1,201 research outputs found

    Stephen Fried, Learning from Fred Harvey

    No full text
    https://digitalrepository.unm.edu/cswr_willard/1001/thumbnail.jp

    Book Review: The Middle Ages : [Rezension zu:] The Middle Ages. Johannes Fried. Harvard University Press. 2015

    No full text
    In Johannes Fried’s The Middle Ages, the author makes his case for an alternative interpretation of the medieval period as much more sophisticated than commonly thought, writes Ignas Kalpokas. The book intricately traces how ideas and systems of thought that we now consider quintessentially modern European ways of life, thinking and culture stemmed from this time period

    Modifying the rat grimace scale for the sub-second assessment of acute pain

    No full text
    The goal of this study is to improve the way pain is measured in rodents. A previous 2019 publication by Dr. Nathan T. Fried utilized slow-motion videography and statistical modeling to analyze hind paw withdrawal caused by painful stimuli. Upon reanalyzing the one-second slow-motion videos from his study, there was more data in the facial features of the rat, which was not characterized in his work. A 2011 study performed in Dr. Jeffrey Mogil’s lab led to the development of the Rat and Mouse Grimace Scales (RGS, MGS), which measure facial features of pain in these rodents. However, their measurement using the Grimace Scale relied on 30 minutes of video analysis. This project further applies the RGS to the one-second slow-motion videos to assess facial rat grimace in response to different painful stimuli.Winner: Second Place, 2022 Paul Robeson Library Undergraduate Research Award

    Revisiting the Fried Chicken Recipe

    No full text
    Twenty-five years ago, Gary Lawson introduced us to legal theory’s tastiest analogy. He told us about a late-eighteenth-century recipe for making fried chicken and how we ought to interpret it. Lawson’s pithy essay has much to be praised. Yet, even twenty-five years later, there remains more to be said about legal theory’s most famous recipe. In particular, there remains much more to be said about the recipe’s author, a person (or, perhaps, group of people) whom Lawson does not discuss. Lawson’s analysis of the recipe leads him to an “obvious” conclusion: the recipe’s meaning is its original public meaning. If we consider those who wrote the recipe and their joint act of recipe-writing, however, I question whether that conclusion remains so obvious. This Essay takes a closer look at the chefs who wrote the fried chicken recipe and their act of recipe-writing that produced it. I argue that the meaning of the fried chicken recipe is not its original public meaning but is rather the meaning the chefs intended the recipe to have, even on Lawson’s own terms

    Protein modifications in baked versus fried tortilla chips

    No full text
    Lipid oxidation is recognized as the greatest problem in chemical stabilization of processed foods during storage. Lipid co-oxidations caused by reactions of lipid oxidation intermediates and products with other molecules, particularly proteins, are known, but their impact on food quality (production of off-flavors and odors, loss of color and nutritional value, and texture deterioration) remains largely unexplored, and relatively little is known about the mechanisms involved. However, it is likely that co-oxidations account for much of the “damage” normally attributed to lipid oxidation and provide footprints of lipid oxidation that are not detected in general assays of lipid oxidation. In this research, primary experiments have compared the difference between proteins in baked and fried tortilla chips to distinguish thermal effects of processing from co-oxidation by lipids. Preliminary results showed little difference in protein solubility in fresh baked or fried chips, yet gel electrophoresis revealed significant lipid-mediated differences in disulfide cross-linking in fried chips even immediately after processing without incubations. Schiff base formation was present, but only at low levels, indicating that it is not a major source of cross-linking in early stages of oxidation. Cross-linking continued to develop even more extensively in fried chips during storage at 40 and 60 ºC, and included free radical in addition to disulfide cross-linking. Western blots revealed the presence of protein carbonyls, important co-oxidation products, in most protein fractions in tortilla chips and notably in zeins. Surprisingly, more carbonyls were observed in baked chips with lower lipid content. To determine the connections between these protein changes and lipids, lipid oxidation is being followed in all systems by lipids extractability, free fatty acids, aldehydes and peroxides.M.S.Includes bibliographical referencesIncludes vitaby Yuan Don

