147 research outputs found
Annihilators of principal ideals in the exterior algebra
No full textKoç, Cemal (Dogus Author) -- Esin, Songül (Dogus Author)In this paper we describe annihilators of principal ideals of exterior algebras. For odd elements we establish formulae for dimensions of their principal ideals and their annihilators. For even elements we exhibit (multiplicative) generators for annihilator ideals
Comparative law at a crossroads
No full textA book which seeks to bring a fresh
approach to many of the issues in comparative law was launched in
December 2007 at the IALS. The author, a co-editor of Comparative
Law: A Handbook, explains what the new volume is seeking to
achieve. Article by Esin Örücü (Honorary Senior Research Fellow
and Professor Emeritus of Comparative Law, University of Glasgow
and Professor Emeritus of Comparative Law, Erasmus Universiteit
Rotterdam) published in Amicus Curiae - Journal of the Society
for Advanced Legal Studies. The Journal is produced by the
Society for Advanced Legal Studies at the Institute of Advanced
Legal Studies, University of London
Comparative law at a crossroads
No full textA book which seeks to bring a fresh approach to many of the issues in comparative law was launched in December 2007 at the IALS. The author, a co-editor of Comparative Law: A Handbook, explains what the new volume is seeking to achieve. Article by Esin Örücü (Honorary Senior Research Fellow and Professor Emeritus of Comparative Law, University of Glasgow and Professor Emeritus of Comparative Law, Erasmus Universiteit Rotterdam) published in Amicus Curiae - Journal of the Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London
Analysis of nonlinear compartmental model using a reliable method
No full textThe goal of this work is to investigate nonlinear models and their complexity using techniques that are universal and have connections to historical and material aspects. Using the premise of a constant population that is uniformly mixed, a nonlinear compartmental model that depicts the movement between voter classes is taken into consideration. In the current work, we investigate the dynamical framework that supports the interactions between the three parties. It is discussed how rate change affects various metrics. The conditions for boundedness, stability, existence, and other dynamics are obtained. We derive the effects of generalizing the model in any order. The current study supports investigations into complex real-world issues and forecasts of necessary plans. © 2023 The Author(s
A Novel Study of Morlet Neural Networks to Solve the Nonlinear HIV İnfection System of Latently İnfected Cells
No full textThe aim of this study is to provide the numerical outcomes of a nonlinear HIV infection system of latently infected CD4+ T cells exists in bioinformatics using Morlet wavelet (MW) artificial neural networks (ANNs) optimized initially with global search of genetic algorithms (GAs) hybridized for speedy local search of sequential quadratic programming (SQP), i.e., MW-ANN-GA-SQP. The design of an error function is presented by designing the MW-ANN models for the differential equations along with the initial conditions that represent the HIV infection system involving latently infected CD4+ T cells. The precision and persistence of the presented approach MW-ANN-GA-SQP are recognized through comparative studies from the results of the Runge-Kutta numerical scheme for solving the HIV infection spread system in case of single and multiple trails of the MW-ANN-GA-SQP. Statistical estimates with ‘Theil's inequality coefficient’ and ‘root mean square error’ based indices further validate the sustainability and applicability of proposed MW-ANN-GA-SQP solver. © 2021 The Author
The Evaluation of Procalcitonin as a Diagnostic and Prognostic Marker of Bacterial Infections in Febrile Neutropenic Patients
No full textObjective: The aim of this study was to evaluate the role of procalcitonin (PCT) in the diagnosis, prognosis and follow-up of bacterial infections in febrile neutropenic patients in comparison to the standard parameter, C-reactive protein (CRP). Methods: 40 febrile neutropenic episodes of 37 patients with cancer undergoing chemotherapy were classified as fever of unknown origin (FUO), microbiologically or clinically documented infection. Four sequential serum samples were obtained at the onset of neutropenia, on the first and third days of fever and on the day of defervescence, or on day 5 or 7 of an unresolved fever. Results: At the onset of neutropenia, the PCT levels were found to be normal whereas CRP levels were found to be elevated in all patients. With the febrile episode, PCT levels were elevated in all types of infections which were significantly higher for documented infections compared to FUO (p< 0.05). Procalcitonin levels differed significantly between patients with and without severe sepsis (p<0.001), and the highest levels were seen on the third day of fever. PCT levels decreased rapidly in afebrile patients treated successfully, whereas they remained significantly higher for patients unresponsive to therapy (p<0.001). Conclusions: In conclusion, PCT could be suggested as a useful marker, and was superior to CRP for early diagnosis of documented infections, assessment of the severity of infection and response to therapy in febrile neutropenic patients
The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells
