3,127 research outputs found
Human-data interaction in healthcare
No full textIn this chapter, we focus on an emerging strand of IT-oriented research, namely Human-Data Interaction (HDI) and on how this can be applied to healthcare. HDI regards both how humans create and use data by means of interactive systems, which can both assist and constrain them and the operational level of data work, which is both work on data and by data. Healthcare is a challenging arena where to test the potential of HDI towards a new, user-centered perspective on how to support and assess “data work”. This is especially true in current times where data are becoming increasingly big and many tools are available for the lay people, including doctors and nurses, to interact with health-related data. This chapter is a contribution in the direction of considering health-related data through the lens of HDI, and of framing data visualization tools in this strand of research. The intended aim is to let the subtler peculiarities among different kind of data and of their use emerge and be addressed adequately. Our point is that doing so can promote the design of more usable tools that can support data work from a user-centered and data quality perspective and the evidence-based validation of these tools
Designing Solutions for the Commons
No full textThe regeneration of the commons occurs through direct involvement of groups of people who interact closely with spaces, and who aim to improve the overall quality of life and experiences connected with those spaces. This process starts from an increased consciousness towards places that do not belong to the private realm but are public or can potentially be used by the society Revealing the commons means being aware of the potentialities of these “hidden places” to not only connect people with them, but for people to also create a previously unknown sense of community and ownership among themselves. By showing best practices developed by the Polimi DESIS Lab in the city of Milan and its surroundings, this paper reveals: how design relates to this process; the relationship between the time of involvement and the effectiveness of the results the short- and long-term impacts of these interventions; and the legacy of the regeneration, including both failures and successes
System-Events Toolbox. Designing a System of Events that Relies on Local Resources to Create Urban Places for Social Cohesion
No full textThis chapter is a reflection on the use of public spaces in towns and the development of a system-events toolbox to make them places of social cohesion. It is the result of a 3-year action research developed together with POLIMI DESIS Lab of the Department of Design to develop design solutions to open up the public spaces of the campus to its surrounding neighborhood. The results have been tested in an event format called “il Sabato della Bovisa” held at the “Durando Campus” of the Politecnico di Milano. It presents a series of initiatives to understand, observe, and benefit designed by members of a public university to trigger a process of knowledge exchange between local residents and students in a climate of conviviality
A folkloristic image of homeland in the novel „The Issa valley“ by Czesław Miłosz
No full texte-ISSN 2029-8692The article reveals that the novel The Issa valley by Czesław Miłosz aims to represent the Issa valley as a preserver of an archaic cultural heritage, mainly by using folklore genres which have preserved mythical thinking (mythological songs, belief legends and historical legends). It may be observed that nearly all folklore material at least in some detail is associated with the river Issa – the fulcrum of the represented world. In the novel, folklore material is employed when the author seeks to reveal a junction of paganism and Christianity and the battle between them, which continues both in the collective world outlook of the inhabitants of the Issa valley and in the inner world of a particular person. Orienting himself to folkloristic prototypes, the author in his novel epitomizes individual characters. Moreover, the article discloses that mythological songs about the Sun and the Moon, which in the novel are introduced as registered on the river Issa (Nevėžis is a prototype of Issa), in reality are taken from a song collection by L. Rėza Dainos oder Litthauische Volkslieder (1825), published in Lithuania Minor.Kultūrų studijų katedra / Department of Cultural StudiesHumanitarinių mokslų fakultetas / Faculty of HumanitiesVytauto Didžiojo universitetas / Vytautas Magnus Universit
IssA activity; MALDI-TOF MS
