231 research outputs found
Faire un stage de recherche à LAM. Entretien avec Arnaud Dupuy, stagiaire LAM
No full textFree consultation with a Doctor of mobile health team has Madagacar. Author : Docteur Ando. Licence : CC BY SA. https://commons.wikimedia.org/wiki/File:Free_consultation_with_a_Doctor_of_mobile_health_team_has_Madagacar.jpg En mai-juin 2019, Arnaud Dupuy a accompli un stage au laboratoire Les Afriques dans le monde, encadré par Jean-Philippe Berrou, enseignant-chercheur en économie. Il a été impliqué dans deux programmes de recherches pluridisciplinaires concernant l’aire africaine. Qu’est..
Françoise Dupuy (1925-2022) : a dança como afirmação da vida
No full textObituary written in honor of Françoise Dupuy (1925-2022), one of the most talented and engaged dancers of her generation in Europe, heiress to the Hellerau-Laxenburg tradition, a famous school of Dalcroze Eurhythmics and dance directed by Valeria Kratina and Rosalia Chladek. The text intertwines the most important episodes of Madame Dupuy artistic career with memories of encounters, conversations and subtle learnings experienced by the author in internships held in France and during her memorable appearance, on stage, at the age of 82, at the V Internacional Dance Biennial of Santos, South coast of São Paulo, Brazil.Obituário poético dedicado a Françoise Dupuy (1925-2022), una de las danzarinas más talentosas y comprometidas de su generación en Europa, heredera directa de la tradición de Hellerau-Laxenburg, reconocida escuela dalcroziana de gimnasia rítmica y danza dirigida por Valeria Kratina y Rosalia Chladek. La narración entrelaza los episodios más importantes de la carrera artística de Madame Dupuy con recuerdos de encuentros, conversaciones y sutiles aprendizajes vividos por el autor en sus estagios realizados en Francia y durante su memorable aparición en escena, a los 82 años, en la V Bienal Internacional de Danza de Santos.A Obituário-poético consagrado à Françoise Dupuy (1925-2022), uma das dançarinas mais talentosas e engajadas de sua geração na Europa, herdeira direta da tradição de Hellerau-Laxemburgo, renomada escola dalcroziana de ginástica rítmica e dança liderada por Valeria Kratina e Rosalia Chladek. A narrativa entrelaça os episódios mais importantes da trajetória artística de madame Dupuy com as memórias dos encontros, conversas e aprendizados sutis vivenciados pelo autor em estágios realizados na França e durante a sua memorável aparição, em cena, aos 82 anos, na V Bienal Internacional de Dança de Santos
Gold(I)-catalyzed synthesis of furans and pyrroles via alkyne hydration
No full textFurans and pyrroles were prepared via the gold(I)-catalyzed alkyne hydration of diynes. The use of [Au(IPr)OH] as precatalyst in a silver-free protocol permits low catalyst loadings and in situ generation of the active cationic gold species. A detailed computational study confirmed the experimental results and supports the proposed mechanism
Enrique Dupuy de Lôme: His ‘Estudios sobre el Japón’ (1895) and the 19th-century European imperialism
No full textEste estudio analiza la obra Estudios sobre el Japón, escrita por el diplomático español Enrique Dupuy de Lôme en 1895. Estos tres elementos (obra, autor y fecha) permiten apreciar interconexiones entre Estados Unidos, Japón y España a finales del siglo xix. Una época en la que el imperialismo y los estados-nación formaban parte de la dinámica internacional. Como se demuestra aquí, estos elementos eran un problema para España que amenazaba su legitimidad en las lejanas colonias del Atlántico y del Pacífico, como Dupuy sostiene, un peligro. Aunque, la prioridad es analizar Estudios sobre el Japón, estableciendo la cronología de confección de las diferentes partes de la obra, en última instancia, todo ello se vincula con el imperialismo japonés y estadounidense y la creación del estado nación japonésThis study analyzes the work ‘Estudios sobre el Japón’ (Studies about Japan), written by the Spanish diplomat Enrique Dupuy de Lôme in 1895. These three elements (work, author and date) show us interconnections between the United States, Japan and Spain by the end of the 19th century. During this time, imperialism and nation states were taking part in the international context. From the Spanish point of view, these elements constituted a threat to the legitimacy of Spain in the Atlantic and Pacific´s colonies, or as Dupuy argues, a danger. Although our priority is to analyze Estudios sobre el Japón providing a chronology of the development of the different parts of the book, at the end, it is possible to appreciate a link between the results and the Japanese and United States imperialism, and the rise of Japan as a nation stateEl artículo forma parte del proyecto “Construcciones del yo: narraciones y representaciones del sujeto moderno entre lo personal y lo colectivo, siglos XVII-XIX” (MINECO-HAR2014-53802-P
Unité et diversité. Réflexion sur l'oeuvre de René-Jean Dupuy (1918-1997)
