7,964 research outputs found
Jonathan Ned Katz Author Event: The Daring Life and Dangerous Times of Eve Adam
No full text“The Daring Life and Dangerous Times of Eve Adams,” interview with author, Jonathan Ned Katz, moderated by Emily Weiner (WWU) and organized by Congregation Beth Israel
Contemporary Literature. Analysis of Jonathan Bazzi's novels
No full textopenDopo una breve panoramica della letteratura italiana degli ultimi vent’anni si analizzano i due romanzi di Jonathan Bazzi "Febbre" e "Corpi minori" dai punti di vista formale, stilistico e tematico. Si discute inoltre il rapporto tra social media, autofiction e autore; nel capitolo 4 si riporta l'intervista che Bazzi ci ha gentilmente concesso, in cui questi argomenti vengono ripresi.
Si individuano alcune differenze che i testi mostrano rispetto alla letteratura moderna, e gli aspetti che hanno in comune con quella contemporanea; nel fare questo si accennano quindi alcune caratteristiche della società che li ha prodotti.The paper starts off with a brief overview of the contemporary Italian literature; then the reader is guided through an analysis of Jonathan Bazzi's novels, "Febbre" ("Fever") and "Corpi minori" ("Minor bodies"), both translated in English and published by Scribe. The relationship between author, autofiction and social media will also be discussed; in chapter four the reader will find the interview Bazzi kindly granted us
Administration and Curricula of the Introductory Graduate Music Research Course
No full textThe introductory research course is an integral part of many graduate music programs, yet there have been few studies that discuss its curricula across institutions. A questionnaire was sent to instructors of the course to identify shared pedagogical approaches among North American schools of music. The survey was divided into sections that prompted respondents to identify issues discussed in the course, including the types and titles of resources, research methodologies, and library use topics. With a response rate of over 40 percent, the survey also contains valuable data concerning the professional identifications of instructors, assignments used for grading, common textbooks, perception of the course’s efficacy, and more. Shared features of the course included the importance of electronic resources; the minimal use of Internet-mediated instruction formats; a strong preference for English-language materials; and a focus on resources such as databases, style guides, collected works, monuments of music, and thematic catalogs over and above others such as repertoire guides, discographies, directories, and iconographies.Peer reviewedThis publication first appeared in Notes Volume 71, Number 3, March 2015, pp. 448-478. This material may not be copied or reposted without explicit permission. Copyright 2015, Jonathan Sauceda
Citizen participation in news
No full textThe process of producing news has changed significantly due to the advent of the Web, which has enabled the increasing involvement of citizens in news production. This trend has been given many names, including participatory journalism, produsage, and crowd-sourced journalism, but these terms are ambiguous and have been applied inconsistently, making comparison of news systems difficult. In particular, it is problematic to distinguish the levels of citizen involvement, and therefore the extent to which news production has genuinely been opened up. In this paper we perform an analysis of 32 online news systems, comparing them in terms of how much power they give to citizens at each stage of the news production process. Our analysis reveals a diverse landscape of news systems and shows that they defy simplistic categorisation, but it also provides the means to compare different approaches in a systematic and meaningful way. We combine this with four case studies of individual stories to explore the ways that news stories can move and evolve across this landscape. Our conclusions are that online news systems are complex and interdependent, and that most do not involve citizens to the extent that the terms used to describe them imply
To what extent is Lemuel Gulliver in Gulliver’s Travels by Jonathan Swift a reflection of the writer with regard to political and religious views, and attitudes toward women and the concept of family?
No full textThis extended essay is an examination of the extent to which the protagonist Lemuel Gulliver in Gulliver’s Travels is a reflection of Jonathan Swift. It involves the exploration of this research question in terms of politics, religion, attitude to women and family; with references to this piece of literature and some secondary resources when necessary. The quotations from published literary criticism are either refuted by examples from the novel or supported in the light of evidence from the novel. Other secondary resources include Swift’s two other prose works, The Modest Proposal and A Letter to a Very Young Lady on Her Marriage, which are referred to briefly for clarification of the evidence. The purpose of this study is to analyse in what ways and to what extent the protagonist is an author-surrogate in the abovementioned ways.
This essay is comprised of two sections, namely “politics and religion” and “women and family”, each focusing on a particular aspect of the investigation. In the first section, Swift’s political and religious standpoint is discussed extensively in order to correctly evaluate Gulliver’s paradigm. By making connections between the beliefs of the author and those of Gulliver, the relation between the two is established to support the claim of this essay. In the second section, the female figures in the novel and Gulliver’s perception of them are inspected. The plot is also taken into consideration in this part of the inquiry although the central focus is on the persona.
