55 research outputs found
Alternative Therapeutics Against Antimicrobial-Resistant Pathogens
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Response of confined aquatic biota to mine depressurization water in Beaver Creek reservoir
No full textBeaver Creek Reservoir was formed as a result of diverting the natural flow of Beaver Creek away from mine and plant areas and southward to the Athabasca River via Poplar Creek. The diversion was initiated in the fall of 1975 with the closure of the Beaver Creek Dam; filling of the reservoir was completed in the spring of 1976. When it became necessary to remove mine depressurization water from the mining area, Syncrude was granted permission by the Government of Alberta to discharge this effluent into Beaver Creek Reservoir, on the condition that chloride levels in water entering Poplar Creek did not exceed 400 mg/L above ambient levels. The present study was designed to investigate the survival of selected organisms in Beaver Creek Reservoir during 1979. The primary objective was to determine the response of selected species of aquatic biota to saline mine depressurization water after average dilution in the Beaver Creek Reservoir. More specific requirements of the study were: a) the study was to be carried out entirely within the Beaver Creek Reservoir using test organisms held in situ; b) the study must include three sampling locations and three replicates of each test organism at each station; c) test organisms must include: periphyton (on artificial substrates), native species of fish (white sucker and fathead minnow), and native species of invertebrates (either Gammarus or Hyalella); and d) field studies were to be conducted between June and October, 1979 and were to examine both short and long term effects
Ser down: ambiente hipermídia para o esclarecimento da síndrome de down
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnológicoO nascimento de uma criança com Síndrome de Down, é muitas vezes um acontecimento embaraçoso para aqueles que a atendem. As dificuldades vão da habilidade para firmar o diagnóstico até a tranqüilidade para informá-lo à família, preparando-a para aceitar a criança e ajudá-la em seu desenvolvimento. Este trabalho é direcionado ao paciente Down e sua família buscando melhor atendê-los em suas necessidades de saúde. Mas se dirige principalmente ao profissional de saúde pois conhece-se a escassez de informações disponíveis sobre esta Síndrome, embora exista uma grande quantidade de informações médicas sobre esta doença em nosso meio, elas são pouco conhecidas por pais, voluntários e outros profissionais de saúde. Assim o Sistema de Hipermídia para o Esclarecimento da Síndrome de Down, visa contribuir para que o usuário iniciante ou não na área da informática, possa utilizar o computador na aprendizagem sobre esta Síndrome, bem como sua descoberta e principais característica
Humoral and lung immune responses to Mycobacterium tuberculosis infection in a primate model of protection
No full textAbstractRecently we reported (Mehra et al., 2013), that lung granulomas from Mycobacterium bovis Bacille Calmette–Guérin (BCG)-vaccinated cynomolgus macaques exhibit upon challenge with M. tuberculosis a more balanced expression of α- and β-chemokines, relative to comparable samples from sham-vaccinated animals by comparative transcriptomics. Here, we studied the recruitment of immune cells to blood and lungs in M. tuberculosis-infected macaques as a function of prior BCG-vaccination. Vaccination initially enhanced the levels of both macrophages and lymphocytes in blood. In contrast, significantly more CD4+ lymphocytes were later recruited to the lungs of sham-vaccinated animals compared with earlier times/BCG vaccinated animals. BCG-vaccination had a short-lived impact on the anti-M. tuberculosis response. M. tuberculosis continued to replicate in the lung even in the wake of increased CD4+ T cell recruitment to primate lungs, indicating that immune subversive mechanisms are key to its survival in vivo
Should Elderly Patients Presenting with Facial Injuries Have a Targeted Follow-Up in Place?
