2,301 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Consolidation by MF-ERS of mechanically alloyed Al powder
No full textThe aim of this work is to study the viability of producing, by medium-frequency electrical resistance
sintering (MF-ERS), compacts from mechanically alloyed aluminium powders. The MF-ERS process was
carried out using different values of current intensity (6, 8, 10 and 11 kA) and dwelling (heating) times
(400, 700 and 1000 ms). Results were compared with compacts processed by the conventional cold
pressing and sintering route (850 MPa and 650 C-1h). Depending on the processing route different
properties were obtained. The final porosity of the MF-ERS compacts (23.6e7%) can be as low, under the
tougher tested sintering conditions, as that of the conventionally produced compacts (6%). The compacts
obtained by MF-ERS are less ductile, with lower compression strength than that obtained by the conventional route. Furthermore, a similar electrical resistance and higher microhardness can be reached by
the MF-ERS process, despite the duration of the consolidation process is only a fraction of that of the
conventional process.Ministerio de Economía y Competitividad DPI2015-69550-C2-1-PFondo Europeo de Desarrollo Regional (FEDER) DPI2015-69550-C2-2-
MDQ positive people's searching for effective and ineffective treatments for bipolar disorders: a screening study in France
No full textINTRODUCTION:
The objective was to estimate the rate of subjects who tested positive at a screening for bipolar disorders among the people insured by a French Health Company, and subsequently to measure treatment patterns.
METHODS:
Cross-sectional postal survey on the "Mutuelle Générale de l'Education Nationale" (MGEN) policyholders. A self-rated questionnaire was sent by mail to 20,099 individuals randomly selected among MGEN policyholders. Tools: questionnaire on socio-demographic variables and health-care use; Mood Disorder Questionnaire (MDQ); Composite International Diagnostic Interview Short Form Self-Administered (CIDI-SA).
RESULTS:
Responders were 10,288 (53%). The prevalence of MDQ positivity (MDQ(+)) was 3.6%. The respondents older than 65 showed the lowest frequencies. High frequencies were recorded by the people who had left work because of long term sickness and by people with invalidity. Subjects having a diagnosis of ICD-10 major depression were found to be at risk. Positive subjects had no more contacts with general practitioners than negative subjects; on the contrary they had more contacts with psychiatrists, alternative medicine professionals, psychologists, psychoanalysts, spiritual guides or welfare workers. MDQ+ subjects had a higher risk to use all kinds of psychodrugs, including antidepressants (27.7%, OR=2.7, CI95% 1.9-3.9).
DISCUSSION:
The prevalence of MDQ(+) was similar to the surveys in the USA and Italy. The use of ADs in people with MDQ(+) and MDD diagnosis needs to be taken into account when managing the public health-care system. A large rate of positive subjects reported to have used ineffective treatments for bipolar disorders.
LIMITS:
Relative low response rate and observational design
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake
No full textIn Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly related to drug toxicity and reduced efficacy in some regions. Miltefosine (MF), the only oral drug available for leishmaniasis treatment, is not widely available and has not yet been approved for human use in Brazil. Our group previously reported the existence of differential susceptibility among L. (V.) braziliensis clinical isolates. In this work, we further characterized three of these isolates of L. (V.) braziliensis chosen because they exhibited the lowest and the highest MF half maximal inhibitory concentrations and were therefore considered less tolerant or more tolerant, respectively. Uptake of MF, and also of phosphocholine, were found to be significantly different in more tolerant parasites compared to the less sensitive isolate, which raised the hypothesis of differences in the MF transport complex Miltefosine Transporter (MT)-Ros3. Although some polymorphisms in those genes were found, they did not correlate with the drug susceptibility phenotype. Drug efflux and compartmentalization were similar in the isolates tested, and amphotericin B susceptibility was retained in MF tolerant parasites, suggesting that increased fitness was also not the basis of observed differences. Transcriptomic analysis revealed that Ros3 mRNA levels were upregulated in the sensitive strain compared to the tolerant ones. Increased mRNA abundance in more tolerant isolates was validated by quantitative PCR. Our results suggest that differential gene expression of the MT transporter complex is the basis of the differential susceptibility in these unselected, naturally occurring parasites
Efectos del tratamiento temprano de clase III mediante ortopedia de disyunción y máscara facial a corto y largo plazo
No full textObjetivo: Observar los efectos del tratamiento ortopédico temprano de las clases III
esqueléticas con expansión rápida maxilar y mascarilla a corto y largo plazo.
