1,270 research outputs found
Avian area vasculosa and CAM as rapid in vivo pro-angiogenic and antiangiogenic models.
No full textAngiogenesis, the development of new blood vessels from preexisting ones, is driven by coordinated signaling pathways governed by specific molecules, hemodynamic forces, and endothelial and periendothelial cells. The processes involve adhesion, migration, and survival machinery within the target endothelial and periendothelial cells. Factors that interfere with any of these processes may therefore influence angiogenesis either positively (pro-angiogenesis) or negatively (antiangiogenesis). The avian area vasculosa (AV) and the avian chorioallantoic membrane (CAM) are two useful tools for studying both angiogenesis and antiangiogenesis since they are amenable to both intravascular and topical administration of target, agents, are relatively rapid assays, and can be adapted very easily to study angiogenesis-dependent processes, such as tumor growth. Both models provide a physiological setting that permits investigation of pro-angiogenic and antiangiogenic agent interactions in vivo
Einige überlegungen zu der zweiten gruppe navigantes in augustins dialog de beata vita
No full textAt the beginning of the series of Augustine’s earliest extant literary works are the three philosophical dialogues Contra Academicos, De beata vita and De ordine, which were composed in the autumn of 386 during Augustine’s otium philosophandi in Cassiciacum. In the introductions of all three works, the marine metaphors are widely used. The author compares human life with a stormy sea and sees as the only salvation the port of philosophy. In beata v. 1. 2 Augutin compares the people to whom philosophy can accommodate with navigantes, which he groups in tria genera. Although the people who belong to the respective group are described in detail, the author does not mention names. This arouses research interest and justifies the attempt to propose a representing person for each group.
The present work sets itself the goal by parallel reading of beata v. 1. 2, with some passages from Cicero’s Epistulae, Tusculanae disputationes and De officiis to make a new proposal. And this in addition to the currently existing assumption that Romanianus, to whom the dialogue Contra Academicos is dedicated, should be considered as a representative of the second group of seafarers. However, the author of the present work now ventures a completely new approach, in which Cicero can be accepted as a representative of this group
O „Damianie Capenece” Aleksandra Świętochowskiego. Zmagania z legendą
No full textThe objective of this paper is to analyse Aleksander Świętochowski’s debut novella series O życie [Oh Life], with particular emphasis on the opening novella. The reflections focus on Damian Capenko, a novella showcasing its relationship with the worldview of the second half of the 19th century and tendentious literature. The author proposes an interpretation of the work in the light of Dumania pesymisty [Musings of a Pessimist], an earlier series of texts by Świętochowski, one of the most outstanding creators of Positivist literature in Poland. As a result of the analyses, the relationship between the texts and the initial ideas of the Polish Positivism programme is explained, along with the apparent artistic inconsistency of the series. Celem artykułu jest analiza debiutanckiego cyklu nowelistycznego O życie Aleksandra Świętochowskiego, ze szczególnym uwzględnieniem utworu otwierającego tom. Rozważania koncentrują się na opowiadaniu Damian Capenko, ukazując jego związek ze światopoglądem drugiej połowy XIX wieku, literaturą tendencyjną. Autor proponuje interpretację utworu w świetle Dumań pesymisty, wcześniejszego cyklu wypowiedzi publicystycznych Świętochowskiego, jednego z najwybitniejszych twórców literatury pozytywizmu w Polsce. W wyniku przeprowadzonych analiz wyjaśniony zostaje związek tekstów z początkowymi ideami programu polskiego pozytywizmu, a także pozorna niespójność artystyczna cyklu
Arterial hypertension - definition, epidemiology, etiology, complications and treatment
No full textIlko Agnieszka, Wudarczyk Beata, Czyż Rafał, Jankowska-Polańska Beata. Arterial hypertension - definition, epidemiology, etiology, complications and treatment. Journal of Education, Health and Sport. 2018;8(8):533-541. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1319007
http://ojs.ukw.edu.pl/index.php/johs/article/view/5693
https://pbn.nauka.gov.pl/sedno-webapp/works/871749
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).
1223 Journal of Education, Health and Sport eissn 2391-8306 7
© The Authors 2018;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2018. Revised: 28.06.2018. Accepted: 22.07.2018.
