97 research outputs found
31.4 GENETIC, IMMUNOLOGICAL AND BIOCHEMICAL MARKERS OF TREATMENT RESPONSE IN SCHIZOPHRENIA
No full textThe existence of the autobiographical theatre expression : the affecting presence of the dramatic writer in own work
No full textL'autobiographie pose problème quand elle est envisagée dans le genre théâtral. Du fait que l'auteur dramatique s'exprime par la bouche d'êtres fictifs, la parole des personnages ne pourrait être assimilée à la sienne. Pourtant, il semble que, tant dans les dialogues qu'elles donnent à entendre que dans les situations, personnages et lieux qu'elles mettent en scène certaines pièces, en particulier à partir du XVIIIe siècle, qui constitue une étape majeure dans l'expression de soi, portent en elles les signes d'une expression autobiographique. Si l'autobiographie n'existe pas au théâtre dans les termes dégagés par des théoriciens comme P. Lejeune ou G. Gusdorf, nous étudions ici les modalités sous lesquelles elle se manifeste néanmoins, quasiment toujours de manière cachée, implicite, ambiguë, détournée mais affective. En plus d'une méthode qui permettrait, au lecteur d'une part, au spectateur d'autre part, d'identifier et d'attester cette expression autobiographique en dégageant certains aspects textuels et scéniques, nous nous attachons à réfléchir à l'expression autobiographique avec la relation qu'entretiennent les oeuvres de notre corpus avec le public, une relation toute entière épanouie dans l'émotion. Des sentiments qu'accompagnent des réactions physiques ressenties par le lecteur/spectateur sont donc générées par la reconnaissance de la voix de l'auteur dans un drame qui mêle autobiographie et fiction. Nous nous intéressons à l'expression autobiographique de l'auteur dramatique dans la perspective d'une relation particulière de celui-ci avec le public, relation qui contraste avec les principes brechtiens qui ont dominé la création théâtrale au XXe siècle.The autobiographical genre is a problem when it is considered inside the theatral genre. Because the dramatical author express himself through the mouth of fictional characters, the words of the characters could not be considered as the expression of the author himself. However, it seems that through the dialogues that can be heard, the situations, the characters and the places that are staged, some plays, especially since the 18th century, which represents a major step in self-expression, contains the signs of an autobiographical expression. Although the autobiographical genre as defined by P. Lejeune or G. Gusdorf does not exists in the theatre genre, we will study here how it nevertheless expresses itself, that is to say almost always in a hidden, implicit, ambiguous, diverted, but probable way. We will think of a method allowing the reader, but also the member of the audience, to identify and testify the presence of this autobiographical expression by emphazising some textual and scenic aspects. We will also work on connecting the autobiographical expression with the relationship that live the authors of the new work contained in our corpus with the audience. This relationship being fully opend up in emotion. Some feelings, coming with physical reactions felt by the reader/audience, are created by the recognition of the author's voice in a drama that mixes autobiographical and fiction. We will take an interest in the autobiographical expression of the dramatical author through the perspective of his particular relationship with the audience, relationship that contrasts with Brecht's principles, which have ruled the theatrical creation in the 20th century
APLIKASI SISTEM MANAGEMENT SERVIS DI PT. DINAR TECH SHARE-E (EXCELLENT COMPUTER SEMARANG) MENGGUNAKAN PHP MySql
No full textAlong with the times now everything should be based Digital. In this case the work is so, so applications in the process of servicing will be easier to do in serving konsumen.Teknologi communication is growing very rapidly as more and more public demand for these technologies. Being a Customer Service is not easy, so in this case required the assistance program of work. To ensure a satisfactory service. Things have been done and which have not been done on designing Service Application Program will be discussed in the final section of this report. In this case as the author of each day doing the work is carried out in the efforts to help the problem. Based on the major servicing and satisfactory service, the support of all employees is necessary
