147 research outputs found
Animal Man: Morrison\u27s Reflection on the Author
No full textGrant Morrison’s Animal Man debuted in DC Comics in 1988. For seven years as its author, Morrison explored themes of animal rights, conservationism, postmodernism, existentialism, and even free will all through their careful deconstruction of the superhero genre. In “Animal Man: Morrison’s Reflection on the author”, Ellie Harwood analyzes major portions of Morrison’s comic to identify their commentary on the relationship between people, animals, and fictional characters, and the moral ramifications of those relationships. Harwood achieves this through identifying the similarities between how Morrison portrays animals in the comic, as well as how they portray their own characters on a meta level, and the fundamental similarities between both parties. This essay primarily focuses on how the exploitation of animals is unequivocally tied to the process behind storytelling itself, and how both play into humanity’s intrinsic, primal desire for violence. By identifying the line Morrison draws between fiction and reality, then blurring it, the text’s moralistic claims become clear
De ombligo a ombligo: Notes on Embodiment and Translation
No full textA translation of the poem What will we know by Ellie Epp, translated by Juliana Borrero, with notes by the author and the translator.Traducción del poema What will we know de Ellie Epp acompañado de comentarios de la autora y de la traductora, Juliana Borrero.Traduction du poème What will we know, d'Ellie Epp, accompagnée de remarques de l'auteure et de la traductrice, Juliana Borrero.Tradução do poema What will we know, de Ellie Epp, por Juliana Borrero, com notas da autora e da tradutora
A Conversation with Char Booth
No full textWelcome to a special audio edition of In the Library with the Lead Pipe. Ellie Collier talks to Char Booth, E-Learning Librarian at the University of California at Berkeley and author of Informing Innovation: Tracking Student Interest in Emerging Library Technologies at Ohio University, a book length research report recently published by ACRL and available [...
A Conversation with Librarian-Editors
No full textIn brief: Ellie Collier interviews several librarian-editors about the publishing process, with a focus on “call for chapters” style books. Introduction: I began working on In the Library with the Lead Pipe in 2008 as a founding editor and author, despite hating to write. The prospect seemed too exciting to let my own dislike of writing […
You are never too young to learn about democracy
No full textThe question of how to ensure that young people understand their role in a democracy has yet to be properly answered, with turn-out amongst first time voters continuing to sag. Ellie Levenson, the author of a book which seeks to introduce toddlers to democracy, argues that normalising the activity of voting is the best way to contribute to solving this problem
Collegeville Connections: Publishing for Christian Writers
No full textAre you looking to publish your faith writing? Agent, editor, and writer Jevon Bolden joins author Ellie Roscher in a discussion about the business of Christian publishing. They will address your discernment about working with an agent, the query process and how explicit you should be about your faith in writing
Psychoanalysis Ellie Chu Portrayed from Freud's and Maslow's Theories in "The Half of It" Movie
No full textPsychology is the science that studies human behavior which is applied in analyzing human personality. This journal examines the application of the psychological theories of Sigmund Freud (Id, Ego, and Superego) and Abraham Maslow (physiological needs, safety needs, love and belonging needs, self-esteem, and self-actualization) in analyzing Ellie Chu the main character of the film "The Half of It". The author uses the descriptive qualitative research method to explain Ellie Chu's character. The author obtained data from watching the film "The Half of It" which was released by Netflix in 2020 and reading the script for the film "The Half of it". Directed by Alice Wu, this film follows the journey of Ellie Chu, a talented young writer who gets entangled in a journey of finding a complex identity in her small town. This analysis aims to show how the application of Freud's and Maslow's theories provides insight into Ellie's character development and motivation throughout the film. By exploring her subconscious desires and the fulfillment of her needs, we gain a deeper understanding of her actions, decisions, and emotional journey. Understanding the psychological underpinnings of Ellie's character increases our appreciation of the film's themes of identity, love, and self-discovery. It is hoped that from this analysis the readers can also be inspired by the story of Ellie Chu who can take responsibility for truth, honesty, and sacrifice
Investigating SETD1A as a novel epigenetic regulator of parp inhibition
No full textPoly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have transformed the treatment of BRCA1-deficient tumours and further evidence suggests their efficacy also extends to deficiencies in other genetic factors associated with homologous recombination (HR), including ATM. However, the clinical success of these compounds is hampered by resistance, as well as a lack of good biomarkers to determine which patients are likely to benefit from PARPi treatment. Recent findings identified the lysine methyltransferase SETD1A as a novel factor conferring PARPi resistance in BRCA1-deficient cells by restoring HR. In this thesis I build upon these previous findings to ask if SETD1A contributes to PARPi resistance in ATM-deficient cells and determine the mechanisms responsible.