    A Scanning Tunneling Microscope with a Wide Sampling Range

    No full text
    This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Review of Scientific Instruments and may be found at https://aip.scitation.org/doi/10.1063/1.1141110.Construction of a simple scanning tunneling microscope (STM) is described. This STM is suitable for atmospheric, controlled atmosphere, and high vacuum (but not UHV) work. This STM is especially wen suited for determining surface topography on the 0.1 nm scale when images must be obtained over a wide sampling region (mm). Interchangeable piezo heads allow the STM to be used either for atomic resolution or for large (800 X 800 urn) area scans. Atomic resolution pictures of the graphite surface demonstrate that this design is suitable for use with structures smaller than 0.1 nm. An image of a thin film of Au, deposited on pyrex, is also presented.K.W. Hipps, Glenn Fried, and Dale Fried. (1990). A Scanning Tunneling Microscope with a Wide Sampling Range. Review of Scientific Instruments. 61 1869-1873

    Modernism and the discovery of finitude

    No full text
    The discovery of finitude, after all, is a discovery of something that must have been true of human concepts from the start. Philosopher has a way of accounting for the mutual imbrication of classification and evaluation, which Fried argues is crucial to the modernist condition. Stephen Davies's remarks come in the context of a critique of "The Role of Theory in Aesthetics," a classic article by Morris Weitz from 1956, which influentially argued that "art" should be understood as a family resemblance concept in Wittgenstein's sense. Consider Weitz's worry that aestheticians who deploy definitions of art are smuggling subjective judgments of value into ostensibly objective accounts. Despite his claims about their supreme value, consider how bizarre aesthetic theories must actually look to Weitz. Despite their obvious differences, Dickie's account and that of Weitz both rely on a blunt distinction between classification and evaluation

    Does HIV accelerate the aging process? An assessment of clinical, ophthalmic and serum parameters in HIV-infected individuals in South Africa

    No full text
    HIV-infected individuals are at increased risk of age-related non-AIDS morbidity and mortality compared with HIV-uninfected persons. It is speculated that HIV-infected individuals may not only be aging chronologically, but also undergoing accelerated biological aging. This is supported by clinical reports of conditions classically associated with the normal aging process appearing at an earlier age in HIV-infected persons compared to age-matched controls. Chronological age is an imprecise measure of biological aging due to inter-individual differences in rates of aging and therefore ‘biomarkers of aging’ may be used to assess biological age. The eye may be a uniquely useful site as a model of aging. It is easily accessible for examination and several components can be measured and assessed objectively e.g. lens density, retinal vascular calibre, corneal endothelial cell counts and the retinal nerve fibre layer thickness. This case-control study of 504 adults recruited from one district in Cape Town, South Africa assessed whether HIV-infected individuals have more advanced ocular aging, systemic frailty and cellular senescence than an HIV-uninfected group of similar age. Accelerated biological aging was demonstrated in HIV-infected individuals compared to their uninfected counterparts. HIV infection was also associated with frailty. Ocular parameters provided evidence of greater aging within the HIV-infected group, particularly objective measurement of retinal vascular calibre and lens density. These data suggest that as well as increased biological aging at a cellular and systemic level, ocular aging occurs as part of the accelerated aging phenotype in HIV infection. This study provides novel data about accelerated biological aging in sub-Saharan Africa and a platform for addressing future research questions relating to accelerated aging trajectories in HIV infection, the relative contributions of the infection and antiretroviral therapy, and whether biological age is dependent upon the duration of untreated disease or nadir CD4 count. As the HIV-infected population continues to age and expand, accelerated biological aging may have wideranging implications for the burden and management of HIV-related morbidity

    Supplemental_Material – Supplemental material for An innovative SMS intervention to improve adherence to stimulants in children with ADHD: Preliminary findings

    No full text
    Supplemental material, Supplemental_Material for An innovative SMS intervention to improve adherence to stimulants in children with ADHD: Preliminary findings by Ronna Fried, Maura DiSalvo, Caroline Kelberman, Amos Adler, Debra McCafferty, K Yvonne Woodworth, Allison Green, Itai Biederman, Stephen V Faraone and Joseph Biederman in Journal of Psychopharmacology</p
    corecore