447 research outputs found
Achieving Foundation Accountability and Transparency: Lessons From the Robert Wood Johnson Foundation’s \u3ci\u3eScorecard\u3c/i\u3e
No full text· The purpose of this article is to help foundations in their accountability and transparency efforts by sharing lessons from one foundation’s journey to develop a scorecard.
· A commitment to funding and sharing the results from rigorous evaluations set the tone for Robert Wood Johnson Foundation (RWJF) accountability.
· The Scorecard is a powerful tool for RWJF to set goals, track organizational effectiveness, and motivate responses to shortcomings.
· Foundations can tailor their scorecard to include what best serves their needs.
· With its Scorecard, RWJF found that comparative and quantitative measures are the most powerful forces to motivate change.
· Setting targets motivates staff to focus their efforts on certain areas and make improvements
On the association of terrestrial gamma-ray bursts with lightning and implications for sprites
No full textMeasurements of ELF/VLF radio atmospherics (sferics) at Palmer Station, Antarctica, provide evidence of active thunderstorms near the inferred source regions of two different gamma-ray bursts of terrestrial origin [Fishman et al., 1994]. In one case, a relatively intense sferic occurring within ±1.5 ms of the time of the gamma-ray burst provides the first indication of a direct association of this burst with a lightning discharge. This sferic and many others launched by positive cloud-to-ground (CG) discharges and observed at Palmer during the periods studied exhibit 'slow tail' waveforms, indicative of continuing currents in the causative lightning discharges. The slow tails of these sferics are similar to those of sferics originating in positive CG discharges that are associated with sprites
Lengua e identidad: a propósito de una publicación reciente
No full textEl objetivo principal de este artículo es mostrar el contenido de una publicación relativamente reciente en torno a la amplia problemática de "lengua e identidad", que ofrece una recopilación de una serie de publicaciones del sociólogo del lenguaje y sociolingüista J. A. Fishman al respecto. En las reflexiones finales se trata de enfatizar la importancia de las contribuciones de este autor."Hizkuntza eta identitatea" arazo zabalei buruzko argitalpen aski berri baten edukia azaltzea da artikulu honen helburu nagusia. J. A. Fishman hizkuntzaren soziologo eta soziolinguistaren zenbait lan biltzen ditu obra horrek. Amaierako hausnarketetan autore horren ekarpenen garrantzia nabarmentzen saiatzen gara.L'objectif principal de cet article est de montrer le contenu d'une publication relativement récente concernant la vaste problématique de "langue et identité", qui offre une compilation d'une série de publications du sociologue du langage et sociolinguiste J. A. Fishman à ce sujet. Dans les réflexions finales, il s'agit de mettre l'accent sur l'importance des contributions de cet auteur.The main objective of this article is to show the content of a relatively recent publication on the ample issue on "language and identity", that offers a summary of a series of publications by language sociologist and socio-linguist J. A. Fishman in this regard. In the final reflections the intention is to emphasise the importance of the contributions by this author
Electroretinographic abnormalities in parents of patients with Leber Congenital Amaurosis who have Heterozygous GUCY2D mutations
No full textBackground Leber congenital amaurosis (LCA) is an infrequently encountered congenital form of retinitis pigmentosa with marked genetic and clinical heterogeneity. Thus far, 10 genes have been identified in this disorder since 1996. In the future, LCA may become treatable by gene and/or pharmacological intervention, and these therapies will likely be gene specific, giving major significance to rapid gene identification and gene-phenotype studies. Objective To test the hypothesis that parents of patients with LCA have identifiable electroretinographic and psychophysical changes. Subjects, Materials, and Methods Complete eye examinations and electroretinographic studies were performed on 2 sets of parents whose offspring were diagnosed as having LCA and who were found to carry a mutation in 1 of the 10 LCA genes—GUCY2D. One set of parents also underwent static perimetry threshold measurements. Results We found that single flash-light–adapted a- and b-wave amplitudes, 30-Hz flicker, or both cone signals were significantly decreased in amplitude in 4 heterozygotes, while 2 parents showed delayed 30-Hz flicker implicit times. Electroretinographic rod-mediated signals were normal in 2 of the heterozygotes, but subnormal in 2. Static perimetry testing showed normal thresholds in the 2 heterozygotes tested. Main Outcome Measures Single flash-light–adapted a- and b-wave amplitudes and implicit times, 30- or 32-Hz flicker amplitudes and implicit times, rod-mediated signals, and dark-adapted, rod-mediated thresholds. Conclusions Some carrier parents of patients with LCA and a GUCY2D mutation develop measurable, cone and possibly rod abnormalities most consistent with a mild cone-rod dysfunction. This correlates well with the known retinal expression pattern of GUCY2D, which is considerably higher in cone compared with rod photoreceptor cells. <br/
Prolonged Fever With Pulmonary Nodules in a 4-Month-Old Baby
No full text[No abstract available]Absalon MJ, 2008, PEDIATR BLOOD CANCER, V50, P1147, DOI 10.1002-pbc.21454; Anderson MS, 2005, PEDIATRICS, V115; DENNIS O, 1978, AM J ROENTGENOL, V130, P29; FISHMAN AP, 2002, MANUAL PULMONARY DIS, P26; Freeman AF, 2003, PEDIATR PULM, V36, P102, DOI 10.1002-ppul.10333; Newburger JW, 2004, PEDIATRICS, V114, P1708, DOI 10.1542-peds.2004-2182; PICAZO MDM, 2006, RADIOLOGIA, V48, P14; Rowley AH, 2007, NELSON TXB PEDIAT, P1036; Swensen SJ, 2003, RADIOLOGY, V226, P756, DOI 10.1148-radiol.226302003611
History of psychotherapy : continuity and change /