No full textExchange Rate Pass-Through into Import Prices: The Case of Chile
No full textIn this paper we estimate the exchange rate pass-through (ERPT) into disaggregated import price data at monthly frequency. We work with import prices both at the border and at the wholesale level, and our results are consistent with the idea of a high ERPT— complete in the long-run—which has not declined for both pricing levels. In the shortrun, however, wholesale prices seem to be less sensitive to exchange rate variations. This may indicate the existence of a pass-through less than perfect in the distribution chain from prices at the border to its wholesale counterpart. In addition, we find weak evidence of asymmetric pass-through from appreciations versus depreciations for the aggregate import indexes. Finally, we also explore if the high and not declining ERPT is given by the fact that Chilean imports are concentrated in products with such ERPT, and our results support the view that this is not the case.
Saccadic eye movements in the dark while performing an automatized sequential high-speed sensorimotor task
No full textFoerster RM, Carbone E, Koesling H, Schneider WX. Saccadic eye movements in the dark while performing an automatized sequential high-speed sensorimotor task. Journal of Vision. 2012;12(2)(8):1-15.Saccades during object-related everyday tasks select visual information to guide hand movements. Nevertheless, humans can perform such a task in the dark provided it was automatized beforehand. It is largely unknown whether and how saccades are executed in this case. Recently, a long-term memory (LTM)-based direct control mode of attention during the execution of well-learned sensorimotor tasks, which predicts task-relevant saccades in the dark, was proposed (R. M. Foerster, E. Carbone, H. Koesling, & W. X. Schneider, 2011). In the present study, participants performed an automatized speed-stacking task in the dark and in the light while their eye movements were recorded. Speed stacking is a sequential high-speed sensorimotor object manipulation task. Results demonstrated that participants indeed made systematic eye movements in the dark. Saccadic scan paths and the number of fixations were highly similar across illumination conditions, while fixation rates were lower and fixation durations were longer in the dark. Importantly, the eye reached a location ahead of the hands even in the dark. Finally, neither eye–hand dynamics nor saccade accuracy correlated with hand movement durations in the dark. Results support the hypothesis of an LTM-based mode of attention selection during the execution of automatized sequential high-speed sensorimotor tasks
Modelagem em hipermídia de um tutorial para criação de maquetes eletrônicas /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico
Overlapping signals for translational regulation and packaging of influenza A virus segment 2
No full textInfluenza A virus segment 2 mRNA expresses three
polypeptides: PB1, PB1-F2 and PB1-N40, from AUGs
1, 4 and 5 respectively. Two short open reading
frames (sORFs) initiated by AUGs 2 and 3 are also
present. To understand translational regulation in
this system, we systematically mutated AUGs 1–4
and monitored polypeptide synthesis from
plasmids and recombinant viruses. This identified
sORF2 as a key regulatory element with opposing
effects on PB1-F2 and PB1-N40 expression. We
propose a model in which AUGs 1–4 are accessed
by leaky ribosomal scanning, with sORF2 repressing
synthesis of downstream PB1-F2. However, sORF2
also up-regulates PB1-N40 expression, most likely
by a reinitiation mechanism that permits skipping of
AUG4. Surprisingly, we also found that in contrast to
plasmid-driven expression, viruses with improved
AUG1 initiation contexts produced less PB1 in
infected cells and replicated poorly, producing
virions with elevated particle:PFU ratios. Analysis
of the genome content of virus particles showed
reduced packaging of the mutant segment
2 vRNAs. Overall, we conclude that segment
2 mRNA translation is regulated by a combination
of leaky ribosomal scanning and reinitiation, and
that the sequences surrounding the PB1 AUG
codon are multifunctional, containing overlapping
signals for translation initiation and for segmentspecific
packaging
Empirically Analyzing the Impacts of U.S. Export Credit Programs on U.S. Agricultural Export Competitiveness
No full textThis paper looked at the on the ongoing debate on the use of public export credit programs and their impact on US exports. Our results indicate that cost saving is significant beneficial to the importing countries as a result of the export credit programs. There is also an increase in US exports as a result of the US export credit programs. However, there is a reduction in cost savings to the importing countries when the length of repayment of export credit is 180 days. Thus, the more restrictive terms and conditions of officially supported export credits which the WTO is trying to discipline based on their implicitly subsidized components will have some adverse impact on the importing countries.International Relations/Trade,
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