1,149 research outputs found
LUP877258 Supplemental Material - Supplemental material for Pregnancy outcomes in women with rheumatic diseases: a real-world observational study in Japan
No full textSupplemental material, LUP877258 Supplemental Material for Pregnancy outcomes in women with rheumatic diseases: a real-world observational study in Japan by E Sugawara, M Kato, Y Fujieda, K Oku, T Bohgaki, S Yasuda, T Umazume, M Morikawa, H Watari and T Atsumi in Lupus</p
A Questionnaire Study of Leadership in General Medicine: General Physicians in Japan are Facing Challenges in Education and Research [Response to Letter]
Get PDFRisa Hirata,1 Masaki Tago,1 Hiromizu Takahashi,2 Takashi Watari,3 Kiyoshi Shikino,4,5 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of General Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan; 3Integrated Clinical Education Center, Kyoto University Hospital, Kyoto, Japan; 4Department of General Medicine, Chiba University Hospital, Chiba, Japan; 5Department of Community-Oriented Medical Education, Chiba University Graduate School of Medicine, Chiba, Japan; 6Department of General Medicine and Emergency Care, Toho University School of Medicine, Tokyo, Japan; 7Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi, JapanCorrespondence: Masaki Tago, Department of General Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan, Tel +81 952 34 3238, Fax +81 952 34 2029, Email [email protected]
Duck Curve Aware Dynamic Pricing and Battery Scheduling Strategy Using Reinforcement Learning
Get PDFWatari D., Taniguchi I., Onoye T.. Duck Curve Aware Dynamic Pricing and Battery Scheduling Strategy Using Reinforcement Learning. IEEE Transactions on Smart Grid , (2023); https://doi.org/10.1109/TSG.2023.3288355.The duck curve is becoming a global problem in energy technology due to the rapid increase in solar power adoption and the rise of prosumers. To address this issue, a resource aggregator (RA) has emerged to provide flexible solutions through aggregating the prosumers and demand response such as dynamic pricing. This paper proposes an optimal strategy for the RA that dispatches dynamic pricing to the prosumers and leverages the battery system at both RA and prosumer levels. The proposed method is based on a model-free deep reinforcement learning (DRL) algorithm to optimize each prosumer’s retail prices and schedule usage of the RA’s battery power station. An objective reward function is used to maximize the RA’s profit, minimize the prosumer’s cost, and maximize the improvement of the duck curve. The performance of the proposed DRL-based strategy was demonstrated by simulation experiments using actual wholesale price, demand, and PV generation data. The results show that the proposed strategy can improve the standard deviation and peak-to-average ratio of net load by up to 57.1% and 23%, respectively
Precise Classification of Generalists is Necessary to Establish Evidence in General Medicine [Response to Letter]
Get PDFRisa Hirata,1 Masaki Tago,1 Kiyoshi Shikino,2,3 Takashi Watari,4 Hiromizu Takahashi,5 Yosuke Sasaki,6 Taro Shimizu7 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Department of General Medicine, Chiba University Hospital, Chiba, Japan; 3Department of Community-Oriented Medical Education, Chiba University Graduate School of Medicine, Chiba, Japan; 4Integrated Clinical Education Center, Kyoto University Hospital, Kyoto, Japan; 5Department of General Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan; 6Department of General Medicine and Emergency Care, Toho University School of Medicine, Tokyo, Japan; 7Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi, JapanCorrespondence: Masaki Tago, Department of General Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan, Tel +81 952 34 3238, Fax +81 952 34 2029, Email [email protected]
Vector-like pairs and Brill–Noether theory
No full textAbstractHow likely is it that there are particles in a vector-like pair of representations in low-energy spectrum, when neither symmetry nor anomaly consideration motivates their presence? We address this question in the context of supersymmetric and geometric phase compactification of F-theory and Heterotic dual. Quantisation of the number of generations (or net chiralities in more general term) is also discussed along the way. Self-dual nature of the fourth cohomology of Calabi–Yau fourfolds is essential for the latter issue, while we employ Brill–Noether theory to set upper bounds on the number ℓ of vector-like pairs of chiral multiplets in the SU(5)GUT (5+5¯) representations. For typical topological choices of geometry for F-theory compactification for SU(5) unification, the range of 0≤ℓ≲4 for perturbative unification is not in immediate conflict with what is already understood about F-theory compactification at this moment
Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89
Get PDFThe murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells. Protection of BALB/c (H-2d) mice against a lethal murine cytomegalovirus challenge infection is achieved by vaccination with a recombinant vaccinia virus, MCMV-ieI-VAC, expressing pp89 as the only murine cytomegalovirus gene product. The protection is entirely mediated by T lymphocytes of the CD8+ subset. In the present report, we analyzed the molecular basis of the recognition of pp89 by BALB/c CD8+ cytolytic T lymphocytes. A series of internal and terminal deletion mutants of gene ieI was constructed and cloned in vaccinia virus, and the antigenicity and immunogenicity of the fragments of pp89 expressed by the recombinants were studied. A region of only one-sixth of the protein, from amino acids 154 to 249 and encoded by the fourth exon of gene ieI, was sufficient for both the recognition in vitro of the protein by pp89-specific cytotoxic T lymphocytes and the induction in vivo of pp89-specific cytotoxic T lymphocytes. By using synthetic peptides, the sequence between residues 161 and 179, which is located within the defined domain, was identified as an epitope presented to BALB/C cytotoxic T lymphocytes by the class I major histocompatibility antigen Ld
