807 research outputs found
Gad65 is recognized by t-cells, but not by antibodies from nod-mice
No full textSince the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice, a useful model for human Type 1 diabetes, we found that these T-cells proliferate spontaneously when incubated with human GAD65, but only marginally after incubation with GAD67, both recombinated in the baculovirus system. No effect was observed with non-diabetic NOD mice or with T-cells from H-2 identical NON-NOD-H-2g7 control mice. It has been published previously that NOD mice develop autoantibodies against a 64kDa protein detected with mouse beta cells. In immunoprecipitation experiments with sera from the same NOD mice and 33S-methionine-labelled GAD, no autoantibody binding could be detected. We conclude firstly that GAD65 is an important T-cell antigen which is relevant early in the development of Type 1 diabetes and secondly that there is an antigenic epitope in the human GAD65 molecule recognized by NOD T-cells, but not by NOD autoantibodies precipitating conformational epitopes. Our results therefore provide further evidence that GAD65 is a T-cell antigen in NOD mice, being possibly also involved in very early processes leading to the development of human Type 1 diabetes
Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy = Aspects of fitness sports pairs dance in dance competition sports style standard performance assessment tests strength – 20 m gear swing
No full textPilewska Wiesława, Matczak Paweł. Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy = Aspects of fitness sports pairs dance in dance competition sports style standard performance assessment tests strength – 20 m gear swing. Journal of Education, Health and Sport. 2015;5(11):595-605. eISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35706
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A595-605
http://pbn.nauka.gov.pl/works/684904
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Original Text published © The Author (s) 2015. Pilewska Wiesława, Matczak Paweł. Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy. Quality in Sport. 2015;1(1):45-54. eISSN 2450-3118.
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport (null) 2391-8306 7
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland.
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.11.2015. Revised 20.11.2015. Accepted: 30.11.2015.
Wiesława Pilewska, Paweł Matczak
Instytut Kultury Fizycznej, Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Aspekty sprawności sportowej w rywalizacji tanecznej par tańca sportowego stylu standardowego na podstawie oceny wyników próby wytrzymałości 20 m – bieg wahadłowy
Aspects of fitness sports pairs dance in dance competition sports style standard performance assessment tests strength – 20 m gear swing
Streszczenie
Cel pracy
W niniejszej pracy podjęto próbę charakterystyki poziomu zdolności wytrzymałościowych par C-S klasowych tańca sportowego stylu standardowego
w odniesieniu do aspektów sportowej działalności tanecznej.
Materiał
Grupę badawczą stanowiły sportowe pary taneczne, trenujące w Toruńskim Klubie Tanecznym Dance & Dance. Grupa liczyła 22 osoby tworząc 11 par. Wiek badanych mieścił się w przedziale 16-22 lata. Grupa na turniejach prezentowała grupę wiekową powyżej 15 lat. W badanej grupie dwie pary prezentowały klasę „C”, sześć klasę „B”, dwie pary klasę „A”, jedna para klasę „S”.
Metody badawcze
Do pomiaru wytrzymałości wykorzystano 20-metrowy bieg wahadłowy. Test polegał na pokonywaniu 20 metrowych odcinków w określonym czasie. Sygnały określające tempo znajdowały się na nagraniu pozyskane ze strony Narodowego Centrum Badania Kondycji Fizycznej (ncbkf.pl). Niemożność utrzymania tempa lub spóźnienie się na sygnał oznaczający rozpoczęcie kolejnego cyklu, był znakiem do ukończenia testu.
Wyniki i wnioski
• W grupie tancerzy C-S klasowych, stylu standardowego odnotowano istotną statystycznie p≥0,01 współzależność pomiędzy uzyskiwanymi wynikami próby 20 metrowego biegu wahadłowego a ich poziomem sportowym.
• We wszystkich grupach (tancerzy i tancerek) odnotowano wprost proporcjonalny charakter współzależności pomiędzy wynikiem sportowym a poziomem zdolności wytrzymałościowych (określonych wynikami 20 metrowego biegu wahadłowego).
• Na przykładzie najlepszych par wnioskować można że profil pary powinien ukazywać dominację partnera w poziomie wytrzymałością a ich partnerki powinny prezentować 60-70% poziomu partnera. Zarówno mniejsza jak i większa różnica wykazują tendencję do słabszych wyników sportowych i charakteryzowała pary o niższym poziomie sportowym.
Słowa kluczowe: taniec towarzyski, styl standardowy, 20-metrowy bieg wahadłowy, poziom sportowy.
Abstract
Aim of the study
In this paper, an attempt to level the characteristics of endurance capacity C-S couples sporty style dance class standard in relation to aspects of dance sport activities.
Materials
The research group sports were couples dancing, Training in Torun Club & Dance the Dance Dance. The group consisted of 22 people forming 11 pairs. The age of respondents ranged from 16-22 years. The group presented the age-group tournaments over 15 years. In the group of two pairs presented a class "C" six class "B", two pairs of class "A", one pair of class "S".
Research Methods
Used to measure the strength of a 20-meters gear swing. The test was to overcome the 20 meters sections at a given time. Signals determining the pace were on record obtained from the National Center for the Study of Physical Constitution (ncbkf.pl).Inability to keep pace or late in the signal indicating the start of the next cycle, was a sign to complete the test.
