18 research outputs found
The Eucharist - the Source of Family Life
No full textThe author identifies the celebration of Passover in Israel as a precursor of the celebration of the Eucharist, noting its pedagogical function in the family. The parallel significance of the symbolism of Passover and the Eucharist in Christian life is disucssed. A series of statements about the Eucharist from the Christian standpoint demonstrate its centrality in the spiritual lives of behevers
Education of the conscience - education for a new age
No full textThe conscience is »the place« of the most intimate dialogue between God and man. It is, therefore, the source and the beginning of every dialogue between people. Education of the conscience means purification of this source, providing it with objectivity and benevolence. Jesus Christ does not employ the word »conscience«. He uses the word »heart« instead, thus encompassing man as a whole. The heart is »man's most mysterious nucleus and sanctuary where he is alone with God, whose voice echoes through his own intimate worlds (GS, No. 16). One can have an uneducated, malformed conscience, but it is not necessarily a bad one.
Education of the conscience is founded, first of all, on our acknowledgment and acceptance of the will of God during every moment and in every situation of our life, and our making it the measure of our thoughts and acts. In the attempt to educate the conscience, two essential elements must be taken into account: acceptance of changing our thoughts and attitudes; there must be clear light, clear perception, clear principles according to which our attitudes are to be changed.
In our country: religious ignorance influencing practical attitudes in the process of renewal of the motherland; irresponsibility in the preparedness to serve others; »lackey mentality« which sees only the negative; relets of communist mentality: »Take as much as possible, give as little as possible!« In the world: moral principles are weak; human will is incapable of choosing the true and the good, instead of the agréable and the useful; desire of the stronger for domination over the weaker; in principle, a negative attitude towards everything catholic
The language of literary tourism and the promotion of literary places: The special case of Sherlock Holmes
No full textopenThe literary tourism has developed quickly over time. This kind of tourism has an ancient origin and it only recently has joined the cultural tourism. There are reviews about the background of literary tourism and the different kinds of genres met with their relative language. London is an important example of a city of many authors and places for a lot of works and, in particular, it can be mentioned for the adventures of Sherlock Holmes. His famous address 221B Baker Street has been necessarily created and it brings a lot of tourists curious to visit the apartment built on literary references every year. Sir Arthur Conan Doyle was an author, a journalist and a doctor, and he has written many works using different genres. About 60 of them tell the cases of Sherlock Holmes and his roommate John Watson. These are written as journals and it is introduced the science of deduction, that represents the ideals of Victorian time such as resourceful, smart and insightful. It is possible to find many museums and sites around the world dedicated to the detective, but only four of them are remarkable because they recreate the apartment, where the two friends live. These last can be found in Lucens, Meirigen, Minnesota and London. The literary places are an important part of the tourism and especially the people fond of the sleuth require to visit them
Spindle dynamics model explains chromosome loss rates in yeast polyploid cells
No full textFaithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In the model system Saccharomyces cerevisiae, the rate of chromosome loss in haploid and diploid cells is measured to be one thousand times lower than the rate of loss in isogenic tetraploid cells. Currently it is unknown what constrains the number of chromosomes that can be segregated with high fidelity in an organism. Here we developed a simple mathematical model to study how different rates of chromosome loss in cells with different ploidy can arise from changes in (1) spindle dynamics and (2) a maximum duration of mitotic arrest, after which cells enter anaphase. We apply this model to S. cerevisiae to show that this model can explain the observed rates of chromosome loss in S. cerevisiae cells of different ploidy. Our model describes how small increases in spindle assembly time can result in dramatic differences in the rate of chromosomes loss between cells of increasing ploidy and predicts the maximum duration of mitotic arrest.BN/Liedewij Laan La
Disability, Desire, and the Lyric in Seventeenth-Century France
No full textThis thesis asks whether seventeenth-century French lyric poets’ depiction of disability challenges entrenched ideals of beauty, gender, sexuality, and form. It contends that by interrogating the rich and varied imagery of disability found in lyric verse, we deepen our understanding of how French writers and readers of this century interpreted desire and the human body.
The primary corpus comprises unpublished manuscripts and printed sources, grouping lyrics thematically rather than by author. This approach treats the poems as a heterogenous collective, enabling a discussion of lesser-known, unpublished, and anonymous poets. Named poets in this corpus include Paul Scarron, Denis Sanguin de Saint-Pavin, Anne de Rohan-Soubise, Charles Vion d’Alibray, François Maynard, and Théophile de Viau. Some poets write about their personal experiences of disability, while others portray disabled protagonists or draw upon imagery of disability in their verse. This thesis puts their lyrics into dialogue with several theoretical approaches to disability through a Critical Disability Studies framework. The chapters deal with crip theory, metaphor theory, the grotesque and carnivalesque, spatial theory, queer theory, transhumanism, and posthumanism. The poets’ negotiation of bodily regimes holds much in common with their concurrent negotiation of the formal constraints of lyric verse, allowing this thesis to ask why poetry – and the seventeenth-century lyric in particular – is so replete with imagery of disability.
Due to its examination of the intersections between disability, gender, and sexuality, this thesis will be of interest to scholars of gender and sexuality as well as those studying disability and early modern French literature. Seventeenth-century authors working under a different set of bodily regimes were more likely to imagine disability in ways unfamiliar to twenty-first-century readers, so this research also questions current assumptions about what disability is and is not, while nuancing existing theoretical frameworks used to read disability in literature
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
No full textCardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27–42] years old; diabetes duration: 21 [15–27] years; HbA1c: 8.3% [7.4–9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio=0.39; 95% confidence interval=0.17–0.90; p=0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes163297299CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPNão temNão tem12/25490-8; 09/09276-3The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) to D.P.S.-B. (12/25490-8) and to M.L.C.-G. (09/09276-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) to S.N.A.; and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) to M.L.C.-
