1,721,234 research outputs found
Compte rendu de Ligeti (K.), Simonato (M.) (eds). Chasing Criminal Money. Challenges and Perspectives on Asset Recovery in the EU
No full textLigeti (K.), Simonato (M.) (eds). – Chasing Criminal Money. Challenges and Perspectives on Asset Recovery in the EU, Oxford: Hart Publishing, 2017. 400 p., ISBN: 978150991207
A pathogenetic hypothesis of temporal lobe epilepsy
No full textTemporal lobe epilepsy is the most common type of epilepsy in adults. It frequently develops in previously normal nervous tissue, secondary to trauma, tumour or stroke. The disease has a tendency to progress toward generalization and neurologic deficits. The pathogenesis of temporal lobe epilepsy is still unclear. In this article, a hypothesis is proposed suggesting that a cascade of biological events may underlie its development and progression. These include increased excitatory amino acid release, NMDA receptor activation, influx of calcium into neurones, activation of calcium-dependent enzymes (including phospholipase A2), immediate early gene expression, and synthesis of new proteins. Positive and negative feedback loops as well as other events, taking place in parallel, are also hypothesized. The clinical and pharmacological ramifications of this working hypothesis are discussed. © 1993 The Italian Pharmacological Society
Dynorphin and epilepsy
No full textStudies on dynorphin involvement in epilepsy are summarised in this review. Electrophysiological, biochemical and pharmacological data support the hypothesis that dynorphin is implicated in specific types of seizures. There is clear evidence that this is true for complex partial (limbic) seizures, i.e. those characteristic of temporal lobe epilepsy, because: (1) dynorphin is highly expressed in various parts of the limbic system, and particularly in the granule cells of the hippocampus; (2) dynorphin appears to be released in the hippocampus (and in other brain areas) during complex partial seizures; (3) released dynorphin inhibits excitatory neurotransmission at multiple synapses in the hippocampus via activation of κ opioid receptors; (4) κ opioid receptor agonists are highly effective against limbic seizures. Data on generalised tonic-clonic seizures are less straight forward. Dynorphin release appears to occur after ECS seizures and κ agonists exert a clear anticonvulsant effect in this model. However, more uncertain biochemical data and lack of efficacy of κ agonists in other generalised tonic-clonic seizure models argue that the involvement of dynorphin in this seizure type may not be paramount. Finally, an involvement of dynorphin in generalised absence seizures appears unlikely on the basis of available data. This may not be surprising, given the presumed origin of absence seizures in alterations of the thalamo-cortical circuit and the low representation of dynorphin in the thalamus. In conclusion, it may be suggested that dynorphin plays a role as an endogenous anticonvulsant in complex partial seizures and in some cases of tonic-clonic seizures, but most likely not in generalised absence. This pattern of effects may coincide with the antiseizure spectrum of selective κ agonists
Life history and geographical distribution of the walnut twig beetle, Pityophthorus juglandis (Coleoptera: Scolytinae), in southern Europe
No full textHOLISTIC APPROACH TO MATERIALS SELECTION IN PROFESSIONAL APPLIANCES INDUSTRY
No full textMaterials selection contributes in pre-evaluating product’s material performance and impact in the production process. Applied to professional food processing appliances, the research aim is to develop a versatile method for materials selection that could help engineers and designers to evaluate both quantitative and qualitative properties of materials. The challenge of the new method is the correlation between material durability properties with their sensorial perception (visual, tactile and auditory), through the evaluation of user-interaction aspects of products and materials
The Social Reuse of Confiscated Assets in EU Member States: From Current Experiences to an EU Policy for a 'Powered-by-Citizens' Fight Against Crime
No full textThere is currently a lack of knowledge on legislation and practices regarding the social reuse of confiscated assets in the EU.
This Chapter aims to respond to the following questions: which Member States envisage the social reuse of confiscated assets? Could other Member States adopt it and, if so, under which conditions? Based on the lessons learnt from current social reuse experiences, which European standards could be suggested for it? In answering these questions, it presents the results of the EU funded project RECAST - REuse of Confiscated Assets for social purposes: towards common EU Standards
WASHING MACHINE COMPRISING A VIBRATION ABSORBER ARRANGEMENT AND A CONTROL METHOD USING SAID VIBRATION ABSORBER ARRANGEMENT
No full textThe present disclosure relates to a laundry washing machine (1), comprising a
rotatable drum (19), carried by and adapted to rotate in relation to a drum frame (11), a
suspension arrangement carrying the drum frame in relation to a base structure,
located under the washing machine and on which the washing machine rests. At least
one vibration absorber arrangement (29) is provided being attached to the drum frame
and forming a spring-mass system having a resonant frequency. The vibration absorber
arrangement comprises a carrier rod (33) and a mass (31), a proximal end of the
carrier rod being attached to the drum frame at an attachment point and wherein the
mass is suspended by the carrier rod at a distance from the attachment point, the
distance may be variable to change said resonant frequency
What is the biological significance of the targeting of BDNF in the dendrites ? Lessons from epilepsy and cortical development.
No full textWASHING MACHINE AND A PISTON DAMPER THEREFORE
No full textThe present disclosure relates to a laundry washing machine (1) comprising a rotatable
drum (11), and a suspension arrangement (17,19) devised to carry the drum (11) in
relation to a base structure (5), located under the washing machine and on which the
washing machine rests, wherein the suspension arrangement comprises at least one
piston damper (33). A speed sensing arrangement is provided, determining the rotating
speed of the drum, and the piston damper 33 comprises a clamp arrangement (35,37),
devised to decrease its friction, based on a determined rotating speed and by means of
the clamp arrangement, when the rotating speed increases, reaching a threshold value.
Thereby suitable damping can be provided both at high and low speed
The Problematic Nature of Asset Recovery Measures: Recent Developments of the Italian Preventive Confiscation
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