395 research outputs found
Data for: Analysis of Financial Instruments on Capital Structure in Telecommunication Companies in Indonesia
No full textDataset working paper ANALYSIS OF FINANCIAL INSTRUMENTS ON CAPITAL STRUCTURE IN TELECOMMUNICATION COMPANIES IN INDONESIA (HERLINA) DOCTORAL PROGRAM STUDENTSHASANUDDIN [email protected]
MSI-low, a real phenomenon which varies in frequency among cancer types.
No full textThis study assessed whether low-level microsatellite instability (MSI-L) is a phenomenon specific to colorectal cancers or is also present in other tumour types. Breast (grade III ductal and lobular), endometrial and ovarian carcinomas, as well as colorectal cancers, were analysed for MSI-L using eight microsatellite markers. The markers were selected from a panel that had previously been shown to be sensitive for the detection of MSI-L in colorectal cancers. It was found that MSI-L was present in 30 of 87 (35%) colorectal cancers, 2 of 59 (3%) grade III breast carcinomas, 1 of 35 (3%) lobular breast cancers, 16 of 50 (32%) endometrial cancers, and 9 of 34 (26%) ovarian cancers. These results suggest that MSI-L is a very rare occurrence in breast carcinomas, but does occur as a real phenomenon in colorectal, endometrial, and ovarian carcinomas, which are all part of the hereditary non-polyposis colon cancer (HNPCC) syndrome. PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem
Identificação de alcalóides e acetogeninas diretamente em tecidos de folhas e sementes de Annona rugulosa (Annonaceae) por DESE-MSI
No full textOrientadora : Profª. Drª. Francinete Ramos CamposDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba, 26/02/2016Inclui referências : f. [70-77]Área de concentração: Insumos, medicamentos e correlatosResumo: A ionização de dessorção por eletrospray (DESI) acoplada a espectrometria de massas (MS) é uma técnica capaz de analisar amostras sólidas e em condições ambientes com sensibilidade e especificidade. Devido a facilidade de manuseio e a obtenção de resultados em tempo real, a DESI-MS vem sendo utilizada em diversos tipos de aplicações, como por exemplo, análises forenses, produtos naturais, biomédicas, entre outras. A capacidade de realizar mass spectrometry imaging (MSI) é muito explorada na análise de biomoléculas diretamente em tecidos animais e vegetais. Esta técnica foi utilizada para obtenção de MSI de alcaloides e acetogeninas por DESI direta em tecidos de folhas e da DESI indireta (imprint) da semente de Annona rugulosa. Estes metabólitos foram previamente identificados nos extratos em metanol, através da infusão direta por ESI(+)-HRMS, utilizando-se o erro do defeito de massas e a fragmentação em cela de colisão do tipo HCD. Para a obtenção dos dados por DESI-MSI, foram utilizados os seguintes parâmetros: voltagem do capilar +5 kV; metanol como solvente do spray; fluxo de 3 ?L.min-1. Foram identificados nos extratos das folhas e sementes, onze alcaloides e oito acetogeninas. Dentre os alcaloides identificados, sete são aporfínicos (anonaina, nornantenina, N-nornuciferina, xilopina, litseferina, asimilobina e norisocoridina/isoboldina), dois oxoaporfínicos (lanuginosina e liriodenina) e dois benziltetrahidroisoquinolínicos (magnococlina/N-metilcoclaurina e reticulina), e dentre as acetogeninas, sete com grupo hidroxila no C-4, confirmados através da perda neutra do anel ?-lactona (112 Da). Estes mesmos metabólitos foram identificados por DESI-MSI. Esta técnica se mostrou eficaz para a análise rápida de alcaloides e acetogeninas em tecidos vegetais de A. rugulosa, com mínimo ou nenhum preparo de amostra. Palavras chave: Alcaloides; Acetogeninas; DESI imaging; Annona rugulosa; mass spectrometry imagingAbstract: The desorption electrospray ionization (DESI) coupled with mass spectrometry (MS) is a technique able to analyze solid samples at ambient conditions, with sensitivity and specificity. Due to ease of handling and the obtaining of real time results, the DESI-MS has been used in various applications, like forensics, natural products, biomedical analyzes, and others. The ability to obtain molecular imaging is much exploited in biomolecules analyzes in animal and vegetal tissues. This technique was used to obtain the mass spectrometry