81 research outputs found
Balance dysfunction the most significant cause of in-hospital falls in patients taking hypnotic drugs
No full textThe purpose of this study was to investigate the fall rate of each patient who took the hypnotic drug and the factor associated with falls
The changes of improvement upper limb function predict surgical outcome after laminoplasty in one year in patients with cervical spondylotic myelopathy: A retrospective study
No full textCervical spondylotic myelopathy preoperative prognostic factors include age, and preoperative severity and duration of illness. However, there are no reports on the relationship between changes in physical function during hospitalization and postoperative course, and in recent years, the length of hospital stay has shortened. We aimed to investigate whether changes in physical function during hospitalization can predict the postoperative outcome
The impact of spinal surgery on the locomotive syndrome in patients with lumbar spinal stenosis
No full text・The Japanese Orthopaedic Association defines locomotive syndrome as patients with reduced motor function. We reported the effect of surgical treatment on clinical decision limit 3 (CDL3), which corresponds to physical frailty.
・We investigated improvement factors for locomotive syndrome CDL stage 3 in patients with lumbar spinal stenosis in a retrospective study.
・Seventy-one patients who underwent surgical treatment were included in the study.
・Factors associated with improvement in locomotive syndrome were analyzed using multivariate logistic analysis and decision tree analysis
Phase angle is related to physical function and quality of life in preoperative patients with lumbar spinal stenosis
No full textThis study showed that there was a relationship between phase angle, physical function, and QOL in patients with lumbar spinal canal stenosis. Phase angle was also found to be related to lumbar spine function as measured by the questionnaire. Thus, phase angle may be a useful indicator for patients with lumbar spinal canal stenosis
Jenis Dan Wujud Pesan Moral Pada Tokoh Utama?????Oshin Dalam Novel?????Oshin Bagian 6-8 Karya Hashida Sugako???????
Get PDFThe moral of the literature obtained through literature the reader is always in a good sense. Because the moral contained in the literature generally reflects the views of the author of life, his views on the values of truth that is to be conveyed to the reader. Oshin Novel is a novel written by Hashida Sugako. This novel take on aspects of Japanese society after setting state before and after World War II. This study looks at Oshin Moral section 6-8 of the novel Oshin Sugako Hashida work through problem formulation: What type and form of moral message conveyed by the author of the novel Oshin section 6-8 Sugako Hashida work? With the aim of obtaining a description of the type and form of moral teachings contained in the novel Oshin Oshin section 6-8 Sugako Hashida work. The data of this study totaled 15 data. This study uses a descriptive analysis of the study, the analysis methods used to analyze data sources and methods used to analyze descriptive data analysis. The results of this study show that the novel part 6-8 Oshin Sugako Hashida work contained some moral teachings. Among them are teaching in the life Oshin himself covering, confidence, despair, hate, loneliness. Furthermore, the human moral teachings such as the relationship of husband and wife, the parents' relationship with their children, and the love of a husband or wife, children, parents, neighbors and country.Keyword : morality of messag
Walking exercise combined with neuromuscular electrical stimulation of antagonist resistance improved muscle strength and function for elderly people: A pilot study
Get PDF久留米大学博士（医学）2016年度doctoral thesi
Changes of improvement in upper limb function predict surgical outcome after laminoplasty in 1 year in patients with cervical spondylotic myelopathy: a retrospective study
No full textAbstract Background Cervical spondylotic myelopathy preoperative prognostic factors include age, preoperative severity, and disease duration. However, there are no reports on the relationship between changes in physical function during hospitalization and postoperative course, and in recent years, the length of hospital stay has shortened. We aimed to investigate whether changes in physical function during hospitalization can predict the postoperative outcome. Methods We recruited 104 patients who underwent laminoplasty for cervical spondylotic myelopathy by the same surgeon. Physical functions, including Simple Test for Evaluating Hand Function (STEF), grip strength, timed up and go test, 10-m walk, and time to stand on one leg, were assessed at admission and discharge. Patients with the Japanese Orthopaedic