No full textMALDI-TOF MS-based protease assays. Each reaction consists of 1mM substrate peptide and 1 micromolar IssA protease (IMG GeneID 2558297680; purified from heterologous Pichia pastoris). Reaction buffer was 10 mM sodium acetate, pH 5.2. figure 5a = canonical flg22 as substrate (QRLSTGSRINSAKDDAAGLQIA)figure 5b = Dyella japonica MF79 flg22 as substrate (ERLSSGMRINSAKDDAAGLAIS)figure 5c = AtPEP1 from Arabidopsis thaliana as substrate (ATKVKAKQRGKEKVSSGRPGQHN)figure 6s= canonical flg22 substrate as in figure 5a, but IssA was either inactivated by treatment with PMSF or mock treated.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Ecological Role of Dry-Habitat Chimpanzees (Pan troglodytes schweinfurthii) at Issa, Ugalla, Tanzania
No full textabstract: Identifying the ecological role, or niche, that a species occupies within their larger community elucidates environmental adaptability and evolutionary success. This dissertation investigates the occupied niche of chimpanzees (Pan troglodytes schweinfurthii) living in an open, dry savanna-woodland environment by examining patterns of resource use and interspecific interactions. Data were collected October 2010--November 2011 at Issa, in the Ugalla region of western Tanzania, which is one of the driest, most open, and seasonal habitats inhabited by chimpanzees. Unlike most primatological studies which employ methods that include focal follows, this study focused instead on observing 'resource patches' for chimpanzees. Patch focals allow for the observation of all animals within a study area; capture resources that are not used by the study species; and are particularly well suited for unhabituated communities. In order to better understand relationships between environment and behavior, data collected at Issa are compared with published data from other chimpanzee populations. Issa chimpanzees were expected to have broader resource use than forest chimpanzees, as well as increased competition with other fauna, due to fewer available resources. However, in contrast to the assumption of food scarcity in dry habitats, dietary resources were available throughout the year. Like other populations, the diet of Issa chimpanzees consisted of mostly fruit, but unlike at other sites, the majority of plants consumed were woodland species. Additionally, although chimpanzees and other fauna shared spatial and dietary resources, there was only nominal overlap. These results point to extremely low levels of indirect competition between chimpanzees and other fauna. Despite extensive study of forest chimpanzees, little is known about their role within their faunal community in open, dry habitats, nor about how greater seasonality affects resource use. This project addresses both of these important issues and fosters novel approaches in anthropological studies, especially in reference to chimpanzee ecology and evolution. Understanding current chimpanzee behavioral relationships with their environments shapes hypotheses about their pasts, and also informs predictions about behaviors of similar taxa in paleo-environments. Lastly, examining the ecological role of chimpanzees within their larger communities will influence the formation of, as well as evaluate, conservation strategies.Dissertation/ThesisPh.D. Anthropology 201
MONOKLONALA T-CELLSPOPULATIONER VID MYELODYSPLASTISKT SYNDROM
No full textMyelodysplastiskt syndrom (MDS) är ett hematologiskt sjukdomstillstånd som orsakas av genetiska avvikelser av hematopoetiska stamceller i benmärg. MDS har varierande symptom men anemi är den vanligaste och om det inte upptäcks så kan MDS leda till akut myeloid leukemi (AML). Studier visar att det upptäckts monoklonala T-cells population vid MDS. Vid diagnostisering av MDS undersöks benmärgsaspiratsprover. I den här studien undersöktes om det uppkommer klonal T-cells populationer hos patienter med MDS. Det möjliggörs genom att studera och identifiera cellernas ytmarkörer, differentierings kluster (CD) och T-cellreceptor beta constant 1 (TRBC1) på T-cellsreceptorer (TCR) med hjälp av flödescytometri metoden. En panel av 10 antikroppar, T1 C10 panelen som har TRBC1 antikroppar används i flödescytometri för immunofenotypning. 238 prover från 2020 och 22 prover från 2024 analyserades och sammanställdes för att ge ett sammantaget resultat som presenterades i ett stapeldiagram och beräknades med Fisher's exact test vilket visade resultaten att monoklonalitet i T cellerna var inte signifikant hos patienter med MDS jämfört med de som inte hade MDS. Den möjliga förklaringen för det här resultat kan vara det ökade antal patientprover som användes i denna studie och deras hälsotillstånd jämfört med de i tidigare studier. Nyckelord: Differentierings Kluster (CD), Flödecytometri, Immunophenotypning, monoklonalitet, Myelodysplastiskt syndrom (MDS), T-cellreceptor beta constant 1 (TRBC1) Myelodysplastic syndrome (MDS) is a hematological disease state caused by genetic abnormalities of hematopoietic stem cells in the bone marrow. MDS has varying symptoms, but anemia is the most common and if undetected, MDS can lead to acute myeloid leukemia (AML). Studies show that monoclonal T-cell population has been detected in MDS. When diagnosing MDS, bone marrow aspirate samples are examined. This study investigated whether clonal T-cell populations arise in patients with MDS. This is made possible by studying and identifying the cells' surface markers, differentiation cluster (CD) and T cell receptor beta constant 1 (TRBC1) on T cell receptors (TCR) using the flow cytometry method. A panel of 10 antibodies, the T1 C10 panel which have TRBC1 antibodies is used in flow cytometry for immunophenotyping. 