3,771 research outputs found
Transcripts for dissertation, "Iron fellows : commitment and activism in a poor people's movement"
No full textThis set contains transcripts from Marcos Perez's dissertation project. Data is available by request to interested scholars and students. Visitors may not download the files without express permission from the author. Visitors may not make copies of the transcripts, nor distribute any part of them separately. To request access, please contact [email protected]
Assessing the genotoxic effects of two lipid peroxidation products (4-oxo-2-nonenal and 4-hydroxy-hexenal) in haemocytes and midgut cells of Drosophila melanogaster larvae
No full textMarcos, Ricard/0000-0001-7891-357XWOS: 000403625000001PubMed: 28343031Lipid peroxidation products can induce tissue damage and are implicated in diverse pathological conditions, including aging, atherosclerosis, brain disorders, cancer, lung and various liver disorders. Since in vivo studies produce relevant information, we have selected Drosophila melanogaster as a suitable in vivo model to characterise the potential risks associated to two lipid peroxidation products namely 4-oxo-2-nonenal (4-ONE) and 4-hydroxy-hexenal (4-HHE). Toxicity, intracellular reactive oxygen species production, and genotoxicity were the end-points evaluated. Haemocytes and midgut cells were the evaluated targets. Results showed that both compounds penetrate the intestine of the larvae, affecting midgut cells, and reaching haemocytes. Significant genotoxic effects, as determined by the comet assay, were observed in both selected cell targets in a concentration/time dependent manner. This study highlights the importance of D. melanogaster as a model organism in the study of the different biological effects caused by lipid peroxidation products entering via ingestion. This is the first study reporting genotoxicity data in haemocytes and midgut cells of D. melanogaster larvae for the two selected compounds. (C) 2017 Elsevier Ltd. All rights reserved
Courageous women in media: Marcos and censorship in the Philippines
No full textWhen Philippine President Ferdinand Marcos declared Martial Law in 1972, press freedom became the first casualty in the country that once boasted of being the 'freest in Asia'. Printing presses, newspaper offices, television and radio stations were raided and padlocked. Marcos was especially fearful of the press and ordered the arrest of journalists whom he charged with conspiring with the 'Left'. Pressured into lifting martial law after nearly 10 years, Marcos continued to censor the media, often demanding publishers to sack journalists whose writing he disapproved of. Ironically, he used the same 'subversive writings' as proof to Western observers that freedom of the press was alive and well under his dictatorship. This article looks at the writings of three female journalists from the Bulletin Today. The author examines the work of Arlene Babst, Ninez Cacho-Olivares, and Melinda de Jesus and how they traversed the dictator's fickle, sometimes volatile, reception of their writing. Interviewed is Ninez Cacho-Olivare, who used humour and fairy tales in her popular column to criticise Marcos, his wife, Imelda, and even the military that would occasionally 'invite' her for questioning. She explains an unwritten code of conduct between Marcos and female journalists that served to shield them from total political repression
Producing Ferdinand E. Marcos, the Scholarly Author
No full textThisarticle discusses the compelling evidence—found in various primaryand secondary sources and analyzed through methods drawn from bookhistory and plagiarism detection—that not one of the books authored byPres. Ferdinand E. Marcos was actually written by him. Thearticle alsoshows how many of “Marcos’s” books had either plagiarized content(e.g., republishing contents from previous works) or were “padded” withlengthy appendices. It also explains the seemingly far-reaching distributionnetwork of these books. Lastly, thearticle looks into how these books,although they have not been republished for decades, continue to servetheir intended functions.KEYWORDS: FERDINAND E. MARCOS • BOOK HISTORY • GHOSTWRITING • PLAGIARISM• ADRIAN CRISTOBA
Lladró: análisis de la creación cultural de una estética : de la tradición industrial de la cerámica valenciana a la recepción social de una marca
No full textLa investigación profundiza en las relaciones que una empresa, marca de carácter y repercusión internacional como la fábrica de porcelanas Lladró, pero profundamente anclada en la propia cultura local valenciana, establece respecto a conceptos tan controvertidos como su papel a medio camino entre un objeto industrial entendido éste como modelo de producción en serie, artesano y artístico, las complejas relaciones que establece respecto a su valor como arte o su vinculación al mundo del kitsch, y de que forma este concepto puede ser revisado, a través precisamente, de las propias producciones estéticas de Lladró.
También, de qué modo se articula todo ello en el marco de nuestra propia cultura visual, mediante el análisis y la conceptualización de las principales narrativas que emanan de las imágenes generadas por las porcelanas figurativas de la marca, y que relaciones y significados se establecen con nuestro ámbito cultural y con otros productos de la propia cultura visual.
