19 research outputs found
Réforme territoriale et repositionnement des métropoles en Pologne
No full textPointing out that Poland is the first central – or eastern-European country to have adopted the institutional and territorial framework of a decentralised state, the author seeks to show how the stakes involved in the realization of this reform brought to light lines of force or weakness in the Polish territorial organization. She does so by studying the criteria for delimiting regions, the location of political resistance to reform, and electoral results. These fault lines highlight a Poland in turmoil, characterized by competing identities clamouring for existence, those giving expression to local rivalries and those giving voice to more intense regional – and, so, urban – fragmentation. Lydia Coudroy de Lille shows to what extent the urban world has invigorated the democratic debate and may lead to a turn-around in the organisation of Polish territory
Cello techniques and performing practices in the nineteenth and early twentieth centuries
No full textThis thesis comprises a study of cello performance practices throughout the nineteenth century and into the early decades of the twentieth. It is organised in terms of the increasing complexity of the concepts which it examines, as they are to be found in printed and manuscript music, instrumental methods and larger treatises, early recordings, concert reviews and pictures. Basic posture is considered along with different ways of holding the
bow. The development of the tail-pin shows that even when it was widely used, the older posture was still referred to as a model. Some implications for tone quality and tonal
projection are considered in the light of the shape of the arms. Some connections between the cellist's posture and that recommended by etiquette books are explored. The
functionality of the left hand and arm, and the development of modem scale fingerings, show that there was a considerable period of overlap between newer and older practices, with modern scale fingerings evolving over a long period of time. Similarly, views on the function of the right wrist in bowing are shown to change gradually, moving towards a more active upper arm movement with less extreme flexibility of the wrist. Two central expressive techniques especially associated with string playing arc considered in the context of the cello, namely vibrato and portamento. These topics are examined in the light of written indications in music, recommendations in cello treatises, and the practices evidenced in early recordings. The sources for this study can be brought into an overall
framework of a constant dialogue between `theory', as expressed in verbal instructions to the learner, or general a priori reflections about the cello, and `practice', manifested in performing editions and early recordings, or in individual acts of reception. A wide divergence is noted, both between theory and practice in general, and in terms of different styles of playing observable at any one time. It is suggested that tensions between practice
and critical disapproval can be resolved in terms of Lacanian discourse. Several test cases are used in order to compare several different recordings of the same works. The question of the musical character of the cello is discussed in terms of widespread assumptions about its gendered identity. A wide range of sources suggest that this moved from a straightforwardly `masculine' identity expressed through a controlling, elevated eloquence to a less clearly defined one, incorporating the 'feminine', with a greater stress on uninhibited emotional expression. Some performance implications for this change of view are pursued with respect to specific repertoires. Broad conclusions stress the importance of the diversity of performance practices as opposed to unifying generalisations
High-flow nasal cannula compared with continuous positive airway pressure : a bench and physiological study.
No full textHigh-flow nasal cannula (HFNC) is extensively used for acute respiratory failure. However, questions remain regarding its physiological effects. We explored 1) whether HFNC produced similar effects to continuous positive airway pressure (CPAP); 2) possible
explanations of respiratory rate changes; 3) the effects of mouth opening. Two studies were conducted: a bench study using a
manikin’s head with lungs connected to a breathing simulator while delivering HFNC flow rates from 0 to 60 L/min; a physiological crossover study in 10 healthy volunteers receiving HFNC (20–60 L/min) with the mouth open or closed and CPAP 4 cmH2O
delivered through face mask. Nasopharyngeal and esophageal pressures were measured; tidal volume and flow were estimated
using calibrated electrical impedance tomography. In the bench study, nasopharyngeal pressure at end-expiration reached 4
cmH2O with HFNC at 60 L/min, whereas tidal volume decreased with increasing flow. In volunteers with HFNC at 60 L/min, nasopharyngeal pressure reached 6.8 cmH2O with mouth closed and 0.8 cmH2O with mouth open; P < 0.001. When increasing
HFNC flow, respiratory rate decreased by lengthening expiratory time, tidal volume did not change, and effort decreased (pressure-time product of the respiratory muscles per minute); effort was equivalent between CPAP and HFNC 40 L/min and became
lower at 60 L/min (P = 0.045). During HFNC with mouth closed, and not during CPAP, resistance to breathing was increased,
mostly during expiration. In conclusion, mouth closure during HFNC induces a positive nasopharyngeal pressure proportional to
flow rate and an increase in expiratory resistance that might explain the prolonged expiration and reduction in respiratory rate
and effort, and contribute to physiological benefits.