images (MSI) of eleven alkaloids and eight acetogenins by DESI direct in the leaf tissue and by DESI indirect (imprint) of the seed of Annona rugulosa. These metabolites was previously identified by direct infusion ESI(+)-HRMS, the metabolites were identified through their mass defect error and mass spectrometry tandem in a HCD collision cell. To obtain the molecular images by DESI-MSI, the following parameters were optimized: capillary voltage +5 kV; methanol as solvent spray, flow of 3 ?L.min-1. Among the alkaloids identified, seven are aporphine (anonaine, nornantenine, N-nornuciferine, xylopine, litseferine, asimilobine and norisocorydine/isoboldine), two oxoaporphine (lanuginosine and liriodenine) and two benzyltetrahydroisoquinoline (magnococline/N-methylcoclaurine and reticuline), and among the acetogenins, seven have a hydroxyl group at the C-4, which are confirmed through the neutral loss of the ?-lactone ring (112 Da). These same metabolites were also identified by DESI-MSI. These technique proved be effective to determine alkaloids and acetogenins in vegetal tissues of A. rugulosa, with minimum or non-sample preparation. Keywords: Alkaloids; Acetogenins; DESI imaging; Annona rugulosa; mass spectrometry imagin
Análisis De Los Roles, Funcionales y Competencias Del Modelo MSI-B-Learning
No full textB-Learning is translated like “blended learning”, i.e. it combining classroom learning with virtual training. Pedagogy and Didactics of Higher Education Group presents a b-learning implementation cycle and teacher roles, entitled “MSI b-learning model”, establishing initial, interaction Especialista en docencia universitaria. Coordinador de proyectos de infraestructura en PCA-Proyectistas Civiles and feedback stages. Each one establishes competences and functions from teacher. This paper proposes and makes a thorough analysis about relationships founded between functions and duties of teacher in his different roles, in interaction stage from MSI b-learning model, which feeds researches conducted by Pedagogy and Didactics of Higher Education group, making one analysis the current context and forecasting education in mixed learning places.El B-Learning se traduce como “Aprendizaje Combinado”; es decir combina la enseñanza presencial con formación virtual. El grupo pedagogía y didáctica de la educación superior (PYDES), plantea un ciclo para la implementación de b-learning y roles del docente, titulado “Modelo MSI b-learning”, el cual proponelas fases inicial, interacción y retroalimentación; en cada una, se establecen las funciones y competencias del docente.El presente documento plantea y realiza un análisis en profundidad, de las relaciones encontradas entre competencias y funciones del docente en sus diferentes roles, en la fase de interacción del modelo MSI b-learning; el cual retroalimenta las investigaciones realizadas por el grupo pedagogía y didáctica de la educación superior, realizando un análisis en un contexto actual y proyectando la educación en espacios mixtos de aprendizaje
Análisis De Los Roles, Funcionales y Competencias Del Modelo MSI-B-Learning
No full textB-Learning is translated like “blended learning”, i.e. it combining classroom learning with virtual training. Pedagogy and Didactics of Higher Education Group presents a b-learning implementation cycle and teacher roles, entitled “MSI b-learning model”, establishing initial, interaction Especialista en docencia universitaria. Coordinador de proyectos de infraestructura en PCA-Proyectistas Civiles and feedback stages. Each one establishes competences and functions from teacher. This paper proposes and makes a thorough analysis about relationships founded between functions and duties of teacher in his different roles, in interaction stage from MSI b-learning model, which feeds researches conducted by Pedagogy and Didactics of Higher Education group, making one analysis the current context and forecasting education in mixed learning places.El B-Learning se traduce como “Aprendizaje Combinado”; es decir combina la enseñanza presencial con formación virtual. El grupo pedagogía y didáctica de la educación superior (PYDES), plantea un ciclo para la implementación de b-learning y roles del docente, titulado “Modelo MSI b-learning”, el cual proponelas fases inicial, interacción y retroalimentación; en cada una, se establecen las funciones y competencias del docente.El presente documento plantea y realiza un análisis en profundidad, de las relaciones encontradas entre competencias y funciones del docente en sus diferentes roles, en la fase de interacción del modelo MSI b-learning; el cual retroalimenta las investigaciones realizadas por el grupo pedagogía y didáctica de la educación superior, realizando un análisis en un contexto actual y proyectando la educación en espacios mixtos de aprendizaje
