117,634 research outputs found
A new crayfish of the genus Cambarus Erichson, 1846 (Decapoda: Cambaridae) from an under-sampled habitat type in central Ten- nessee, USA
No full textTaylor, Christopher A., Soucek, David J., Organ, Edward L. (2006): A new crayfish of the genus Cambarus Erichson, 1846 (Decapoda: Cambaridae) from an under-sampled habitat type in central Ten- nessee, USA. Zootaxa 1200: 29-41, DOI: 10.5281/zenodo.264644
Exotoxice activities of Corynebacterium-pseudotuberculosis
No full textPT: J; CR: BARKSDALE L, 1981, J CLIN MICROBIOL, V13, P335 BERNHEIMER AW, 1963, J GEN MICROBIOL, V30, P455 BERNHEIMER AW, 1980, INFECT IMMUN, V29, P123 CARNE HR, 1940, J PATHOL BACTERIOL, V51, P199 CARNE HR, 1957, NATURE, V178, P701 CARNE HR, 1978, NATURE, V271, P246 DOTY RB, 1964, AM J VET RES, V25, P1679 FRASER G, 1961, NATURE, V189, P246 FRASER G, 1962, VET REC, V74, P753 GOEL MC, 1972, J COMP PATHOL, V75, P345 JOLLY RD, 1965, J COMP PATHOL, V75, P417 LINDER R, 1978, BIOCHIM BIOPHYS ACTA, V530, P236 LINDER R, 1982, ARCH BIOCHEM BIOPHYS, V213, P395 LOMBIN LH, 1982, CAN J COMP MED, V46, P109 LOVELL R, 1966, RES VET SCI, V7, P302 MOLLBY R, 1978, BACTERIAL TOXINS CEL, P367 MUCKLE CA, 1983, AM J VET RES, V44, P1149 ONON EO, 1979, BIOCHEM J, V177, P181 REED LJ, 1938, AM J HYG, V27, P493 SOUCEK A, 1967, BIOCHIM BIOPHYS ACTA, V144, P180 SOUCEK A, 1974, J HYG EP MI, V18, P327 SOUCEK A, 1981, BIOCH BIOPHYS ACTA, V227, P116 SOUCKOVA A, 1972, TOXICON, V10, P501; NR: 23; TC: 10; J9: CURR MICROBIOL; PG: 4; GA: C0335Source type: Prin
Magnetic field imaging in biological systems with nanometric resolution
No full textRecent developments of engineered nitrogen-vacancy (NV) centres in diamonds offer promising avenues for the creation of sensitive nanoscale probes, pivotal for quantum measurements and diagnostic applications in nanomedicine. The aim of this work is to enable these sensor applications by studying NV photodynamics, investigating the effects of the environment and developing advanced quantum sensor chips. In this thesis, we include both fluorescent nanodiamond particles (NDs) and NV-containing single crystal diamond. Initially, we study the fundamental physics governing signal generation, exploring the photodynamics of a single NV center and analysing its spin-contrast properties. Subsequently, we probe the impact of the crystal environment on the photoelectrical signals and quantum efficiency, determining the possible origins of non-standard phenomena such as positive photocurrent detected magnetic resonance (PDMR). We demonstrate the usage of ground-state level anti-crossing (GSLAC) in photoelectrical spin-state readout.
In the second part of the thesis, we focused on the development of a quantum chip for both single-crystal diamond and ND particles. Two types of prototypes were designed and fabricated, with numerical modelling employed to elucidate microwave field distribution and resonance patterns. For single crystal diamond chips, in-depth testing is conducted to mitigate microwave-induced interference, which is critical for detecting low photocurrents from single NV centres. Additionally, we explore the potential for integrating this chip into a microfluidic chamber. The chip for the nanodiamond particles was evaluated for its heating properties, which are crucial for keeping neurons alive, using theoretical calculations and experimental measurements using a nanodiamond probe. Furthermore, we also perform the in vitro sensing of the magnetic field at the attached nanodiamonds to the neuron cells.
In summary, our research represents a significant step forward in harnessing the capabilities of engineered NV centers in diamond for quantum sensing applications, offering promising prospects in both fundamental research and practical diagnostics in nanomedicine
Rottlerin inhibits ROS formation and prevents NFkB activation in MCF-7 and HT-29 cells
No full textRottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKC delta, although it can inhibit many kinases and has several biological effects. Among them, we recently found that Rottlerin inhibits the Nuclear Factor kappaB (NFkappaB), activated by either phorbol esters or H(2)O(2). Because of the redox sensitivity of NFkappaB and on the basis of Rottlerin antioxidant property, we hypothesized that Rottlerin could prevent NFkappaB activation acting as a free radicals scavenger, as other natural polyphenols. The current study confirms the antioxidant property of Rottlerin against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in vitro and against oxidative stress induced by H(2)O(2) and by menadione in culture cells. We also demonstrate that Rottlerin prevents TNFalpha-dependent NFkappaB activation in MCF-7 cells and in HT-29 cells transfected with the NFkappaB-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFkappaB via several pathways and in several cell types
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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