196,105 research outputs found
Toxicological screening after the REMEDI
No full textThe REMEDI™ will no longer be supported. Therefore, we had to introduce a new procedure for the general unknown screening. We introduced the GC-MS screening procedure published by Maurer et al. (1) and compared its performance with the REMEDI™ for the four different drug classes: antidepressants, antipsychotics, non-opioid analgesics and anticonvulsants.
Half of the urine sample has been hydrolysed by acid hydrolyses and then been combined
with the other half. Trimipramine-d3 has been added as internal standard and liquid-liquid extraction was performed with dichloromethane/ isopropanol/ethylacetate. The organic phase was evaporated and the residue derivatized with acetanhydride/pyridine using microwave energy.
After evaporation, the residue was dissolved in 50 μl toluene/ethylacetat
e and injected into a TraceTM GC 2000 coupled to a MD 800 mass spectrometer (ThermoQuest, San José, USA). With the exception of sertraline, all antidepressants used in Switzerland could be detected with both methods below the concentration usually found in urine after therapeutic use (cU). The GC-MS procedure had a higher sensitivity for all compounds analysed. Many antipsychotic drugs are only minimally excreted in urine as unchanged drug. Therefore, the detection limit of the
parent drug was often much higher than the cU. The metabolites however could be detected
sufficiently. With the exception of amisulpride, sulpiride and tiapride, all antipsychotics had a
higher sensitivity with the GC-MS procedure.
The non-opioid analgesics and anticonvulsants can only incompletely be detected by the REMEDI™. With the GC-MS procedure all acid drugs of the before mentioned drug classes can only be detected in toxic concentrations. The introduction of a second extraction step using an acidic pH did not improve the sensitivity.
In conclusion, the modified GC-MS screening procedure allows a very complete detection of the antidepressants, antipsychotics, non-opioid analgesics and anticonvulsants. The disadvantage of this new procedure is a turnaround time of about 2 hours
La identidad una actividad : ser maestro / E. Remedi, M. Landesmann, V. Edwards, P. Aristi, A. Castañeda.
No full textSe interroga acerca del quehacer del maestro, lo que para ellos implica, la representación que tienen de su trabajo en el aula
Currículum : maestro y conocimiento / R.M. Torres, E. Remedi, M. Landesmann, V. Edwards.
No full textSe pretende recuperar la discusión acerca del conocimiento y el contenido escolar. Se distinguen dos momentos el primero que tiene que ver con la configuración curricular y el segundo en su etapa de transmisión en el salón de clases
Translation of the REMEDI[e]S (Review of potentially inappropriate MEDIcation pr[e]scribing in Seniors) explicit criteria into seminatural language for use in prescription support systems: A multidisciplinary consensus.
No full textBy recovering data in an ordered manner and at the right time, clinical decision support systems (CDSSs) are designed to help healthcare professionals make decisions that improve patient care.The aim of the present study was to translate the REMEDI[e]s tool's explicit criteria, France's first reference list of potentially inappropriate drugs for the elderly, into seminatural language, in order to implement these criteria as alert rules and then enable their computer coding in a CDSS.This work was carried out at Lille University Hospital by a team of clinical pharmacists with expertise in the use of pharmaceutical decision support systems, in collaboration with the authors of the REMEDI[e]s tool. A total of 3 multi-professional consensus meetings were required to discuss the construction of each rule in seminatural language and the coding choices.All REMEDIES criteria (n=104) were translated into seminatural language. This study is the first to have translated the 104 REMEDI[e]s explicit criteria into seminatural language.One of the study's strengths relates to the close collaboration between the authors of the REMEDI[e]s tool and experts in CDSS programming rules; this ensured the exactitude of the seminatural language translations and limited (mis)interpretations.Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
IDENTIDADES ACADÉMICAS: DE LA UTOPÍA A LA PRODUCTIVIDAD
No full textEn un trabajo anterior hemos explorado las transformaciones de las identidades institucionales de dos generaciones de psicólogos de la UNAM. Aquellas generaciones fueron los primeros actores de un innovador cambio curricular implementado en la institución en la década de los años setenta y que ha marcado profundamente las identidades académicas de ambas generaciones. Desde entonces ha habido cambios importantes en las formas de gestión institucional particularmente con la implementación de nuevas formas de regulación del trabajo académico que plantean nuevas exigencias a los académicos en términos de evaluación, de productividad y de reconocimiento. Algunas de nuestras preguntas hoy se anudan alrededor de los procesos de reestructuración de las identidades académicas de miembros de distintas generaciones, en función de los nuevos modelos de gestión universitaria. Interesa particularmente observar las distintas dinámicas y “ acomodos” identitarios en función de los procesos y trayectos previos, particularmente en aquellos que construyeron en un primer momento sus identidades académicas encontrando un fuerte sostenimiento en modelos utópicos innovadores y vivieron momentos de dolorosas rupturas y aquellos que ingresaron posteriormente en la universidad, con una ausencia de proyectos institucionales que les pudiera interpelar y constituir nichos para el anclaje de sus identificaciones
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
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