683 research outputs found
Targeted metabolomics data
No full textThe chemicals, standards and extraction protocol used as the same as given in Loupit et al. (2022) The analysis protocol was the same as described by Loupit et al. (2020) with some modifications and a different column (Agilent ZORBAX RRHD SB-C18 (2.1 mm x 100 mm, 1.8 μm)).
Loupit G, Prigent S, Franc C, De Revel G, Richard T, Cookson SJ, Fonayet JV. 2020. Polyphenol Profiles of Just Pruned Grapevine Canes from Wild Vitis Accessions and Vitis vinifera Cultivars. Journal of Agricultural and Food Chemistry 68, 13397-13407.
Loupit G, Prigent S, Prodhomme D, Spilmont AS, Hilbert G, Franc C, de Revel G, Ollat N, Valls Fonayet J, Cookson SJ. 2022. Identifying early metabolite markers of successful graft union formation in grapevine Horticultural Research 9, uhab070
Dataset for 'A yellow polariton condensate in a dye filled microcavity'
No full textIncluded here are the raw datasets for the dispersion imaging and interferometry in the paper A yellow polariton condensate in a dye filled microcavity. / Cookson, Tamsin; Georgiou, Kyriacos; Zasedatelev, Anton; Grant, Richard T.; Virgili, Tersilla; Cavazzini, Marco; Galeotti, Francesco ; Clark, Casper; Berloff, Natalia G.; Lidzey, David G.; Lagoudakis, Pavlos G. In: Advanced Optical Materials, 05.05.2017.
The dataset is an updated version of the dataset DOI:10.5258/SOTON/D0093 and should be used in preference.</span
Racism Reflected in Colour Blind Novel (1968) by Catherine Cookson: Critical Race Theory
No full textThis research is the study of racism reflected in Colour Blind novel (1968) by Catherine Cookson viewed from critical race theory. The purpose of this research is to analyze the racism reflected in Colour Blind novel (1968) by Catherine Cookson based on critical race theory. Method of data collection is conducted by analyzing and interpreting descriptively while the techniques of data analysis is a descriptive technique. The results of this research are: 1) The researcher finds the indicators of racism in Colour Blind as seen from critical race theory by Richard Delgado and Jean Stefancic (2001). 2) The researcher describes the racism happened in the novel Colour Blind. 3) The author takes the issue "racism" because in that year discrimination is an unfair treatment that usually happens by the majority groups towards minority groups that lead to racism in society
appendices_online_supp – Supplemental material for Estimating Social Variation in the Health Effects of Changes in Health Care Expenditure
No full textSupplemental material, appendices_online_supp for Estimating Social Variation in the Health Effects of Changes in Health Care Expenditure by James Love-Koh, Richard Cookson, Karl Claxton and Susan Griffin in Medical Decision Making</p
sj-xlsx-1-prv-10.1177_26320770231204993 – Supplemental material for How Far Can Interventions to Increase Income Improve Adolescent Mental Health? Evidence From the UK Millennium Cohort Study and Next Steps
No full textSupplemental material, sj-xlsx-1-prv-10.1177_26320770231204993 for How Far Can Interventions to Increase Income Improve Adolescent Mental Health? Evidence From the UK Millennium Cohort Study and Next Steps by Aase Villadsen, Elliott Aidan Johnson, Richard Cookson and Matthew Thomas Johnson in Journal of Prevention and Health Promotion</p
Halotriazolium axle functionalised [2]rotaxanes for anion recognition: investigating the effects of halogen-bond donor and preorganisation.
