6,450 research outputs found
Os verbos psicológicos e a queda da preposição A no português do Brasil
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Este é um trabalho de sintaxe comparativa entre os verbos psicológicos no italiano e do PB. Trata do desaparecimento da preposição a nos DPs experienciadores em sentenças com verbos psicológicos que apresentam o tema na posição de sujeito no PB. Como Belletti & Rizzi (1988) consideramos estes verbos inacusativos e com o experienciador numa posição mais alta do que o tema. Note que os verbos têm dois argumentos. No PB, o sujeito desses verbos não reage bem a testes como o do clítico anafórico, de pro arbitrário e da passivização. No entanto, os testes evidenciam que o sujeito desses verbos não é argumento externo do verbo. Ao mesmo tempo o objeto experienciador, ao ser substituído por um quantificador universal, tem escopo sobre um WH tema, mostrando que o c-comanda. Reafirmamos que este tipo de verbo não atribui caso acusativo estrutural, mas, por outro lado, atribui caso acusativo inerente. Queremos propor que a preposição a se tornou específica para atribuir caso acusativo inerente. Como ela não é um atribuidor "forte", nos contextos em que compete com o verbo para atribuir caso ela desaparece. Quando o DP experienciador aparece deslocado à esquerda ela reaparece porque as marcas casuais se diluem e precisam ser reforçadas
O curso de licenciatura em educação física da Universidade Federal de Santa Catarina: suas concepções de ensino e de educação física
No full textDissertação (mestrado) - Universidade Federal de Santa Maria. Centro de Educação Fisica e Desporto
Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
No full textCancer cells and tissues exhibit genome wide
hypomethylation and regional hypermethylation. CpGmethylation
of DNA (MeCpG-DNA) is defined as the
formation of a C–C covalent bond between the 5′-C of
cytosine and the –CH3 group of S-adenosylmethionine.
Removal of the sole –CH3 group from the methylated
cytosine of DNA is one of the many ways of DNAdemethylation,
which contributes to activation of transcription.
The mechanism of demethylation, the candidate
enzyme(s) exhibiting direct demethylase activity and
associated cofactors are not firmly established. Genomewide
hypomethylation can be obtained in several ways by
inactivation of DNMT enzyme activity, including covalent
trapping of DNMT by cytosine base analogues. Removal of
methyl layer could also be occurred by excision of the
5-methyl cytosine base by DNA glycosylases. The importance
of truly chemically defined direct demethylation of
intact DNA in regulation of gene expression, development,
cell differentiation and transformation are discussed in this
contribution
Estimación de factores de ajuste para el peso y la edad en hembras de la raza Carora
No full textFifty-eight thousand eight hundred ans sixty two weights taken from 12,081
females were analyzed from the Carora breed aging from 30 to 2,500 days to
obtain the adjustment coefficients of the weight for the age and the age for the
weight. To analyze the weight, a mix animal model has been adapted which
included the fix effect of the age grouped into 244 classes of 10 days each,
meanwhile, for the analysis of the age in the model the weights grouped into 14
classes of 50 kg each were introduced. The curves of the weight and the age was
calculated based on the estimated means of the factors “type of age” by the weight
and the factor “type of weight” for the age, obtained from both models. The two
curves explained with a high determination coefficient the variability of both the
weight (R2=0.994) and the age (R2=0.992). The cow reaches the mature weight
from 67 to 75 months of age, that is, the third and fourth lactation. The use of
these coefficients would allow the breeders to foresee the age when a heifer that
belongs to a determine type of weight, reaches the typical weight for the service
and obtain information about the precocity.Se analizaron 58.862 pesos tomados de 12.081 hembras de la raza Carora
de edad comprendida entre 30 y 2.500 días, para obtener los coeficientes de ajuste
del peso para la edad y de la edad para el peso. Para analizar el peso se ha
adaptado un modelo animal mixto que incluyó el efecto fijo de la edad agrupada
en 244 clases de 10 días cada una, mientras que para el análisis de la edad en el
modelo fueron introducidos los pesos agrupados en 14 clases de 50 kg cada una.
Las curvas del peso y de la edad se cálculo con base en a las medias estimadas de
los factores ‘clase de edad’ por el peso y del factor ‘clase de peso’ para la edad,
obtenidos de los dos modelos. Las dos curvas explicaron con un elevado coeficiente
de determinación la variabilidad tanto del peso (R2=0,994) como de la edad
(R2=0,992). La vaca llega al peso maduro entre los 67 y los 75 meses de edad, es
decir, entre la tercera y la cuarta lactancia. El uso de estos coeficientes permitirá
a los criadores prever el peso a una determinada edad. Además, permite al criador
prever la edad a la cual una novilla, que pertenece a una determinada clase
de peso, llega al peso típico para el servicio y de obtener información sobre la
precocidad
Accuracy of Fiber Propagation Evaluation Using Phenomenological Attenuation and Raman Scattering Models in Multiband Optical Networks
No full textThe constant growth of IP data traffic, driven by sustained annual increases surpassing 26%, is pushing current optical transport infrastructures towards their capacity limits.
Since the deployment of new fiber cables is economically demanding, ultra-wideband transmission is emerging as a promising cost-effective solution, enabled by multi-band amplifiers and transceivers spanning the entire low-loss window of standard single-mode fibers. In this scenario, accurate modeling of frequency-dependent fiber parameters is essential to reliably describe optical signal propagation. In particular, the combined impact of attenuation variations with frequency and inter-channel stimulated Raman scattering (SRS) fundamentally shapes the power evolution of wide wavelength division multiplexing (WDM) combs and directly affects nonlinear interference (NLI) generation, as well as the amount of ASE noise.
