3,026 research outputs found
The effect of high- and low-frequency previews and sentential fit on word skipping during reading
No full textIn a previous gaze-contingent boundary experiment, Angele and Rayner (2013) found that readers are likely to skip a word that appears to be the definite article the even when syntactic constraints do not allow for articles to occur in that position. In the present study, we investigated whether the word frequency of the preview of a 3-letter target word influences a reader’s decision to fixate or skip that word. We found that the word frequency rather than the felicitousness (syntactic fit) of the preview affected how often the upcoming word was skipped. These results indicate that visual information about the upcoming word trumps information from the sentence context when it comes to making a skipping decision. Skipping parafoveal instances of the therefore may simply be an extreme case of skipping high-frequency words
Functional expression cloning reveals proapoptotic role for protein phosphatase 4
No full text© 2003 Nature Publishing Group All rights reservedFunctional expression cloning strategies are highly suitable for the analysis of the molecular control of apoptosis. This approach has two critical advantages. Firstly, it eliminates prior assumptions about the properties of the proteins involved, and, secondly, it selectively targets proteins that are causally involved in apoptosis control and which affect the crucial cellular decision between survival and death. The application of this strategy to the isolation of cDNAs conferring resistance to dexamethasone and italic gamma-irradiation resulted in the isolation of a partial cDNA for the catalytic subunit of protein phosphatase 4 (PP4). Cells transfected with this partial cDNA in an expression vector downregulated PP4 and were resistant to both dexamethasone and UV radiation, as demonstrated by both membrane integrity and colony-forming assays. These observations suggest that PP4 plays an important proapoptotic role in T lymphocytes.M. Mourtada-Maarabouni, L. Kirkham, B. Jenkins, J. Rayner, T.J. Gonda, R. Starr, I. Trayner, F. Farzaneh and G.T. William
On the impact of transport model errors for the estimation of CO2 surface fluxes from GOSAT observations
No full textA series of observing system simulation experiments is presented in which column averaged dry air mole fractions of CO2 (X-CO2) from the Greenhouse gases Observing SATellite (GOSAT) are made consistent or not with the transport model embedded in a flux inversion system. The GOSAT observations improve the random errors of the surface carbon budget despite the inconsistency. However, we find biases in the inferred surface CO2 budget of a few hundred MtC/a at the subcontinental scale, that are caused by differences of only a few tenths of a ppm between the simulations of the individual X-CO2 soundings. The accuracy and precision of the inverted fluxes are little sensitive to an 8-fold reduction in the data density. This issue is critical for any future satellite constellation to monitor X-CO2 and should be pragmatically addressed by explicitly accounting for transport errors in flux inversion systems. Citation: Chevallier, F., L. Feng, H. Bosch, P. I. Palmer, and P. J. Rayner (2010), On the impact of transport model errors for the estimation of CO2 surface fluxes from GOSAT observations, Geophys. Res. Lett., 37, L21803, doi:10.1029/2010GL044652.</p
RRS Charles Darwin Cruise CD177, 12-29 Nov 2005. RAPID Mooring Cruise Report
No full textThis report describes mooring operations and underway measurements conducted during RRS Charles Darwin Cruise CD177. Cruise CD177 was conducted between 12 November 2005 and 29 November 2005. The first part of the cruise consisted of a transit from Falmouth, UK to Santa Cruz de Tenerife, Tenerife with mooring preparation conducted on this leg. Further scientific staff joined in Santa Cruz de Tenerife for the second leg that started on the 19 November. The cruise finished in Tenerife on the 29 November.This cruise was completed as part of the United Kingdom Natural Environment Research Council (NERC) funded RAPID Programme to monitor the Atlantic Meridional Overturning Circulation at 26.5ºN. The primary purposes of this cruise were to service the two key moorings (EB1 and EB2) on the eastern boundary of the 26.5ºN mooring array and to deploy two Pressure Inverted Echosounders (PIES). The array was first deployed in 2004 during RRS Discovery cruises D277 and D278 (Southampton Oceanography Centre Cruise Report No. 53) in order to set up a pre-operational prototype system to continuously observe the Atlantic Meridional Overturning Circulation (MOC). It was subsequently serviced on RRS Charles Darwin cruise CD170 and RV Knorr cruise KN182-2 (both covered in National Oceanography Centre Southampton Cruise Report No. 2). The array will be further refined and refurbished during subsequent years.This cruise was planned in response to mooring losses suffered in the first year of the 26.5ºN array deployment. The two key eastern boundary moorings were subjected to damage through suspected fishing activity causing the loss of data above 1200m at the eastern boundary. To reduce the risk of data loss we plan to service the two key moorings on a six-monthly cycle.Instruments deployed on the array consists of a variety of current meters, bottom pressure recorders and CTD loggers which, combined with time series measurements of the Florida Channel Current and wind stress estimates, will be used to determine the strength and structure of the MOC at 26.5ºN. (http://www.noc.soton.ac.uk/rapidmoc