Geometric Origin of Large Lepton Mixing in a Higher Dimensional Spacetime
No full textThe large mixing in the lepton sector observed in the recent neutrino-oscillation experiments strongly suggest that nature of left-handed lepton doublets is very different from that of left-handed quark doublets. This means that there is a big disparity between the matter multiplets 5^*'s and 10's in the SU(5) unified theory. We show that this big difference can be explained in a six-dimensional spacetime compactified on the T^2/Z_3 orbifold. That is, we propose to put three families of 5^*'s on three equivalent fixed points of the orbifold and the three 10's in the two-dimensional bulk. We construct an explicit model realizing this situation and show that the democratic mass structure in the lepton sector is naturally obtained and hence the model explains the observed bi-large lepton mixing and simultaneously the required small mixing U_e3. The mass matrices and mixing in the quark sector are also briefly discussed.The large mixing in the lepton sector observed in the recent neutrino-oscillation experiments strongly suggest that nature of left-handed lepton doublets is very different from that of left-handed quark doublets. This means that there is a big disparity between the matter multiplets 5^*'s and 10's in the SU(5) unified theory. We show that this big difference can be explained in a six-dimensional spacetime compactified on the T^2/Z_3 orbifold. That is, we propose to put three families of 5^*'s on three equivalent fixed points of the orbifold and the three 10's in the two-dimensional bulk. We construct an explicit model realizing this situation and show that the democratic mass structure in the lepton sector is naturally obtained and hence the model explains the observed bi-large lepton mixing and simultaneously the required small mixing U_e3. The mass matrices and mixing in the quark sector are also briefly discussed.The large mixing in the lepton sector observed in the recent neutrino-oscillation experiments strongly suggests that nature of left-handed lepton doublets is very different from that of left-handed quark doublets. This means that there is a big disparity between the matter multiplets 5 ∗ 's and 10 's in the SU(5) unified theory. We show that this big difference can be explained in a six-dimensional spacetime compactified on the T 2 / Z 3 orbifold. That is, we propose to put three families of 5 ∗ 's on three equivalent fixed points of the orbifold and the three 10 's in the two-dimensional bulk. We construct an explicit model realizing this situation and show that the democratic mass structure in the lepton sector is naturally obtained and hence the model explains the observed bi-large lepton mixing and simultaneously the required small mixing U e 3 . The mass matrices and mixing in the quark sector are also briefly discussed
A Solution to the Doublet-Triplet Splitting Problem in the Type IIB Supergravity
No full textThe doublet--triplet mass splitting problem is one of the most serious problems in supersymmetric grand unified theories (GUTs). A class of models based on a product gauge group, such as the SU(5)_{GUT} times U(3)_H or the SU(5)_{GUT} times U(2)_H, realize naturally the desired mass splitting that is protected by an unbroken R symmetry. It has been pointed out that various features in the models suggest that these product-group unification models are embedded in a supersymmetric brane world. We show an explicit construction of those models in the supersymmetric brane world based on the Type IIB supergravity in ten dimensions. We consider T^6/(Z_{12} times Z_2) orientifold for the compactified six extra dimensions. We find that all of the particles needed for the GUT-symmetry-breaking sector are obtained from the D-brane fluctuations. The three families of quarks and leptons are introduced at an orbifold singularity, although their origin remains unexplained. This paper includes extensive discussion on anomaly cancellation in a given orbifold geometry. Relation to the Type IIB string theory, realization of R symmetry as a rotation of extra-dimensional space, and effective superpotential at low energies are also discussed
Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection.
Get PDFCXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans. In spite of the important role that CXCR4 plays in infection with feline immunodeficiency virus, expression on PBMC in vivo was unaffected by infection with either a primary or a cell culture-adapted virus strain
Capture of bacteria by flexible carbon nanotubes
Get PDFCapture of bacteria with flexible carbon nanotubes (CNTs) was done in vitro. Bundles of single-walled carbon nanotubes (SWCNTs) or multi-walled carbon nanotubes (MWCNTs) was mixed with Streptococcus mutans. Precipitation assays and colony-forming unit formation assays showed free S. mutans in the solution was significantly decreased by the addition of the CNTs. Observation of the precipitate by scanning electron microscopy showed bacterial adhesion to CNTs. It has been shown that CNTs of different diameters have significantly different effects on the precipitation efficiency, and the manners in which they capture the cells are different. We found that MWCNTs (diameter of approximately 30 nm) had the highest precipitation efficiency, which was attributable to both their adequate dispersibility and aggregation activity. From observations by scanning electron microscopy, bundles of SWCNTs and thin MWCNTs (diameter of approximately 30 nm), which were moderately flexible, were easily wound around the curved surface of S. mutans. Bare CNTs having high adhesive ability could be useful as biomaterials, e.g., as tools for the elimination of oral pathogens at the nano-level
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