14,732 research outputs found
Candidate genes colocalized to linkage regions in inflammatory bowel disease
No full textBackground and Aims: The genes encoding for tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor receptor (EGFR) and the vitamin D receptor (VDR) are colocalized to inflammatory bowel disease-associated linkage regions on chromosomes 6, 7 and 12. An association study of these gene polymorphisms with ulcerative colitis or Crohn's disease and a stratification according to disease phenotypes was performed in order to identify gentically homogenous subgroups. Patients and Methods: 119 healthy, unrelated controls, 95 patients with Crohn's disease and 93 patients with ulcerative colitis were genotyped for the (G to A) -308 TNF-alpha promoter polymorphism on chromosome 6, the codon 497 EGFR polymorphism on chromosome 7 and the Taql polymorphism of the VDR gene on chromosome 12. After genotyping, patients were stratified according to the respective disease phenotype. Results: A disequilibrium in the distribution of the VDR genotypes was found in patients with ulcerative colitis compared to controls (p = 0.024). In fistulizing and fibrostenotic Crohn's disease the `TT' genotype was significantly reduced compared with other phenotypes (p = 0.006), whereas the `tt' genotype was found more frequently (p = 0.04). The frequency of the WT allele of the EGFR gene was significantly higher in ulcerative colitis (p = 0.04) than in controls. Further significant differences, concerning the associations of the different polymorphisms and disease susceptibility or clinical phenotypes, were not observed. Conclusions: Regardless of the disease phenotype, the associations between the polymorphisms and inflammatory bowel disease investigated herein are modest, even after stratification for the disease phenotypes. Hence, these polymorphisms are unlikely to confer the reported linkage between inflammatory bowel disease and chromosomes 6, 7 and 12. Copyright (C) 2002 S. Karger AG, Basel
Una interpretación de a-ka-na-jo ( a3-ka-na-jo)
No full textThe author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word.The author studies the word a-ka-na-jo in the PY Cn 328 tablet and taking into account some factors she proposes αγναιος as the reading of this word
Environmental influences over the last 16 ka on compound-specific δ13C variations of leaf wax n-alkanes in the Hani peat deposit from northeast China
No full textCompound-specific carbon isotope ratios (δ13C) of leaf wax n-alkanes (C21-C33 odd carbon numbered n-alkanes) were measured in the Hani peat sequence from northeast China. These data were compared with lipid biomarker compositions to assess changes in local vegetation and paleoclimate for the last 16 ka The δ13C values of n-alkanes range between -36.6 and -30.7‰, showing that the compounds originate from C3 plants. Much larger variations (∼5.4‰) in the n-alkane δ13C values than those of atmospheric CO2 during the last 16 ka (< 0.5‰) indicate that the isotopic values were affected by environmental factors in addition to the postglacial δ13C variations in the atmospheric reservoir. The stratigraphic records of δ13C reveal decoupled fluctuations among the individual n-alkanes, particularly between 15.5 to 11.4 ka. Synchronous excursions in the δ13C offsets among individual n-alkanes (Δδ13C) and lipid biomarker paleoplant proxies (Paq, and C23/C31 and C27/C31) from 14.9 to 13.2 ka and 12.7 to 11.6 ka suggest that vegetational changes are the most likely causes for the decoupled δ13C variations. Parallel fluctuations of the δ13C values of terrestrial higher plant-derived C29 and C31 n-alkanes and the n-alkane average chain-length (ACL) from 11 to 6 ka indicate that the δ13C variations responded to net evaporation changes. Negative shifts in the n-alkane δ13C values coinciding with the ACL decreases at 10.5-9.3 ka and 8.1 ka indicate the short-term onset and fluctuations of the summer monsoon strength in eastern China during the early Holocene
NRF2 and chemoprevention: signaling, epigenetics and role in intestinal carcinogensis
No full textPrevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage. Chemoprevention becomes an increasing important concept and has led to the intense research about the mechanisms of actions of various chemopreventive compounds. They can be generally classified into blocking agents and suppressing agents. The chemopreventive compounds usually prevent or slow progression of cancer by maintaining a low oxidative stress and inflammatory environment in cells. This is brought about by the activation of Nrf2, the key protein being investigated in our lab. In this dissertation, I will be discussing the use of compounds as suppressing agents and blocking agents, how compounds activates Nrf2 signaling, how novel Nrf2 interaction partner IQGAP1 mediates Nrf2-Keap1 signaling axis, how expression level of Nrf2 could be regulated epigenetically, apart from the well-known post-translational control by Keap1-Ubiquitinase-Protesome axis and finally how loss of Nrf2 could enhance intestinal tumorigenesis in Apc(min/+) mice.Ph.D.Includes bibliographical referencesIncludes vitaby Ka Lung Cheun
