171,932 research outputs found
Senescence and pre-malignancy: How do tumors progress?
No full textCellular senescence is a tumor suppressor response that has been observed both in vitro and in vivo, and features of senescence have been documented in various human premalignant lesions, including melanoma, colon and lung adenoma, prostatic intraepithelial neoplasia, and others. The fact that a subset of these lesions eventually progress to malignant invasive tumors suggests that premalignant cells can either bypass or escape the senescent response. Much work has been done to understand the mechanisms underlying such progression, but it remains unclear whether tumors progress by evasion of senescence induction, or by disruption of senescence maintenance, or whether both mechanisms can occur in human cancer development. This review presents the current evidence for mechanisms of senescence evasion and reversion, and discusses what has been learnt about this process using in vitro and in vivo experimental systems. As we learn more about the key signaling effectors of senescence, the hope is that appropriate targets will be identified for preservation and-or re-induction of senescence in human tumors. Such knowledge may also find application in better estimation of risks of cancer progression in individual premalignant lesions, which will lead to more accurate allocation of appropriate treatment options for such patients. © 2011 Elsevier Ltd.Acosta JC, 2008, CELL, V133, P1006, DOI 10.1016-j.cell.2008.03.038; Bartkova J, 2006, NATURE, V444, P633, DOI 10.1038-nature05268; Beausejour CM, 2003, EMBO J, V22, P4212, DOI 10.1093-emboj-cdg417; Berman HK, 2010, CANCER PREV RES, V3, P579, DOI 10.1158-1940-6207.CAPR-10-0073; Bihani T, 2004, CELL CYCLE, V3, P1201; Braig M, 2005, NATURE, V436, P660, DOI 10.1038-nature03841; BRASH DE, 1991, P NATL ACAD SCI USA, V88, P10124, DOI 10.1073-pnas.88.22.10124; BURCH HB, 1995, ENDOCRIN METAB CLIN, V24, P663; Busuttil RA, 2006, DNA REPAIR, V5, P52, DOI 10.1016-j.dnarep.2005.07.006; BUTTRAM VC, 1981, FERTIL STERIL, V36, P433; Campisi J, 2007, NAT REV MOL CELL BIO, V8, P729, DOI 10.1038-nrm2233; Campisi J, 2005, CELL, V120, P513, DOI 10.1016-j.cell.2005.02.003; Cappell M S, 2007, Minerva Gastroenterol Dietol, V53, P351; Chakrabarti J, 2004, BRIT J CANCER, V91, P954, DOI 10.1038-sj.bjc.6602059; Chang BD, 1999, CANCER RES, V59, P3761; Chen ZB, 2005, NATURE, V436, P725, DOI 10.1038-nature03918; Collado M, 2005, NATURE, V436, P642, DOI 10.1038-436642a; Collins LC, 2005, CANCER-AM CANCER SOC, V103, P1778, DOI 10.1002-cncr.20979; Coppe JP, 2008, PLOS BIOL, V6, P2853, DOI 10.1371-journal.pbio.0060301; Courtois-Cox S, 2006, CANCER CELL, V10, P459, DOI 10.1016-j.ccr.2006.10.003; Cristofalo VJ, 2005, EXP GERONTOL, V40, P836, DOI 10.1016-j.exger.2005.08.005; Dankort D, 2007, GENE DEV, V21, P379, DOI 10.1101-gad.1516407; Denchi EL, 2005, MOL CELL BIOL, V25, P2660, DOI 10.1128-MCB.25.7.2660-2672.2005; Dhomen N, 2009, CANCER CELL, V15, P294, DOI 10.1016-j.ccr.2009.02.022; Dickinson SI, 2010, CANCER CONTROL, V17, P214; di Fagagna FD, 2008, NAT REV CANCER, V8, P512, DOI 10.1038-nrc2440; Di Micco R, 2006, NATURE, V444, P638, DOI 10.1038-nature05327; Di Micco R, 2011, NAT CELL BIOL, V13, P292, DOI 10.1038-ncb2170; DIMRI GP, 1995, P NATL ACAD SCI USA, V92, P9363, DOI 10.1073-pnas.92.20.9363; Dirac AMG, 2003, J BIOL CHEM, V278, P11731, DOI 10.1074-jbc.C300023200; Farrell WE, 1998, ANN