En el desarrollo de la primera parte, abordamos nuestro análisis y aproximación de la industria cultural de porcelanas Lladró, vinculándola a los procesos de relación que esta establece con conceptualizaciones de tipo teórico y estético. Analizamos pues, su papel como producto industrial, las relaciones de posicionamiento social que Lladró establece respecto a la categoría artística y de qué manera estas relaciones fundamentan su esencia estética. Vinculado con ello, que marcos establece hacia otro tipo de conceptos como la artesanía, y de que forma Lladró se sitúa en una encrucijada de relaciones que analizamos entre el arte, la artesanía y la industria, llegando incluso a valorar sus relaciones respecto a la propia cultura de masas desarrollada a finales del siglo XX, el estudio del papel que el museo como institución jugará en la estrategia de posicionamiento y de reafirmación de sus propios valores estéticos, las estrategias de posicionamiento de su producto para impregnarlo de valores sociales y de qué forma todo esto se va vinculando claramente con la construcción de una estética propia y determinada.
En la segunda parte de nuestra tesis, centramos nuestro desarrollo analítico en una mirada profunda hacia el conjunto de la producción cerámica de Lladró, producción de porcelana figurativa, no en forma de catalogación sistemática, sino a través de la delimitación de las principales narrativas visuales y constructos sociales y culturales que nos presenta Lladró en sus piezas a nivel global y de qué forma estas van construyendo un discurso unificado y una estética propia, reconocida ya internacionalmente, y perfectamente establecida en la cultura visual de su tiempo, que es también el nuestro
CFD based aerodynamic redesign of a Marcos LM600
No full textThe final years of the 1960s mark the introduction of aerodynamics to the field of motorsport and they have grown to be inextricably connected ever since. The competing cars in nearly every motorsport category are fitted with aerodynamic devices while Formula One teams actually have departments that are primarily concerned with the aerodynamic design of their vehicles. The GT-class is another motorsport category that hosts cars that are predominantly shaped with the aim to optimize aerodynamic efficiency. The Marcos LM600 is one of the cars that competes in the GT-class and forms the sculpture of this thesis. The subject of this thesis is to enhance the aerodynamic characteristics of the Marcos LM600 through utilization of Computational Fluid Dynamics (CFD). This implies that on going through this report a number of modifications to the Marcos LM600 will be presented with the aim of obtaining an aerodynamically improved racing car. In a sense the Marcos LM600 thus resembles a sculpture that assumes its final shape after a succession of modifications. The aerodynamic characteristics that are of primary significance to a racing car are the downforce and drag. The obvious target is to maximize the downforce and downforce-to-drag ratio. Apart from this force ratio, the downforce distribution between the wheel axes is another important racing car characteristic. The actual handling stability of the car is determined by the force balance between the front and rear wheels. Too much ”grip” on the front wheels causes oversteer, while too much rear wheel grip causes understeer. Thus when designing racing cars, the aerodynamicist should take into account the front wheel and rear wheel downforce and to obtain either a vehicle with neutral steer or slightly oversteer1. However, vehicle handling is beyond the scope of this thesis, which is why the Marcos LM600 will only be optimized in terms of downforce and drag, leaving out their effect on the vehicle stability.Aerospace Engineerin
NF-κB Mediates the Expression of TBX15 in Cancer Cells.
No full textTBX15 is a T-box transcription factor essential for development, also proposed as a marker in prostate cancer; and, recently, its antiapoptotic function indicates a role in carcinogenesis. Regulation of TBX15 is uncovered. In this study, we investigated the regulation of TBX15 expression in human cancer cells, by analyzing the regulatory function of a 5'-distal conserved region of TBX15. Bisulfite sequencing showed high methylation of the CpG island contained in this region that was not correlated with TBX15 mRNA levels, in the cancer cell lines analyzed; however, after 5-aza-dC treatment of TPC-1 cells an increase of TBX15 expression was observed. We also found a significant response of TBX15 to TNF-α activation of the NF-κB pathway using five cancer cell lines, and similar results were obtained when NF-κB was activated with PMA/ionomycin. Next, by luciferase reporter assays, we identified the TBX15 regulatory region containing two functional NF-κB binding sites with response to NF-κBp65, mapping on the -3302 and -3059 positions of the TBX15 gene. Moreover, a direct interaction of NF-κBp65 with one of the two NF-κB binding sites was indicated by ChIP assays. In summary, we provide novel data showing that NF-κB signaling up-regulates TBX15 expression in cancer cells. Furthermore, the link between TBX15 and NF-κB found in this study may be important to understand cancer and development processes
The impact of beef and soybean protein demand on carbon emissions in Argentina during the first two decades of the twenty-first century
