291 research outputs found
Diebold Symposium Schedule 2009
No full text1 Broadside. Designed using Microsoft PowerPoint. 48"W x 36"HSchedule for the Diebold Symposium held Thursday, April 30, to Saturday, May 2, 2009 on the campus of Kalamazoo College. “The Evolution of Words and Other Memes” was the Keynote Address and delivered by Dr. Daniel Dennett, Tufts University, Austin B. Fletcher Professor of Philosophy, and author of Darwin’s Dangerous Idea.Kalamazoo College. Department of Biology. Diebold Symposium, 200
Johannes Diebold (1842–1929) – cecilian movement promoter from Freiburg
No full textArtykuł zawiera opis działalności Johannesa Diebolda – organisty, kompozytora i muzyka kościelnego. Był animatorem ruchu cecyliańskiego we Freiburgu. Skomponował wiele utworów chóralnych przeznaczonych zarówno dla chórów amatorskich, jak i profesjonalnych. Często w utworach chóralnych stosował akompaniament organowy. Większą część twórczości stanowią utwory organowe przeznaczone do użytku liturgicznego. Autor stosuje w nich głównie techniki polifoniczne. Kompozycje organowe ujmował w takie formy, jak: preludium, postludium, fuga, fugetta, trio. Diebold odegrał znaczącą rolę jako wydawca i popularyzator ówczesnej muzyki organowej. Zbiory wydawanej przez siebie światowej literatury organowej stanowią do dziś istotną pomoc dydaktyczną i repertuarową dla muzyków kościelnych.This article describes the activities of Johannes Diebold – organist, composer and church musician. He was an organizer of the Cecilian movement in Freiburg. He composed many choral works for both amateur and professional choirs. He often used organ accompaniment in his choral works. The greater part of his oeuvre consists of organ works intended for liturgical purposes. The author uses mainly polyphonic techniques. He arranged his organ compositions into such forms as a prelude, postlude, fugue, fughetta and trio. Diebold played a significant role as a publisher and promoter of organ music at that time. The collections of worldwide organ literature he published are still an important teaching and performing aid for church musicians today
The Effect of TiO2 Nanomaterials on the Bacterial Community in Nitrifying Sequencing Batch Reactors
No full textMicrosoft PowerPoint presentation slidesRapid development and widespread use of nanotechnology has resulted in the increased presence of nanomaterials in wastewater streams. Biological wastewater treatment has the potential to be a crucial technique in capturing and modifying nanomaterials before they enter the environment. However, little is known about the effects of nanomaterials on microbial communities involved in the wastewater treatment process. This project implemented qPCR and RT-qPCR to examine the impact of TiO2 nanoparticles on the bacterial community by measuring the expression of amoA in Nitrosomonas and nsg (a Nitrobacter specific gene) along with the induction of the antibiotic resistance gene, sulI, in a typical nitrifying activated sludge system. Six lab-scale sequencing batch reactors (SBRs) were set up and fed with synthetic wastewater suitable for nitrification. Three test conditions were examined in duplicate reactors: nano-sized TiO2, bulk-TiO2, and no-TiO2 control. Quantification of amoA and nsg levels and expression did not suggest inhibition of the nitrification process as result of nano- or bulk-TiO2 exposure. Quantification of sulI did not suggest induction of sulfonamide resistance. This project provides important genetic information on the effect of TiO2 nanomaterials on the bacterial community in an experimental paradigm that accurately replicates a simulated nitrifying activated sludge system.Unavailable to the public at the request of the author, 2/9/15. This work, along with some other related work, was published in the journal "Water Research": http://www.sciencedirect.com/science/article/pii/S004313541400637X as "Microbial community response of nitrifying sequencing batch reactors to silver, zero-valent iron, titanium dioxide and cerium dioxide nanomaterials"Kalamazoo College. Department of Biology. Diebold Symposium, 201
Preliminary assessment of the ATHENA/WFI non-X-ray background