Material y método: La búsqueda se realizó en las bases de datos de Pubmed, Medline y
Scopus. Se obtuvieron al inicio un total de 1132 artículos que aplicados los criterios de
inclusión y exclusión fueron elegidos finalmente para dicha revisión un total de 12
artículos.
Resultados: Los efectos obtenidos en el tratamiento temprano a corto plazo, mostraron
mejoras medias significativas de SNA en 1,66º; SNB -0,68º y ANB 2,26º. Y en lo
referente al grado de recidiva se obtuvieron valores medios de recaída de 1,55º para SNB
y 1,45º para ANB. Sin embargo, SNA resultó mantenerse estable a largo plazo.
Conclusiones: El tratamiento temprano de la maloclusión de clase III con RME/MF ha
demostrado tener efectos significativos en SNA, SNB y ANB a corto plazo y estos efectos
parecen resultar favorables también a largo plazo mejorando así dicha maloclusión
esquelética.Aim: To observe the effects of orthopedic treatment of skeletal classes III with rapid
maxillary expansion and facemask in the short and long term.
Material and method: The search was carried out in Pubmed, Medline and Scopus
databases. Initially, a total of 1132 articles were obtained, and after applying the inclusion
and exclusion criteria, 12 articles were finally chosen for the review.
Results: The effects obtained in the early treatment in the short term, showed significant
mean improvements of SNA in 1.66º; SNB -0.68º and ANB 2.26º. And regarding the
degree of recurrence, mean relapse values of 1.55º for SNB and 1.45º for ANB were
obtained. However, SNA turned out to be stable in the long term.
Conclusions: Early treatment of class III malocclusion with RME/MF has been shown
to have significant effects on SNA, SNB and ANB in the short term and these effects
seem to be favorable in the long term as well, thus improving the said skeletal
malocclusion.Universidad de Sevilla. Grado en Odontologí
Envelope filter sequence to delete blinks and overshoots
No full textBackground: Eye movements have been used in control interfaces and as indicators
of somnolence, workload and concentration. Different techniques can be used to
detect them: we focus on the electrooculogram (EOG) in which two kinds of interference
occur: blinks and overshoots. While they both draw bell-shaped waveforms, blinks
are caused by the eyelid, whereas overshoots occur due to target localization error and
are placed on saccade. They need to be extracted from the EOG to increase processing
effectiveness.
Methods: This paper describes off- and online processing implementations based
on lower envelope for removing bell-shaped noise; they are compared with a 300-msmedian
filter. Techniques were analyzed using two kinds of EOG data: those modeled
from our own design, and real signals. Using a model signal allowed to compare
filtered outputs with ideal data, so that it was possible to quantify processing precision
to remove noise caused by blinks, overshoots, and general interferences. We analyzed
the ability to delete blinks and overshoots, and waveform preservation.
Results: Our technique had a high capacity for reducing interference amplitudes
(>97%), even exceeding median filter (MF) results. However, the MF obtained better
waveform preservation, with a smaller dependence on fixation width.
Conclusions: The proposed technique is better at deleting blinks and overshoots than
the MF in model and real EOG signals
Assessing the effects of electromagnetic fields generated by submarine power cables on the soft-bottom community: An ecological in-situ study
No full textThis study represents the first in situ investigation into the effects of magnetic fields (MFs) on soft-bottom macrofauna communities, laying the groundwork for further studies to better understand their potential consequences on marine ecosystems. Conducted in the Natural Park of the Strait (Southern Iberian Peninsula), the study measured MFs generated by HVAC cables and assessed their impact on soft-bottom macrofauna communities by comparing areas exposed to MFs with two control areas at different depths. Measured MF intensities were relatively low, with a maximum deviation from background levels of 34 nT near the cable, decreasing to 1 nT at 250 m distance. These intensities are considerably lower than those typically used in laboratory experiments inducing physiological effects (0.1–30 mT). Results revealed an increasing pattern of species richness (S) with depth, associated with sediment stability and different sediment characteristics. While analyses did not show significant effects of the magnetic field on macrobenthic communities overall, some indications were observed, such as decreased species richness at the deepest station and community homogenization across depths in the cable area compared to control zones. However, the varying patterns observed across different sites and depths necessitate further investigation, particularly considering the differences in MF intensities between field settings and controlled laboratory environments
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