Clonogenic survival and immunofluorescent DNA repair assays revealed SETD1A knockdown reduced olaparib sensitivity in ATM-deficient cells through partial restoration of HR, driven by abrogation of H3K4 methylation. On the other hand, Cas9-mediated gene editing of SETD1A increased PARPi sensitivity in the absence of ATM, which was attributed to depletion of residual SETD1A protein expression and increased p53 expression. Based on its role as a H3K4 methyltransferase, we performed RNA-sequencing analysis revealing SETD1A-dependent transcription of the crossover junction endonuclease EME1 correlated with olaparib sensitivity. Accordingly, loss of EME1 phenocopied loss of SETD1A, inducing PARPi resistance and restoring HR in BRCA1 or ATM-deficient cells.
In conclusion, loss of SETD1A or EME1 may underlie PARPi resistance in the clinic and their expression or activity could offer potential new biomarkers to predict patient response and improve outcomes following PARPi treatment
Leg Clubs® : a clinically and cost-effective approach to lower limb management
No full textLeg ulcers affect 55000-90000 people, predominantly aged over 65, in the UK at any one time. Traditional care, delivered in people’s homes by district nurses or in GP clinics, is costly and often not effective, with slow healing rates and a high incidence of recurrence. A social model of leg ulcer clinics developed by the author has been shown to improve healing and reduce recurrence within a highly cost-effective framework that delivers genuine patient empowerment, public health education and social outreach. This paper outlines the rationale for the Leg Club, its clinical and social impact, and the infrastructure behind it. It also considers the challenges to establishing and running a Leg Club
Investigation of PGC-1α function in zebrafish
No full textAnimal life must carefully balance energetic resources with physiological demands to promote growth and ensure survival. Energy serves as a valuable resource to cope with ever-changing environmental demands and requires complex regulatory networks to ensure efficient energy utilization. In mammals, PGC-1α (Peroxisome Proliferator Activated Receptor Co-Activator 1 α) is a master regulator of metabolism coordinating many essential metabolic processes. However, the importance of PGC-1α is currently unknown amongst lower vertebrates, despite controversy suggesting divergent roles for PGC-1α in teleost species. Here, I describe the creation of a mutant zebrafish line dedicated to uncovering the role of PGC-1α in zebrafish. In chapter 2, I disrupted an evolutionary conserved region upstream of the PGC-1α promoter, simultaneously increasing PGC-1α expression in skeletal muscle 4-fold and decreasing PGC-1α expression in cardiac muscle 4-fold. This mutation increased O2 consumption in white muscle fibres and doubled the resting metabolism in juvenile zebrafish demonstrating that PGC-1α retains its role as a metabolic regulator in fish. In chapter 3, I hypothesized that PGC-1α mutant zebrafish experience impaired growth due to having a decreased metabolic efficiency. Mutant zebrafish larvae displayed decreased heart rate alongside increased yolk fatty acid (FA) content, indicating decreased FA metabolism during early development. Surprisingly, mutant adult zebrafish had increased FA metabolism, resisted growth when presented with a high-fat diet and decreased Dihomo-Gamma-Linoleic-Acid in skeletal muscle, a FA that prevents mitochondrial leakage. In summary, this mutation greatly impedes the metabolic function of zebrafish and provides a promising model for the continued study of PGC-1α in lower vertebrate muscles.Includes bibliographical references (pages 86-106).Chapter 2, entitled "An evolutionary conserved regulatory sequence dictates PGC-1α exoression in Zebrafish striated muscles" is co-authored with Kurchaba by Michael Charette (study design and methodology) and Christophe LeMoine (study design, data curation, methodology, analysis, and writing). Chapter 3, entitled "Altered PGC-1α expression in Zebrafish limits growth irrespective of nutrient consumption" is co-authored with Kurchaba by Ellie Duncan (methodology and data analysis) and Christophe LeMoine (study design, data curation, methodology, analysis, and writing)"In partial fulfillment of the requirements for the degree of Master of Science, Evironmental and Life Sciences.
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