2,681 research outputs found
Retrospektive Analyse der VRE-Infektion und -Kolonisationsrate in einem hämatologisch-onkologischen Patientenkollektiv für die Jahre 2017 und 2018
No full textIV, 92 Seiten ; Illustrationen, Diagramm
Optimierung einer transkutanen Immunisierungsstrategie gegen Influenza-Peptide
No full textVII, 94 Seiten ; Illustrationen, Diagramm
Evidence based leadership
No full textAuthor Markus PodduikinMasterarbeit Johannes Kepler Universität Linz 2024Arbeit gesperr
Improving the search for monitoring tools using recommender technology
No full textAuthor Markus Eisl BSc.Masterarbeit Universität Linz 2023Arbeit gesperr
Improving the search for monitoring tools using recommender technology
No full textAuthor Markus Eisl BSc.Masterarbeit Universität Linz 2023Arbeit gesperr
metal-organic framework 4H, 4H-octafluoroazobenezene perfluoroazobenzene
No full textauthor: Markus RödlKumulative Masterarbeit aus einem ArtikelMasterarbeit University of Innsbruck 2022Arbeit gesperr
metal-organic framework 4H, 4H-octafluoroazobenezene perfluoroazobenzene
No full textauthor: Markus RödlKumulative Masterarbeit aus einem ArtikelMasterarbeit University of Innsbruck 2022Arbeit gesperr
Strategi Pelayanan Lintas Budaya Berdasarkan Markus 4:1-34
No full textHarming & Katarina, Cross-cultural Service Strategy based on Mark 4: 1-34. The author conducted a study of the text of Mark 4: 1-34 using qualitative research literature study using the biblical hermeneutic principle. Based on the analysis of the text of Mark 4: 1-34 the authors find there are four cross-cultural service strategies namely by understanding local culture, using media. Harming & Katarina, Strategi Pelayanan Lintas budaya Berdasarkan Markus 4:1-34. Penulis melakukan penelitian terhadap teks Markus 4:1-34 dengan menggunakan penelitian kualitatif studi pustaka dengan menggunakan prinsip hermeneutik Alkitab. Berdasarkan analisis terhadap teks Markus 4:1-34 penulis menemukan ada empat strategi pelayanan lintas budaya yaitu dengan memahami budaya lokal, menggunakan media yang ada dalam budaya, memberdayakan potensi yang ada, dan menciptakan terobosan
A study on the effects of calreticulin del52 mutation on neutrophil adhesion : Results from CALRdel52 knock-in mice and characterization of a novel CALRdel52 Catchup mouse model
No full textIn the pathophysiology of classical Philadelphia-negative myeloproliferative neoplasms (MPNs), JAK2-
V617F represents the most prevalent underlying disease driver mutation followed by deletion mutations
in the gene encoding the endoplasmatic reticulum chaperone calreticulin (CALR). Patients harboring
CALRdel mutations are at a lower risk of thrombosis as opposed to JAK2-V617F mutation carriers, but
this difference in thrombotic risk has yet not been clarified at the molecular level. Our research group
has shown for the first time that a JAK2-V617F-mediated shift of neutrophil-bound integrins to the high-
affinity conformation leads to increased thrombus formation by strengthening neutrophil adhesion to
the endothelial adhesion molecule vascular cell adhesion molecule 1 and lymphocyte function-
associated antigen 1. Contrary to JAK2-V617F, much remains unknown regarding the effect CALRdel on
neutrophil biology. In this doctoral thesis, we employ a novel neutrophil-specific CALRdel Catchup model
and a hematopoietic-specific VavCre CALRdel mouse model to evaluate the impact of CALRdel on
neutrophil function. In both murine models, CALRdel was not associated with increased integrin-
mediated adhesion. Interestingly, a decreased binding of CALR-mutated neutrophils to E-selectin under
flow and partially under static conditions was observed. In addition, CALRdel-expressing neutrophils
were not capable of inducing a chronic myeloproliferative phenotype as assessed by similar blood
counts and spleen size of CALRdel/+ Catchup mice compared to their wild-type counterparts. As opposed
to a recently described JAK2-V617F Catchup mouse model, CALRdel/+ Catchup mice did not exhibit
elevated levels of key pro-inflammatory cytokines, which points towards a minor role of CALRdel-
expressing granulocytes in chronic non-resolving inflammation of MPNs. Our findings indicate that JAK2-
V617F and CALRdel differentially regulate neutrophil-related adhesion and inflammation in the
pathogenesis of MPNs
Hemmbarkeit von humanen T-Zellen durch den FLT3-Kinase-Inhibitor Midostaurin im Vergleich zum SRC-Kinase-Inhibitor Dasatinib
No full textUniversität Magdeburg, Dissertation, 2016vorgelegt von Christine Höding, geb.: Seidler geb. 23.04.1986 in Magdebur
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