Susceptibility genes in ischemic stroke and intracranial atherosclerosis: clinical and autopsy studies
No full textStroke is the third leading cause of death and the most common cause of disability in the world. To relieve the heavy burden of stroke, we need to understand the mechanisms that will form the basis of improved prevention and treatment. Epidemiological studies have found evidence for a genetic influence on the common form of stroke. However the genetic of stroke is still in its infancy. Subclinical intracranial atherosclerosis is sometime a predisposing factor for ischemic stroke (IS). This study was carried out to elucidate genetic factors influencing the complex phenotype of IS and subclinical intracranial atherosclerosis.<p>In the Belgium Stroke Study (BSS), we collected 237 middle-aged (45-60 yrs) patients with small vessel occlusion (SVO) or large vessel atherosclerosis (LVA) IS, according to the Acute Stroke Treatment (TOAST) criteria, 326 ethnicity and gender matched subjects were used as controls. We tested variants in cholesterol-related candidate genes (sterol regulatory element binding protein, SREBP, SREBP-cleavage activating protein, SCAP, Apolipoprotein E, APOE, and Proprotein convertase subtilisin/kexin type 9, PCSKA) for association with IS. Significant gene-IS associations were further tested in a Finnish autopsy collection of 1004 cases with a quantitative assessment of atherosclerosis in the circle of Willis.<p>While we could not detect any significant association between polymorphisms in the SREBP and SCAP genes and IS, we found evidence for association at the APOE and PCSK9 loci. The APOE &949;4+ genotype was related to a more severe intracranial atherosclerosis score in men, and within the most common APOE &949;3/&949;3 genotype group a higher risk of IS was associated with the G-allele at the -219G/T promoter polymorphisms. At PCSK9, the minor allele (G) of the tagging E670G polymorphism appeared as a significant predictor of LVA (OR = 3.52, 95% CI 1.25-9.85; p = 0.017). Accordingly, in the Finnish autopsy series, G-allele carriers tended to have more severe allele copy number-dependent (p=0.095) atherosclerosis in the circle of Willis and in its branches. <p>Our findings in this unique combination of clinical and autopsy data suggest a multifaceted role of apoE on the risk of cerebrovascular diseases. The APOE &949;4+ genotype did not predict the risk of IS, but was associated with severity of subclinical intracranial atherosclerosis in men. In contrast, the promoter variants affecting apoE expression were significant predictors of IS, suggesting that quantitative rather than qualitative variation of apoE is related to IS independently of subclinical intracranial atherosclerosis. Furthermore, we demonstrated that PCSK9 associates with the risk of LVA stroke subtype, and suggest that the risk is related to the severity of the underlying intracranial atherosclerosis. <p>Atherogenesis is considered as an active, inflammatory process, interleukin (IL)-18 a proinflammatory cytokine, is thought to play a central role in the development of atherosclerosis and more specifically in plaque rupture. We genotyped four haplotype tagging polymorphisms at the IL18 gene in the BSS and the Finnish autopsy series. The minor alleles of the IL18 -607 and +127 polymorphisms, as well as the haplotype carrying both minor alleles, associated with IS after adjustment for all cardiovascular risk factors. No association was seen with the development of subclinical intracranial atherosclerosis. Our findings suggest that variation in the IL18 gene influences the acute atherosclerotic IS event, but not the previous development of subclinical intracranial atherosclerosis, suggesting a causal role of IL18 in the vulnerability of cerebral arterial atherosclerotic plaques to acute rupture and subsequent thrombosis. <p><p>Doctorat en Sciences médicalesinfo:eu-repo/semantics/nonPublishe
Strategi penyelenggaraan untuk sistem penyaman udara berpusat pada bangunan-bangunan kerajaan
No full textTujuan Sistem Penyaman Udara dan Pengudaraan Mekanikal (ACMV) adalah untuk
mengekalkan keadaan selesa di ruang berhawa dingin tanpa mengira keadaan persekitaran luar.