The Effect of Morphometry, Land-Use and Lithology on Landslides Susceptibility: An Exploratory Analysis
No full textGIS features provide simple and useful tools for landslides susceptibility and hazard studies, allowing the identification and the quantification of predisposing factors, and their relative importance. In lithologically homogeneous areas, the most influent factor of landslides is slope morphometry, in particular inclination, height and form. Moreover, within a hydrographic basin, landslides are coupled with drainage network. In fact landslides density and drainage density are positively correlated. Furthermore, human activity strongly influences the development of landslides. In our previous works, we introduced MSI (Morphometric Slope Index) as general index for slope morphometry, combining the main linear and areal morphometric features (area, form, length, inclination, width). Its formula is: MSI=A3D/A2D·L·Rc (where A3D is the three-dimensional area of the slope, A2D is its plan area, L is the slope length and Rc is the circularity ratio). We tested MSI as driver of different erosion landforms, demonstrating its influence in determining, on the one hand, the development and the final arrangement of calanchi drainage network (the typical Italian badlands), and, on the other hand, the erosion processes within them, mainly gullies and landslides. The present study is an exploratory application of this index to landslides susceptibility, aimed to analyze the combined effect of slope morphometry (summarized in MSI), lithology and land-use on the distribution of landslides in small catchments. The study is located in the Italian periadriatic foredeep, in the Abruzzo Region. This study has reinforced our perspective about the validity of the application of the techniques of geomorphometric analysis to the landslides susceptibility. Especially we consider this approach an efficient tool to summarize different controlling factors
Late attentional processes potentially compensate for early perceptual multisensory integration deficits in children with autism: evidence from evoked potentials
No full textSensory processing deficits and altered long-range connectivity putatively underlie Multisensory Integration (MSI) deficits in Autism Spectrum Disorder (ASD). The present study set out to investigate non-social MSI stimuli and their electrophysiological correlates in young neurotypical adolescents and adolescents with ASD. We report robust MSI effects at behavioural and electrophysiological levels. Both groups demonstrated normal behavioural MSI. However, at the neurophysiological level, the ASD group showed less MSI-related reduction of the visual P100 latency, greater MSI-related slowing of the auditory P200 and an overall temporally delayed and spatially constrained onset of MSI. Given the task design and patient sample, and the age of our participants, we argue that electro-cortical indices of MSI deficits in ASD: (a) can be detected in early-adolescent ASD, (b) occur at early stages of perceptual processing, (c) can possibly be compensated by later attentional processes, (d) thus leading to normal MSI at the behavioural level. © 2020, The Author(s)
Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas
