236 research outputs found
Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines
No full textQuercetin, the major constituent of flavonoid and widely present in fruits and vegetables, is an attractive compound for cancer prevention due to its beneficial anti proliferative effects, showing a crucial role in the regulation of apoptosis and cell cycle signaling. In vitro studies have demonstrated that quercetin specifically influences colon cancer cell proliferation. Our experiments, using human colon adenocarcinoma cells, confirmed the anti proliferative effect of quercetin and gave intriguing new insight in to the knowledge of the mechanisms involved. We observed a significant increase in the expression of the endocannabinoids receptor (CB1-R) after quercetin treatment. CB1-R can be considered an estrogen responsive receptor and quercetin, having a structure similar to that of the estrogens, can interact with CB1-R leading to the regulation of cell growth. In order to clarify the contribution of the CB1-R to the quercetin action, we investigated some of the principal molecular pathways that are inhibited or activated by this natural compound. In particular we detected the inhibition of the major survival signals like the PI3K/Akt/mTOR and an induction of the pro apoptotic JNK/JUN pathways. Interestingly, the metabolism of β-catenin was modified by flavonoid both directly and through activated CB1-R. In all the experiments done, the quercetin action has proven to be reinforced by anandamide (Met-F-AEA), a CB1-R agonist, and partially counteracted by SR141716, a CB1-R antagonist. These findings open new perspectives for anticancer therapeutic strategies
Grazia Deledda’s autobiographical masks
No full textAll’interno della produzione di Grazia Deledda, Cosima è il personaggio più autobiografico, come si può notare dagli esempi riportati. È anche possibile scorgere assonanze tra l’autrice ed altre tre figure femminili protagoniste delle sue opere: Regina, protagonista di Nostalgie, Nina di Il Paese del Vento e Maria Concezione di La chiesa della solitudine.Among Grazia Deledda’s characters, Cosima is the most autobiographical one, as we can notice from the examples. Concordance can be noticed between the author and the female characters of her works: Regina is the main character of Nostalgie, Nina in Il Paese del Vento and Maria Concezione in La chiesa della solitudine
Maria Grazia Turri, Gli oggetti che popolano il mondo. Ontologia delle relazioni, Roma, Carocci, 2012, pp. 239
No full textThe text offers a Critical Review of "Gli oggetti che popolano il mondo. Ontologia delle relazioni" by Maria Grazia Turri. The author critically reflects on the book by considering its methodologies, its arguments, and its relation with other books of the same type and on the same subject.Il testo propone una Lettura Critica del libro "Gli oggetti che popolano il mondo. Ontologia delle relazioni" di Maria Grazia Turri. L'autrice riflette criticamente sul libro considerandone le metodologie, gli argomenti e il nesso con altri libri dello stesso tipo e sullo stesso argomento
LE MASCHERE AUTOBIOGRAFICHE DI GRAZIA DELEDDA
No full textWithin the production of Grazia Deledda, Cosima is the most autobiographical character, as can be seen from the examples shown. It is also possible to see similarities between the author and three other female figures protagonists of her works: Regina, protagonist of Nostalgie, Nina of The Country of the Wind and Maria Concezione of The church of solitude.All’interno della produzione di Grazia Deledda, Cosima è il personaggio più autobiografico, come si può notare dagli esempi riportati. È anche possibile scorgere assonanze tra l’autrice ed altre tre figure femminili protagoniste delle sue opere: Regina, protagonista di Nostalgie, Nina di Il Paese del Vento e Maria Concezione di La chiesa della solitudine.
Abstract
Within the production of Grazia Deledda, Cosima is the most autobiographical character, as can be seen from the examples shown. It is also possible to see similarities between the author and three other female figures protagonists of her works: Regina, protagonist of Nostalgie, Nina of The Country of the Wind and Maria Concezione of The church of solitude
Appunti per una storia dello spazio: piazza Tahrir e reti virtuali nell'Egitto della rivoluzione
No full textIl lavoro si presenta come un’analisi della rivoluzione di piazza Tahrir, alla riscoperta della riappropriazione dello spazio della piazza da parte della popolazione, attraverso l’utilizzo combinato dei social network e dei media tradizionali. La prima parte a cura di Mattia Bonfanti analizza il contesto dei 18 giorni di rivoluzione al Cairo. Il mancato ascolto delle istanze democratiche e un contesto politico affetto da cronica corruzione e miopia della classe dirigente egiziana, ha portato allo scoppio della protesta di piazza Tahrir il 25 gennaio 2011, i cui esiti restano a tutt’oggi controversi. La seconda parte a cura di Maria Grazia Montella si delinea come una riflessione sull’exploit dei social media come “ritorno alla fisicità” e riscoperta delle manifestazioni spaziali e fisiche del dissenso. La connessione tra lo spazio virtuale della rete e lo spazio fisico della piazza è storica, politica e culturale e si innesta nelle riflessioni prese in prestito da Lefebvre e Foucault.The work presents an analysis of the Egyptian uprising and of its most known rich place Tahrir Square. The process of re-appropriation of the space of the square through the combined use of social networks and traditional media is traced through the division in two parts. The first one outlines the political context and the eighteen days of the uprising in Cairo. The author identifies the principal causes of the revolution burst in the failure in listening the people’s request for democracy and in the chronic corruption of the government. The second part argues that the massive usage of the social networks has to be seen as a back to the physical, a revival of spatial and physic demonstration of the dissent. The connection between the virtual space of the internet and the real space of the square is historical, political, and cultural and it has to be sought in Foucault and Lefebvre reflections