In this work, we review a set of analytical approximations based on phenomenological approaches for frequency-dependent attenuation and Raman scattering gain, and analyze their impact on achieving an effective balance between computational efficiency and physical fidelity. Through extensive analyses performed with the open-source software GNPy (version 2.12, Telecom Infra Project) on an optical line system exploring multi-band scenarios spanning C+L+S, C+L+E, and U-to-E transmission, we demonstrate that the proposed approximations reproduce the reference SRS power evolution and NLI profiles with root mean square errors (RMSEs) consistently below 0.03 dB, and down to the 10^-3 to 10^-2 dB range for the most accurate configurations.
Although the current implementation does not yet provide a direct reduction in computational time, the proposed framework lays the groundwork for future developments toward closed-form or semi-analytical solutions, enabling more efficient modeling and optimization of ultra-wideband optical transmission
Haplotyping Populations by Pure Parsimony. Complexity, Exact and Approximation Algorithms
No full textIn this paper we address the pure parsimony haplotyping problem: Find a minimum number of haplotypes that explains a given set of genotypes. We prove that the problem is APX-hard and present a 2(k-1)-approximation algorithm for the case in which each genotype has at most k ambiguous positions. We further give a new integer-programming formulation that has (for the first time) a polynomial number variables and constraints. Finally, we give approximation algorithms, not based on linear programming, whose running times are almost linear in the input size
Genetic relationships among taurine (Bos taurus) and zebu (Bos indicus) populations as revealed by blood groups and blood protein
No full textGenetic relationships among nine cattle populations (Bos indicus and Bos taurus) were investigated using blood group antigenic factors and biochemical loci, for a total of 46 polymorphisms. All the analysed breeds live in hot climatesof Africa (Azaouak, Adamawa-Gudali, Small East African Zebu, Surqo, Brown Atlas, N'Dama, Somba), Central America (Carora), and Italy (Modicana). The study was carried out on 891 unrelated animals. Average heterozygosity ranged between 0.25 and 0.31 and showed higher values in B. indicus (zebu) populations (Azaouak, Adamawa-Gudali, Small East African Zebu, Surqo). Genetic distances between breeds were used for dendrogram construction. Two main clusters shared B. taurus and B. indicus. Within taurine (B. taurus) breeds, European or European like taurine populations (Modicana, Brown Atlas and Carora) clustered together, most probably because of the consistent presence of Brown Swiss genes in all of them. Another cluster involved the two African taurine populations (N'Dama and Somba). Multivariate analyses (Principal Component Analysis, Correspondence Analysis) of the allelic frequencies confirmed the breed clustering obtained. Overall relationships among breeds reflected remarkable genetic affinity between some of them
High sensitivity and noise immune method to detect impedance cardiography characteristic points using wavelet transform
No full textIn this study, a real-time fast parallelized processing technique for C-point locations is presented. Singularity detector adopting a multiscale wavelet transform is used for impedance cardiography signal processing. Both theoretical analysis and experimental results show the method reliability and sensitivity. Moreover, the algorithm noise immunity has been tested adding Gaussian noise with a variable variance to the real ICG signal. Test results with minimum interferences from noise and artefacts have been obtaine
Facial Uplift: Plastic Surgery, Cosmetics, and the Retailing of Whiteness in the Work of Maria Cristina Mena
No full textThis article analyzes how Mexican American author María Cristina Mena’s short magazine fiction boldly illustrates the emerging U.S. beauty industry as effectively producing whiteness for sale in the neocolonial marketplace. Her representations of Mexican women’s use of cosmetics articulate how the beauty industry both lends structure to and is structured by the idea of race; at the same time, she reminds her audience that the impact of beauty products and services is in large part determined by the political and economic context of the goods themselves. Through the techniques of role reversals, character development and dramatic irony, Mena’s stories portray the U.S. beauty industry as a dynamic trade that exports new forms of whiteness across its southern border. Far from depicting Mexican women as passive consumers in the neocolonial marketplace, however, Mena shows how beauty products and services can be appropriated as limited yet potent acts of resistance.This article was published as Schuller, Kyla. "Facial Uplift: Plastic Surgery, Cosmetics, and the Retailing of Whiteness in the Work of Maria Cristina Mena," Journal of Modern Literature, Vol. 32, No. 4 (Summer 2009), pp. 82-104. No part of this article may be reproduced, stored in a retrieval system, transmitted, or distributed, in any form, by any means, electronic, mechanical, photographic, or otherwise, without the prior permission of Indiana University Press. For educational re-use, please contact the Copyright Clearance Center (508-744-3350). For all other permissions, please visit Indiana University Press' permissions page.Peer reviewe
Prognostic role of clusterin in resected adenocarcinomas of the lung
No full textPrognostic role of clusterin in resected adenocarcinomas of the lung.
Panico F, Casali C, Rossi G, Rizzi F, Morandi U, Bettuzzi S, Davalli P, Corbetta L, Storelli ES, Corti A, Fabbri LM, Astancolle S, Luppi F.
Source
Section of Respiratory Diseases, Department of Oncology, Haematology & Pulmonology, University of Modena and Reggio Emilia, Modena, Italy.
Abstract
RATIONALE:
Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30-50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung.
OBJECTIVES:
We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung.
FINDINGS:
The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin.
CONCLUSIONS:
Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB
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