No full textWOS: 000402150300005PubMed ID: 27402681Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown that silibinin inhibits experimentally induced malignancies of the liver, prostate, skin, and colon as well as promotes inhibition of the proliferation of cancer cell lines in vitro. This study aimed to investigate the effects of silibinin on the human breast carcinoma cell lines MDA-MB-231 and MCF-7 in monolayer and spheroid cultures. Method: The MDA-MB-231 and MCF-7 cell lines were cultured in both monolayer and spheroid cultures. Cells were treated with silibinin at 24, 48, and 72 h of incubation. The 5-bromo-2-deoxyuridine labeling index was used to determine the cells of the synthesis phase. Poly-ADP-ribose-polimerase immunohistochemical staining and the terminal deoxynucleotidyl transferase dUTP nick and labeling assay were used to determine the death of cells in both the monolayer and spheroid cultures. Results: An half maximal inhibitory concentration dose of silibinin in MDA-MB-231 and MCF-7 cells was 100 mu M/mL at 24, 48, and 72 h of incubation. Terminal deoxynucleotidyl transferase dUTP nick and labeling positive cells and active poly-ADP-ribose-polimerase were detected after treatment with silibinin in both the monolayer and spheroid cultures. The dead cell count was higher in the MDA-MB-231 and MCF-7 cell lines with silibinin applied than in the controls. Conclusions: Our study demonstrated that silibinin applications enhanced terminal deoxynucleotidyl transferase dUTP nick and labeling positive cells and active poly-ADP-ribose-polimerase in comparison to the control in both the monolayer and spheroid cultures.Mugla Sitki Kocman UniversityMugla Sitki Kocman UniversityThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The present study was supported by the Research Fund of Mugla Sitki Kocman University. Some parts of this manuscript were presented at the 5th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels 9-12 September 2014, Isparta
Forecasting Istanbul monthly temperature by multivariate partial least square
No full textWeather forecasting, especially for temperature, has always been a popular subject since it affects our daily life and always includes uncertainty as statistics does. The goals of this study are (a) to forecast monthly mean temperature by benefitting meteorological variables like temperature, humidity and rainfall; and (b) to improve the forecast ability by evaluating the forecasting errors depending upon the parameter changes and local or global forecasting methods. Approximately 100 years of meteorological data from 54 automatic meteorology observation stations of Istanbul that is the mega city of Turkey are analyzed to infer about the meteorological behaviour of the city. A new partial least square (PLS) forecasting technique based on chaotic analysis is also developed by using nonlinear time series and variable selection methods. The proposed model is also compared with artificial neural networks (ANNs), which model nonlinearly the relation between inputs and outputs by working neurons like human brain. Ordinary least square (OLS), PLS and ANN methods are used for nonlinear time series forecasting in this study. Major findings are the chaotic nature of the meteorological data of Istanbul and the best performance values of the proposed PLS model
Management of displaced radial neck fractures in children: percutaneous pinning vs. elastic stable intramedullary nailing
No full textBackground: The treatment of radial neck fractures in children varies according to the displacement, angulation, and skeletal maturity. There is a general agreement that displaced radial neck fractures with more than 30 angulations (Judet type III and IV fractures) should be surgically treated. There are several treatment possibilities for Judet type III and IV fractures including percutaneous pin reduction, elastic stable intramedullary nailing (ESIN), and open reduction with or without internal fixation. In this retrospective study we compared the clinical and radiographical outcomes, and complications following intramedullary versus percutaneous pinning in displaced radial neck fractures in children. Materials and methods: Between 2000 and 2011, 20 patients were treated using closed reduction: in 12 cases we used percutaneous pinning, and in 8 cases we used ESIN. According to Judet classification the two groups were composed as follows: 10 (77 %) type III and 3 (23 %) type IV fractures in the percutaneous pinning group; 4 (57 %) type III, and 3 (43 %) type IV fractures in the ESIN group. Results: After an average of 42 months, excellent results in Mayo elbow performance scores (MEPS) were obtained in 71 and 69 % of ESIN and percutaneous pinning groups respectively, with good results in the remaining cases apart from one fair case (8 %) in the percutaneous pinning group. After a radiological evaluation, all fractures healed in excellent or good alignment. When comparing the two groups, the subjects treated with the ESIN technique had higher range of motion (ROM) in flexion, extension and pronation. No patients developed complications, except three cases of asymptomatic enlargements of the radial head, reported only in the percutaneous pinning group. Conclusion: In this research the clinical outcome, assessed with the MEPS, and the radiological alignment, were comparable between the subjects that were treated with percutaneous pinning and those with ESIN techniques; whereas the ESIN technique demonstrated higher ROM in flexion, extension and pronation. The ESIN technique seems to be the ideal approach both for the higher ROM values and for the absence of complications. © 2012 The Author(s)
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