Sistem penyejukan bangunan berperanan sebagai fungsi penting yang menyediakan
persekitaran yang selesa untuk penghuni bangunan. Sesungguhnya, sistem penyejukan
bangunan berorientasikan permintaan dengan strategi pengurusan bangunan lestari yang sangat
diharapkan untuk menyeimbangkan antara penggunaan bangunan dan permintaan tenaga. Oleh
itu, untuk meningkatkan keberkesanan sistem penyelenggaraan penghawa dingin berpusat di
bangunan-bangunan kerajaan, pelbagai strategi penyelenggaraan digunakan dan diperkenalkan
untuk memastikan penghuni bangunan dapat menikmati kecekapan penyelenggaraan yang
dikendalikan dengan strategi penyelenggaraan yang terbaik dan berkesan. Untuk mengatasi
masalah ini, kajian ini memfokuskan pada bangunan-bangunan kerajaan sebagai kajian kes.
Keadaan selesa biasanya merujuk pada julat suhu, kelembapan relatif, kebersihan dan
pengedaran udara untuk memenuhi keperluan keselesaan penghuni di ruang berhawa dingin.
Oleh itu, sistem air sejuk penghawa dingin diperlukan untuk beroperasi sepanjang tahun untuk
menjaga keadaan selesa di bangunan komersial, hotel, bangunan industri dan bangunan-
bangunan kerajaan. Oleh yang demikian, tujuan kertas projek ini adalah untuk mencadangkan pelbagai strategi penyelenggaraan yang lebih mantap dalam meningkatkan mutu yang terbaik dalam penyelenggaraan sistem penyaman udara yang berpusat pada bangunan-bangunan
kerajaan. (Abstract by author
Looking for the unique gesture : Practice and theory in the work of Alwin Nikolais
No full textNikolaïs a prolongé la pensée de Laban et l'a enrichie en l'expérimentant sur les corps-mêmes des danseurs de sa compagnie. son approche s'est développée dans un va-et-vient constant entre les 'principles' et l'expérience sensible du corps dansant. les éléments de langage chorégraphique (qualités de 'motion', 'shape'...) et les outils pédagogiques de nikolaïs (décentrement, 'gestalt' ou totalité reconnaissable, triade technique-improvisation-composition...) se sont élaborés sans être soumis à un savoir théorique extérieur. Cet enseignement consiste à munir le corps et l'esprit d'un savoir et d'une conscience immédiate des facteurs entrant en jeu dans le mouvement dansé. L'étude tendra à affirmer que là où il y a pédagogie, il y a théorie. la 'theory' est chez Nikolaïs un moment d'investigation à travers l'improvisation où concept, chorégraphie et performances sont instantanés. l'improvisation, un des éléments-clés de la modernité en danse, semble donc représenter le processus privilégié où pratique et théorie se confondent ou se vérifient l'une l'autre. Par ailleurs, sera aussi questionnée la prétendue "universalité" des outils et éléments de syntaxe de Nikolaïs, par l'analyse du contexte particulier des années 1950 (historique, socio-politique, artistique et technologique) et l'idéologie très liée à la personnalité de son créateur et à l'engouement qu'il a suscité. On se propose donc de déconstruire le modèle en empruntant une troisième voie au-delà de l'héritage fidèlement entretenu ou rejeté pour tenter, en contrant la présence diffuse de cet enseignement en France, une réhabilitation et une analyse qui questionneront la pertinence et les enjeux de cette pensée aujourd'hui.Nikolais, trying out Laban's ideas with his company's dancers, carried these ideas further and developed them. His approach evolved, as he continuously moved back-and-forth from principles to the physical experience of the dancing body. The elements of Nikolais' choreographic language (the qualities of motion, shape...) and his pedagogic tools : decentralisation, gestalt (i.e. a recognizable whole), the triad of technique/improvisation/composition, evolved without being based on any external theory. His teaching aimed to getting the body and the mind to know and to be instantly aware of the elements involved in the dance movement. This study tends to whow that all pedagogy implies the rpesence of a theory. For Nikolais, theory proceeds from a amoment of improvisation wherein concept, choreography and performance are simultaneous. Improvisation, one of the key elements of modern dance, thus seems to be a preferred process, where practice and theory are merged, or serve to reinforce one another. In addition, we shall also question the supposed "universality" of Nikolais' tools and syntaxic elements through an analysis of the particular context of the 1950s (historic, socio-political, artistic, and technological) ; as well as the ideology, attributable to the personality of its author and the fervor surrounding him. Thus, our intention is to "deconstruc" the model by taking a third path, neither upholding faithfully the heritage nor rejecting it, and, in view of its widespread teaching in France, to attempt a rehabilitation and an analysiso f the pertinence of these ideas for our time and what is at stak