No full textSpanning almost the entire second half of the twentieth century, and concerning the majority of domains of international law, and intensified by numerous borrowings from the history of political thought, philosophy, and sociology, the work of René-Jean Dupuy is at once of a striking density and yet of a remarkable diversity. It doesn't lose, however, its unity, which is grounded in the author's constant willingness to probe the change from the "world of cities" to the "City of the world". Profoundly influenced by the work of Georges Scelle, it's in a structural resolution of the problem raised by the multiplicity of "powers" that René-Jean Dupuy surveys the elements for such an evolution. Nevertheless, having quickly perceived the limits of his works, he turned more decisively towardq "ethics". Thus, Dupuy essentially studies how the different actors of the international legal order regard the international community and humanity. Consequently, he proposes to determine the meanings to organize the plurality of the ethics in the underlying unity of what Dupuy labels englobants, the emergence of which wwas precipitated by the upheavals that occurred during the twentieth century. This shift from "powers" to "ethics" does not form a break in the work of an author who would progressively abandon legal analysis in order to devote himself to works of a sociological or indeed of a philosophical nature. The work of René-Jean Dupuy rests entirely on an equivalence that he borrows from Scelle : law is at the conjunction of ethics and power. Thus, the work of Dupuy firts and foremost questions the jurist and calls him to reflect upon the role of his discipline when confronted by the challenges of the "earth city" under construction, and in so doing, on his place as a member of this city.Embrassant la quasi-intégralité de la seconde moitié du XXème siècle, traitant de la majorité des domaines couverts par le droit international, et enrichie par de nombreux emprunts à l'histoire des idées politiques, à la philosophie, ou encore, à la sociologie, l'oeuvre de René-Jean Dupuy est d'une remarquable densité et d'une grande diversité. Elle n'en perd pas pour autant son unité, laquelle réside dans la volonté constante de l'auteur de sonder les voies d'un passage du "monde des cités" à la "Cité du monde". Fortement influencé par Georges Scelle, c'est dans une résolution "structurelle" du problème posé par la multiplicité des "pouvoirs" que René-Jean Dupuy cherche dans un premier temps les éléments d'une telle évolution. En percevant toutefois les limites, il se tourne plus résolument vers les "éthiques". Il étudie essentiellement, dans cette perspective, les représentations que se font de la communauté internationale et de l'humanité les différents acteurs de l'ordre juridique international. Il se propose alors de déterminer les moyens à même d'ordonner la pluralité des éthiques dans l'unité que sous-tendent ces deux "englobants" dont les bouleversements survenus au cours du XXème siècle ont précipité l'émergence. Ce glissement, des "pouvoirs" vers les "éthiques", ne dessine pas une rupture dans l'oeuvre d'un auteur qui délaisserait progressivement l'analyse juridique pour verser exclusivement dans la sociologie, voire la philosophie. L'oeuvre de René-Jean Dupuy repose tout entière sur une équation qu'il emprunte à Scelle : le droit est à la conjonction de l'éthique et du pouvoir. Aussi interpelle-t-elle au premier chef le juriste qu'elle convoque à une réflexion sur le rôle de sa discipline face aux défis lancés à la "Cité terrestre" en construction, ce faisant, sur sa place en tant que membre de cette Cité
Unité et diversité. Réflexion sur l'oeuvre de René-Jean Dupuy (1918-1997)
No full textSpanning almost the entire second half of the twentieth century, and concerning the majority of domains of international law, and intensified by numerous borrowings from the history of political thought, philosophy, and sociology, the work of René-Jean Dupuy is at once of a striking density and yet of a remarkable diversity. It doesn't lose, however, its unity, which is grounded in the author's constant willingness to probe the change from the "world of cities" to the "City of the world". Profoundly influenced by the work of Georges Scelle, it's in a structural resolution of the problem raised by the multiplicity of "powers" that René-Jean Dupuy surveys the elements for such an evolution. Nevertheless, having quickly perceived the limits of his works, he turned more decisively towardq "ethics". Thus, Dupuy essentially studies how the different actors of the international legal order regard the international community and humanity. Consequently, he proposes to determine the meanings to organize the plurality of the ethics in the underlying unity of what Dupuy labels englobants, the emergence of which wwas precipitated by the upheavals that occurred during the twentieth century. This shift from "powers" to "ethics" does not form a break in the work of an author who would progressively abandon legal analysis in order to devote himself to works of a sociological or indeed of a philosophical nature. The