1,700 research outputs found
Laser Cutting of Stainless Steel Thin Sheets with Pulsed Nd:Yag Laser
No full textThe parameters of laser cutting mainly depend on material and from thickness. In
case of a given material and thickness many settings can be chosen. In this article we examine
the laser cutting of 0,4 mm thickness stainless steel sheets with pulsed Nd:YAG laser. We
examine the effect of cutting speed on cut quality in case of three different combinations of
pulse energy and pulse frequency.
Good cut quality and relatively high cutting speed can be achieved with 800 Hz and 20.7 mJ
setting, we can cut higher speed, but poor cut quality with 400 Hz and 49 mJ setting
Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation.
No full textA proof of concept of a BioMEMS glucose biosensor using microfabricated SU-8 films
Full text linkThe present project investigated and proved the concept of developing a novel
BioMEMS glucose micro-biosensor using a simple one-step microfabrication process of
the widely used SU-8 polymer. More specifically, the study focused on the investigation
of the suitability of the SU-8 polymer as a matrix for enzyme immobilisation that is
carried out during the microfabrication process. A comparative study between
commercially available SU-8 and “customised” SU-8 solutions showed that the
optimum concentration of photo-initiator for stress reduction can be achieved easier
with “customised” SU-8 solutions. The most appropriate type of microstructure for the
SU-8 matrix and the corresponding required microfabrication process were defined and
encapsulation of the enzyme GOx in the SU-8 solution was accomplished. A detailed
experimental investigation of the immobilised enzyme’s activity inside the SU-8 matrix,
was carried out using amperometric detection of hydrogen peroxide in a 3-electrode setup.
SU-8 films were immersed in a buffer solution and the platinum working electrode
was brought in close contact with the film. Films without enzyme showed negligible
variation in current upon the addition of glucose, as opposed to films with encapsulated
enzyme which showed a very clear increase in current. Experiments using films of
increased thickness or enzyme concentration, showed a higher response, thus proving
that the enzyme remained active not only on the film’s surface, but inside the matrix as
well. In the fluorescence spectroscopy experiments, the utilisation of the tris (4,7-
diphenyl-1,10-phenanthroline) ruthenium(II) dichloride oxygen indicator, which was
also captured in the polymer matrix during the microfabrication process, was proven to
be very sensitive to glucose concentration changes during the glucose oxidation and
there was no photo-bleaching.
The experimental investigations proved that the proposed concept of using SU-8
matrices for the immobilisation of biomolecules, is a valid proposal for the construction
of a BioMEMS glucose biosensor. An important outcome was the successful
immobilisation of glucose oxidase in SU-8 microfabricated structures. The enzyme still
showed activity despite the “hostile” conditions during microfabrication The proof of
principle of enzyme immobilisation in SU-8 films opens up new possibilities for
combining BioMEMS with biosensors and organic electronics
Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation
Full text linkBackground
Central Asia and the Indian subcontinent represent an area considered as a source and a reservoir for human genetic diversity, with many markers taking root here, most of which are the ancestral state of eastern and western haplogroups, while others are local. Between these two regions, Terai (Nepal) is a pivotal passageway allowing, in different times, multiple population interactions, although because of its highly malarial environment, it was scarcely inhabited until a few decades ago, when malaria was eradicated. One of the oldest and the largest indigenous people of Terai is represented by the malaria resistant Tharus, whose gene pool could still retain traces of ancient complex interactions. Until now, however, investigations on their genetic structure have been scarce mainly identifying East Asian signatures.
Results
High-resolution analyses of mitochondrial-DNA (including 34 complete sequences) and Y-chromosome (67 SNPs and 12 STRs) variations carried out in 173 Tharus (two groups from Central and one from Eastern Terai), and 104 Indians (Hindus from Terai and New Delhi and tribals from Andhra Pradesh) allowed the identification of three principal components: East Asian, West Eurasian and Indian, the last including both local and inter-regional sub-components, at least for the Y chromosome.
Conclusion
Although remarkable quantitative and qualitative differences appear among the various population groups and also between sexes within the same group, many mitochondrial-DNA and Y-chromosome lineages are shared or derived from ancient Indian haplogroups, thus revealing a deep shared ancestry between Tharus and Indians. Interestingly, the local Y-chromosome Indian component observed in the Andhra-Pradesh tribals is present in all Tharu groups, whereas the inter-regional component strongly prevails in the two Hindu samples and other Nepalese populations.
