978 research outputs found
Using high energy angle resolved photoelectron spectroscopy to reveal the charge density in solids
No full textSignal transduction via MHC class-I molecules in T cells
No full textT-lymphocytter, MHC class I, signal transductio
Angle Resolved Photoemission from Nd1.85Ce0.15CuO4 using High Energy Photons: A Fermi Surface Investigation
No full textWe have performed an angle resolved photoemission study on a single crystal of the optimally
electron doped (n-type) cuprate superconductor Nd2xCexCuO4 (x 0:15) at a photon energy of 400 eV.
The Fermi surface is mapped out and is, in agreement with earlier measurements, of hole-type with the
expected Luttinger volume. However, comparing with previous low energy measurements, we observe a
different Fermi surface shape and a different distribution of spectral intensity around the Fermi surface
contour. The observed Fermi surface shape indicates a stronger electron correlation in the bulk as
compared to the surface
Tro i vardagen : En studie av en undervisningsmodells effekter gällande elevers förståelse och engagemang i religionskunskap
No full textStudy: Degree project in teacher education, Advanced level, 15 hp University of Skövde Title: Religious belief in everyday life – a study of the effects of a teaching model focusing on religious belief in everyday life Number of pages:42 Author: Johanna Claesson Tutor: Kennert Orlenius Date: Jan 2009 Keywords: Religious study, students´ understanding, students´ commitment, Buddhism This paper presents the execution and the result of a project examining how a tutorial model (called the model of everyday religious practice) focusing on how Buddhism is expressed in the daily life of Buddhists believers, affects students understanding of and commitment in religious studies. In the project, Thai students have partaken by producing sex posters and a picture-show with the help of their own photographs and short texts. However, the picture-show was mainly produced by the author of this paper. These posters and the picture-show were brought to Sweden to figure as teaching material during a lesson in religious studies for students in year eight in a Swedish school. The Swedish students participated in focus-discussions about religion as well as religious studies before and after this lesson in order to make it possible to analyse the lesson´s affects, regarding understanding and commitment, on the students. In the result of this paper, this tutorial model appears, on one hand, to encourage students to commitment in religious studies by adding an emotive dimension to the lesson which helps the students to an authentic experience. On the other hand, it is not unequivocal whether the students did gain understanding or not for religious studies. The lesson enabled the students to see that they are likely to experience some usefulness of religious studies in their lives outside school and thereby the students gained some understanding for the subject. However, it is not clear whether this understanding is complete or not. It is likely that the teacher in planning the lessons also need to take two other tutorial models, presented in this paper, in consideration. Finally, this paper ends with a discussion about which impact the result of this study might have on how religious studies are thought in Swedish schools
Fear reactions in trained and untrained horses from dressage and show-jumping breeding lines
No full textHorses' fear reactions are hazardous to both horses and human beings, but iris not clear whether fear is influenced more by training or by other factors such as genetics. The following study was designed to detect differences between young, untrained (U) and older, well-trained (T) horses of dressage (D), show-jumping (J), and mixed (M) genetic lines with regard to intensity of reaction and ease of habituation to a frightening stimulus. In five consecutive trials, 90 horses were exposed to a standardized fear-eliciting stimulus where intensity and duration of the reactions were recorded. Repeated measures analysis showed that flight reactions by J were less intense (p 0.1) different between the disciplines, as indicated by similar slopes for all measurements, but reaction vigour declined faster for T than for U. These findings indicate that there may be a genetic basis for less strong, though not shorter-lasting, fear reactions in J compared to D or M lines of horses. Research including the estimation of genetic correlations between traits related to fearfulness and to performance would be required to verify this assumption. (c) 2010 Elsevier B.V. All rights reserved
Genome-scale analyses of health-promoting bacteria: probiogenomics.