No full textIncludes bibliographical references and index.A century of psychotherapy, 1860-1960 / Robin L. Cautin -- Psychotherapy, 1960 to the present / Patrick H. DeLeon ... [et al.] -- Psychoanalytic theories of psychotherapy / David L. Wolitzky -- Behavioral theories of psychotherapy / Daniel B. Fishman, Simon A. Rego, and Katherine L. Muller -- Humanistic and experiential theories of psychotherapy / Jeanne C. Watson, Rhonda N. Goldman, a d Leslie S. Greenberg -- Family systems theories of psychotherapy / David R. Chabot -- Cognitive theories of psychotherapy / Steven D. Hollon and Raymond DiGiuseppe -- Multicultural approaches to psychotherapy / Lillian Comas-Díaz -- Integrative approaches to psychotherapy / Marvin R. Goldfried, Carol R. Glass, and Diane B. Arnkoff -- Psychotherapy research and its achievements / Michael J. Lambert -- Unresolved questions and future directions in psychotherapy research / Bruce E. Wampold, Steven D. Hollon, and Clara E. Hill -- Psychotherapy research centers and groups / Judith V. Jordan ... [et al.] -- Psychotherapy patients / Eugene J. D'Angelo ... [et al.] -- Treatment modalities / Alan S. gurman ... [et al.] -- Psychotherapy for specific disorders / Lynn P. Rehm ... [et al.] -- Training systems and sites / Elizabeth A. Klonoff ... [et al.] -- Psychotherapy supervision / Allen K. Hess -- Ethics in psychotherapy / Norman Abeles and Gerald P. Koocher -- Into the future : retrospect and prospect in psychotherapy / John C. Norcross, Donald K. Freedheim, and Gary R. VandenBos
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
No.552 Steve Frishman
No full textTranscript (38 pages) of interview by Danielle Endres with Steve Frishman on November 13, 2009Frishman (b. 1944) was born in Washington D.C. He is a technical consultant for the law firm representing the State of Nevada in its contention of the Department of Energy\u27s application to the Nuclear Regulatory Commission for a license for the Yucca Mountain repository. Prior to this, Frishman worked as a Technical-Policy Coordinator for the Nevada Agency for Nuclear Projects. He discusses graduate school in Texas, running a local newspaper, serving as a commissioner on the Texas Coastal and Marine Council, and working for the Texas state government when a site in Texas was being considered for a high level nuclear waste repository. He first came to Nevada to work as a consultant for the Nevada Agency for Nuclear Projects, and was involved in the fight against the Yucca Mountain repository. Fishman describes some of the technical problems with the Yucca Mountain site, and the differences between Department of Energy science and independent science on the site. He ends by taking about some of the alternatives to the Yucca Mountain site. Nuclear Technology Project. Interviewer: Danielle Endre
Detailed optical and near-infrared polarimetry, spectroscopy and broad-band photometry of the afterglow of GRB 091018 : polarization evolution
No full textFollow-up observations of large numbers of gamma-ray burst (GRB) afterglows, facilitated by the Swift satellite, have produced a large sample of spectral energy distributions and light curves, from which their basic micro- and macro-physical parameters can in principle be derived. However, a number of phenomena have been observed that defy explanation by simple versions of the standard fireball model, leading to a variety of new models. Polarimetry can be a major independent diagnostic of afterglow physics, probing the magnetic field properties and internal structure of the GRB jets. In this paper we present the first high-quality multi-night polarimetric light curve of a Swift GRB afterglow, aimed at providing a well-calibrated data set of a typical afterglow to serve as a benchmark system for modelling afterglow polarization behaviour. In particular, our data set of the afterglow of GRB 091018 (at redshift z = 0.971) comprises optical linear polarimetry (R band, 0.13-2.3d after burst); circular polarimetry (R band) and near-infrared linear polarimetry (Ks band). We add to that high-quality optical and near-infrared broad-band light curves and spectral energy distributions as well as afterglow spectroscopy. The linear polarization varies between 0 and 3per cent, with both long and short time-scale variability visible. We find an achromatic break in the afterglow light curve, which corresponds to features in the polarimetric curve. We find that the data can be reproduced by jet break models only if an additional polarized component of unknown nature is present in the polarimetric curve. We probe the ordered magnetic field component in the afterglow through our deep circular polarimetry, finding P circ < 0.15per cent (2σ), the deepest limit yet for a GRB afterglow, suggesting ordered fields are weak, if at all present. Our simultaneous R- and Ks-band polarimetry shows that dust-induced polarization in the host galaxy is likely negligible
Understanding The GLAST Burst Monitor Detector Calibration: A Detailed Simulation Of The Calibration Including The Environment
No full textThe GLAST Burst Monitor (GBM) is the secondary instrument on NASA's next Gamma-ray mission GLAST. It will enhance the capabilities of GLAST by locating and detecting cosmic gamma-ray bursts at lower energies by the use of 12 NaI detectors (energy range 10 keV to 1 MeV) and 2 BGO-detectors (energy range 150 keV to 30 MeV). GBM was built in a close collaboration between the MPE and the Marshall Space Flight Center (MSFC). The angular and energy response of each GBM detector has been calibrated using various radioactive sources at different incidence angles relative to the detector in a laboratory environment at the MPE in 2005. To facilitate the understanding of the reconstruction of the detector response, a detailed simulation of the whole laboratory environment and the setup of the calibration source were performed. A modified version of the CERN GEANT 4 simulation software (provided by collaborators at the Los Alamos National Laboratory) was used
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