The complete sequencing of mtDNAs from unresolved haplogroups also provided informative markers that greatly improved the mtDNA phylogeny and allowed the identification of ancient relationships between Tharus and Malaysia, the Andaman Islands and Japan as well as between India and North and East Africa. Overall, this study gives a paradigmatic example of the importance of genetic isolates in revealing variants not easily detectable in the general population
IMPLEMENTASI LAYANAN INFORMASI KARIR UNTUK MEMBANTU KESIAPAN PESERTA DIDIK DALAM PEMILIHAN KARIR DI SMA YP UNILA BANDAR LAMPUNG
No full textABSTRAK
Peneliti memperoleh gambaran bahwa peserta didik Di SMA
YP UNILA Bandar Lampung masih ada beberapa siswa yang masih
bingung tentang sekolah lanjutan setelah dari SMA dan juga
menentukan arah hidupnya atas apakah ingin melanjutkan
pendidikan ke perguruan tinggi atau bekerja. Berdasarkan hal
tersebut penulis tertarik untuk djudul “Implementasi Layanan
Informasi Karir Untuk Membantu Kesiapan Peserta Didik Dalam
Pemilihan Karir di SMA YP UNILA Bandar Lampung”. Adapun
Tujuan dari penelitian ini pertama, untuk mengetahui dan
manganalisis bagaimana Implementasi layanan informasi karir untuk
membantu kesiapan peserta didik dalam pemilihan karir di SMA YP
UNILA Bandar Lampung. Kedua, Untuk mengetahui dan
manganalisis apa saja hambatan-hambatan yang ada dalam
implementasi layanan informasi karir untuk membantu kesiapan
peserta didik dalam pemilihan karir di SMA YP UNILA Bandar
Lampung. Ketiga, Untuk mengetahui dan manganalisis seperti apa
hasil daripada implememtasi layanan informasi karir untuk
membantu kesiapan peserta didik dalam pemilihan karir di SMA YP
UNILA Bandar Lampung.
Metode Penelitian adalah pendekatan kualitatif, penelitian ini
termasuk kedalam jenis penelitian lapangan (field research).
Penelitian ini menggunakan teknik pengumpulan data berupa
wawancara, observasi dan dokumentasi. Data primer sumber data
yang didapat melalui wawancara dengan guru bimbingan dan
konseling. Data sekunder didapat melalui media perantara yang
dapat berupa dokuementasi dari responden yaitu guru bimbingan dan
konseling di SMA YP UNILA Bandar Lampung. Penelitian ini
dilaksanakan mulai dari perencanaan yang berupa penyusunan RPL
(Rancangan Perencanaan Layanan). Kemudian dalam pelaksanaanya
pertama, kegiatan pendahuluan. Kedua, kegiatan inti dan ketiga,
kegitan penutup. Kemudian setelah selesai pelaksanaanya dilanjut
dengan tahap akhir yakni tahap evaluasi. Pada tahap evaluasi dalam
implementasi layanan informasi tentang karir untuk membantu
kesiapan peserta didik dalam pemilihan karir di SMA YP UNILA
Bandar Lampung dilakukan melalui dua tahap evaluasi yakni
evaluasi proses dan evaluasi hasil. Dimana Kedua jenis evaluasi ini
penting dalam memastikan efektivitas dan keberhasilan suatu
aktivitas atau proyek.
iv
Berdasarkan pada hasil penelitian yang dilakukan oleh peneliti
seputar Implementasi layanan informasi tentang karir untuk
membantu kesiapan peserta didik dalam pemilihan karir di SMA YP
UNILA Bandar Lampung tedapat hambatan dalam pelaksanaanya
berupa kurang akuratnya informasi yang didapat, kemudian
keberagaman karir dari tiapindividu peserta didik. Akan tetapi hasil
dari implementasi layanan informasi tentang karir untuk membantu
kesiapan peserta didik dalam pemilihan karir di SMA YP UNILA
Bandar Lampung yakni tentunya peserta didik dapat memperoleh
solusi dari layanan informasi karir terkait pemilihan karir mereka.
Kata Kunci : Implementasi, Layanan Informasi Karir, Peserta
Didik
v
ABSTRACT
The researcher obtained an illustration that there were still
some students at YP UNILA SMA Bandar Lampung who were still
confused about going to secondary school after high school and also
determining the direction of their life whether they wanted to
continue their education to college or work. Based on this, the
author is interested in the title "Implementation of Career
Information Services to Assist Students' Readiness in Career
Choices at SMA YP UNILA Bandar Lampung". The objectives of this
research are 1. To find out and analyze how career information
services are implemented to help students' readiness in choosing a
career at SMA YP UNILA Bandar Lampung. 2. To find out and
analyze what obstacles exist in implementing career information
services to help students' readiness in choosing a career at SMA YP
UNILA Bandar Lampung. 3. To find out and analyze the results of
implementing career information services to help students' readiness
in choosing a career at SMA YP UNILA Bandar Lampung.
The research method is a qualitative approach, this research
is included in the type of field research. This research uses data
collection techniques in the form of interviews, observation and
documentation. Primary data is a source of data obtained through
interviews with guidance and counseling teachers regarding the
Implementation of Career Information Services to Assist Students'
Readiness in Career Choices at YP UNILA SMA Bandar Lampung.
Secondary data sources are obtained through intermediary media
which can be in the form of documentation from respondents,
namely guidance and counseling teachers at SMA YP UNILA
Bandar Lampung. This research was carried out starting from
planning in the form of preparing an RPL (Service Planning Plan).