NEW & NOTEWORTHY High-flow nasal cannula generates positive airway pressure and reduces respiratory rate. Our findings
confirm these physiological effects when the mouth is kept closed. An increased resistance to breathing induces a longer expiratory phase, which leads to decreased respiratory rate and minute ventilation, and therefore to a decreased respiratory workload,
counterbalancing the increased pressure-time product per liter. These effects are less apparent with the mouth open and are
not observed with continuous positive airway pressure
Image_1_Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.JPEG
No full textObjectives: To investigate the association of plasma LPS mass with mortality and inflammation in patients with peritonitis-induced septic shock (SS).Design: Longitudinal endotoxin and inflammatory parameters in a multicentric cohort of SS.Patients: Protocolized post-operative parameters of 187 SS patients collected at T1 (12 h max post-surgery) and T4 (24 h after T1).Intervention:Post-hoc analysis of ABDOMIX trial.Measurements and Results: Plasma concentration of LPS mass as determined by HPLC-MS/MS analysis of 3-hydroxymyristate, activity of phospholipid transfer protein (PLTP), lipids, lipoproteins, IL-6, and IL-10. Cohort was divided in low (LLPS) and high (HLPS) LPS levels. The predictive value for mortality was tested by multivariate analysis. HLPS and LLPS had similar SAPSII (58 [48.5; 67]) and SOFA (8 [6.5; 9]), but HLPS showed higher death and LPS to PLTP ratio (p median, the risk of death in HLPS (38%) was higher than in LLPS (24%; p Conclusions: Combination of high LPS mass concentration and high SAPS II is associated with elevated mortality in peritonitis-induced SS patients.</p
Table_3_Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.DOCX
No full textObjectives: To investigate the association of plasma LPS mass with mortality and inflammation in patients with peritonitis-induced septic shock (SS).Design: Longitudinal endotoxin and inflammatory parameters in a multicentric cohort of SS.Patients: Protocolized post-operative parameters of 187 SS patients collected at T1 (12 h max post-surgery) and T4 (24 h after T1).Intervention:Post-hoc analysis of ABDOMIX trial.Measurements and Results: Plasma concentration of LPS mass as determined by HPLC-MS/MS analysis of 3-hydroxymyristate, activity of phospholipid transfer protein (PLTP), lipids, lipoproteins, IL-6, and IL-10. Cohort was divided in low (LLPS) and high (HLPS) LPS levels. The predictive value for mortality was tested by multivariate analysis. HLPS and LLPS had similar SAPSII (58 [48.5; 67]) and SOFA (8 [6.5; 9]), but HLPS showed higher death and LPS to PLTP ratio (p median, the risk of death in HLPS (38%) was higher than in LLPS (24%; p Conclusions: Combination of high LPS mass concentration and high SAPS II is associated with elevated mortality in peritonitis-induced SS patients.</p
Table_2_Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.DOCX
No full textObjectives: To investigate the association of plasma LPS mass with mortality and inflammation in patients with peritonitis-induced septic shock (SS).Design: Longitudinal endotoxin and inflammatory parameters in a multicentric cohort of SS.Patients: Protocolized post-operative parameters of 187 SS patients collected at T1 (12 h max post-surgery) and T4 (24 h after T1).Intervention:Post-hoc analysis of ABDOMIX trial.Measurements and Results: Plasma concentration of LPS mass as determined by HPLC-MS/MS analysis of 3-hydroxymyristate, activity of phospholipid transfer protein (PLTP), lipids, lipoproteins, IL-6, and IL-10. Cohort was divided in low (LLPS) and high (HLPS) LPS levels. The predictive value for mortality was tested by multivariate analysis. HLPS and LLPS had similar SAPSII (58 [48.5; 67]) and SOFA (8 [6.5; 9]), but HLPS showed higher death and LPS to PLTP ratio (p median, the risk of death in HLPS (38%) was higher than in LLPS (24%; p Conclusions: Combination of high LPS mass concentration and high SAPS II is associated with elevated mortality in peritonitis-induced SS patients.</p
MOESM1 of Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study
No full textAdditional file 1: Table S1. Clinical and biological parameters collected under high-flow nasal oxygen therapy before the first separation attempt according to the reason for acute respiratory failure among the 22 patients who failed the separation attempt
Table_1_Endotoxin Mass Concentration in Plasma Is Associated With Mortality in a Multicentric Cohort of Peritonitis-Induced Shock.DOCX
