6,640 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
PHARMACEUTICAL STANDARDIZATION OF TAMRA YOGA
No full textRasa oushadies are the potent Ayurvedic preparations mainly containing metals and minerals. These oushadies possess a wide range of therapeutic efficacy and are considered superior because of their qualities like small dose, quick action, palatability and longer shelf life. Tamra Yoga is an important Rasa oushadi described in Rasa Tantra Sara Va Siddha Prayoga Sangraha indicated for the management of the disease Vataja Shula, Gulma and Ajirna. The ingredients present in the “Tamra Yoga†are Tamra Bhasma, Yashtimadhu, Trikatu, Souvarchala Lavana, Chincha Kshara and Bharjitha Hingu. The main pharmaceutical procedures involved in the preparation of Tamra Yoga are Shodhana, Bhavana, Marana, Amrutikarana, Chincha Kshara nirmana, Hingu bharjana, Churna nirmana and preparation of capsules of Tamra Yoga. The specific pharmaceutical blend of these contents can result in a more effective formulation. Till date, no research work has been carried out to standardize this formulation. Therefore the present study has been planned to standardize the method of preparation of Tamra Yoga according to the method explained in the classical literature. Keywords: Tamra Yoga, Shodhana, Bhavana, Marana, Amrutikarana, Chincha Kshara nirmana, Standardization.Â
Les diminutifs basques avec ch
No full textSe presentan formaciones similares a los diminutivos vascos con "ch" en España y América latina. Se dan ejemplosThe author introduces similar formations to the Basque diminutive "ch" in Spain and Latin America. Examples are provide
PHARMACEUTICAL STANDARDIZATION OF BALADI MANDURAM
No full textObjective: Baladi Manduram (BM) is one of the most impairment and potent herbo-mineral formulation described in Ayurvedic classics viz., Rasa Kamadhenu and Rasayoga sagara specified for the management of the disease Amlapitta. BM contains Mandura Bhasma, Balamula, Satavarimula, Erandamula, Yava, Pippali, Jiraka, Twak, Ela, Patra, Nagakesara and Guda. Till now no research work has been carried out to standardize the preparation of BM. The main objective of the present study is to standardize the method of preparation of BM according to the conventional method mentioned in classical literatures. Methods: Shodhana, Bhavana, Marana, Churna nirmana and Paka are the main pharmaceutical procedures involved in the preparation of BM. Mandura was subjected to Shodhana by Nirvapa in Gomutra Triphala Kashaya for 7 times. Shodhita Mandura thus obtained was triturated with Kumari Swarasa and subjected to Gaja puta for 7 times. Mandura Bhasma thus otained was added to the guda paka along with the fine powders of herbal ingredients. Then the homogenous mixture of BM was made in the form of capsules of 500mg. Results: 1380 g of BM was prepared from 1264g of Mandura Bhasma, 100g each of Balamula, Satavarimula, Erandamula and Yava, 50g each of Pippali and Jiraka and 8g each of Twak, Ela, Patra and Nagakesara. Conclusion: All these procedures can be considered ideal in the standardization of the preparation of Baladi Manduram. Keywords: Baladi Manduram, Shodhana, Bhavana, Marana, Churna nirmana, Paka, Standardization
EVALUATION OF ANTIOXIDANT ACTIVITY OF RAJATA BHASMA & RAJATA YOGA
No full textChange in life style has resulted in the increased production of free radicals in the body which not only raise the oxidative stress but also plays an important role in the immune system dysfunction. Now a day, human body is continuously exposed to different types of agents that result in production of reactive species called as ‘free radicals’. Diabetes is a group of metabolic diseases characterized by high levels of blood sugar (hyperglycemia). Many evidences from experiments have proved that free radicals and oxidative stress play a major role in complications of Diabetes mellitus like coronary heart disease, Neuropathy, Nephropathy, Retinopathy and stroke. In Ayurveda, the syndrome Diabetes mellitus has been covered under the broad heading of Prameha. Rajata Yoga is mentioned in Rasa Tarangini and indicated in all types of Prameha. Rajata bhasma, Twak churna, Ela churna and Patra Churna are the main ingredients of Rajata Yoga. The aim of present study is to evaluate the in vitro anti oxidant activity of Rajata bhasma & Rajata Yoga. The method followed to evaluate the anti oxidant activity is 1, 1- diphenyl 2- picrrylhydrazyl (DPPH) radical scavenging assay has been used in the determination of In- vitro antioxidant activity.Results: Significant Inhibition percentage of Rajata bhasma & Rajata Yoga was seen in increasing order of percentage when sample concentration (100µl, 200µl, 300µl, 400µl, 500µl) was increased. Rajata bhasma showed 69.86% of inhibition and Rajata Yoga showed 80.10% of inhibition in 500 µl sample concentrations respectively
Pharmaceutical Standardization of Malatyadi Taila
No full textSnehakalpana plays an important role in treatment both internally and externally. When used for topical application it has the potential to diffuse locally in soft tissues and produce the desired therapeutic action. The specific pharmaceutical blend of these contents can result in a more effective formulation. Malatyadi Taila is one such formulation mentioned in Chakradutta, clamied to be beneficial in Darunaka. The ingredients are Malati patra, Karaveera moola, Chitraka moola, Karanja beeja. Therefore, this formulation is selected to study its efficacy in Darunaka. The main pharmaceutical procedures involved in the preparation of Malatyadi Taila are Shodhana, Churna nirmana, Kalka nirmana and Taila paka. The specific pharmaceutical blend of these contents can result in a more effective formulation. Therefore, the present study has been planned to standardize the method of preparation of Malatyadi Taila according to the method explained in the classical literature