Then in the first implementation, preliminary activities. Second, core
activities and third, closing activities. Then after completion of the
implementation, it continues with the final stage, namely the
evaluation stage. At the evaluation stage, the implementation of
career information services to help students' readiness in choosing a
career at SMA YP UNILA Bandar Lampung was carried out through
two evaluation stages, namely process evaluation and results
evaluation. Where these two types of evaluation are important in
ensuring the effectiveness and success of an activity or project.
Based on the results of research conducted by researchers
regarding the implementation of information services about careers
vi
to help students' readiness in choosing a career at SMA YP UNILA
Bandar Lampung, there are obstacles in its implementation in the
form of less accurate information obtained, then the diversity of
careers for each individual student. However, the result of
implementing information services about careers to help students'
readiness in choosing a career at YP UNILA High School Bandar
Lampung is that of course students can get solutions from career
information services regarding their career choices.
Keyword : Implementation, Career Information Services, Student
Electrochemical determination of cysteine based on conducting polymers/gold nanoparticles hybrid nanocomposites
No full text[[abstract]]In this study, a hybrid nanocomposite consisting of a conducting polymer and gold nanoparticles (AuNPs) is fabricated onto a screen-printed carbon electrode (SPCE). A thin layer of poly(3,4-ethylenedioxythiophene)(PEDOT) is coated electrochemically on a bare SPCE; then, the nano-sized AuNPs are embedded by electrochemical deposition. The resultant SPCE/PEDOT/AuNPs-modified electrode is characterized by electrochemical methods, field emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The SPCE/PEDOT/AuNPs-modified electrode possesses great catalytic activity for the oxidation of cysteine in various pH buffer solutions (pH 2.0-8.0). The selectivity of the method is demonstrated by the separation of the oxidation peaks at up to 240 mV for cysteine and glutathione in pH 6.0 buffer solutions. The effects of the oxidizable interferences are also investigated. Flow-injection amperometry is performed for 0.5-200 mu M of cysteine in pH 4.0 buffer solutions, and a linear calibration plot with a slope of 0.115 mu A/mu M is obtained. The detection limit (S/N = 3) is 0.05 mu M. Additionally, the proposed methods obtain satisfactory results in the detection of cysteine-containing medicine samples. (C) 2011 Elsevier Ltd. All rights reserved.[[note]]SC
Perinatal and Infant Health Outcomes among Neonates Born to Aboriginal Parents in Taiwan
No full textYeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release
Full text linkTerpenes are naturally occurring compounds produced by plants that are of great commercial interest in the food, agricultural, cosmetic, and pharmaceutical industries due to their broad spectra of antibacterial, antifungal, anthelmintic, membrane permeation enhancement, and antioxidant biological activities. Applications of terpenes are often limited by their volatility and the need for surfactants or alcohols to produce stable, soluble (non-precipitated) products. Yeast particles (YPs) are hollow, porous microspheres that have been used for the encapsulation of terpenes (YP terpenes) by passive diffusion of terpenes through the porous YP cell walls. We here report the development of a second generation YP encapsulated terpene technology that incorporates the stimuli-responsive control of terpene release using biodegradable pro-terpene compounds (YP pro-terpenes). YP terpenes and YP pro-terpenes were both produced, in which high levels of carvacrol, eugenol, thymol and geraniol were encapsulated. The YP pro-terpenes show higher encapsulation stability than YP terpenes due to pro-terpenes being non-volatile solids at room temperature and stable in suspensions at neutral pH. YP pro-terpenes and YP terpenes were evaluated for biological activity in antibacterial, antifungal and anthelmintic assays. The YP pro-terpenes retained the full biological activity of the parent terpene compound
Logical Form and Truth-Conditions
Full text linkThis paper outlines a truth-conditional view of logical form, that is, a view according to which logical form is essentially a matter of truth-conditions. Section 1 provides some preliminary clarifications. Section 2 shows that the main motivation for the view is the fact that fundamental logical relations such as entailment or contradiction can formally be explained only if truth-conditions are formally represented. Sections 3 and 4 articulate the view and dwell on its affinity with a conception of logical form that has been defended in the past. Sections 5-7 draw attention to its impact on three major issues that concern, respectively, the extension of the domain of formal explanation, the semantics of tensed
discourse, and the analysis of quantification.
Este artículo esboza una concepción veritativo-condicional de la forma lógica, es decir, una concepción de acuerdo con la cual la forma lógica es esencialmente una cuestión de condiciones de verdad. La sección 1 proporciona algunas clarificaciones preliminares. La sección 2 muestra que la principal motivación para esta concepción es el hecho de que hay relaciones lógicas fundamentales, como la implicación o la contradicción, que sólo pueden explicarse formalmente si las condiciones de verdad se representan formalmente. Las secciones 3 y 4 articulan dicha concepción y profundizan en su afinidad con una concepción de la forma lógica que ha sido defendida en el pasado. Las secciones 5 a 7 destacan su impacto sobre tres asuntos principales que conciernen, respectivamente, a la extensión del dominio de las explicaciones formales, la semántica del discurso temporalizado, y el análisis de la cuantificación
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