Arterial hypertension - definition, epidemiology, etiology, complications and treatment
Agnieszka Ilko1, Beata Wudarczyk2 ([email protected]), Rafał Czyż3, Beata Jankowska-Polańska4
1 Graduate of Wroclaw Medical University
2 Department of Nursing, Faculty of Medicine and Health Science, University of Zielona Góra
3 Department of Emergency Medicine, Wroclaw Medical University
4 Department of Internal Nursing, Faculty of Health Sciences, Wroclaw Medical University
Agnieszka Ilko- orcid - https://orcid.org/0000-0003-4607-477X
Beata Wudarczyk - orcid - https://orcid.org/0000-0003-0495-8630
Rafał Czyż - orcid - https://orcid.org/0000-0001-5504-4543
Beata Jankowska-Polańska - orcid – https://orcid.org/0000-0003-3132-8044
Abstract
Arterial hypertension is classified as a chronic disease. It belongs to the group of disease that increase the risk of occurrence of cardiovascular complications, which if left untreated can lead to sudden death. It is estimated that in Poland currently 32% of the population suffers from arterial hypertension. Despite great progress in the diagnosis and treatment of hypertension, it is still a huge medical-socio-economic problem. Increasing the emphasis on patient education can significantly affect self-control, adaptation to recommendations and, consequently, in the future perspective will reduce the mortality rate among patients with this disease. The aim of this work is to draw attention to the still present problems of patients with hypertension by presenting the currently valid definition, epidemiology, etiology of the disease, complications and methods of treatment.
Key words: arterial hypertension, definition, epidemiology, etiology, complications, treatmen
Nuove acquisizioni sullo Specchio di Illuminazione della Beata Illuminata Bembo
No full textThe discovery of some fifteenth-century manuscripts of the Specchio di Illuminazione of Beata Bembo in the so-called “Archivio della Beata Caterina”, kept in the Archbishop’s General Archive of Bologna, has opened up new and completely unexpected perspectives on the hagiography of St. Catherine of Vigri, revealing a multiform and complex evolution of this work. Two new editions have emerged, different from the one known so far: one shorter and widely epitomized, the second longer, with significant inserts, concentrated mainly in chapters VI-IX. Based on some significant clues, the author hypothesizes that this drafting chronologically precedes that of the so-called “autograph” and that it has been the subject of a series of second thoughts and complaints by the author herself or her circle. Some 16th century codices have also emerged, witnesses of the drafting known so far, but not without interest. Very recent paleographic studies had questioned the real autography of the edited manuscript. A first examination of the new acquisitions seems to confirm that they do not derive from the “autograph”, presenting several lessons and disjunctive errors.La scoperta di alcuni manoscritti del XV secolo dello Specchio di Illuminazionedella Beata Bembo nel cosiddetto “Archivio della Beata Caterina”,custodito presso l’Archivio generale arcivescovile di Bologna, ha spalancatonuove prospettive, del tutto inattese, sull’agiografia di santa Caterina de’Vigri, rivelando un’evoluzione multiforme e complessa di quest’opera. Sono emerse due nuove redazioni, diverse da quella finora nota: l’una più breve e ampiamente epitomata, la seconda più lunga, con significativi inserti, concentrati soprattutto nei capitoli VI-IX. Sulla base di alcuni indizi significativi, l’autore ipotizza che questa redazione preceda cronologicamente quella del cosiddetto “autografo” e che sia stata oggetto di una serie di ripensamentie di censure da parte dell’autrice stessa o della sua cerchia. Sonoemersi anche alcuni codici del XVI secolo, testimoni della redazione finoranota, ma non privi di interesse. Recentissimi studi paleografici avevano messo in discussione la reale autografia del manoscritto edito. Un primo esame delle nuove acquisizioni sembra confermare che esse non derivino dall’“autografo”, presentando diverse lezioni ed errori disgiuntivi
Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.