Association (JOA) score improvement rate of 50% or more were defined as the improved group. Decision tree analysis was investigated factor for identifying improvement in the JOA score. According to this analysis, we divided into two groups using age. Then, we conducted a logistic regression analysis to identify factors that improve the JOA score. Results The improved and non-improved groups had 31 and 73 patients, respectively. The improved group was younger (p = 0.003) and had better improved Δgrip strength (p = 0.001) and ΔSTEF (p < .0007). Age was significantly positively correlated with disease duration (r = 0.4881, p = < .001). Disease duration exhibited a significant negative correlation with the JOA score improvement rate (r = − 0.2127, p = 0.031). Based on the decision tree analysis results, age was the first branching variable, with 15% of patients ≥ 67 years showing JOA score improvement. This was followed by ΔSTEF as the second branching factor. ΔSTEF was selected as the factor associated with JOA improvement in patients ≥67 years (odds ratio (OR) 1.06, 95% confidence interval (CI) 1.01–1.12, p=.0268); in patients <67 years, Δgrip strength was identified (OR 1.30, CI 1.04‒1.62, p=.0049). Conclusions In the improved group, upper limb function improved more than lower limb function from the early postoperative period. Upper limb function changes during hospitalization were associated with outcomes one year postoperatively. Improvement factors in upper extremity function differed by age, with changes in grip strength in patients < 67 years and STEF in patients ≥ 67 years, reflecting the outcome at one year postoperatively
Correction: Changes of improvement in upper limb function predict surgical outcome after laminoplasty in 1 year in patients with cervical spondylotic myelopathy: a retrospective study
No full textDNA methylation is not necessary for the inactivation of the Tam3 transposon at non-permissive temperature in Antirrhinum
Get PDFIt has been proposed that DNA methylation plays an important role in the inactivation of transposons. This view stems from a comparison of the degree of methylation of transposons in the active and inactive state. However, direct evidence for the degree of methylation required for the suppression of transposition has not been reported. Transposon Tam3 in Antirrhinum majus undergoes somatic reversal of its transposition activity, which is tightly controlled by temperature: low temperature around 15℃ permits transposition, high temperatures around 25℃ strongly inhibits it. Our previous study had shown that the methylation state of the Tam3 end regions is negatively correlated with the Tam3 transposition frequency. The results of the present study reveal that the inactive state of Tam3 copies at high temperature is unlikely to be directly coupled to the methylation state. Treatment with methylation inhibitors (5-azacytidine or 5-azacytidine+ethionine) does not affect Tam3 excision frequency in calli derived from Antirrhinum hypocotyls. The results suggest that methylation is not essential for the suppression of Tam3 transposition at high temperature, but rather that some other mechanism(s) involved in the control of Tam3 transposition may be obscured by methylation
Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells.
Get PDFThe cellular uptake pathway for a gene vector is an important factor in transgene expression. We previously constructed an original gene vector, multifunctional envelope-type nano device (MEND). The use of octaarginine (R8), a cell-penetrating peptide dramatically enhanced the transfection activity of the MEND since efficient cellular uptake via macropinocytosis, while the R8 should overcome its poor cell selectivity. Here we prepared an R8-MEND equipped with GALA (a peptide for endosomal escape) (R8/GALA-MEND) coated with hyaluronic acid (HA) (HA-R8/GALA-MEND), a natural ligand for cancer cells overexpressing CD44. We investigated the cellular uptake pathway of the HA-R8/GALA-MEND and the R8/GALA-MEND using HCT116 cells overexpressing CD44. Both carriers were taken up by cells mainly via macropinocytosis, whereas only the HA-R8/GALA-MEND was partially internalized into cells via a CD44-mediated pathway. Investigation of transgene expression showed that the HA-R8/GALA-MEND had a high transfection activity in HCT116 cells via both macropinocytotic and CD44-mediated pathways. On the other hand, the value for the HA-R8/GALA-MEND was significantly decreased compared with the value for the R8/GALA-MEND in NIH3T3 cells (CD44-negative cells). These findings indicate that the HA-coating controls the intracellular pathway for R8-modified nanocarriers, and that a CD44-mediated pathway is an important route for transgene expression
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