No full textWe quantified and analyzed the effect that the domestic and international demand for beef and soybean proteins had on carbon emissions in Argentina during the first two decades of the twenty-first century. We also analyzed the influence of both factors on the national deforestation rates. Principal component analysis and simple regression analyses were in turn used to detect components that maximize data variance, and to quantify relevant relationships. Our results show that not all activities considered carbon sources had the same impact on carbon emissions, and not all carbon emissions are equally affected by domestic and international demand of proteins throughout the period 2001–2018. We found a relevant association of both the domestic and international demand with carbon emissions during a first 2001–2009 period, and a less-significant one during a second 2010–2018 period. Deforestation (P 0.05) were the factors that decreasingly explained carbon emissions. Biased assumptions about the impact of protein demand on carbon emissions in Argentina should be cautiously taken unless they are supported by robust scientific evidence.Fil: Ricard, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Pampa; ArgentinaFil: Mayer, Marcos Alejandro. Universidad Nacional de La Pampa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Viglizzo, Ernesto Francisco. Universidad Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Radiosensitivity of radiotherapy patients: The effect of individual DNA repair capacity
No full textIndividual radiosensitivity is a critical problem in radiotherapy because of the treatment restrictions it imposes. We have tested whether induction/repair of genomic lesions correlates with the acute cutaneous effects of radiotherapy. Peripheral blood samples of 56 healthy volunteers and 18 patients with breast cancer were studied. DNA damage and DNA repair capacity were assessed in vitro (alkaline comet assay). Patients without skin reaction did not show significant differences from healthy individuals, with respect to either initial or radiation-induced DNA damage. Similar DNA repair kinetics, fitting a decreasing exponential response, were observed in both groups, and there were no significant differences in residual genotoxic damage. In contrast, patients exhibiting acute side effects showed significantly lower DNA repair ability and significantly more residual damage, compared to patients without radiotoxicity. This approach may help to identify patients who are at greater risk of radiotherapy side effects. However, many other factors, such as dosimetry, irradiated volume, and lifestyle should also be considered in the evaluation of individual radiosensitivity.Fil: Ocolotobiche, Eliana Evelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Dauder, Ricard Marcos. Universitat Autònoma de Barcelona; EspañaFil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata; Argentin
Parrhesía e loucura no exemplo de Estamira
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Filosofia, Florianópolis, 2015.Um autor como Michel Foucault (1926-1984), ao apresentar um estudo extenso sobre saber, poder e ética, deixa o leitor com dúvidas e indagações: O sujeitado ao poder não teria como se contrapor à submissão? O poder psiquiátrico, com seus saberes sobre a loucura, seria tão poderoso assim? Na tentativa de responder estas questões, estabeleceu-se como objetivo geral investigar a parrhesía e a loucura no exemplo de Estamira. Como pressuposto metodológico, optou-se pelos escritos de Michel Foucault sobre a temática da loucura. Na análise do documentário a respeito de Estamira, produzido por Marcos Prado em 2004, foram analisadas algumas cenas, fundamentando-se, sobretudo, em seus últimos escritos, de 1980 a 1984, do Collège de France. O pensamento último de Foucault evidencia uma preocupação histórica do que seria o cuidado de si e a parrhesía no período da Grécia Clássica, por volta do séc. IV a.C., o período helênico romano séc. I e II d.C. e os primeiros cristãos (IV a V d.C.). O autor consegue perceber, na antiguidade grega, a existência de uma subjetividade que não segue normas, a qual se torna uma prática de liberdade (práticas ascéticas), uma busca de como dizer a verdade (parrhesía) que leva a uma constituição ética atrelada à estética da existência da vida do sujeito. Conclui-se, com base nas análises históricas foucaultianas, que o exemplo de Estamira nos remete a uma ?ontologia do presente?, ?ontologia dos discursos verdadeiros?, uma concepção de subjetividade, de verdade e de filosofia de vida para o indivíduo, com sua loucura, transformar sua vida e ser diferente do que é, governando a si mesmo pela parrhesía, ser franco, falar a verdade.Abstract : An author such as Michel Foucault (1926-1984) when presenting an extensive study of knowledge, power and ethics, leaves the reader with doubts and questions: The subjected to power could not possibly oppose itself from submission? The psychiatric power, with its knowledge about insanity, would be that powerful? In the attempt to answer these questions, it was established as a general objective to investigate the parrhesia and insanity in the case of Estamira. For the methodological presupposition, it was chosen the writings of Michel Foucault on the theme of madness. In the documentary film analysis about Estamira, produced by Marcos Prado in 2004, some scenes were analyzed mostly based in his later writings, from 1980 to 1984, from the Collège de France. The final thought of Foucault reveals a historical concern of what would be the self care and the Parrhesia in the Classical Greece period from around the IV century B.C., the Roman Hellenistic period during the I and II century A.D. and the early Christians (IV to V A.D.). The author is able to perceive that in Greek antiquity, the existence of a subjectivity that does not follow rules, which turns to a practice of freedom (ascetic practices), a search for how to tell the truth (parrhesia) leading to an ethical constitution tied to the aesthetics of existence of the subject´s life. The conclusion is, based on Foucault's historical analysis, that the example of Estamiranos refers to an "ontology of the present", "ontology of real discourses," a conception of subjectivity, truth and life philosophy for the individual, with his insanity, to transform his life and be different than it is, ruling himself through parrhesia, be honest and to tell the truth
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