1,721,023 research outputs found
Biopharmaceutical and pharmacokinetic aspects of captopril administration in children
Full text linkCatedra Tehnologia medicamentelor USMF „Nicolae Testemiţanu”The main pharmacokinetic parameters and molecular structure data of captopril were highlighted. On the basis of this parameters of molecular structural data correspondency to Lipinski's rule or "rule of five” were established. The percentage of ionized molecules of captopril was calculated in different segments of the gastrointestinal tract. According to these data the oral administration of captopril do not create problems of absorption.
Au fost evidenţiaţi principalii parametri farmacocinetici şi datele structural-moleculare ale captoprilului. În baza acestor parametri s-a stabilit corespinderea datelor structural moleculare conform regulii lui LIPINSKI sau „regula celor 5”. A fost calculat procentul de molecule neionizate ale captoprilului în diferite segmente ale tractului gastrointestinal. Conform acestor date administrarea pe cale orală a captoprilului, nu ar crea probleme de absorbţie
Development of method for phenobarbital dosing in operculated capsules for children
Full text linkCatedra Tehnologia medicamentelor, IP USMF „Nicolae Testemiţanu“Rezumat. A fost elaborată metoda spectrofotometrică de dozare a fenobarbitalului în capsule operculate (5 mg), fiind o metodă exactă, specifică,
reproductibilă avînd o eroare relativă de ±1,84%. Metoda spectrofotometrică se recomandă de a fi inclusă în monografi a farmacopeică
temporară la Capsule fenobarbital 5 mg, la compartimentul dozare.Summary. A spectrophotometric method was developed for the dosage of Phenobarbital in operculated capsules (5 mg). This is an exact, specific,
reproducible method, having a relative error of ± 1.84%. The spectrophotometric method is recommended to be included in the temporary pharmacopoeial monograph on Phenobarbital Capsules 5 mg at the dosing compartment
Study on the technological processes and the quality of the boiled-smoked sausages
No full textFișierul atașat conține: Rezumat, Abstract, Cuprins, Introducere, Bibliografie.Scopul tezei de master este studiul proceselor tehnologice și ameliorarea calității salamurilor fiert-afumate.
Obiectivele propuse spre analiză sunt:
1. Analiza caracteristicilor materiilor prime și a compoziției chimice a cărnii
2. Aditivii alimentari admiși pentru prepararea produselor tratate termic
3. Selectarea și studierea rețetelor clasice și modernizate de fabricare a salamurilor fiert-afumate
4. Analiza punctelor critice de control în urma elaborării planului HACCP
La analiza documentară o importanță deosebită s-a atras la siguranța și calitatea produselor alimentare care se crează în procesul de producere şi se manifestă în procesul de consum. În formarea calităţii produselor finite, participă materia primă şi organizarea procesului tehnologic, aceste două noţiuni fiind în interdependenţă.
Memoriu explicativ cuprinde următoarele capitole:
1. Studiul bibliografic;
2. Tehnologia și tehnico de fabricare a salamurilor fiert-afumate;
3. Implimentarea sistemului de management al siguranței alimentului.
Fiecare capitol are descrierea sa, unde sunt arătate scheme bloc de fabricare, tabele, descrierea produsului finit, materiilor prime și altor materiale de bază. Toată informația privind elaborarea tezei a fost culeasă din surse bibliogafice ca: biblioteci, agepi, internet, ș.a.
Total 74 pagini, 28 tabele, 9 figuri. Bibliografie 52.The purpose of the master's thesis is to study technological processes and to improve the quality of boiled-smoked sausages:
The objectives proposed for analysis are:
1. Analyzing the characteristics of raw materials and the chemical composition of the meat
2. Food additives admitted for the preparation of heat-treated products
3. Selection and study of classical and modernized recipes for the production of boiled-smoked salami
4. Analyzing critical control points following the HACCP plan
In documentary analysis, a particular importance was attached to the safety and quality of food products that are created in the production process and are manifested in the consumption process. In the formation of the quality of the finished products, the raw material and the organization of the technological process participate, these two notions being interdependent.
Explanatory memo includes the following chapters:
1. The bibliographic study;
2. Technology and technical production of boiled-smoked sausages;
3. Implementing the food safety management system.
Each chapter has its description, where block manufacturing schemes, tables, description of the finished product, raw materials and other base materials are shown. All the information on the thesis was collected from bibliographic sources such as: libraries, agepi, internet, etc.
Total 74 pages, 28 tables, 9 figures. Bibliography 52
Study of topic preparations with propolis extract – for the skin treatment
Full text linkCatedra de tehnologie a medicamentelor,
Universitatea de Stat de Medicină și Farmacie
„Nicolae Testemițanu” din Republica MoldovaIntroducere. Elaborarea formelor farmaceutice noi
cu conținut de propolis, pentru tratamentul maladiilor
dermatologice reprezintă o direcție importantă de cercetare
din domeniul sănătății ale Rep. Moldova. Gravitatea
bolilor de piele poate fi diferită, de la minore la cele
care pot pune în pericol viaţa unei persoane. Conform
datelor estimate de OMS, prevalenţa bolilor de piele rămâne
a fi o problemă actuală datorită indicelui statistic
destul de înalt.
Scopul lucrării. În acest studiu ne-am propus ca
obiectiv formularea, prepararea, analiza și eficacitatea
preparatelor cu extract de propolis folosite în tratamentul
diferitor afecțiuni ale pielii.
Material și metode. Sinteza și studiul datelor din
diverse reviste medicale și farmaceutice autohtone și internaţionale,
cercetări și date statistice, precum și documentarea
cu receptura magistrală.
Rezultate. Preparatele cu conținut de propolis se folosesc
pe larg în practica medicală, stimulând producţia
de colagen și elastine, cu efecte pronunțate antibacteriene,
antioxidante, antiacneice, regenerante și cicatrizante. Sunt
indicate în infecţii și arsuri, bătături și cheratite, răni
vechi, micoze, negi și aluniţe.
Concluzii. Tratamentul maladiilor de piele este unul
complex, complicat, care include o ambianță de preparate
de uz intern și topic. Estimările efectuate, arată că
medicii din instituțiile medicale din Rep. Moldova prescriu
preparate industriale și magistrale cu conținut de
propolis utilizate în tratamentul topic al bolilor de piele.Introduction. The development of new pharmaceutical
forms containing propolis for the treatment of dermatological
diseases is an important research direction in
the health branch for the Republic of Moldova. The severity
of skin diseases can be different, from minor to those
that can be danger for human life. According to data estimated
by OMS, the prevalence of skin diseases remains
a current problem due to the rather high statistical index.
The aim of the study. In this study we proposed as
an objective the formulation, preparation, analysis and
efficacy of the preparations with propolis extract in the
treatment of the different sections of the skin.
Material and methods. Synthesis and study of facts
from various national and international medical and
pharmaceutical journals, research and statistical data, as
well as documentation with the master’s receipt.
Results. Propolis-containing preparations are widely
used in medical practice, stimulating the production
of collagen and elastin, with pronounced antibacterial,
antioxidant, antacneic, regenerating and healing actions.
They are indicated in infections and burns, bruises and
keratose, old wounds, mycoses, warts and moles.
Conclusions. The treatment of skin diseases is a
complicated complex, which includes an environment
of preparation for internal and topical use. Estimates
which was making, show that doctors from the medical
institutions of the Republic of Moldova prescribe the
industrial and master preparation with propolis used
in the topical treatment of skin diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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