MED, V30, P192, DOI 10.3109-07853899808999403; Feldser DM, 2007, CANCER CELL, V11, P461, DOI 10.1016-j.ccr.2007.02.026; Ferbeyre G, 2000, GENE DEV, V14, P2015; Fonseca R, 1997, ANN INTERN MED, V127, P1013; Gauthier ML, 2007, CANCER CELL, V12, P479, DOI 10.1016-j.ccr.2007.10.017; Gire V, 1998, MOL CELL BIOL, V18, P1611; Goldman R, 2003, J NUTR, V133, p965S; Gosselin K, 2009, CANCER RES, V69, P7917, DOI 10.1158-0008-5472.CAN-08-2510; Gray-Schopfer VC, 2006, BRIT J CANCER, V95, P496, DOI 10.1038-sj.bjc.6603283; Ha L, 2007, P NATL ACAD SCI USA, V104, P10968, DOI 10.1073-pnas.0611638104; Haggman MJ, 1997, J UROLOGY, V158, P12, DOI 10.1097-00005392-199707000-00004; Hanahan D, 2000, CELL, V100, P57, DOI 10.1016-S0092-8674(00)81683-9; Hartmann LC, 2005, NEW ENGL J MED, V353, P229, DOI 10.1056-NEJMoa044383; Jasperson KW, 2010, GASTROENTEROLOGY, V138, P2044, DOI 10.1053-j.gastro.2010.01.054; Kennedy AL, 2010, CELL DIV, V5, DOI 10.1186-1747-1028-5-16; Kortlever RM, 2006, NAT CELL BIOL, V8, P877, DOI 10.1038-ncb1448; Kosar M, 2011, CELL CYCLE, V10, P457, DOI 10.4161-cc.10.3.14707; Krtolica A, 2001, P NATL ACAD SCI USA, V98, P12072, DOI 10.1073-pnas.211053698; Kuilman T, 2010, GENE DEV, V24, P2463, DOI 10.1101-gad.1971610; Kuilman T, 2008, CELL, V133, P1019, DOI 10.1016-j.cell.2008.03.039; Lee Erica H, 2010, Plast Reconstr Surg, V125, p188e, DOI 10.1097-PRS.0b013e3181d6e89a; Levy A, 2003, FRONT NEUROENDOCRIN, V24, P94, DOI 10.1016-S0091-3022(03)00012-8; Lukasova E, 2005, J LEUKOCYTE BIOL, V77, P100, DOI 10.1189-jlb.0704388; Majumder PK, 2008, CANCER CELL, V14, P146, DOI 10.1016-j.ccr.2008.06.002; Mallette FA, 2007, J BIOL CHEM, V282, P34938, DOI 10.1074-jbc.M707074200; Mallette FA, 2007, CELL CYCLE, V6, P1831; Michaloglou C, 2005, NATURE, V436, P720, DOI 10.1038-nature03890; Moiseeva O, 2006, MOL BIOL CELL, V17, P1583, DOI 10.1091-mbc.E05-09-0858; Mooi WJ, 2006, NEW ENGL J MED, V355, P1037, DOI 10.1056-NEJMra062285; Nardella C, 2008, GENE DEV, V22, P2172, DOI 10.1101-gad.1699608; Narita M, 2003, CELL, V113, P703, DOI 10.1016-S0092-8674(03)00401-X; Narita M, 2006, CELL, V126, P503, DOI 10.1016-j.cell.2006.05.052; PAGE DL, 1994, WORLD J SURG, V18, P32; Park YS, 2008, ANN SURG ONCOL, V15, P1968, DOI 10.1245-s10434-008-9927-9; Roberson RS, 2005, CANCER RES, V65, P2795, DOI 10.1158-0008-5472.CAN-04-1270; Rodier F, 2009, NAT CELL BIOL, V11, P973, DOI 10.1038-ncb1909; Saab R, 2010, THESCIENTIFICWORLDJO, V10, P727, DOI 10.1100-tsw.2010.68; Saab R, 2009, CANCER RES, V69, P440, DOI 10.1158-0008-5472.CAN-08-1892; Sabah M, 2007, APPL IMMUNOHISTO M M, V15, P64, DOI 10.1097-01.pai.0000201809.43554.ed; Sage J, 2003, NATURE, V424, P223, DOI 10.1038-nature01764; Sarkisian CJ, 2007, NAT CELL BIOL, V9, P493, DOI 10.1038-ncb1567; Schmitt CA, 2007, BBA-REV CANCER, V1775, P5, DOI 10.1016-j.bbcan.2006.08.005; Schmitt CA, 2002, CELL, V109, P335, DOI 10.1016-S0092-8674(02)00734-1; Serrano M, 2001, CURR OPIN CELL BIOL, V13, P748, DOI 10.1016-S0955-0674(00)00278-7; Shamma A, 2009, CANCER CELL, V15, P255, DOI 10.1016-j.ccr.2009.03.001; Shay JW, 2004, ONCOGENE, V23, P2919, DOI 10.1038-sj.onc.1207518; Skomedal H, 1999, GYNECOL ONCOL, V73, P223, DOI 10.1006-gyno.1999.5346; Soucek L, 2008, NATURE, V455, P679, DOI 10.1038-nature07260; STEIN GH, 1985, J CELL PHYSIOL, V122, P343, DOI 10.1002-jcp.1041220303; Sun PQ, 2007, CELL, V128, P295, DOI 10.1016-j.cell.2006.11.050; Takahashi A, 2006, NAT CELL BIOL, V8, P1291, DOI 10.1038-ncb1491; Tateishi