No full textWe present a preliminary assessment of the non-X-ray background for the WFI on board ATHENA conducted at IAAT in the context of the collaborative background and radiation damage working group activities. Our main result is that in the baseline configuration originally assumed for the camera the requirement on the level of non-X-ray background could not be met. In light of the results of Geant4 simulations we propose and discuss a possible optimization of the camera design and pinpoint some open issues to be addressed in the next phase of investigation. One of these concerns the possible contribution to the non-X-ray background from soft protons and ions funneled to the focal plane through the optics. This is not quantified at this stage, here we just briefly report on our ongoing activities aimed at validating the mechanisms of proton scattering at grazing incidence
Forecasting the Term Structure of Variance Swaps
No full textRecently, Diebold and Li (2003) obtained good forecasting results for yield curves in a reparametrized Nelson-Siegel framework. We analyze similar modeling approaches for price curves of variance swaps that serve nowadays as hedging instruments for options on realized variance. We consider the popular Heston model, reparametrize its variance swap price formula and model the entire variance swap curves by two exponential factors whose loadings evolve dynamically on a weekly basis. Generalizing this approach we consider a reparametrization of the three-dimensional Nelson-Siegel factor model. We show that these factors can be interpreted as level, slope and curvature and how they can be estimated directly from characteristic points of the curves. Moreover, we analyze a semiparametric factor model. Estimating autoregressive models for the factor loadings we get termstructure forecasts that we compare in addition to the random walk and the static Heston model that is often used in industry. In contrast to the results of Diebold and Li (2003) on yield curves, no model produces better forecasts of variance swap curves than the random walk but forecasting the Heston model improves the popular static Heston model. Moreover, the Heston model is better than the flexible semiparametric approach that outperforms the Nelson-Siegel model.Term structure, Variance swap curve, Heston model, Nelson-Siegel curve, Semiparametric factor model
Linkages between American and European Publicly Traded Airline Companies - Evidence Resulting from the Diebold-Yilmaz Method
No full textIn this paper, the author implemented the Diebold and Yilmaz approach to analyse the connectedness between the major American and European publicly traded airline companies. The author calculated the return and volatility spillover index for the whole sample using a dynamic rolling sample analysis. The results show that all airlines are significantly linked but there is a clear division into two markets. It was found that return spillovers are more intensive than volatility spillovers. Moreover, the average connectedness level is higher in the U.S. market for returns as well as for volatility. An increase of connectedness occurred due to the certain events: issues linked with the condition of the global economy and long-term crude oil price changes.W artykule przedstawiono wyniki badania powiązań w świetle metody Diebolda i Yilmaza pomiędzy notowaniami najważniejszych linii lotniczych w Stanach Zjednoczonych i w Europie. Wyznaczono indeks powiązań dla dziennych zwrotów i zmienności dla całej próby oraz w ujęciu dynamicznym. Wyniki badania wskazują, że notowania wszystkich analizowanych linii lotniczych są ze sobą powiązane, ale istnieje wyraźny podział na dwa rynki. Powiązania między rynkiem europejskim a amerykańskim są znacznie słabsze niż efekty zarażania pomiędzy liniami lotniczymi z jednego rynku. Efekty zarażania są silniejsze dla zwrotów niż dla zmienności. Ponadto średni poziom indeksu powiązań jest wyższy w Stanach Zjednoczonych niż w Europie. Na zmiany poziomu powiązań w czasie miały wpływ wydarzenia z otoczenia makroekonomicznego i rynku kapitałowego oraz długotrwała zmiana poziomu ceny ropy naftowej
A setup for soft proton irradiation of X-ray detectors for future astronomical space missions
No full textDevelopment and testing of instrumentation for space-based ultraviolet and x-ray astronomy
No full textRegulation und Funktion von Glucagon-like Peptide 1 und 2 unter inflammatorischen Bedingungen