PHARMACEUTICAL STANDARDIZATION OF RAJATA YOGA
No full textRasa Shastra is a branch of Ayurveda which deals with the processing of minerals and metals having therapeutic importance. Rajata comes under the group of metals having high therapeutic values. Minerals and metals are mostly used in the form of bhasma. There is no specific anupana mentioned for Rajata, it depends upon dosha and disease. Rajata bhasma when given with proper Anupana is indicated in all types of diseases. Rajata Yoga is one such formulation mentioned in Rasa Tarangini, indicated in Prameha. Rajata bhasma, Twak churna, Ela churna and Patra churna are the main ingredients. The present study has been planned to standardize the method of preparation of a Herbo-mineral formulation i.e., Rajata Yoga. Samanya Shodhana and Visesha Shodhana procedures were adopted for Rajata patra (50g). After Visesha Shodhana, 48g of obtained coarse Rajata patra were subjected to Marana with equal quantity of Kajjali (48g) and sufficient quantity of Kumari Swarasa as bhavana dravya. Totally 25 putas were given to attain Rajata bhasma (90g) which passed all bhasma lakshanas as mentioned in our classics. Rajata bhasma (45g) was mixed with Trijataka churna (Twak churna-300g; Ela churna -300g and Patra churna – 300g) to form homogenous 945g of Rajata Yoga. Thus it can be concluded that Supaka i.e. neither less nor more heat is desirable and is essential for making a drug safe and efficacious
Pharmaceutical Standardization of Mayaphaladi Churna
No full textRasa Shastra is the pharmaceutical branch of Ayurveda. As like any other medical system, success of Ayurvedic treatment also depends upon quality of medicine prescribed to the patient. The integral part of Rasa Shastra lies in the successful pharmaceutical process. Rasa oushadis are the potent Ayurvedic preparations mainly containing metals and minerals. These oushadis possess a wide range of therapeutic efficacy and are considered superior because of their qualities like small dose, quick action, palatability and longer shelf life. Mayaphaladi Churna is an important Rasa oushadi described in Rasa Tantra Sara Va Siddha Prayoga Sangraha- Part 2, Streerogadhikara indicated for the management of the diseases Swetapradara and Yonibramsha. The ingredients present in the ‘Mayaphaladi Churna’ are Kukkutanda twak bhasma (Egg Shell Ash), Shuddha Sphatika (Alum), Mayaphala Churna (Quercus Infectoria Oliv.), Amalaki Churna (Emblica Officinalis Gearth), Ashwagandha Churna (Withania Somnifera Linn.) and Sita Churna (Sugar Candy). The main pharmaceutical procedures involved in the preparation of Mayaphaladi Churna are Shodhana, Marana, Churna nirmana and preparation of Mayaphaladi Churna. The specific pharmaceutical blend of these contents can result in a more effective formulation. Therefore the present study has been planned to standardize the method of preparation of Mayaphaladi Churna according to the method explained in the classical literatures.
Keywords: Mayaphaladi Churna, Shodhana, Marana, Churna Nirmana, Standardization
PHARMACEUTICAL STANDARDIZATION OF SHATPALA GANDHAKA CHURNA
No full textRasa oushadis are the potent Ayurvedic preparations mainly containing metals and minerals. These Oushadis possess wide range of therapeutic efficacy and are considered superior because of their qualities like small dose, quick action, palatability and longer shelf life. Shatpala Gandhaka churna is an important Rasa oushadi described in Vaidya chintamani- Kushtha prakaranam indicated for all types of Kushtha, Grahani, Gulma, Mandagni. Shatpala Gandhaka Churna contains Shuddha Gandhaka, Shuddha Bhallataka, Shuddha Chitrakamula twak, Triphala, Vidanga, Trikatu, Trijataka, Chanaka, and Jeeraka. The main pharmaceutical procedures adopted in this study are Shodhana, Churna nirmana and preparation of capsule of Shatpala Gandhaka Churna. The specific pharmaceutical blend of these contents can result in a more effective formulation. Till now, no research work has been carried out to standardize this formulation. Therefore the present study has been planned to standardize the method of preparation of Shatpala Gandhaka churna according to the method explained in the classical literature.
PHARMACEUTICAL STANDARDIZATION OF AMRITAMANJARI
No full textRasa Shastra is the pharmaceutical branch of Ayurveda. As like any other medical system, success of Ayurvedic treatment also depends upon quality of medicine prescribed to the patient. The integral part of Rasa Shastra lies in the successful pharmaceutical process. Rasaoushadis are the potent Ayurvedic preparations mainly containing metals and minerals. These Oushadis possess wide range of therapeutic efficacy and are considered superior because of their qualities like small dose, quick action, palatability and longer shelf life. Amritamanjari is an important Rasa oushadi described in Bhaishajya Ratnavali- Amavata Adhikarana indicated in Amavata. Amritamanjari contains Suddha Hingula (Cinnabar), Suddha Vatsanabha (Aconitum ferox), Suddha Tankana (Borax), Pippali (Piper longum), Maricha (Piper nigrum) and Jatikosa (Jatiphala- Myirstica fragrans). The pharmaceutical procedures adopted in this study are Shodhana, Churnanirmana and preparation of Vati of Amritamanjari. The specific pharmaceutical blend of these contents can result in a more effective formulation. Till now, no research work has been carried out to standardize this formulation. Therefore the present study has been planned to standardize the method of preparation of Amritamanjari according to the method explained in the classical literature
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