No full textThe human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples
Real-time PCR analysis of genes encoding tumor antigens in esophageal tumors and a cancer vaccine
No full textTumor antigens are the primary target of therapeutic cancer vaccines. We set out to define and compare the expression pattern of tumor antigen genes in esophagus carcinoma biopsies and in an allogeneic tumor lysate-based cancer vaccine, MelCancerVac. Cells used for vaccine production were treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR) to determine whether this treatment could improve the profile of tumor antigen genes expressed in these cells. In addition, the presence of MAGE-A tumor antigen protein was evaluated in the purified tumor cell lysate used in the production of the vaccine. Quantitative PCR was used to assay 74 tumor antigen genes in patients with squamous cell carcinoma of the esophagus. 81% (13/16) of tumors expressed more than five cancer/testis (CT) antigens. A total of 96 genes were assayed in the tumor cell clone (DDM1.7) used to make tumor cell lysate for vaccine preparation. Gene expression in DDM1.7 cells was compared with three normal tissues; 16 tumor antigen genes were induced more than ten-fold relative to normal tissues. Treatment with 5-aza-CdR induced expression of an additional 15 tumor antigens to a total of 31. MAGE-A protein was detected in cell lysate by Western blot at an estimated concentration of 0.2 micrograms/ml or 0.01% of the total protein
Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins
No full textThe molecular interactions of the Src homology 2 (SH2) domain and the N-terminal proline-rich sequence motifs (pro-1 to pro-5) of the SH2 protein Shb with other components were presently characterised. Using a degenerate phosphopeptide library the preferred binding site for the Shb SH2 domain was determined to pTyr-Thr/Val/Ile-X-Leu at positions +1 to +3 relative the phosphotyrosine residue. Experiments with competing peptides and platelet-derived growth factor (PDGF) beta-receptor mutants with Y to F substitutions in autophosphorylation sites revealed multiple binding sites for the Shb SH2 domain in the receptor. The Shb SH2 domain also binds to in vitro phosphorylated fibroblast growth factor receptor-1 (FGFR-1) mainly through position Y776. The receptor experiments suggest that other residues besides the +1 to +3 positions may also be of significance for Shb binding. The pro-4/pro-5 motif of Shb binds in vitro particularly well to the Src, p85 alpha PI3-kinase and Eps8 SH3 domains expressed as GST fusion proteins. However, the GST-SH3 domain fusion proteins tested bind in vitro to peptides corresponding to the pro-1 to pro-5 motifs of Shb with low affinity and selectivity, suggesting that sequences outside the core proline motif may also be important for Shb-SH3 domain interactions. In vivo association between Shb-SH3 domain proteins v-Src and Eps8 was detected by coimmunoprecipitation. PDGF treatment did not affect the association between Eps8 and Shb. The data suggest that Shb is an adaptor protein linking SH3 domain proteins to tyrosine kinases or other tyrosine phosphorylated proteins
Bättre kan det sägas : Om transformation som berättargrepp i Stig Claessons författarskap
No full textThe objective of this paper is to examine narrative techniques used by the Swedish author Stig Claesson, especially his transformations of texts out of the own authorship into new stories. In order to achieve my objective, I will specifically study two novels; Rosine (1991) and Efter oss syndafloden (2002) and the method practiced will be intentional reading, as described by H. Porter Abbott. For the analysis I will, with the complementary support of Abbott and Beata Agrell, turn to Gerard Genette and his theories concerning transformation and transtextuality, in particular its sub idiom hypertextuality. As a result of my analysis, various subgroups of transformation used by Claesson are identified, but also proven is how Claesson, largely by utilizing two of them; transvocalisation and transvaluation, provides the reader with the implied author of his own choice. Moreover, my investigation demonstrates how Claesson when reusing narratives already told by himself, i.e. transforming hypotexts of his own into hypertexts, recycles characters; reprocesses master as well as sub plots; alters trivial details; re-interprets events; switches from one narrative view to another, all well documented techniques described by Genette as elements of transformation
Bättre kan det sägas : Om transformation som berättargrepp i Stig Claessons författarskap
No full textThe objective of this paper is to examine narrative techniques used by the Swedish author Stig Claesson, especially his transformations of texts out of the own authorship into new stories. In order to achieve my objective, I will specifically study two novels; Rosine (1991) and Efter oss syndafloden (2002) and the method practiced will be intentional reading, as described by H. Porter Abbott. For the analysis I will, with the complementary support of Abbott and Beata Agrell, turn to Gerard Genette and his theories concerning transformation and transtextuality, in particular its sub idiom hypertextuality. As a result of my analysis, various subgroups of transformation used by Claesson are identified, but also proven is how Claesson, largely by utilizing two of them; transvocalisation and transvaluation, provides the reader with the implied author of his own choice. Moreover, my investigation demonstrates how Claesson when reusing narratives already told by himself, i.e. transforming hypotexts of his own into hypertexts, recycles characters; reprocesses master as well as sub plots; alters trivial details; re-interprets events; switches from one narrative view to another, all well documented techniques described by Genette as elements of transformation
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