work of René-Jean Dupuy rests entirely on an equivalence that he borrows from Scelle : law is at the conjunction of ethics and power. Thus, the work of Dupuy firts and foremost questions the jurist and calls him to reflect upon the role of his discipline when confronted by the challenges of the "earth city" under construction, and in so doing, on his place as a member of this city.Embrassant la quasi-intégralité de la seconde moitié du XXème siècle, traitant de la majorité des domaines couverts par le droit international, et enrichie par de nombreux emprunts à l'histoire des idées politiques, à la philosophie, ou encore, à la sociologie, l'oeuvre de René-Jean Dupuy est d'une remarquable densité et d'une grande diversité. Elle n'en perd pas pour autant son unité, laquelle réside dans la volonté constante de l'auteur de sonder les voies d'un passage du "monde des cités" à la "Cité du monde". Fortement influencé par Georges Scelle, c'est dans une résolution "structurelle" du problème posé par la multiplicité des "pouvoirs" que René-Jean Dupuy cherche dans un premier temps les éléments d'une telle évolution. En percevant toutefois les limites, il se tourne plus résolument vers les "éthiques". Il étudie essentiellement, dans cette perspective, les représentations que se font de la communauté internationale et de l'humanité les différents acteurs de l'ordre juridique international. Il se propose alors de déterminer les moyens à même d'ordonner la pluralité des éthiques dans l'unité que sous-tendent ces deux "englobants" dont les bouleversements survenus au cours du XXème siècle ont précipité l'émergence. Ce glissement, des "pouvoirs" vers les "éthiques", ne dessine pas une rupture dans l'oeuvre d'un auteur qui délaisserait progressivement l'analyse juridique pour verser exclusivement dans la sociologie, voire la philosophie. L'oeuvre de René-Jean Dupuy repose tout entière sur une équation qu'il emprunte à Scelle : le droit est à la conjonction de l'éthique et du pouvoir. Aussi interpelle-t-elle au premier chef le juriste qu'elle convoque à une réflexion sur le rôle de sa discipline face aux défis lancés à la "Cité terrestre" en construction, ce faisant, sur sa place en tant que membre de cette Cité
Structure of gel phase DPPC determined by X-ray diffraction
No full textHigh resolution low angle x-ray data are reported for the gel phase of DPPC lipid bilayers, extending the previous q range of 1.0 Å−1 to 1.3 Å−1, and employing a new technique to obtain more accurate intensities and form factors |F(q)| for the highest orders of diffraction. Combined with previous wide angle x-ray and volumetric data, a space filling model is employed to obtain gel phase structure at a mesoscopic level. This analysis provides direct evidence that the hydrocarbon chains from opposing monolayers are mini-interdigitated, consistent with the previously well-established result that the opposing monolayers are strongly coupled with respect to their chain tilt directions. Even more detailed structural features are described that have not been obtained from experiment but that could, in principle, be obtained from simulations that would first be validated by agreement with the wide angle and the new low angle |F(q)| x-ray data.Fil: Nagle, John F.. University of Carnegie Mellon; Estados UnidosFil: Cognet, Pierre. University of Carnegie Mellon; Estados UnidosFil: Dupuy, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Tristram-Nagle, Stephanie. University of Carnegie Mellon; Estados Unido
Histórias do mestre-dançarino-escritor Dominique Dupuy: uma vida em estado de arte (e combate)
No full textReview of the book La Sagesse du Danseur (The Wisdom of the Dancer), by Dominique Dupuy (1930-2024), one of the most emblematic figures of French contemporary dance. The work (originally published in 2011) is a poetic essay in which the author weaves together autobiographical memories of a long-lived artistic career (over 70 years) with profound reflections on dance, on the development of the dancer and on the secrets of teaching this ancient and magical language. To carry out this work, we focused on the Italian version of this work (La Saggezza del Danzatore, 2014), masterfully translated by historian Eugenia Casini Ropa under the watchful eyes of the author.Reseña del libro La Sagesse du Danseur (La Sabiduría del Danzarín), escrito por Dominique Dupuy (1930-2024), una de las figuras más emblemáticas de la danza contemporánea francesa. La obra, publicada originalmente en 2011, es un ensayo poético en el que el autor entrelaza recuerdos autobiográficos de una longeva trayectoria artística (más de 70 años) con profundas reflexiones sobre la danza, sobre el devenir del danzarín y sobre los secretos de la enseñanza de este lenguaje ancestral y mágico. Para realizar este trabajo nos centramos en la versión italiana de esta obra (La Saggezza del Danzatore, 2014), magistralmente traducida por la historiadora Eugenia Casini Ropa bajo la atenta mirada del autor.Dupuy (1930-2024), uma das figuras mais emblemáticas da dança contemporânea francesa. A obra, publicada originalmente em 2011, é um ensaio poético no qual o autor costura rememorações autobiográficas de uma longeva trajetória artística (mais de 70 anos) com profundas reflexões sobre a dança, sobre o devir do dançarino e sobre os segredos da transmissão dessa linguagem ancestral e mágica. Para efetivar o nosso trabalho, debruçamo-nos sobre a versão italiana dessa obra, intitulada La Saggezza del Danzatore (2014) e magistralmente traduzida pela historiadora Eugenia Casini Ropa com a cumplicidade do autor