238 samples from 2020 and 22 samples from 2024 were analyzed and compiled to give a circumstantial result which was presented in a bar graph and Fisher's exact test was calculated which showed the results that monoclonality in the T cells was not significant in patients with MDS compared to those who did not have MDS. The possible explanation for this result could be the increased number of patient samples used in this study and their health status compared to those in previous studies. Keywords: Cluster of differentiation (CD), Flow cytometry, Immunophenotyping, monoclonality, Myelodysplastic syndrome (MDS), T-cell receptor beta constant 1 (TRBC1
MONOKLONALA T-CELLSPOPULATIONER VID MYELODYSPLASTISKT SYNDROM
No full textMyelodysplastiskt syndrom (MDS) är ett hematologiskt sjukdomstillstånd som orsakas av genetiska avvikelser av hematopoetiska stamceller i benmärg. MDS har varierande symptom men anemi är den vanligaste och om det inte upptäcks så kan MDS leda till akut myeloid leukemi (AML). Studier visar att det upptäckts monoklonala T-cells population vid MDS. Vid diagnostisering av MDS undersöks benmärgsaspiratsprover. I den här studien undersöktes om det uppkommer klonal T-cells populationer hos patienter med MDS. Det möjliggörs genom att studera och identifiera cellernas ytmarkörer, differentierings kluster (CD) och T-cellreceptor beta constant 1 (TRBC1) på T-cellsreceptorer (TCR) med hjälp av flödescytometri metoden. En panel av 10 antikroppar, T1 C10 panelen som har TRBC1 antikroppar används i flödescytometri för immunofenotypning. 238 prover från 2020 och 22 prover från 2024 analyserades och sammanställdes för att ge ett sammantaget resultat som presenterades i ett stapeldiagram och beräknades med Fisher's exact test vilket visade resultaten att monoklonalitet i T cellerna var inte signifikant hos patienter med MDS jämfört med de som inte hade MDS. Den möjliga förklaringen för det här resultat kan vara det ökade antal patientprover som användes i denna studie och deras hälsotillstånd jämfört med de i tidigare studier. Nyckelord: Differentierings Kluster (CD), Flödecytometri, Immunophenotypning, monoklonalitet, Myelodysplastiskt syndrom (MDS), T-cellreceptor beta constant 1 (TRBC1) Myelodysplastic syndrome (MDS) is a hematological disease state caused by genetic abnormalities of hematopoietic stem cells in the bone marrow. MDS has varying symptoms, but anemia is the most common and if undetected, MDS can lead to acute myeloid leukemia (AML). Studies show that monoclonal T-cell population has been detected in MDS. When diagnosing MDS, bone marrow aspirate samples are examined. This study investigated whether clonal T-cell populations arise in patients with MDS. This is made possible by studying and identifying the cells' surface markers, differentiation cluster (CD) and T cell receptor beta constant 1 (TRBC1) on T cell receptors (TCR) using the flow cytometry method. A panel of 10 antibodies, the T1 C10 panel which have TRBC1 antibodies is used in flow cytometry for immunophenotyping. 238 samples from 2020 and 22 samples from 2024 were analyzed and compiled to give a circumstantial result which was presented in a bar graph and Fisher's exact test was calculated which showed the results that monoclonality in the T cells was not significant in patients with MDS compared to those who did not have MDS. The possible explanation for this result could be the increased number of patient samples used in this study and their health status compared to those in previous studies. Keywords: Cluster of differentiation (CD), Flow cytometry, Immunophenotyping, monoclonality, Myelodysplastic syndrome (MDS), T-cell receptor beta constant 1 (TRBC1
Compact Toeplitz Operators for Weighted Bergman Spaces on Bounded Symmetric Domains
No full textLet Omega subset of C(d) be an irreducible bounded symmetric domain of type (r, a, b) in its Harish-Chandra realization. We study Toeplitz operators T(g)(v) with symbol g acting on the standard weighted Bergman space H(v)(2) over Omega with weight nu. Under some conditions on the weights nu and nu (0) we show that there exists C(nu, nu (0)) > 0, such that the Berezin transform (g) over tilde nu 0 of g with respect to H(nu 0)(2) satisfies: parallel to(g) over tilde (nu 0)parallel to(infinity) C where C is a constant depending on (r, a, b).DFG (Deutsche Forschungsgemeinschaft
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