Nearby fibroblasts' response to multiple acupuncture needle revolutions on fibroblast populated collagen gels
No full textAcupuncture is an ancient Chinese healing practice, and an alternative therapy for alleviating pain and chronic disorders. For over twenty years, research is trying to understand the mechanisms that lead to its therapeutic effect. Our laboratory investigates the cellular and molecular events in the connective tissue that occur by acupuncture needling. An in vitro assay was developed to evaluate some of the potential contributors to acupuncture’s effects using a cellular collagen gel as a loose connective tissue mimic. It was hypothesized besides immediate changes to cells under mechanical loading from an acupuncture needle, there were chemical factors released to nearby cells in acupuncture. This thesis investigates whether mechanically stimulating collagen gels with fibroblasts at different revolutions would release chemical factors to nearby fibroblasts where flow cytometry was used to observe cell proliferation as an indicator. Results reveal mechanically stimulating cellular collagen gels at different revolutions does not cause any changes in cell proliferation to nearby cells. However, dead stained mechanically stimulated cellular collagen gels showed cell death occurs around the acupuncture needle. It is possible there were no effects in cell proliferation because when a cellular collagen gel was needle manipulated, some chemical factors were released into the nearby cells. Then as needle manipulation increased, more chemical factors were released, but restricted by the larger amount of cell death around the needle from the increasing rotation.M.S.Includes bibliographical referencesby Ka Po Ch
Duan wei xia mu xie lei de xin xing he nei DNA fen zi xi tong biao ji zhi jian ding
No full textLeung Ka Chun.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 100-110).Abstracts also in Chinese.Title from PDF title page (viewed on 21, September, 2016).Leung Ka Chun
San zhong chao jian dai teng hu dui gao wen de sheng li fan ying ji zhuan lu ti yan jiu
No full textWong, Ka Wing Karen.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 143-157).Abstracts also in Chinese.Title from PDF title page (viewed on 30, November, 2016).Wong, Ka Wing Karen
The application of S-band polarimetric radar measurements to Ka-band attenuation prediction
No full textIn September 1993, the National Aeronautics and Space Administration's Advanced Communications Technology Satellite (ACTS) was deployed into a geostationary orbit near 100° W longitude. The ACTS satellite employs two Ka-band beacons, one at 20.185 GHz and another at 27.505 GHz. Impairments due to rain attenuation and tropospheric scintillations will significantly affect new technologies for this spectrum. Heavy rain at Ka-band can easily produce 30 dB of attenuation along the propagation path. Propagation experiments being conducted in seven different climatic zones involve multiyear attenuation measurements along the satellite-earth slant path. Measurements in the B2 climatic zone are made with an ACTS propagation terminal located in northeast Colorado. In order to gain more understanding about the physical processes that are responsible for Ka-band attenuation, the Colorado State University CHILL S-band polarimetric radar is used to take radar measurements along the slant path. The Colorado Front Range experiences a variety of weather conditions throughout the year ranging from upslope rain conditions to winter storms. Four such events measured along the slant path are illustrated in this paper. They include two convective cases and two "bright-band" cases. The S-band polarimetric radar data is used to initialize radar-based attenuation-prediction models, which are applied to the four precipitation events described. The comparisons of predicted attenuation to measured attenuation are quite good. It was also found during the course of the experiment that water droplets standing on the antenna surface can cause appreciable attenuation at Ka-band frequencies. That finding needs to be recognized in future model development and statistical analysis
Amritlal Nagar Ke Upannyas \u27Manas Ka Hans\u27 Ka Vaistichya
No full textThe entire life of Tulsidas of \u27Manas Ka Hans\u27 is disturbed by the ambushes of struggles and achieves the peak of faith. Goswami Tulsidas\u27s literature, his description and grand form are one with the unshakable land of \u27faith\u27, this is universally accepted. The prevailing legends, available evidence and the author\u27s own contemplation made Tulsi Das a living legend and scholar of public life. Artistic, Sushtu, Ragakrit, Udantakaran, Darun, Knowledge-Making, Past-oriented, Story-telling, Implore, Akhyata, Scholarly, Gharsthika, Emotionless, Philanthropic
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