Eye movement sequences during simple versus complex information processing of scenes in autism spectrum disorder
No full textMinshew and Goldstein (1998) postulated that autism spectrum disorder (ASD) is a disorder of complex information processing. The current study was designed to investigate this hypothesis. Participants with and without ASD completed two scene perception tasks: a simple “spot the difference” task, where they had to say which one of a pair of pictures had a detail missing, and a complex “which one's weird” task, where they had to decide which one of a pair of pictures looks “weird”. Participants with ASD did not differ from TD participants in their ability to accurately identify the target picture in both tasks. However, analysis of the eye movement sequences showed that participants with ASD viewed scenes differently from normal controls exclusively for the complex task. This difference in eye movement patterns, and the method used to examine different patterns, adds to the knowledge base regarding eye movements and ASD. Our results are in accordance with Minshew and Goldstein's theory that complex, but not simple, information processing is impaired in ASD.<br/
Parafoveal-foveal overlap can facilitate ongoing word identification during reading: evidence from eye movements.
No full textReaders continuously receive parafoveal information about the upcoming word in addition to the foveal information about the currently fixated word. Previous research (Inhoff, Radach, Starr, & Greenberg, 2000) showed that the presence of a parafoveal word that was similar to the foveal word facilitated processing of the foveal word. We used the gaze-contingent boundary paradigm (Rayner, 1975) to manipulate the parafoveal information that subjects received before or while fixating a target word (e.g., news) within a sentence. Specifically, a reader's parafovea could contain a repetition of the target (news), a correct preview of the posttarget word (once), an unrelated word (warm), random letters (cxmr), a nonword neighbor of the target (niws), a semantically related word (tale), or a nonword neighbor of that word (tule). Target fixation times were significantly lower in the parafoveal repetition condition than in all other conditions, suggesting that foveal processing can be facilitated by parafoveal repetition. We present a simple model framework that can account for these effects
RV Ronald H. Brown Cruise RB0602 and RRS Discovery Cruise D304, Rapid Mooring Cruise Report March and May 2006
No full textThis report describes the mooring operations conducted during RV Ronald H. Brown Cruise RB0602 and RRS Discovery Cruise D304. Cruise RB0602 was conducted between 9 March 2006 and 28 March 2006, and Cruise D304 was conducted between 12 May 2006 and 6 June 2006.These mooring operations were completed as part of the United Kingdom Natural Environment Research Council (NERC) funded RAPID Programme to monitor the Atlantic Meridional Overturning Circulation at 26.5ºN. The primary purpose of these cruises was to service the 26.5ºN mooring array first deployed in 2004 during RRS Discovery cruises D277 and D278 (SOC cruise report number 53), and serviced in 2005 during RRS Charles Darwin Cruise CD170 and RV Knorr Cruise KN182-2 (NOCS cruise report number 2), and RRS Charles Darwin Cruise CD177 (NOCS cruise report number 5).Cruise RB0602 was from Barbados to Charleston, SC, and covered the Western Boundary moorings deployed on KN182-2. Cruise D304 was to and from Tenerife and covered the Eastern Boundary and Mid-Atlantic Ridge moorings deployed on cruises CD170 and CD177. These cruises are the second annual refurbishment of an array of moorings deployed across the Atlantic in order to set up a pre-operational prototype system to continuously observe the Atlantic Meridional Overturning Circulation (MOC). Cruise CD177 was an intermediate service cruise to obtain data from the two principal Eastern Boundary moorings six months after deployment. This array will be further refined and refurbished during subsequent years. The instruments deployed on the array consists of a variety of current meters, bottom pressure recorders, CTD loggers and Inverted Echosounders, which, combined with time series measurements of the Florida Channel Current and wind stress estimates, will be used to determine the strength and structure of the MOC at 26.5ºN. (http://www.noc.soton.ac.uk/rapidmoc)<br/
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