In the conclusion, it is validated that Gulliver is a reflection of Jonathan Swift with regard to political and religious vision, and attitude towards women and family, by juxtaposing and assembling the main elements of personification of Gulliver and Jonathan Swift’s personal ideas and experiences
Multivariate methods for the statistical analysis of hyperdimensional high-content screening data
No full textThesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2014.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references.In the post-genomic era, greater emphasis has been placed on understanding the function of genes at the systems level. To meet these needs, biologists are creating larger, and increasingly complex datasets. In recent years, high-content screening (HCS) using RNA interference (RNAi) or other perturbation techniques in combination with automated microscopy has emerged as a promising investigative tool to explore intricate biological processes. Image-based HC screens produce massive hyperdimensional data sets. To identify novel components of the DNA damage response (DDR) after ionizing radiation, we recently performed an image-based HC RNAi screen in an osteosarcoma cell line. Robust univariate hit identication methods and manual network analysis identied an isoform of BRD4, a bromodomain and extra-terminal domain family member, as an endogenous inhibitor of DDR signaling. However, despite the plethora of data generated from our and other HC screens, little progress has been made in analyzing HC data using multivariate computational methods that exploit the full richness of hyperdimensional data and identify more than just the most salient knockdown phenotypes to gain a detailed understanding of how gene products cooperate to regulate complex cellular processes. We developed a novel multivariate method using logistic regression models and least absolute shrinkage and selection operator regularization for analyzing hyperdimensional HC data. We applied this method to our HC screen to identify genes that exhibit subtle but consistent phenotypic changes upon knockdown that would have been missed by conventional univariate hit identication approaches. Our method automatically selects the most predictive features at the most predictive time points to facilitate the more ecient design of follow-up experiments and puts the identied hits in a network context using the Prize-Collecting Steiner Tree algorithm. This method offers superior performance over the current gold standard for the analysis of HC RNAi screens. A surprising finding from our analysis is that training sets of genes involved in complex biological phenomena used to train predictive models must be broken down into functionally coherent subsets in order to enhance new gene discovery. Additionally, we found that in the case of RNAi screening, statistical cell-to-cell variation in phenotypic responses in a well of cells targeted by a single shRNA is an important predictor of gene dependent events.by Jonathan Rameseder.Ph. D
GSU Sponsors Noted Activist, Author Jonathan Kozol
No full textActivist, educator, and author, Jonathan Kozol, has never been one to mince words or soften his stance. He has spent his life denouncing inequities in education and working tirelessly to elicit conversation and excite change.
On June 23, at 7 p.m., Governors State University’s Metropolitan Institute for Leadership in Education (MILE) will sponsor an appearance by Kozol to discuss the problems and possibilities of public school education
Some remarks upon a pamphlet, entitl’d, A letter to the seven lords of the committee, appointed to examine Gregg. By the author of the Examiner
No full textProteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer
No full textDespite optimal radiation therapy (RT), chemotherapy and/or surgery, a majority of patients with locally advanced non-small cell lung cancer (NSCLC) fail treatment. To identify novel gene targets for improved tumor control, we performed whole genome RNAi screens to identify knockdowns that most reproducibly increase NSCLC cytotoxicity. These screens identified several proteasome subunits among top hits, including the topmost hit PSMA1, a component of the core 20 S proteasome. Radiation and proteasome inhibition showed synergistic effects. Proteasome inhibition resulted in an 80–90% decrease in homologous recombination (HR), a 50% decrease in expression of NF-κB-inducible HR genes BRCA1 and FANCD2, and a reduction of BRCA1, FANCD2 and RAD51 ionizing radiation-induced foci. IκBα RNAi knockdown rescued NSCLC radioresistance. Irradiation of mice with NCI-H460 xenografts after inducible PSMA1 shRNA knockdown markedly increased murine survival compared to either treatment alone. Proteasome inhibition is a promising strategy for NSCLC radiosensitization via inhibition of NF-κB-mediated expression of Fanconi Anemia/HR DNA repair genes.American Society for Radiation Oncology (Junior Faculty Career Research Training Award)Harvard University. Joint Center for Radiation Therapy (Foundation Grant)Dana-Farber/Harvard Cancer Center (SPORE Developmental Research Project Award in Lung Cancer Research)National Cancer Institute (U.S.) (Award K08CA172354
Activist, Author Jonathan Kozol to Speak at GSU
No full textActivist, educator, and author Jonathan Kozol will speak about raising and education our children in a fair and effective society on April 22, at 6:30 p.m., at Governors State University’s Center for Performing Arts. The event is free and open to the public
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