184 research outputs found
Assembly FG: An Educational Case on MRP II Integrated within ERP
No full textThis case teaches students how discrete (job order) manufacturing companies use Manufacturing Resource Planning (MRP II) within Enterprise Resource Planning (ERP) systems to plan purchase orders for direct materials and shop orders for work-in-process and finished goods. Students simulate MRP II integrated within ERP, using Microsoft Excel to learn MRP II’s bill-of-materials (BOM) Explosion that plans order quantities and MRP II’s scheduling logic that uses lead-times to determine start dates for planned orders. Students explain why MRP II is most practical and effective when executed within ERP and how MRP II can reduce excess inventories, prevent inventory shortages, and help companies deliver quality products to customers on schedule. Also, students explain why BOM, inventory, and lead-time inaccuracies can adversely affect the accuracy of MRP II-planned replenishments and identify controls that reduce the risks of these inaccuracies.Journal Articl
Aesop's Fables II
No full textSee my comments on the first film in the three-film series. In TMCM, the two mice manage to stuff themselves before the two dogs come. The film does a particularly good job of presenting FG, especially in its incremental development of Alexander's getting thirstier and angrier and wearier. AL brings back the earlier face-licking illustration effectively in the arena.Aesop's Fables II. No author, illustrator, or reader acknowledged. Sixteen-millimeter. Living Prose Series. In collaboration with Lumin Films. McGraw-Hill, Inc. Gift of John Carlson, Dec., '95. Also on a metal master tape and two videotape copies
[Artigo retratado] Criminal liability and compulsory in international criminal justice: the case of transnational corporations
No full textThe Editorial Team of the Guanambi Faculty of Law (RDFG) retracted the research because of (i) the scientific paper was previously published by another Brazilian journal, and (ii) we were informed by Tufts University, which the author claims to be bound, that he never composed the teaching staff of the higher education institution.A Equipe Editorial da Revista de Direito da Faculdade Guanambi (RDFG) procedeu à retratação da pesquisa em razão de (i) o artigo científico ter sido publicado anteriormente, por outro periódico brasileiro, e (ii) termos sido informado pela Tufts University, a qual o autor diz ser vinculado, que este jamais compôs o quadro de docentes da referida instituição de ensino superior.
 
Hypocretin/orexin preferentially activates caudomedial ventral tegmental area dopamine neurons
No full textThe hypocretin/orexin (HCRT) neuropeptide system modulates behavioral state and state‐dependent processes via actions on multiple neuromodulatory transmitter systems. Recent studies indicate that HCRT selectively increases dopamine (DA) neurotransmission within the prefrontal cortex (PFC) and the shell subregion of the nucleus accumbens (NAs), but not the core subregion of the nucleus accumbens (NAc). The circuitry underlying the differential actions of HCRT across distinct DA systems is unclear. The current study examined whether HCRT preferentially activates PFC‐ and NAs‐projecting relative to NAc‐projecting DA neurons within the VTA. One week after infusion of the retrograde tracer fluorogold (FG) into the medial PFC, NAc or NAs, animals received a ventricular infusion of HCRT‐1. Subsequent analyses conducted across the rostral‐caudal extent of the VTA determined the degree to which: (i) Fos‐immunoreactivity (ir) was observed within tyrosine hydroxylase (TH)‐ir neurons; (ii) TH‐ir was observed within FG‐ir neurons; and (iii) Fos‐ir was observed within FG‐ir neurons. HCRT significantly increased Fos‐ir in VTA DA (TH‐ir) neurons, primarily in a restricted population of small‐to‐medium‐sized DA neurons located within the caudomedial VTA. Furthermore, within this region of the VTA, PFC‐ and NAs‐projecting TH‐ir neurons were more likely to contain Fos‐ir than were NAc‐projecting TH‐ir neurons. These results provide novel evidence that HCRT selectively activates PFC‐ and NAs‐projecting DA neurons within the VTA, and suggest a potential role for HCRT in PFC‐ and NAs‐dependent cognitive and/or affective processes. Moreover, these and other observations suggest that the dysregulation of HCRT–DA interactions could contribute to cognitive/affective dysfunction associated with a variety of behavioral disorders.Peer reviewedFinal article publisheddopaminehypocretinnucleus accumbensorexinprefrontal cortexventral tegmental are
Young Folk's Library of Choice Literature, Volume I, Number 3, April 16, 1894
No full textThis 32-page pamphlet represents a curiosity. It is No. 3 of April 16, 1894. It thus follows upon another pamphlet in the collection, No. 2 of April 1, 1894. That booklet had the first nine fables contained in Aesop's Fables (1892) by the same author and publisher. This booklet contains the next ten fables in order. The surprise is that it has a different size and cover format than that other pamphlet in the same series. It continues that pamphlet's tradition of blackboard words for each fable and one or two illustrations per fable. The publisher here does not list a San Francisco office in addition to those in Boston, New York, and Chicago. This volume's cover has the top and bottom of the cover of that larger 1892 book, while the other pamphlet has the illustration of FG from the middle of the cover of that book. This Vol. 1, No.3 is listed as No. II on its title page, in the exact place and format in which the other pamphlet is called No. I.Mara L. Prat