No full textThe anion-templated synthesis of three novel halogen-bonding 5-halo-1,2,3-triazolium axle containing [2]rotaxanes is described, and the effects of altering the nature of the halogen-bond donor atom together with the degree of inter-component preorganisation on the anion-recognition properties of the interlocked host investigated. The ability of the bromotriazolium motif to direct the halide-anion-templated assembly of interpenetrated [2]pseudorotaxanes was studied initially; bromide was found to be the most effective template. As a consequence, bromide anion templation was used to synthesise the first bromotriazolium axle containing [2]rotaxane, the anion-binding properties of which, determined by (1) H NMR spectroscopic titration experiments, revealed enhanced bromide and iodide recognition relative to a hydrogen-bonding protic triazolium rotaxane analogue. Two halogen-bonding [2]rotaxanes with bromo- and iodotriazolium motifs integrated into shortened axles designed to increase inter-component preorganisation were also synthesised. Anion (1) H NMR spectroscopic titration experiments demonstrated that these rotaxanes were able to bind halide anions even more strongly, with the iodotriazolium axle integrated rotaxane capable of recognising halides in aqueous solvent media. Importantly, these observations suggest that a halogen-bonding interlocked host binding domain, in combination with increased inter-component preorganisation, are requisite design features for a potent anion receptor
Measuring change in health care equity using small area administrative data – evidence from the English NHS 2001-8
No full textThis study developed a method for measuring change in socio-economic equity in health care utilisation using small area level administrative data. Our method provides more detailed information on utilisation than survey data but only examines socio-economic differences between neighbourhoods rather than individuals. The context was the English NHS from 2001 to 2008, a period of accelerated expenditure growth and pro-competition reform. Hospital records for all adults receiving non-emergency hospital care in the English NHS from 2001 to 2008 were aggregated to 32,482 English small areas with mean population about 1,500 and combined with other small area administrative data. Regression models of utilisation were used to examine year-on-year change in the small area association between deprivation and utilisation, allowing for population size, age-sex composition and disease prevalence including (from 2003-8) cancer, chronic kidney disease, coronary heart disease, diabetes, epilepsy, hypertension, hypothyroidism, stroke, transient ischaemic attack and (from 2006-8) atrial fibrillation, chronic obstructive pulmonary disease, obesity and heart failure. There was no substantial change in small area associations between deprivation and utilisation for outpatient visits, hip replacement, senile cataract, gastroscopy or coronary revascularisation, though overall non-emergency inpatient admissions rose slightly faster in more deprived areas than elsewhere. Associations between deprivation and disease prevalence changed little during the period, indicating that observed need did not grow faster in more deprived areas than elsewhere. We conclude that there was no substantial deterioration in socio-economic equity in health care utilisation in the English NHS from 2001 to 2008, and if anything, there may have been a slight improvement
Socio-economic inequality in small area use of elective total hip replacement in the English NHS in 1991 and 2001
No full textInternational evidence suggests that there are substantial socio-economic inequalities in the delivery of specialist health services, even in the UK and other high-income countries with publicly funded health systems (Goddard and Smith 2001, Dixon et al. 2003, Van Doorslaer, Koolman and Jones 2004, Van Doorslaer et al. 2000). Studies of total hip replacement in the English NHS have yielded particularly striking examples, given that hip replacement is such a common, effective and longestablished health technology. Administrative data show that people living in deprived areas are less likely to receive hip replacement (Chaturvedi and Ben-Shlomo 1995, Dixon et al. 2004) while survey data suggest they may be more likely to need it (Milner et al. 2004). However, previous studies have not examined change in inequality over time. This paper presents evidence on the change in socio-economic inequality in small area use of elective total hip replacement in the English NHS, comparing 1991 with 2001. This was a period of important large-scale health care reform in England, involving at least two significant reforms that might potentially have influenced socio-economic inequality in health care delivery: (1) the introduction and subsequent abolition of the Conservative “internal market” 1991-7, and (2) the introduction in 1995 of a revised NHS resource allocation formula designed to reduce geographical inequalities in health care delivery. Two datasets, for 1991 and 2001, were assembled from routine NHS data sources: Hospital Episode Statistics (HES) on hospital utilisation in England and the corresponding decennial National Censuses in 1991 and 2001. Both datasets contain information on over 8,000 electoral wards in England (over 95% of the total). To improve comparability, a common geography of frozen 1991 wards was adopted. The Townsend deprivation score was employed as an indicator of socio-economic status. Inequality was analysed in two ways. First, for comparability with previous small area studies of hip replacement, by using simple range measures based on indirectly age-sex standardised utilisation ratios (SURs) by deprivation quintile groups. Second, using concentration indices of deprivationrelated inequality in use based on indirectly age-sex standardised utilisation ratios for each individual small area. Each SUR is the observed use divided by the expected use, if each age and sex group in the study population had the same rates of use as the national population.
Future challenges
No full textIn this chapter we discuss some of the challenges facing the field of distributional cost-effectiveness analysis (DCEA). We cover four methodological challenges for researchers: (i) modelling complexities such as economies of scale, spillovers and behavioural responses, (ii) ex post DCEA based on distributions of realised outcomes rather than expected outcomes, (iii) cross-sectoral DCEA combining information about health and non-health dimensions of well-being, and (iv) fair shares DCEA based on distributing in proportion to strength of claim rather than maximising value. We also discuss the practical challenge of making DCEA more useful to decision makers
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