Selective Interaction of Colistin with Lipid Model Membranes
No full textAlthough colistin's clinical use is limited due to its nephrotoxicity, colistin is considered to be an antibiotic of last resort because it is used to treat patients infected with multidrug-resistant bacteria. In an effort to provide molecular details about colistin's ability to kill Gram-negative (G(−)) but not Gram-positive (G(+)) bacteria, we investigated the biophysics of the interaction between colistin and lipid mixtures mimicking the cytoplasmic membrane of G(+), G(−) bacteria as well as eukaryotic cells. Two different models of the G(−) outer membrane (OM) were assayed: lipid A with two deoxy-manno-octulosonyl sugar residues, and Escherichia coli lipopolysaccharide mixed with dilaurylphosphatidylglycerol. We used circular dichroism and x-ray diffuse scattering at low and wide angle in stacked multilayered samples, and neutron reflectivity of single, tethered bilayers mixed with colistin. We found no differences in secondary structure when colistin was bound to G(−) versus G(+) membrane mimics, ruling out a protein conformational change as the cause of this difference. However, bending modulus KC perturbation was quite irregular for the G(−) inner membrane, where colistin produced a softening of the membranes at an intermediate lipid/peptide molar ratio but stiffening at lower and higher peptide concentrations, whereas in G(+) and eukaryotic mimics there was only a slight softening. Acyl chain order in G(−) was perturbed similarly to KC. In G(+), there was only a slight softening and disordering effect, whereas in OM mimics, there was a slight stiffening and ordering of both membranes with increasing colistin. X-ray and neutron reflectivity structural results reveal colistin partitions deepest to reach the hydrocarbon interior in G(−) membranes, but remains in the headgroup region in G(+), OM, and eukaryotic mimics. It is possible that domain formation is responsible for the erratic response of G(−) inner membranes to colistin and for its deeper penetration, which could increase membrane permeability.Fil: Dupuy, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. University of Carnegie Mellon; Estados UnidosFil: Pagano, Isabella. University of Carnegie Mellon; Estados UnidosFil: Andenoro, Kathryn. University of Carnegie Mellon; Estados UnidosFil: Peralta, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. University of Carnegie Mellon; Estados UnidosFil: Elhady, Yasmene. University of Carnegie Mellon; Estados UnidosFil: Heinrich, Frank. University of Carnegie Mellon; Estados UnidosFil: Tristram-nagle, Stephanie. University of Carnegie Mellon; Estados Unido
Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers
No full textIn an effort to provide new treatments for the global crisis of bacterial resistance to current antibiotics, we have used a rational approach to design several new antimicrobial peptides (AMPs). The present study focuses on 24-mer WLBU2 and its derivative, D8, with the amino acid sequence, RRWVRRVRRWVRRVVRVVRRWVRR. In D8, all of the valines are the Denantiomer. We use X-ray low- and wide-angle diffuse scattering data to measure elasticity and lipid chain order. We show a good correlation between in vitro bacterial killing efficiency and both bending and chain order behavior in bacterial lipid membrane mimics; our results suggest that AMP-triggered domain formation could be the mechanism of bacterial killing in both Grampositive and Gram-negative bacteria. In red blood cell lipid mimics, D8 stiffens and orders the membrane, while WLBU2 softens and disorders it, which correlate with D8’s harmless vs. WLBU2’s toxic behavior in hemolysis tests. These results suggest that elasticity and chain order behavior can be used to predict mechanisms of bactericidal action and toxicity of new AMPs.Fil: Kumagai, Akari. University of Carnegie Mellon; Estados UnidosFil: Dupuy, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Arsov, Zoran. Jožef Stefan Institute; EsloveniaFil: Elhady, Yasmene. University of Carnegie Mellon; Estados UnidosFil: Moody, Diamond. University of Carnegie Mellon; Estados UnidosFil: Erns, Robert. University of Maryland; Estados UnidosFil: Deslouches, Berthony. University of Pittsburgh; Estados UnidosFil: Montelaro, Ronald. University of Pittsburgh; Estados UnidosFil: Di, Yuanpu Peter. University of Pittsburgh; Estados UnidosFil: Tristram-Nagle, Stephanie. University of Carnegie Mellon; Estados Unido
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