170,420 research outputs found
Lo spazio del potere civile e religioso nella Palermo normanna. S. Maria dell'Ammiraglio, S. Maria del Cancelliere, S. Maria Nuova o dei Marturano
No full textL'A. affronta lo studio dei poli urbani del potere in epoca normanna, in particolare quello del grande emiro Giorgio di Antiochia, ove sorge la Chiesa di Santa Maria, detta dell'Ammiraglio, di rito greco, e quello del gran cancelliere Matteo di Salerno, ove fonda il monastero di Santa Maria de Latinis o del Cancelliere, in relazione alla configurazione storica della città ed alle trasformazioni cui va incontro
Canine pancytopoenia and hemophagocytic lymphohistiocytosis
No full textLeishmaniasis and rickettsial diseases are endemic and common
in Mediterranean countries and so, as in humans, these
diseases could be an important cause of HLH in dogs and may
respond to similar medications. In conclusion, we think that the
diagnosis of HLH should be considered in dogs with pancytopenia
and, in selected cases, immunosuppressive treatment might
be warranted
How Do Philanthropic Venture Capitalists Choose Their Portfolio Companies?
No full textIn recent years, philanthropic venture capital (PhVC) has developed as a new financing model for social entrepreneurship. First presented by Letts et al. in 1997, PhVC is the application of the venture capital (VC) strategies and techniques to the financing of social enterprises (SE). Like venture capitalists (VCs), PhVCs have developed specialized abilities in selecting entrepreneurial projects. However, while VCs select deals in terms of shareholder value maximization (Amit et al., 1998), PhVCs engage in a partnership aiming at maximizing social impact. Because of the few PhVCs and the high engagement philosophy, a limited number of SE receive support after a tough selection process. Despite the growing interest in PhVC, no study has investigated its selection. Specifically, it is unclear: a) which variables are considered; b) their degree of importance; and c) the relationship with VC variables (Kaplan and Stromberg, 2000). Additionally, no research exists on whether different types of PhVCs consider different screening variables and the existence of differences in US and European selection process
Conformational properties and in vitro antibacterial activity of some diarylsulphones
No full textThe 2-pyridylphenylsulphone, di-2-pyridylsulphone and its p-nitro and p,p'-dinitro derivatives were synthesized and tested for antibacterial activity against a number of gram-positive and gram-negative bacteria. The electric dipole moment of these compounds were also measured (in benzene, 25 degrees) and analyzed in terms of molecular conformation in solution. The derivative compounds bearing a 5-nitro-2-pyridine fragment were found to be the most active in the series examined. Among these the nitro-2-pyridylphenylsulphone was found to have a broad-spectrum effect on gram-positive and gram-negative bacteria. Results of the conformational study in combination with microbiological data allowed discussion on the possible inferences concerning the stereochemical aspects of the interaction of diarylsulphones with bacterial receptor sites
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Rickettsia typhi and Haemophagocytic Syndrome
No full textAppropriate therapy (dexamethasone, cyclosporin,
and etoposide) could save the patient in those cases in which the
pathogen-direct therapy has not been sufficient by itself to control
the disease
The Evolution of the Lyman-alpha Luminosity Function during Reionization
No full textThe time frame in which hydrogen reionization occurred is highly uncertain, but can be constrained by observations of Lyman-alpha (Lya) emission from distant sources. Neutral hydrogen in the intergalactic medium (IGM) attenuates Lya photons emitted by galaxies. As reionization progressed the IGM opacity decreased, increasing Lya visibility. The galaxy Lya luminosity function (LF) is thus a useful tool to constrain the timeline of reionization. In this work, we model the Lya LF as a function of redshift, z = 5 10, and average IGM neutral hydrogen fraction, xH?. We combine the Lya luminosity probability distribution obtained from inhomogeneous reionization simulations with a model for the UV LF to model the Lya LF. As the neutral fraction increases, the average number density of Lya emitting galaxies decreases, and are less luminous, though for xH? ? 0.4 there is only a small decrease in the Lya LF. We use our model to infer the IGM neutral fraction at z = 6.6, 7.0, and 7.3 from observed Lya LFs. We conclude that there is a significant increase in the neutral fraction with increasing redshift: = = - = = ? x z 6.6 0.08+ , x z 7.0 0.28 0.05 H 0.05 0.08 ? ( ) H? ( ) and = = - x z 7.3 0.83+ H 0.07 0.06 ? ( ) . We predict trends in the Lya luminosity density and Schechter parameters as a function of redshift and the neutral fraction. We find that the Lya luminosity density decreases as the universe becomes more neutral. Furthermore, as the neutral fraction increases, the faint-end slope of the Lya LF steepens, and the characteristic Lya luminosity shifts to lower values; hence, we conclude that the evolving shape of the Lya LF not just its integral is an important tool to study reionization
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
The Impact of Cosmic Variance on Inferences of Global Neutral Fraction Derived from Lyα Luminosity Functions during Reionization
No full textWe investigate the impact of field-to-field variation, deriving from cosmic variance, in measured Lyα emitter (LAE) luminosity functions (LFs) and this variation’s impact on inferences of the neutral fraction of the intergalactic medium (IGM) during reionization. We post-process a z = 7 IGM simulation to populate the dark matter halos with LAEs. These LAEs have realistic UV magnitudes, Lyα fluxes, and Lyα line profiles. We calculate the attenuation of Lyα emission in universes with varying IGM neutral fraction, x ̄ H I . In a x ̄ H I = 0.3 simulation, we perform 100 realizations of a mock 2 deg2 survey with a redshift window Δz = 0.5 and flux limit f Lyα > 1 × 10−17 erg s−1 cm−2; such a survey is typical in depth and volume of the largest LAE surveys conducted today. For each realization, we compute the LAE LF and use it to recover the input x ̄ H I . Comparing the inferred values of x ̄ H I across the ensemble of the surveys, we find that cosmic variance, deriving from large-scale structure and variation in the neutral gas along the sightline, imposes a floor in the uncertainty of Δ x ̄ H I ∼ 0.2 when x ̄ H I = 0.3. We explore mitigation strategies to decrease this uncertainty, such as increasing the volume, decreasing the flux limit, or probing the volume with many independent fields. Increasing the area and/or depth of the survey does not mitigate the uncertainty, but composing a survey with many independent fields is effective. This finding highlights the best strategy for LAE surveys aiming at constraining the x ̄ H I of the universe during reionization
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