No full textObjectives: To investigate the association of plasma LPS mass with mortality and inflammation in patients with peritonitis-induced septic shock (SS).Design: Longitudinal endotoxin and inflammatory parameters in a multicentric cohort of SS.Patients: Protocolized post-operative parameters of 187 SS patients collected at T1 (12 h max post-surgery) and T4 (24 h after T1).Intervention:Post-hoc analysis of ABDOMIX trial.Measurements and Results: Plasma concentration of LPS mass as determined by HPLC-MS/MS analysis of 3-hydroxymyristate, activity of phospholipid transfer protein (PLTP), lipids, lipoproteins, IL-6, and IL-10. Cohort was divided in low (LLPS) and high (HLPS) LPS levels. The predictive value for mortality was tested by multivariate analysis. HLPS and LLPS had similar SAPSII (58 [48.5; 67]) and SOFA (8 [6.5; 9]), but HLPS showed higher death and LPS to PLTP ratio (p median, the risk of death in HLPS (38%) was higher than in LLPS (24%; p Conclusions: Combination of high LPS mass concentration and high SAPS II is associated with elevated mortality in peritonitis-induced SS patients.</p
Brain imaging determinants of functional prognosis after severe endocarditis: a multicenter observational study
No full textInternational audienceObjective We developed a detailed imaging phenotype of the cerebral complications in critically ill patients with infective endocarditis (IE) and determine whether any specific imaging pattern could impact prognostic information. Methods One hundred ninety-two patients admitted to the intensive care units of seven tertiary centers with severe, definite left IE and neurological complications were included. All underwent cerebral imaging few days after admission to define the types of lesions, their volumes, and their locations using voxel-based lesion-symptom mapping (VLSM). We employed uni- and multi-variate logistic regression analyses to explore the associations among imaging features and other prognostic variables and the 6-month modified Rankin Scale (mRS) score. Results Ischemic lesions were the most common lesions (75%; mean volume, 15.3 +/- 33 mL) followed by microbleeds (50%; mean number, 4 +/- 7.5), subarachnoidal hemorrhages (20%), hemorrhagic strokes (16%; mean volume, 14.6 +/- 21 mL), and hemorrhagic transformations (10%; mean volume, 5.6 +/- 11 mL). The volume of hemorrhagic transformations, the severity of leukopathy, and the compromises of certain locations on the motor pathway from the VLSM were associated with a poor 6-month mRS score on univariate analyses. However, upon multivariate analyses, no such specific imaging pattern independently predicted the mRS; this was instead influenced principally by age (OR = 1.03 [1.004-1.06]) and cardiac surgery status (OR = 0.06 [0.02-0.16]) in the entire cohort, and by age (OR= 1.04 [1.01-1.08]) and Staphylococcus aureus status (OR= 2.86 [1.19-6.89]) in operated patients. Conclusions In a cohort of severely ill IE patients with neurological complications, no specific imaging pattern could be highlighted as a reliable predictor of prognosis
Richard Cobden, educationist, economist and statesman.
No full textThe aim of the thesis is to show that Richard Cobden
(1804-1865) deserves to be given a significant place in
the history of political, economic and social thought and
also full credit for a range of statesmanship which went
far beyond his well known part in the repeal of the Corn
Laws and the Anglo-French Commercial Treaty of 1860.
Historians have not sufficiently recognised that Cobden
sought to make fundamental changes in British society and
that he tried to initiate them by piecemeal constitutional
methods. He also believed that the British example would
have a powerful influence on other countries and thus
contribute to a new world order.
Cobden had a coherent, although unsystematised,
philosophy, based on certain major assumptions. They were,
firstly, that social progress depends on the interaction
of economic, moral and religious and educational factors;
secondly that progress towards a real political democracy
depends on progress in the former areas. A special problem
in explaining Cobden's philosophy is the fact that the
ideas of two important thinkers with whom he was associated,
George Combe (1788-1858), phrenologist (psychologist) and
Frederic Bastiat (1801-1850), economist, have been belittled
and neglected since Cobden's death. Therefore, the analysis of Cobden's thought necessitated an effort to "rehabilitate't these two thinkers.
Cobden's efforts to transform British politics and society were only partially successful in Britain's
adoption of free trade, a policy not properly understood
by most statesmen and commercial men. His work for
common schools, international schools, lyceums and
educative popular newspapers was a failure and soon
forgotten; his efforts to reform British foreign policy
and implement arms control also failed. After his death,
his followers failed to develop satisfactorily his ideas
for application to social and international problems. These
ideas still have considerable potential
