Lehrerbildung. Bad Heilbrunn: Julius Klinkhardt; 2022: 117-132
Author response to: Peak wall stress and peak wall rupture index in ruptured and asymptomatic intact abdominal aortic aneurysms
No full text[Extract] Dear Editor. The Townsville Hospital and Health Services Study, Education and Research Trust Fund, and Queensland Government supported this work. JG holds a Practitioner Fellowship from the National Health and Medical Research Council (1117061) and a Senior Clinical Research Fellowship from the Queensland Government, Australia. JVM holds an Advance Queensland Mid-Career fellowship from the Queensland Government. TPS holds a Junior Doctor Research Fellowship from the Queensland Government.
We thank Miller and Wittek for the correspondence related to our publication
Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope
No full textThe regulatory immediate-early (IE) protein pp89 of murine cytomegalovirus induces CD8+ T lymphocytes that protect against lethal murine cytomegalovirus infection. The IE1 epitope is the only epitope of pp89 that is recognized by BALB/c cytolytic T lymphocytes (CTL). Using synthetic peptides, the optimal and minimal antigenic sequences of the IE1 epitope have been defined. To evaluate the predictive value of data obtained with synthetic peptides, recombinant vaccines encoding this single T-cell epitope were constructed using as a vector the hepatitis B virus core antigen encoded in recombinant vaccinia virus. In infected cells expressing the chimeric proteins, only IE1 epitope sequences that were recognized as synthetic peptides at concentrations lower than 10(-6) M were presented to CTL. Vaccination of mice with the recombinant vaccinia virus that encoded a chimeric protein carrying the optimal 9-amino-acid IE1 epitope sequence elicited CD8+ T lymphocytes with antiviral activity and, furthermore, protected against lethal disease. The results thus show for the first time that recombinant vaccines containing a single foreign nonameric CTL epitope can induce T-lymphocyte-mediated protective immunity
Can Adverbs Call Attention to Manner of Motion for 2-year-olds Learning Verbs?
No full textIn the current experiment, we propose that adverbs may likewise confer an advantage in verb learning. To our knowledge, no studies have examined the role of adverbs in verb learning in toddlers, although Wittek (2002) demonstrated that the adverb again can support verb learning in certain contexts with 5-year-olds. To test our hypothesis, we adapted A&W’s paradigm, identifying their Sparse Content condition (in which toddlers performed at chance, showing no evidence of verb learning) as an excellent testing ground for our hypothesis. We reasoned that a manner-of-motion adverb would highlight aspects of the event, and therefore aspects of the verb’s meaning
Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89
No full textThe murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells. Protection of BALB/c (H-2d) mice against a lethal murine cytomegalovirus challenge infection is achieved by vaccination with a recombinant vaccinia virus, MCMV-ieI-VAC, expressing pp89 as the only murine cytomegalovirus gene product. The protection is entirely mediated by T lymphocytes of the CD8+ subset. In the present report, we analyzed the molecular basis of the recognition of pp89 by BALB/c CD8+ cytolytic T lymphocytes. A series of internal and terminal deletion mutants of gene ieI was constructed and cloned in vaccinia virus, and the antigenicity and immunogenicity of the fragments of pp89 expressed by the recombinants were studied. A region of only one-sixth of the protein, from amino acids 154 to 249 and encoded by the fourth exon of gene ieI, was sufficient for both the recognition in vitro of the protein by pp89-specific cytotoxic T lymphocytes and the induction in vivo of pp89-specific cytotoxic T lymphocytes. By using synthetic peptides, the sequence between residues 161 and 179, which is located within the defined domain, was identified as an epitope presented to BALB/C cytotoxic T lymphocytes by the class I major histocompatibility antigen Ld
Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
No full textAlthough the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain conditions the CD8+ T-lymphocyte subset can be dispensable for clearance of cytomegalovirus. Mice depleted of the CD8+ T-lymphocyte subset eliminated infectious virus with a clearance kinetics similar to that of normal mice. Adoptive transfer studies revealed that the limitation of virus spread required the cooperation between the CD4+ subset and other cells. Comparison between protective functions generated in fully immunocompetent and in CD8- mice demonstrated that elimination of the CD8+ subset before infection altered the quality of the antiviral immune response. The compensatory protective activity gained by CD4+ cells in CD8- mice was absent in normal mice recovering from virus infection
Learning the meaning of change-of-state verbs : a case study of German child language
No full textCausative change-of-state verbs like 'to open', 'to fill', and 'to wake' are central to both recent theories of grammatical development and theories of lexical structure. This book focuses on how German-speaking children learn the meaning of change-of-state verbs. It offers a thorough characterization of the acquisition of German, embedded in a crosslinguistic perspective. The author provides a comprehensive review of the acquisition literature on that topic and introduces a new account as to how the meaning of these verbs can be learned. The empirical backbone of the investigation are a set of carefully designed experimental studies
Agent-Based Computational Models of Reputation and Status Dynamics
No full textSocial scientists increasingly construe social life as a complex dynamic process, in which macro-level properties of social systems can emerge from individual’s actions in unexpected, unintended, and possibly undesirable ways. Reputation and status differentiation are important examples. This chapter discusses how agent-based computational modelling (ABCM) can be used to better understand the social processes by which the behavioural dynamics that underlie reputation formation can generate social inequality and contribute to status differentiation. The chapter begins with elaborating the foundations of ABCM and subsequently discusses a number of ABCM examples that address the emergence of reputation and status differentiation from simple but fundamental rules of social behaviour and interaction. To further illustrate the method, the chapter presents a formal model that explains the emergence of status differentiation from reputation formation. It closes with a discussion of important future directions in this area, in particular the role that gossip might play in future ABCM work on reputation and status.sponsorship: The work of the first author received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement no. 312290 for the GENDERBALL project.status: Publishe
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