326 research outputs found
Book Review: The Man Who Founded the ANC: A Biography of Pixley Ka Isaka Seme
No full textBook Title: The Man Who Founded the ANC: A Biography of Pixley Ka Isaka SemeBook Author: Bongani Ngqulunga2017. Cape Town, Penguin Random House South Africa. ISBN: 978177022926
Shvatanja Isaka Adižesa o upravljanju promenama i mogućnost njihove implementacije u policijski menadžment
No full textThe paper deals with only one segment of Isaac Adiges’ copious scientific work placing special emphasis on hi side as presented in his book "Control of Changes". The analysis of these ideas suggests that they may be used as an adequate starting point for the foundation and development of the theory as well as the promotion of the police management practice. The author has tried to find adequate answers related to the current security challenges and threats emphasizing an irreplaceable role of the police management in a more efficient control of crime.U ovom radu se izlaže jedan segment iz bogatog naučnog stvaralaštva Isaka Adižesa - konkretno, njegova shvatanja izložena u knjizi Upravljanje promenama. Analiza navedenih shvatanja pokazuje da ona mogu biti odgovarajuće polazište za utemeljenje i izgradnju teorije, kao i za unapređenje prakse policijskog menadžmenta. Rad je uslovljen snažnom potrebom iznalaženja adekvatnih odgovora savremenim bezbednosnim izazovima i pretnjama, a posebno efikasnijeg suzbijanja kriminaliteta i nezamenljive uloge policijskog menadžmenta u tome
Inhibitory effect of sulphated polysaccharide porphyran (isolated from Porphyra yezoensis) on RANKL-induced differentiation of RAW264.7 cells into osteoclasts
No full textSafe and efficient therapeutic agents for bone diseases are required in natural sources. We previously found that edible seaweed-derived polysaccharide porphyran exhibited anti-inflammatory effects through the down regulation of nuclear factor-κB. The aim of this study was to investigate the availability of porphyran as a therapeutic agent for bone diseases. The effects of porphyran on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells were examined. Porphyran suppressed RANKL-induced osteoclast formation in a concentration-dependent manner (6.25–50 μg/ml) without any cytotoxic effects. Furthermore, real-time polymerase chain reaction analyses indicated that porphyran at 50 μg/ml significantly attenuated the RANKL-induced increase in the mRNA levels of osteoclastogenesis-related marker genes such as nuclear factor of activated T cells, tartrate-resistant acid phosphatase, cathepsin K, and matrix metalloproteinase-9 in RAW264.7 cells. To our knowledge, this is the first report showing that edible-seaweed-derived polysaccharide porphyran can suppress RANKL-induced osteoclastogenesis. Our results suggest that porphyran can be used as a safe therapeutic agent to improve osteoclast-related pathological conditions
Speech of the chief rabbi at the funeral of Dr. S. Weszel
No full textGovor vrhovnog rabina Kraljevine SHS dr Isaka Alkalaja na sahrani dr Samuela Vesela (25. maj 1871-19. april 1928), nadrabina aškenaske opštine u Sarajevu.Speech of the chief rabbi of the Kingdom of Serbs, Croats and Slovenes, Dr Isak Alkalaj, at the funeral of Dr Samuel Vesel (May 25, 1871 - April 19, 1928), the head of the Ashkenazi municipality in Sarajevo
Fig. 5 in Lanostane triterpenoids from cultivated fruiting bodies of Ganoderma sichuanense: Determination of the C-25 absolute configuration of ganoderic acid A and its derivatives using the phenylglycine methyl ester (PGME) method
No full textFig. 5. Δδ-Values (δ(S) – δ(R)) of the bis-MTPA esters 28a/28b.Published as part of Chinthanom, Panida, Srichomthong, Kitlada, Rachtawee, Pranee, Boonpratuang, Thitiya, Choeyklin, Rattaket, Feng, Tao, Liu, Ji-Kai & Isaka, Masahiko, 2021, Lanostane triterpenoids from cultivated fruiting bodies of Ganoderma sichuanense: Determination of the C-25 absolute configuration of ganoderic acid A and its derivatives using the phenylglycine methyl ester (PGME) method, pp. 112963 in Phytochemistry (112963) 192 on page 5, DOI: 10.1016/j.phytochem.2021.112963, http://zenodo.org/record/816046
Sacrificing Isaac
No full textNadrabin dr Leopold Fischer je iz Sefer Hajašare, knjige o pravednosti, anonimnog dela popularne etike iz 13. veka, preveo priču o žrtvovanju Isaka. Prevod je veran originalnom tekstu i govori o jednoj od najvećih i najpoznatijih biblijskih priča po kojoj Bog traži od Abrahama (Avrama) da mu kao žrtvu prinese Isaka, svog sina jedinca. Ova neporeciva i nehumana naredba vekovima je bila povod za rasprave, polemike i nova tumačenja i parabola nerešivog, tragičnog i nedopustivog sukoba između vere i morala. Avram je poslušao Boga i po njegovim uputama krenuo ka brdu Morija (danas Brdo Hrama) gde je trebao žrtvovati Isaka. Na tom putu satana ih je nekoliko puta iskušavao ali nije uspeo da ih odvrati od Božije zapovesti. Dokazali su svoju veru i Bog u poslednjem trenutku zaustavlja Avrama, spasava Isaka i daje blagoslov njima i njihovom potomstvu.Senior rabbi Dr. Leopold Fischer translated the story of Isaac's sacrifice from Sefer Ha Yashar, a book on justice, an anonymous work of popular ethics from the 13th century. The translation is the same as the original text and talks about one of the greatest and most famous biblical stories according to which God asks Abraham to sacrifice Isaac, his only son. For centuries, this undeniable and inhumane order has been an occasion for debates, polemics, and new interpretations, and a parable of an unsolvable, tragic, and inadmissible conflict between religion and morality. Abraham obeyed God and, according to his instructions, set out for Mount Moriah (today the Temple Mount) where he was to sacrifice Isaac. On that path, Satan tempted them several times, but he failed to turn them away from God's command. They have proved their faith and God stops Abraham at the last moment, saves Isaac, and gives a blessing to them and their descendants
d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection
No full textKimura T., Sakai S., Isaka Y.. d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection. ChemBioChem , (2025); https://doi.org/10.1002/cbic.202500018.d-Alanine, a rare d-amino acid, exhibits a clear circadian rhythm and is present in organs associated with glucose metabolism. Recent findings have revealed that d-alanine acts on the circadian rhythm, thereby regulating physiological processes related to circadian cycles that are essential for maintaining body homeostasis. The regulation of circadian rhythm by d-alanine is vital for correcting blood glucose levels in diabetic conditions. In viral infections, d-alanine serves as a sensitive biomarker that reflects the severity of the infection, as its level drastically decreases due to consumption. Supplementation with d-alanine is effective to alleviate the progression of viral infections, potentially through the maintenance of the circadian rhythm and its associated immune responses. In addition to its role as a circadian biomarker, d-alanine also functions as a circadian regulator and exerts a wide range of physiological effects. This review summarizes the physiological roles of d-alanine as a circadian metabolite
Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care
No full textAuthor can archive publisher's pdf. Free via Creative Commons: CC-BENCHTOBEDSIDE-2.0. © 2012 BioMed Central Ltd
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