A Multicenter Retrospective Study Comparing Surgical Outcomes Between the Overlap Method and Functional Method for Esophagojejunostomy in Laparoscopic Total Gastrectomy: Analysis Using Propensity Score Matching
No full textBackground: This study aimed to compare the postoperative outcomes after laparoscopic total gastrectomy (LTG) with esophagojejunostomy (EJS) performed using the overlap method or the functional method in a multicenter retrospective study with propensity score matching. Methods: We retrospectively enrolled all patients who underwent curative LTG for gastric cancer at 6 institutions between January 2004 and December 2018. Patients were categorized into the overlap group (OG) or functional group (FG) based on the type of anastomosis used in EJS. Patients in the groups were matched using the following propensity score covariates: age, sex, body mass index, American Society of Anesthesiologists physical status, extent of lymph node dissection, and Japanese Classification of Gastric Carcinoma stage. The surgical results and postoperative outcomes were compared. Results: We identified 69 propensity score-matched pairs among 440 patients who underwent LTG. There was no significant between-group difference in the median operative time, intraoperative blood, or number of lymph nodes resected. In terms of postoperative outcomes, the rates of all complications [Clavien-Dindo (CD) classification >= II; OG 13.0 vs. FG 24.6%, respectively; P=0.082], complications more severe than CD grade III (OG 8.7 vs. FG 18.8%, respectively; P=0.084), and the occurrence of EJS leakage and stenosis more severe than CD grade III (OG 7.3% vs. FG 2.9%, P=0.245; OG 1.5 vs. FG 8.7%, P=0.115, respectively) were comparable. The median follow-up period was 830 days (range, 18 to 3376 d), and there were no differences in overall survival between the 2 groups. Conclusions: There was no difference in surgical outcomes and overall survival based on the type of anastomosis used for EJS after LTG. Therefore, selection of anastomosis in EJS should be based on each surgeon's preference and experience
Land Surface Processes Create Patterns in Atmospheric Residence Time of Water
No full textRecent studies determined the residence time of moisture in the atmosphere to be 8–10 days but with large spatial and temporal differences. An unexplained daily cycle in the probability density function (PDF) of the residence time of land evaporation was observed, which was not present for oceanic evaporation. Moreover, the PDF of atmospheric residence time of oceanic evaporation was found to be a monotonically decreasing, while for land evaporation, this function had increasing probabilities during the first few days and monotonically decreasing probabilities thereafter. This research determines the causes of (I) the daily cycle in this PDF and (II) the shape of the atmospheric residence time PDF. The strong daily cycle in the residence time PDF using ERA-Interim is attributed to the fact that the evaporation and precipitation have the same diurnal cycle in ERA-Interim. Therefore, evaporation entering the atmosphere has the highest probability of returning to the land surface as precipitation at the same moment during the day but possibly a number of days later. Interestingly, this diurnal cycle was almost absent in the simulations forced with GLDAS surface fluxes. Therefore, we conclude that the previously found daily cycle in the atmospheric residence time PDF is due to differences in the diurnal cycles of precipitation in the underlying data sets. Transpiration causes the increasing probabilities during the first days, while bare soil evaporation and canopy interception typically have a monotonically decreasing PDF. Therefore, we conclude that transpiration causes the largest differences in atmospheric residence time between ocean and land evaporation.Water Resource
D2P2: database of disordered protein predictions
No full textWe present the Database of Disordered Protein Prediction (D2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein sequences from 1765 complete proteomes (to be updated as more genomes are completed). Integrated with these results are all of the predicted (mostly structured) SCOP domains using the SUPERFAMILY predictor. These disorder/structure annotations together enable comparison of the disorder predictors with each other and examination of the overlap between disordered predictions and SCOP domains on a large scale. D2P2 will increase our understanding of the interplay between disorder and structure, the genomic distribution of disorder, and its evolutionary history. The parsed data are made available in a unified format for download as flat files or SQL tables either by genome, by predictor, or for the complete set. An interactive website provides a graphical view of each protein annotated with the SCOP domains and disordered regions from all predictors overlaid (or shown as a consensus). There are statistics and tools for browsing and comparing genomes and their disorder within the context of their position on the tree of life.