No full textUrachal cancer (UrC) is a rare but aggressive malignancy often diagnosed in advanced stages requiring systemic treatment. Although cytotoxic chemotherapy is of limited effectiveness, prospective clinical studies can hardly be conducted. Targeted therapeutic treatment approaches and potentially immunotherapy based on a biological rationale may provide an alternative strategy. We therefore subjected 70 urachal adenocarcinomas to targeted next-generation sequencing, conducted in situ and immunohistochemical analyses (including PD-L1 and DNA mismatch repair proteins (MMR)) and evaluated the microsatellite instability (MSI) status. The analytical findings were correlated with clinicopathological and outcome data and Kaplan-Meier and univariable/multivariable Cox regression analyses were performed. The patients had a mean age of 50 years, 66% were male and a 5-year overall survival (OS) of 58% and recurrence-free survival (RFS) of 45% was detected. Sequence variations were observed in TP53 (66%), KRAS (21%), BRAF (4%), PIK3CA (4%), FGFR1 (1%), MET (1%), NRAS (1%), and PDGFRA (1%). Gene amplifications were found in EGFR (5%), ERBB2 (2%), and MET (2%). We detected no evidence of MMR-deficiency (MMR-d)/MSI-high (MSI-h), whereas 10 of 63 cases (16%) expressed PD-L1. Therefore, anti-PD-1/PD-L1 immunotherapy approaches might be tested in UrC. Importantly, we found aberrations in intracellular signal transduction pathways (RAS/RAF/PI3K) in 31% of UrCs with potential implications for anti-EGFR therapy. Less frequent potentially actionable genetic alterations were additionally detected in ERBB2 (HER2), MET, FGFR1, and PDGFRA. The molecular profile strengthens the notion that UrC is a distinct entity on the genomic level with closer resemblance to colorectal than to bladder cancer. This article is protected by copyright. All rights reserved
Data for: Analysis of Financial Instruments on Capital Structure in Telecommunication Companies in Indonesia
No full textDataset working paper ANALYSIS OF FINANCIAL INSTRUMENTS ON CAPITAL STRUCTURE IN TELECOMMUNICATION COMPANIES IN INDONESIA (HERLINA) DOCTORAL PROGRAM STUDENTSHASANUDDIN [email protected] DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Peran Konservatisme Akuntansi Dalam Mengurangi Konflik Pemberi Pinjaman - Pemegang Saham Dalam Kebijakan Deviden
No full textKonservatisme adalah derajat sampai sejauh mana laba diantisipasi.Definisi konservatisme yang paling ekstrim adalah "tidak mengantisipasi laba, tetapi mengantisipasi semua kerugian". Akibat dari konsep tersebut, konservatisme akuntansi akan menurunkan laba dan laba ditahan.
Laba dan laba ditahan merupakan bagian penting yang dipertimbangkan dalam perjanjian hutang. Jumlah laba dan laba ditahan sering digunakan sebagai pembatasan dalam perjanjian hutang untuk membatasi agar tidak terjadi pembayaran berlebih dividen. Dividen biasanya dibagikan jika jumlah laba diiahan mencukupi, yang dinyatakan dengan rasio pernbayaran dividen (payout ratio). Jika jurnlah laba ditahan tinggi, rnaka kernungkinan dividen yang akan dibagikan kepada pernegang saharn akan tinggi pula. Rasia pernbayaran dividen yang tinggi menunjukkan adanya transfer kesejahteraan yang tinggi dari perusahaan ke pernegang saham. Hal inilah yang dipandang sebagai risiko oleh pemberi pinjaman, karena akan rnengurangi keamanan alas klaim tetap rnereka. Maka terjadilah konflik antara pemberi pinjarnan dan pemegang saham atas kebijakan dividen.Pemegang saham menginkan dividen yang tinggi, dan jumlah laba yang ditahan yang tinggi pula.Sedangkan pemberi pinjarnan menginginkan keamanan atas klaim tetap mereka.
Untuk mengurangi risiko atas klaim tetapnya, maka pemberi pinjaman akan memberikan batasan-batasan pada perjanjian hutangnya. Misalnya, pembatasan terhadap pembayaran dividen. Untuk membatasi pembayaran dividen yang berlebih kepada pemegang saharn, pemberi pinjaman dapat memberikan baiasan pada penerapan akuntansi yang menghasilkan jumlah laba dan laba yang ditahan menjadi rendah, misalnya dengan penerapan metode akuntansi yang lebih konservatif. Contoh rnetode akuntansi yang lebih konservatif adalah penyusutan dipercepat, metode penilaian persediaan mana yang lebih rendah antara harga pokok atau harga pasar (lower of cost or market), pembebanan biaya R&D dan advertensi.
Konservatisme akuntansi akan menurunkan laba dan laba ditahan. dan sebagai akibatnya, mengurangi pembayaran dividen. Jadi, konservatisme akuntansi akan mengurangi risiko bagi pemberi pinjaman atas kelebihan pembayaran dividen kepada pemegang saharn (Ahmed et.al., 2002)
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