1,721,043 research outputs found
Role of 18F-FDG PET-CT in head and neck squamous cell carcinoma
No full textThe role of PET-CT imaging in head and neck squamous cell carcinoma during pre-treatment staging, radiotherapy planning, treatment response assessment and post-therapy follow-up is reviewed with focus on current evidence, controversial issues and future clinical applications. in staging, the role of 18F-FDg PET-CT is well recognized for detecting cervical nodal involvement as well as for exclusion of distant metastases and synchronous primary tumours. in the evaluation of treatment response, the high negative predictive value of 18F-FDg PET-CT performed at least 8 weeks from the end of radio-chemotherapy allows prevention of unnecessary diagnostic invasive procedures and neck dissection in many patients, with a significant impact on clinical outcome. on the other hand, in this setting, the low positive predictive value due to possible post-radiation inflammation findings requires special care before making a clinical decision. Controversial data are currently available on the role of PET imaging during the course of radio-chemotherapy. The prognostic role of 18F-FDg PET-CT imaging in head and neck squamous cell carcinoma is recently emerging, in addition to the utility of this technique in evaluation of the tumour volume for planning radiation therapy. Additionally, new PET radiopharmaceuticals could provide considerable information on specific tumour characteristics, thus overcoming the limitations of 18F-FDg
Role of 131I-labelled anti-CEA/CA 19-9 monoclonal antibodies in the diagnosis and follow-up of gastrointestinal tumors
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Taralli S, Sollini M, Milella M, Perotti G, Filice A, Menga M, Versari A, Rufini V. (18)F-FDG and (68)Ga-somatostatin analogs PET/CT in patients with Merkel cell carcinoma: a comparison study.
No full textBackground: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluorodeoxy-
glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use
of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performance of
18F-FDG and 68Ga-somatostatin analog PET/CT in MCC patients.
Results: Fifteen patients (12 males, 3 females; median age 73 years; range 41–81 years) with histologically proven
MCC (4 with unknown primary lesion) who underwent both 18F-FDG and 68Ga-somatostatin analog PET/CT for
staging, re-staging, or treatment response assessment were retrospectively evaluated. Results of both studies
were qualitatively analyzed and compared on a patient- and lesion-based analysis, using histology or clinical/
radiological follow-up as reference standard for final diagnosis. According to final diagnosis, 8/15 patients had at
least one MCC lesion and 7/15 had no evidence of disease. On a patient-based analysis, 18F-FDG and 68Gasomatostatin
analogs correctly classified as positive 8/8 (100% sensitivity) patients and as negative 6/7 (85.7%
specificity) and 5/7 (71.4% specificity) patients, respectively, with no significant difference. On a lesion-based
analysis, 18F-FDG detected 67/75 lesions (89%) and 68Ga-somatostatin analogs 69/75 (92%), with no significant
difference. In four patients with unknown primary MCC, both tracers failed to identify the primary MCC site.
Conclusions: Our preliminary data suggest that 18F-FDG and 68Ga-somatostatin analog PET/CT provide good and
equivalent diagnostic performance, adding interesting insights into the complex MCC biology. However, these
results do not suggest that 18F-FDG PET/CT should be replaced by 68Ga-somatostatin receptor imaging, which
should be performed in addition, according to clinical indication, to the perspective of “personalized medicine.
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Integrazione dell'imaging radiologico con i dati della medicina nucleare: il miglioramento diagnostico nell'accoppiata morfologia e funzione
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Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Unsuspected testicular metastases from Merkel cell carcinoma: a case report with therapeutic implications.
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