© The Author(s) 2012. Published by Oxford University Press
Seifert manifolds that are ramified two-sheeted cyclic coverings. (Spanish)
No full textIf L is a link in the 3-sphere S3, let e:L˜→S3 denote the 2-fold cyclic covering of S3 branched over L. R. H. Fox [Rev. Mat. Hisp.-Amer. (4) 32 (1972), 158–166;] has shown that there is no link L in S3 such that L˜ is S1×S1×S1; the author [ibid. (4) 33 (1973), 32–35] has extended this to Fg×S1 (g≥1), where Fg denotes a closed orientable surface of genus g. In the present article he investigates the following more general question: Given any orientable Seifert fibre space M, determine whether M is homeomorphic to L˜ for some link L⊂S3; if the answer is yes, describe L.
He finds an affirmative answer for all orientable Seifert fibre spaces over a 2-sphere or over a nonorientable closed surface as base B. In these cases a corresponding link L is constructed by using the technique of tangle modification introduced by J. H. Conway [Computational problems in abstract algebra (Proc. Conf., Oxford, 1967), pp. 329–358, Pergamon, Oxford, 1970;], to which corresponds the operation of removing from L˜ a solid torus and sewing it back differently in the covering. For orientable base B of positive genus g, i.e., B=Fg (g≥1), the situation is more complex: (i) The author finds a negative answer to the above question for the fibre spaces (Oog|b) without exceptional fibres, provided b≠±1,±2 and g≥1 (for the notation, see H. Seifert's article [Acta Math. 60 (1933), 147–238; Zbl 6, 83]). (ii) Analyzing the special assumption that the unique nontrivial covering transformation of the 2-fold cover is fibre-preserving, the author obtains a list of Seifert fibre spaces with base Fg, each of which is homeomorphic to L˜ for an appropriate link L in S3. (iii) The verification that this list is complete would depend on an affirmative answer to an unsolved question concerning involutions in Seifert fibre spaces. (iv) Modifying the main question, the author proves that each orientable Seifert fibre space over Fg (g≥0) is a 2-fold cyclic cover branched over a link of Hg, the 3-sphere with g handles attached.
Finally, it is shown how some of these results extend from the class of Seifert fibre spaces to the class of "graph-manifolds'' introduced by F. Waldhausen [Invent. Math. 3 (1967), 308–333; ibid. 4 (1967), 87–117;]. The paper is a fine piece of geometry, being specified throughout with interesting examples.Depto. de Álgebra, Geometría y TopologíaFac. de Ciencias MatemáticasTRUEpu
Non-valvular atrial fibrillation and stroke : implications for management
No full textNonvalvular Atrial Fibrillation is more prevalent with increasing age. It is associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it. Five trials have established the safety of warfarin in reducing the risk by 70% in well selected patients, with stringent monitoring. Thromboembolism, cardiac failure, hypertension and echocardiographic abnormalities identify higher risk patients. The management of NVAF is changing from rate control, to cardioversion and anticoagulation (or use of antithrombotics) to reduce the embolic risk.peer-reviewe
- …