Migration as a risk for security. Risk frames in the Italian news on the Libya war and its aftermath
No full textDi fronte a crisi e conflitti internazionali che ridefiniscono i movimenti migratori verso l’Europa, esaminare la rappresentazione delle migrazioni nei mezzi di comunicazione può essere di grande utilità per comprendere come i rischi per la sicurezza sono percepiti, valutati e messi in connessione nel discorso pubblico. L’autrice offre un contributo in questa direzione attraverso l’analisi del framing delle notizie della stampa italiana durante e dopo l’intervento internazionale in Libia (2011-2012). Pur se molteplici aspetti della relazione migrazioni-sicurezza coesistono nei media, l’analisi automatica del contenuto degli articoli di cinque quotidiani nazionali consente di evidenziare la prevalenza di un frame delle migrazioni come rischio per i paesi di destinazione. L’enfasi su questioni di sicurezza come il terrorismo, la criminalità e l’ordine pubblico, inoltre, contribuiscono a caratterizzare le migrazioni come una vera e propria minaccia, riaffermando la dominanza di un discorso noi-centrico e securitario sul fenomeno migratorio.As crises and conflicts in the Middle East and across Africa reshape migration flows to Europe, looking how migration are represented in the media is of crucial importance to understand how multiple risks to security are understood, evaluated and connected to each other in the public discourse. The author contributes to this effort by analysing the framing of migration risks in the Italian press in a two-year period during and following the international military intervention in Libya in 2011. The examination of frames concerning various security risks through automated content analysis, allows to assess the relative relevance of a migration-as-a-risk frame in the press coverage. Albeit frames dealing with different aspects of the security-migration binomial coexist, the author shows how those concerned with direct threats to destination societies are the most frequent, thus revealing the dominance of a we-centric discourse over migration in the media
Il mio ricordo del Professor Mario Galizia
No full textL'autore ricorda gli insegnamenti del maestro nelgli anni universitari con riferimento al ruolo degli organi di controllo della costituzionalità in particolare nella Francia della V RepubblicaThe author recalls the teachings of Professor Mario Galizia in university years with reference to the role of the supervisory bodies of the constitutionality in particular in France of the Fifth Republi
Qualche nota sui prestiti di origine longobarda nel Glossario Bergamasco Medioevale di Antonio Tiraboschi
No full textAntonio Tiraboschi (1838–1883), one of the most prolific scholars living in Bergamo in the second half of the Nineteen century and the author of the Vocabolario dei Dialetti Bergamaschi Antichi e Moderni (1873) [Dictionary of the ancient and modern Bergamo dialects], is a well-known Romance dialectologist. His research interests, however, included other disciplinary areas, such as palaeography and archival sciences, which
enabled him to compile a Medieval Bergamasco Glossary [Glossario Bergamasco Medioevale], whose manuscript, yet unpublished, is deposited in the local Biblioteca Civica Angelo Mai. In this contribution to the memory of Maria Vittoria Molinari, we provide a description of the semantic domains to which the lexemes of Langobard origins mentioned in the Glossary belong. Most of these lexemes are attested in other Italian
regions, and hence, well-documented in the literature. Accordingly, we will focus on Tiraboschi’s dialectological and linguistic comments, as well as on the linguistic traits displayed by the extracts quoted in order to exemplify each lexical entr
L'Italia dopo il referendum del 4 dicembre 2016:tra rischi di ritorno al passato, delegittimazione politica e prospettive future
No full textL'autore analizza il quadro poltico successivo all'esito referendario del 4 dicembre 2016 contrario alla riforma costituzionale. In questo contesto appare chiaro il ruolo determinante giocato dalla Corte costituzionale con riferimento alla decisione relativa alla costituzionalità della legge elettoraleThe author analyzes the political situation following the outcome of the referendum of December 4, 2016 against the constitutional reform. In this context it is clear the decisive role played by the Constitutional Court with regard to the decision on the constitutionality of the electoral la
La mia casa è il mio Paradiso. Note su alcuni racconti di Aḥmad Bašīr al-'Ayla
No full textAḥmad Bašīr al-'Ayla is one of the most prolific and versatile author of Contemporary Palestinian literary landscape. Although he is probably best known for his long poetic career, he is also a journalist, a novelist, a script editor, a radio producer and a short story writer. In 2016 he published his first collection of short stories entitled Al-ḥabl allaḏī tadallā min al-samā’ (The rope hanging from the sky). The stories included in this work are mainly set in Bengazi, which is the city where the author lives since he was a child, and they focus on the tragedy of war and its disasters, first of all the loss and distruction of houses and buildings. In such a tragic context the concept of “house” assumes a fundamental role in a both literal and allegorical sense. It becomes the symbol of identity, family, homeland, something that people has lost and want to regain at any cost. Through the use of a rich, figurative and icastic language, the stories narrated by Aḥmad Bašīr al-'Ayla make the reader reflect on the horror of war and they also remind us the importance of memory as the only antidote against war atrocities
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