No full textGlucagon-like Peptide 1 is a key component of food dependent insulin secretion. The co-secreted, intestinotrope GLP-2 increases intestinal cell proliferation as well as nutrient absorption in the intestine. Further GLP-1 has cardioprotective properties leading to improvement of cardiac contractility and myocardial function. The mechanisms of cardioprotection are not understood. A direct mechanism seems unlikely as GLP-1 receptors are not expressed on ventricular cardiomyocytes and GLP-1R agonists stay effective in GLP-1R-Knockout mice. GLP-1 is metabolized in a dipeptidedylpeptidase 4 dependent manner, thus DPP-4 Inhibitors (i.e. Linagliptin) can increase GLP-1 levels. DPP-4 inhibitors and GLP-1 agonists are used for the therapy of diabetes mellitus. In cardiovascular diseases such as acute myocardial infarction, pro-inflammatory cytokines are secreted, which have been identified as a stimulus of GLP-1 secretion. This study investigates the cardioprotective relevance of GLP-1 during acute myocardial infarction (MI) in a mouse model (LAD-Ligation) and in patient samples. Patient samples as well as the mouse model showed a transient increase of GLP-1 serum levels after MI. Treatment of mice with the DPP-4 inhibitor Linagliptin increased GLP-1 levels and cardiac contractility. An inverse agonist of the GLP-1R (Exendin-9) and usage of GLP-1R-KO mice prevented this effect, indicating involvement of the GLP-1R. Linagliptin and exogenous GLP-1 increased the respiratory capacity in isolated mitochondria from non-infarcted murine heart tissue, which could explain the improvement of cardiac contractility. On a protein level, the expression of p-AMPK correlated with the effects of GLP-1. In addition, Linagliptin-dependent increase of cardiac contractility was abrogated by AMPK inhibition. These experiments demonstrate that MI is a sufficient stimulus to increase GLP-1 levels, which have cardio protective efficacy. Although these experiments give some molecular insight, the mechanisms of GLP-1R dependent cardio protection remain incompletely understood and will require additional studies. The second part of this study investigates the relevance of GLP-2 for inflammatory bowel diseases (IBD) using patient samples and IBD mouse models (dextran sodium sulfate (DSS), clostridium difficile infection (CDI)). Despite the established use of GLP-2 for the treatment of short bowel syndrome (SBS), its mechanism of action is incompletely understood. Patient samples with Crohn’s disease and ulcerative colitis, lipopolysaccharide (LPS) treated mice as well as mouse colitis models were found to have increased GLP-2 levels in comparison to the controls. Lipopolysaccharide treatment led to a dosage dependent increase of circulating GLP-2 levels in mice. The inflammatory GLP-2 secretion was attributed to pancreatic α-cells. In colitis models DPP-4 inhibition (by Linagliptin) lead to increased GLP-2 levels, reduced serum concentration of the pro inflammatory cytokine Interleukin-6 and improved disease severity. In addition, histological and functional analysis revealed reduced intestinal inflammation and improved gut barrier. In addition to DPP-4 inhibitors, GLP-2 agonists reduced intestinal inflammation (CDI-colitis model). This effect was abrogated by antagonization of the GLP-2R.The presented data demonstrates that inflammatory diseases processes (MI, IBD) increase serum levels of GLP-1/2, while both proteins help to control disease severity. We were able to demonstrate some molecular mechanisms relevant for protective effects. However, additional pre-clinical studies are required to further elucidate the underlying mechanisms
Transistor- und Leitungsmodellierung zum Entwurf von monolithisch integrierten Leistungsverstärkern für den hohen Millimeterwellen-Frequenzbereich
No full textZiel ist der Entwurf von monolithisch integrierten Leistungsverstärkern für den Frequenzbereich von 200 bis über 250 GHz. Dafür sind verlässliche und flexible Leitungs- und Transistormodelle notwendig. Sie werden erstellt und ihre Genauigkeit wird bis 325 GHz bestätigt. Es wird ein Verstärkerkonzept erarbeitet, das maßgeschneidert für den Frequenzbereich und die MMIC-Technologie ist. Es nutzt einen neuartigen Koppler, der kompakte Verstärker mit hoher Bandbreite und Ausgangsleistung ermöglicht
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