U, 2003, RADIOGRAPHICS, V23, P1477, DOI 10.1148-rg.236015526; te Poele RH, 2002, CANCER RES, V62, P1876; Untergasser G, 2003, EXP GERONTOL, V38, P1179, DOI 10.1016-j.exger.2003.08.008; Ventura A, 2007, NATURE, V445, P661, DOI 10.1038-nature05541; Vijg J, 2005, ANN NY ACAD SCI, V1055, P35, DOI 10.1196-annals.1323.007; Wajapeyee N, 2008, CELL, V132, P363, DOI 10.1016-j.cell.2007.12.032; Wu CH, 2007, P NATL ACAD SCI USA, V104, P13028, DOI 10.1073-pnas.0701953104; Xu M, 2008, MOL CELL BIOL, V28, P1713, DOI 10.1128-MCB.01360-07; Xue W, 2007, NATURE, V445, P656, DOI 10.1038-nature05529; Young AP, 2008, NAT CELL BIOL, V10, P361, DOI 10.1038-ncb1699; Zhang RG, 2005, DEV CELL, V8, P19, DOI 10.1016-j.devcel.2004.10.019; Zhang ZH, 2006, MODERN PATHOL, V19, P1339, DOI 10.1038-modpathol.3800655; Zheng Y, 2009, OMICS, V13, P301, DOI 10.1089-omi.2009.001410111
Resgate histórico do Departamento de Tocoginecologia da Universidade Federal de Santa Catarina.
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Tocoginecologia
Phytochemical analysis, antiproliferative against k562 humam chronic myelogenus leukemia, antiviral and hypoglycaemic activities of cedrus species and medicinal plants native from Libanon
No full textThere are four kinds of Cedar, three of them naturally present in the Mediterranean Sea region: Cedrus libani, in Lebanon, Syria and Turky, Cedrus atlantica in Algeria and Morocco, Cedrus brevifolia in Cyprus Island While Cedrus deodara in Himalaya Mountains .
The wood essential oils of C. libani, C .atalantica and C. deodara inhibited the proliferation of k 562 cell line with IC50 Value of 23.38, 59.37 and 37.09 μg.ml-1 respectively. Meanwhile Cedrus libani wood oils showed a percentage of erythroide differentiation of 15% at the concentration of 5μg.ml-1another side Cedrus deodara wood oil was found a percentage of erythroide differentiation of 20% at the concentration 25μg.ml-1 and Cedrus atlantica wood oils indicated a percentage of erythroide differentiation of 12% at concentration 10μg.ml-1
The essential oils obtained from different officinal plants of Lebanon, belonging to the Magnoliophyta division, have been tested for their antiproliferative activity on humanerythroleukemic K562 cells. Satureja montana showed the most interesting biological activity in inhibiting the cell growth and inducing erythroid differentiation of K562 cells The essential oil of Satureja montana was therefore analyzed using a GC/MS (gas chromatography/mass spectrometry) system in order to identify the major constituents and compare them with analysis performed on Satureja hortensis. The major constituent of Satureja hortensis being carvacrol (50.61%) and that of Satureja montana being α-terpineol (12.66%). Satureja Montana essential oil displayed different natural derivatives characterized by higher activity than those present in Satureja hortensis. The common active principles are α-pinene, γ-terpinene, 4-terpineol, α-terpineol, τ-cadinene, τ-cadinol and caryophyllene. Both caryophyllene and α-terpineol showed important antiproliferative effects on K562 cells
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Hipertensão arterial na gestação: avaliação dos resultados maternos e perinatais na maternidade Carmela Dutra de 2002 a 2009.
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Tocoginecologia
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
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