DNA methylation as a new tool for the differential diagnosis between T‐ LBL and lymphocyte‐rich thymoma
No full textAbstract T‐lymphoblastic lymphoma (T‐LBL) and thymoma are two rare primary tumors of the thymus deriving either from T‐cell precursors or from thymic epithelial cells, respectively. Some thymoma subtypes (AB, B1, and B2) display numerous reactive terminal deoxynucleotidyl transferase‐positive (TdT + ) T‐cell precursors masking epithelial tumor cells. Therefore, the differential diagnosis between T‐LBL and TdT + T‐lymphocyte‐rich thymoma could be challenging, especially in the case of needle biopsy. To distinguish between T‐LBL and thymoma‐associated lymphoid proliferations, we analyzed the global DNA methylation using two different technologies, namely MeDIP array and EPIC array, in independent samples series [17 T‐LBLs compared with one TdT + lymphocyte‐rich thymoma (B1 subtype) and three normal thymi, and seven lymphocyte‐rich thymomas compared with 24 T‐LBLs, respectively]. In unsupervised principal component analysis (PCA), T‐LBL and thymoma samples clustered separately. We identified differentially methylated regions (DMRs) using MeDIP‐array and EPIC‐array datasets and nine overlapping genes between the two datasets considering the top 100 DMRs including ZIC1 , TSHZ2 , CDC42BPB , RBM24 , C10orf53 , and MACROD 2. In order to explore the DNA methylation profiles in larger series, we defined a classifier based on these six differentially methylated gene promoters, developed an MS‐MLPA assay, and demonstrated a significant differential methylation between thymomas (hypomethylated; n = 48) and T‐LBLs (hypermethylated; n = 54) (methylation ratio median 0.03 versus 0.66, respectively; p < 0.0001), with MACROD2 methylation status the most discriminating. Using a machine learning strategy, we built a prediction model trained with the EPIC‐array dataset and defined a cumulative score taking into account the weight of each feature. A score above or equal to 0.4 was predictive of T‐LBL and conversely. Applied to the MS‐MLPA dataset, this prediction model accurately predicted diagnoses of T‐LBL and thymoma. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.Institut National Du Cancer https://doi.org/10.13039/50110000636
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
No full textMeta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherited risk. We performed a meta-analysis of ~750 000 high-quality genetic markers on a combined sample of ~14 000 subjects of European and Asian-ancestry (phase I). The most significant findings were further tested in an extended sample of ~17 700 cases and controls (phase II). The results suggest novel association findings near the genes TRANK1 (LBA1), LMAN2L and PTGFR. In phase I, the most significant single nucleotide polymorphism (SNP), rs9834970 near TRANK1, was significant at the P=2.4 × 10−11 level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed. The phase II results were similar, although the heterogeneity test became significant for several SNPs. On the basis of these results and other established risk loci, we used the method developed by Park et al. to estimate the number, and the effect size distribution, of BD risk loci that could still be found by GWAS methods. We estimate that >63 000 case–control samples would be needed to identify the ~105 BD risk loci discoverable by GWAS, and that these will together explain <6% of the inherited risk. These results support previous GWAS findings and identify three new candidate genes for BD. Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD
A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies
No full textLarge scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mechanisms. As systematic dataset integration is becoming essential, we developed methods and performed meta-clustering of gene coexpression links in 11 transcriptome studies from postmortem brains of human subjects with major depressive disorder (MDD) and non-psychiatric control subjects. We next sought enrichment in the top 50 meta-analyzed coexpression modules for genes otherwise identified by GWAS for various sets of disorders. One coexpression module of 88 genes was consistently and significantly associated with GWAS for MDD, other neuropsychiatric disorders and brain functions, and for medical illnesses with elevated clinical risk of depression, but not for other diseases. In support