No full textThe phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K isoforms as a novel anti-tumor approach in glioblastoma. Consistent expression of the PI3K catalytic isoform PI3K p110α was detected in a panel of glioblastoma patient samples. In contrast, PI3K p110β expression was only rarely detected in glioblastoma patient samples. The expression of a module comprising the epidermal growth factor receptor (EGFR)/PI3K p110α/phosphorylated ribosomal S6 protein (p-S6) was correlated with shorter patient survival. Inhibition of PI3K p110α activity impaired the anchorage-dependent growth of glioblastoma cells and induced tumor regression in vivo. Inhibition of PI3K p110α or PI3K p110β also led to impaired anchorage-independent growth, a decreased migratory capacity of glioblastoma cells, and reduced the activation of the Akt/mTOR pathway. These effects were selective, because targeting of PI3K p110δ did not result in a comparable impairment of glioblastoma tumorigenic properties. Together, our data reveal that drugs targeting PI3K p110α can reduce growth in a subset of glioblastoma tumors characterized by the expression of EGFR/PI3K p110α/p-S6
Grażyna joins the game
No full textA review of Radosław Rychcik's Grażyny (Ludwik Solski Theater in Tarnów, premiere: 23.05.2015) presented during the 2nd New Theater Festival in Rzeszów (23-30.10.2015). Beata Kustra interprets the performance mainly through the lens of Maria Janion's book Women and the Spirit of Otherness, quoted at the beginning of the performance. The author attempts to show that Rychcik adopts Janion's perspective, showing Grażyna to be a woman who adopted the male social role and who can become a heroine only posthumously - when her heroic deed becomes a myth. Kustra points out many motifs and devices used by the director and comes to the conclusion that some served only to make the performance more attractive
The hapiness and its search in De Beata Vita of Saint Augustine
No full textSanto Agostinho apresenta a posse de Deus como o porto da felicidade. Deste modo, veremos que com o diálogo De Beata Vita, o autor oferece uma resposta para tal questionamento, a partir de uma noção de felicidade que consiste no perfeito conhecimento de Deus. Assim, abordaremos a referida questão com a finalidade de tornar mais evidente a concepção agostiniana de felicidade e realização humana.Saint Augustine has the possession of God as the happiness of the harbor. Thus, we seethat with the De Vita Beata dialogue, the author offers na answer to this question, from a sense of happiness consists in the perfect knowledge of God. Thus, we will address that question in order to make it clear the Augustinian conception of happiness and human fulfillment.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES
Dynamics of the Developing Chick Chorioallantoic Membrane Assessed by Stereology, Allometry, Immunohistochemistry and Molecular Analysis.
No full textThe chick chorioallantoic membrane (CAM) is a widely used model for the study of angiogenesis, tumour growth, as well as drug efficacy. In spite of this, little is known about the developmental alteration from its appearance to the time of hatching. In the current study the CAM has been studied by classical stereology and allometry. Expression levels of selected angiogenesis-related molecules were estimated by RT-PCR and cell dynamics assessed by proliferation and apoptosis assays. Absolute CAM volume increased from a low of 0.47 ± 0.11 cm3 at embryonic day 8 (E8) to a high of 2.05 ± 0.27 cm3 at E18, and then decreased to 1.6 ± 0.47 cm3 at E20. On allometric analysis, three growth phases were identifiable. Between E8-13 (phase I), the CAM grew fastest; moderately in phase II (E13-18) but was regressing in phase III (E18-20). The chorion, the mesenchyme and the allantoic layers grew fastest in phase I, but moderately in phase II. The mesenchyme grew slowly in phase III while the chorion and allantois were regressing. Chorionic cell volume increased fastest in phase I and was regressing in phase III. Chorionic capillaries grew steadily in phase I and II but regressed in phase III. Both the chorion and the allantois grew by intrinsic cell proliferation as well as recruitment of cells from the mesenchyme. Cell proliferation was prominent in the allantois and chorion early during development, declined after E17 and apoptosis started mainly in the chorion from E14. VEGFR2 expression peaked at E11 and declined steadily towards E20, VEGF peaked at E13 and E20 while HIF 1α had a peak at E11 and E20. Studies targeting CAM growth and angiogenesis need to take these growth phases into consideration
Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway.
No full textAngiogenesis is a highly coordinated, extremely complex process orchestrated by multiple signaling molecules and blood flow conditions. While sprouting mode of angiogenesis is very well investigated, the molecular mechanisms underlying intussusception, the second mode of angiogenesis, remain largely unclear. In the current study two molecules involved in vascular growth and differentiation, namely endoglin (ENG/CD105) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) were examined to unravel their specific roles in angiogenesis. Down- respectively up-regulation of both molecules tightly correlates with intussusceptive microvascular growth. Upon ENG inhibition in chicken embryo model, formation of irregular capillary meshwork accompanied by increased expression of COUP-TFII could be observed. This dynamic expression pattern of ENG and COUP-TFII during vascular development and remodeling correlated with formation of pillars and progression of intussusceptive angiogenesis. Similar findings could be observed in mammalian model of acute rat Thy1.1 glomerulonephritis, which was induced by intravenous injection of anti-Thy1 antibody and has shown upregulation of COUP-TFII in initial phase of intussusception, while ENG expression was not disturbed compared to the controls but decreased over the time of pillar formation. In this study, we have shown that ENG inhibition and at the same time up-regulation of COUP-TFII expression promotes intussusceptive angiogenesis
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