4 research outputs found
Diet quality and income in Rural and Urban China: evidence from the Health and Nutrition Survey
No full textThe specific objective of this paper is the investigation of the link between an improvement in Chinese households’ wealth and the quality of their diet and the role played by this relationship on the overall nutrition transition process. Better economic conditions mean a worsening of the diet in terms of higher energy intakes from fats, only partially compensated by higher fruit and vegetable intakes. China nutrition transition is going on and the rapid economic growth may lead to adverse health consequences if the negative effects of this transition will not be contrasted.Nutrition, diet quality, China, Food Consumption/Nutrition/Food Safety,
I periodici elettronici in biblioteca: nuova frontiera o terra promessa? Bologna, 28 febbraio 2000
No full textE-journals are a very topical subject, considered - in our framework - with a mix of enthusiasm and concern; on one hand there's the enthusiasm for media and technologies more and more in the van and more and more close to research needs, on the other there's the consciousness that in our country some contexts are still too far from these settings. Among the topics covered at the conference: the existing deviation – at least in our Italian outline – between the materials offered by the market and the objective difficulties that libraries have to cope with; organizing/management problems and cooperative settings of library systems in front of the new reality of electronic journals; the old role of the 'serials librarian' who can and must survive this "electronic revolution", provided that this figure is supported by collaboration, coordination and communication with the whole organization that gravitates around him; the future trends in the publishing market; the peer-reviews problem; the role of the author in the scholarly community. Moreover two Italian experiences were illustrated: CIBER (Coordinamento Interuniversitario Basi Dati & Editoria in Rete) and that one by University of Bologna Biomedical Library about the indexing of about 170 e-journals
O "homo viator" na Divina Commedia e no Grande Sertão: veredas
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em LiteraturaEsta tese busca problematizar um estudo comparado entre a Divina commedia e o Grande sertão: veredas a partir da noção de "Homo viator". Para tanto, nossa análise se concentrou sobre a percepção do aprimoramento do viajante que é também o protagonista nas duas obras Este viajante ficcional é concebido segundo um feixe de relações que Dante-autor e Guimarães Rosa realizam ao compor suas obras, de maneira que nos primeiro e segundo capítulos nos detivemos em alguns destes elementos, a saber: a presença da noção de êxodo bíblico bem como do viajante náutico greco-latino na caracterização deste viajante, o recurso ao narrador-protagonista e a composição das obras como literatura de viagem. Para analisar estes elementos nos utilizamos dos postulados da literatura comparada, da teoria dos arquétipos e da metafísica platônica. Por fim, no terceiro capítulo, realizamos um confronto entre dois episódios das referidas obras: a viagem de Ulisses presente no canto XXVI do Inferno e a viagem ao Liso do Sussuarão presente no Grande sertão: veredas. Este estudo tem por finalidade apresentar o "Homo viator" como metáfora da incansável busca humana da verdade.This dissertation performs a comparative study between the Divina Commedia and Grande Sertão: Veredas, having as a starting-point the notion of "Homo viator". Our analysis focuses on the path towards improvement undertaken by the "traveler", who is also the protagonist in both works. This fictional traveler is conceived of as a nexus of relationships that Dante-the-author and Guimarães Rosa construct in the making of each of their works, and it is to some of these relationships that we will pay attention in the first and second chapters, namely: the notion of the biblical exodus; the figure of the Roman-Greek nautical traveler in the characterization of the "homo viator"; the narratorprotagonist as a narrative device; and the caracterization of the works as travel literature. In order to perform an analysis of such elements, we draw our theoretical premises from the field of comparative literature, the theory of archetypes, and Platonic metaphysics. Lastly, in the third chapter, we compare and contrast two episodes from the referred works: the journey undertook by Ulysses in Canto XXVI of the Inferno, and the crossing of the "Liso do Sussuarão" in Grande Sertão: Veredas. The current work aims to present the "Homo viator"as a metaphor for the indefatigable human quest for truth
Significance of PD-L1 in Metastatic Urothelial Carcinoma Treated With Immune Checkpoint Inhibitors
No full textImportance Immune checkpoint inhibitors (ICIs) have broadened the metastatic urothelial carcinoma (mUC) therapeutic scenario. The association of programmed death ligand 1 (PD-L1) with response and survival in patients treated with ICIs is still controversial. Objectives To evaluate the association of PD-L1 with response rate and overall survival among patients with mUC treated with ICIs. Data Sources PubMed, Embase, American Society of Clinical Oncology and European Society for Medical Oncology Meeting Libraries, and Web of Science were searched up to December 10, 2023. Study Selection Two authors independently screened the studies. Included studies were randomized and nonrandomized clinical trials enrolling patients with mUC receiving ICIs with available overall survival (OS), progression-free survival (PFS), or overall response rate (ORR) data, separated between patients with PD-L1-positive and -negative tumors. Data Extraction and Synthesis The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline was followed. Two reviewers independently extracted data. Fixed- or random-effects models were used depending on the heterogeneity among the studies. Main Outcomes and Measures Primary outcomes were odds ratios (ORs) for ORR and hazard ratios (HRs) for OS, comparing patients with PD-L1-positive tumors and patients with PD-L1-negative tumors. Secondary outcomes were the PFS HR between patients with PD-L1-positive and -negative tumors and OS HR between ICI arms and non-ICI arms of only randomized clinical trials. Results A total of 14 studies were selected, comprising 5271 patients treated with ICIs (2625 patients had PD-L1-positive tumors). The ORR was 13.8% to 78.6% in patients with PD-L1-positive tumors and 5.1% to 63.2% in patients with PD-L1-negative tumors, with an association between PD-L1 status and ORR favoring patients with PD-L1-positive tumors (OR, 1.94; 95% CI, 1.47-2.56; P < .001). Median OS ranged from 8.4 to 24.1 months in patients with PD-L1-positive tumors and from 6.0 to 19.1 months in patients with PD-L1-negative tumors. The pooled HR showed a significant reduction for patients with PD-L1-positive tumors compared with those with PD-L1-negative tumors in the risk of death (HR, 0.71; 95% CI, 0.57-0.89; P = .003) and risk of progression (HR, 0.55; 95% CI, 0.44-0.69; P < .001) when ICIs were administered. PD-L1 is not likely to be a predictive biomarker of ICI response. Conclusions and Relevance This systematic review and meta-analysis suggests that PD-L1 expression is associated with improved ORR, OS, and PFS for patients with mUC who receive ICIs, but it is unlikely to be useful as a predictive biomarker. Developing predictive biomarkers is essential to select patients most likely to benefit from ICIs and avoid toxic effects and financial burden with these agents