of the superior discriminative power of this novel approach, we observed no significant enrichment for GWAS-related genes in coexpression modules extracted from single studies or in meta-modules using gene expression data from non-psychiatric control subjects. Genes in the identified module encode proteins implicated in neuronal signaling and structure, including glutamate metabotropic receptors (GRM1, GRM7), GABA receptors (GABRA2, GABRA4), and neurotrophic and development-related proteins [BDNF, reelin (RELN), Ephrin receptors (EPHA3, EPHA5)]. These results are consistent with the current understanding of molecular mechanisms of MDD and provide a set of putative interacting molecular partners, potentially reflecting components of a functional module across cells and biological pathways that are synchronously recruited in MDD, other brain disorders and MDD-related illnesses. Collectively, this study demonstrates the importance of integrating transcriptome data, gene coexpression modules and GWAS results for providing novel and complementary approaches to investigate the molecular pathology of MDD and other complex brain disorders. © 2014 Chang et al
A la recherche du geste unique : pratique et théorie chez Alwin Nikolaïs
No full textNikolais, trying out Laban's ideas with his company's dancers, carried these ideas further and developed them. His approach evolved, as he continuously moved back-and-forth from principles to the physical experience of the dancing body. The elements of Nikolais' choreographic language (the qualities of motion, shape...) and his pedagogic tools : decentralisation, gestalt (i.e. a recognizable whole), the triad of technique/improvisation/composition, evolved without being based on any external theory. His teaching aimed to getting the body and the mind to know and to be instantly aware of the elements involved in the dance movement. This study tends to whow that all pedagogy implies the rpesence of a theory. For Nikolais, theory proceeds from a amoment of improvisation wherein concept, choreography and performance are simultaneous. Improvisation, one of the key elements of modern dance, thus seems to be a preferred process, where practice and theory are merged, or serve to reinforce one another. In addition, we shall also question the supposed "universality" of Nikolais' tools and syntaxic elements through an analysis of the particular context of the 1950s (historic, socio-political, artistic, and technological) ; as well as the ideology, attributable to the personality of its author and the fervor surrounding him. Thus, our intention is to "deconstruc" the model by taking a third path, neither upholding faithfully the heritage nor rejecting it, and, in view of its widespread teaching in France, to attempt a rehabilitation and an analysiso f the pertinence of these ideas for our time and what is at stakeNikolaïs a prolongé la pensée de Laban et l'a enrichie en l'expérimentant sur les corps-mêmes des danseurs de sa compagnie. son approche s'est développée dans un va-et-vient constant entre les 'principles' et l'expérience sensible du corps dansant. les éléments de langage chorégraphique (qualités de 'motion', 'shape'...) et les outils pédagogiques de nikolaïs (décentrement, 'gestalt' ou totalité reconnaissable, triade technique-improvisation-composition...) se sont élaborés sans être soumis à un savoir théorique extérieur. Cet enseignement consiste à munir le corps et l'esprit d'un savoir et d'une conscience immédiate des facteurs entrant en jeu dans le mouvement dansé. L'étude tendra à affirmer que là où il y a pédagogie, il y a théorie. la 'theory' est chez Nikolaïs un moment d'investigation à travers l'improvisation où concept, chorégraphie et performances sont instantanés. l'improvisation, un des éléments-clés de la modernité en danse, semble donc représenter le processus privilégié où pratique et théorie se confondent ou se vérifient l'une l'autre. Par ailleurs, sera aussi questionnée la prétendue "universalité" des outils et éléments de syntaxe de Nikolaïs, par l'analyse du contexte particulier des années 1950 (historique, socio-politique, artistique et technologique) et l'idéologie très liée à la personnalité de son créateur et à l'engouement qu'il a suscité. On se propose donc de déconstruire le modèle en empruntant une troisième voie au-delà de l'héritage fidèlement entretenu ou rejeté pour tenter, en contrant la présence diffuse de cet enseignement en France, une réhabilitation et une analyse qui questionneront la pertinence et les enjeux de cette pensée aujourd'hui
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