101,068 research outputs found
The Observation of Four Separate Fluxional Processes in [Re3(CO)10H3]2-, including an Example of the Rotation of a Re=Re Fragment on ReH(CO)4
No full textMagnetization transfer 13C n.m.r. mesurements have been used to investigate the fluxionality of [Re3(CO)10H3]2– in CD3CN, the lowest energy process being the local scrambling of the carbonyls of the doubly hydride bridged H2Re(CO)3 unit; the next process can be viewed as ‘olefin’ ReH(CO)4, rotation about the ‘acetylene’[(CO)3Re(μ-H)2- Re(CO)3]2–, followed by the single hydride moving to the unbridged edge and finally local carbonyl scrambling on the ReH(CO)4
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Constitutionalising the European Union
No full textEnlargement and treaty reform have moved Europe's constitutional debate into the political spotlight. This important new text outlines the main themes of constitutional debate in the EU, analyzes formal and informal constitution-building since the early days of European integration, and introduces the actors and structures behind treaty chang
Alexander Kraus/ Sabine Reh (Hrsg.): Stadt macht Schule - Wolfsburger Schul- und Stadtplanung zwischen Zeitgeist und Zukunftsvisionen. Göttingen: Wallstein, 2020
No full textNeuhaus T. Alexander Kraus/ Sabine Reh (Hrsg.): Stadt macht Schule - Wolfsburger Schul- und Stadtplanung zwischen Zeitgeist und Zukunftsvisionen. Göttingen: Wallstein, 2020. Bildungsgeschichte (IJHE). 2021;11(1):95-98
PEMANFAATAN BUNYI BAHASA DALAM SERAT WULANG REH KARYA PAKUBUWANA IV (KAJIAN STILISTIKA)
Full text linkThe use of language in Serat Wulang Reh created by Pakubuwana IV, especially related to the utilization of the sounds of language and choice of words. The problems examined this research is how to use the sounds of language in Serat Wulang Reh created by Pakubuwana IV? Data is data write in the form of fragments of the text in which there is the utilization of the sounds of language and choice of words. Data source is the document that Serat Wulang Reh created by Pakubuwana IV consisting of 283 stanzas version of Drs. Darusuprapto published by CV. Citra Jaya, Surabaya in 1982. The data was collected using methods see and record. Data were analyzed using methods distributional and unified method. The process of data analysis using steps or by components: reduction, presentation, verification and drawing conclusions. Preliminary results of this study identified that the utilization of the sounds of language includes purwakanthi swara (assonance), purwakanthi literature (alliteration), purwakanthi lumaksita. The created by Pakubuwana IV using words arkhais including ancient Javanese language diversity. From the use of the language sounds, Pakubuwana IV in his harness purwakanthi swara (assonance) consists of a repetition of vowel [a], [i], [u], [e], [ê], [o], purwakanthi literature (alliteration) consists of a repetition of consonant consonant [b], [d], [g], [h], [j], [k], [l], [m], [n], [ng], [p], [r], [s], [t], [w] and [y], purwakanthi lumaksita ie repetition of syllables and word repetition is productive which makes Serat Wulang Reh as characteristics
Exploring the effects of Merkel cell polyomavirus T antigens expression in REH and MCC13 cells by methylome and transcriptome profiling
No full textMerkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a tripled incidence in the US and Europe over the past decade. Around 80% of MCC is linked to Merkel cell polyomavirus, but the cell of origin remains unknown. We stably introduced Merkel cell polyomavirus (MCPyV)-sT) and LT antigens to MCC13 and REH cell lines, analyzing DNA methylation and gene transcriptional regulation. Gene ontology analysis assessed MCPyV effects, and integrative analysis correlated gene expression and methylation. Expression patterns were compared with 15 previously sequenced primary MCCs. We found that MCPyV-LT induces DNA methylation changes in both cell lines, while MCPyV-sT only affected REH cells. Greater gene expression changes are observed in MCC13 cells, with upregulated genes associated with cellular components and downregulated genes related to biological processes. Integrative analysis of differentially expressed genes (DEG) and differentially methylated regions (DMR) of REH cell lines revealed that no genes were commonly methylated and differentially expressed. The study compared DEGs and DMG in MCC13 and REH cells to overlapping genes in MCPyV-positive cell lines (MKL1, MKL2, and WaGa), identifying hypomethylated genes in the gene body and hypermethylated genes at TSS1500. GO analysis of the two cell lines showed that MCPyV-TAs can downregulate genes in MHC-I pathways; this downregulation offers a target that can be used to create novel and efficient MCC immunotherapy approaches. Finally, it was confirmed that MCPyV-LT controls gene expression in MCC tissues using an integrative investigation of DNA methylation and gene expression
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Full text linkIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Large eddy simulation of transonic turbulent flow over a bump
No full textTransonic turbulent boundary-layer flow over a circular-arc bump has been computed by high-resolution large-eddy simulation of the compressible Navier–Stokes equations. The inflow turbulence was prescribed using a new technique, in which known dynamical features of the inner and outer part of the boundary-layer were exploited to produce a standard turbulent boundary-layer within a short distance of the inflow. This method was separately tested for a flat plate turbulent boundary-layer, for which results compared well with direct numerical simulation databases. Simulation of the bump flow was carried out using high-order methods, with the dynamic Smagorinsky model used for sub-grid terms in the momentum and energy equations. Simulations were carried out at a Reynolds number of 233,000 based on bump length and free-stream properties upstream of the bump. At a back pressure equal to 0.65 times the stagnation pressure, a normal shock was formed near the bump trailing-edge and a peak mean Mach number of 1.16 was observed. Turbulence fluctuations decayed in the favourable pressure gradient region of the flow, before being amplified due to the shock interaction and boundary-layer separation. The effect of Reynolds number on turbulence intensity upstream of the shock is discussed in connection with a laminarisation parameter. With reference to turbulence modelling, anisotropy levels are not unreasonably high in the shock interaction region and shock unsteadiness was not found to be an issue. Of more relevance to the perceived poor performance of models for this type of flow may be the extremely rapid rise and decay of turbulence levels in the separated shear layer immediately under the shock-wave. <br/
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