Results and conclusions
• In the group of dancers C-S class, style standard p≥0,01 reported a statistically significant correlation between the results of those obtained sample of 20 meters gear swing and their level of sport.
• In all groups (dancers) were recorded directly proportional nature of the correlation between the outcome and the level of sports endurance capacity (specific results of 20-meters gear swing).
• For example, the best pairs can be inferred that the profile should show the dominance of a partner in the level of strength and their partners should represent 60-70% of the partner. Both smaller and larger difference tend to be weaker performance was characterized by a pair of sports and a lower level of sports.
Key words: ballroom dancing, style standard, 20-meters gear swing, sports level
Antona Czechowa spojrzenie na bieg historii
No full textAmong the issues, themes and contributions which Anton Chekhov undertook in his works, one may also find the broadly-understood issue of an individual\u27s place in the course of historical events. In this case, and others like it, this writer\u27s opinion stands out among the works of other Russian writers. This is related to the fact that the author of The Steppe is convinced that the individual, and his conscious behaviour, contributes to the behaviour of a group and society. This is in contrast to the reasoning of most Russian writers of those times; however, it proves to be characteristic of Chekhov\u27s thinking
Buchbesprechungen
No full textDoherty-Sneddon, G. (2005): Was will das Kind mir sagen? Die Körpersprache des Kindes verstehen lernen. Bern.
Hopf, C. (2005): Frühe Bindungen und Sozialisation. Weinheim.
Thun-Hohenstein, L. (Hg.) (2005): Übergänge. Wendepunkte und Zäsuren in der kindlichen
Entwicklung. Göttingen.
Westhoff, E. (2005): Geistige Behinderung (er-)leben. Eine Reise in fremde Welten. Norderstedt.
Seiffge-Krenke, I. (Hg.) (2005): Aggressionsentwicklung zwischen Normalität und Pathologie.
Göttingen.
Bieg, S.; Behr, M. (2005): Mich und Dich verstehen. Ein Trainingsprogramm zur Emotionalen
Sensitivität bei Schulklassen und Kindergruppen im Grundschul- und Orientierungsstufenalter.Göttingen.
Ruppert, F. (2005): Trauma, Bindung und Familienstellen. Seelische Verletzungen verstehen und heilen. Stuttgart.
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Frank, C.; Hermanns, L. M.; Hinz, H. (2005): Jahrbuch der Psychoanalyse, Band 50: Trauma: Neue Entwicklungen in der Psychoanalyse. Stuttgart.unknownunknow
Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II
No full textBy using an immunoprecipitation assay, we analysed reactivity of autoantibodies to human recombinant GAD65 and GAD67 in sera from patients with autoimmune polyendocrine syndrome Type II (APS II) with and without Type 1 (insulin-dependent) diabetes mellitus (IDDM) compared to patients with organ-specific autoimmunity. Overall antibodies to GAD65 were correlated with IDDM in all study groups, whereas GAD67 antibodies were associated with IDDM when APS II coexists. Antibodies to GAD65 and GAD67 were detected in 13 (44.8%) and 7 (24.1%) out of 29 APS II patients with IDDM, but in only 4 (13.8%) and 2 (6.9%) out of 29 APS II patients without IDDM, respectively (p < 0.05). In short-standing IDDM (< 1 year), antibodies to GAD67 were significantly more frequent in patients with APS II (5 of 9 [55.6%] subjects) compared to matched diabetic patients without coexisting polyendocrinopathy (1 of 18 [5.6%] subjects) (p < 0.02). The levels of GAD65 (142 ± 90 AU) and GAD67 antibodies (178 ± 95 AU) were significantly higher in patients with polyglandular disease than in patients with isolated IDDM (91 ± 85 AU and 93 ± 57 AU) (p < 0.02). Interestingly, all 11 GAD67 antibody positive subjects also had GAD65 antibodies (p < 0.0001), and in 10 of 11 anti-GAD67 positive sera the GAD67 antibodies could be blocked by either GAD67 or GAD65, suggesting the presence of cross-reactive autoantibodies. No correlation was observed between GAD antibodies and age, sex or any particular associated autoimmune disease, besides IDDM. GAD antibodies were present in only 1 of 6 (16.7%) patients with APS Type I, in 1 of 26 (3.9%) patients with autoimmune thyroid disease but in none of the patients with Addison's disease (n = 16), pernicious anaemia (n = 7) or normal controls (n = 50). Our data suggest distinct antibody specificities reactive to GAD isoforms in APS II and IDDM, which might reflect different mechanisms of autoimmune response in IDDM with coexisting autoimmune polyendocrine autoimmunity
Topography of experience – a journey to yourself
No full textTeatr Amareya & Guests Dom-Bieg-Dom reżyseria: Katarzyna Pastuszak, muzyka: Irek Wojtczak, multimedia: Sylwek Łuczak, Ula Milanowska, kostiumy: Daisuke Tsukuda współorganizatorzy: BUoY Tokio, Zachęta – Narodowa Galeria Sztuki Warszawa premiera w streamingu: 29-30 grudnia 2020 w ramach projektu Niepodległa bez granic: Pol(s)ka w Japonii 202
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