324,864 research outputs found
Reinvented temporality: three projects by Smiljan Radic
No full textA partir do estudo das obras de Smiljan Radic, esta pesquisa busca rastrear os campos ampliados circundantes à arquitetura e o seus rebatimentos nas obras construídas do arquiteto. Por meio da análise de três estudos de caso a Vinícola Vik, o Centro de Artes Cênicas Nave e o Teatro de Bio Bio , este trabalho identifica conceitos recorrentes ao longo de sua trajetória, os quais, ao se integrarem em diferentes escalas, reiteram os processos vinculados às suas pesquisas. Estes aspectos são reflexos de seus estudos realizados no Chile durante sua formação e posteriormente em seu mestrado em Veneza, e que explicitam um mundo conformado por memórias e admirações teóricas. Essas influências abordam desde campos construtivos enraizados na cultura local até referências amplas relacionadas à sua formação acadêmica e que, através de sua obra realizada em maior escala, se expõem ao debate público. Por meio do acesso a fontes primárias, visitas a campo, desenhos autorais, atento às referências explicitadas pelo arquiteto e em textos críticos como os de Sato (2007), Crispiani (2013) e Ursprung (2019), a dissertação sistematiza esses conceitos para identificar de forma direta o reflexo desses elementos em sua obra.Based on the study of Smiljan Radic\'s works, this research seeks to trace the expanded fields surrounding architecture and their reflections in the architect\'s built projects. By analyzing three case studies the Vik Winery, the Nave Center for Performing Arts, and the Bio Bio Theater this study identifies recurring concepts throughout Radic\'s trajectory. These concepts, when integrated at different scales, reaffirm the processes linked to his research. These aspects are reflections of his studies conducted in Chile during his education and later during his masters degree in Venice, revealing a world shaped by memories and theoretical admirations. These influences range from constructional fields rooted in the local culture to broader references related to his academic formation. Through his larger-scale works, these influences are exposed to public discussion. From primary sources, visits to sites, original drawings, and taking into account references provided by the architect and critical texts by authors like Sato (2007), Crispiani (2013), and Ursprung (2019), this dissertation systematizes these concepts to directly identify their reflection in Radic\'s work
Pflege & Robotik: Gemeinsam in die Zukunft
No full textS.22-23Assistenzroboter können in der Pflege unterstützen. Obwohl der Bedarf sehr groß und das Potenzial bekannt ist, nimmt ihre Verbreitung und Anwendung im deutschen Gesundheitswesen nur sehr langsam an Fahrt auf. Darüber sprachen wir mit Dr. Marija Radic, Abteilungsleiterin Unternehmensentwicklung im internationalen Wettbewerb, und Dr. Agnes Vosen - beide forschen am Fraunhofer-Zentrum für Internationales Management und Wissensökonomie IMW.74Nr.1
N-Nitroso products from the reaction of indoles with Angeli's salt
No full textWhile nitroxyl (HNO) has been shown to engage in oxidation and hydroxylation reactions, little is known about its nitrosating potential. We therefore sought to investigate the kinetics of formation and identity of the reaction products of the classical nitroxyl donor Angeli's salt (AS) with three representative tryptophan derivates (melatonin, indol-3-acetic acid, and N-acetyl-l-tryptophan) in vitro. In the presence of oxygen and at physiological pH, we find that the major products generated are the corresponding N-nitrosoindoles with negligible formation of oxidation and nitration products. A direct comparison of the effects of AS, nitrite, peroxynitrite, aqueous NO* solution, and the NO-donor DEA/NO toward melatonin revealed that nitrite does not participate in the reaction and that peroxynitrite is not an intermediate. Rather, N-nitrosoindole formation appears to proceed via a mechanism that involves electrophilic attack of HNO on the indole nitrogen, followed by a reaction of the intermediary hydroxylamine derivative with oxygen. Further in vivo experiments demonstrated that AS exhibits a unique nitrosation signature which differs from that of DEA/NO inasmuch as substantial amounts of a mercury-resistant nitroso species are generated in the heart, whereas S-nitrosothiols are the major reaction products in plasma. These data are consistent with the notion that the generation of nitroxyl in vivo gives rise to formation of nitrosative post-translational protein modifications in the form of either S- or N-nitroso products, depending on the redox environment. It is intriguing to speculate that the particular efficiency of nitroxyl to form N-nitroso species in the heart may account for the positive inotropic effects observed with AS earlier
Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins
No full textBackground
S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins – is a posttranslational modification involved in signal transduction and nitric oxide (NO) transport. Recent studies would also suggest the formation of N-nitrosamines (RNNOs) in proteins in vivo, although their biological significance remains obscure. In this study, we characterized a redox-based mechanism by which N-nitroso-tryptophan residues in proteins may be denitrosated.
Methodology/Principal Findings
The denitrosation of N-acetyl-nitroso Trp (NANT) by glutathione (GSH) required molecular oxygen and was inhibited by superoxide dismutase (SOD). Transnitrosation to form S-nitrosoglutathione (GSNO) was observed only in the absence of oxygen or presence of SOD. Protein denitrosation by GSH was studied using a set of mutant recombinant human serum albumin (HSA). Trp-214 and Cys-37 were the only two residues nitrosated by NO under aerobic conditions. Nitroso-Trp-214 in HSA was insensitive to denitrosation by GSH or ascorbate while denitrosation at Cys-37 was evident in the presence of GSH but not ascorbate. GSH-dependent denitrosation of Trp-214 was restored in a peptide fragment of helix II containing Trp-214. Finally, incubation of cell lysates with NANT revealed a pattern of protein nitrosation distinct from that observed with GSNO.
Conclusions
We propose that the denitrosation of nitrosated Trp by GSH occurs through homolytic cleavage of nitroso Trp to NO and a Trp aminyl radical, driven by the formation of superoxide derived from the oxidation of GSH to GSSG. Overall, the accessibility of Trp residues to redox-active biomolecules determines the stability of protein-associated nitroso species such that in the case of HSA, N-nitroso-Trp-214 is insensitive to denitrosation by low-molecular-weight antioxidants. Moreover, RNNOs can generate free NO and transfer their NO moiety in an oxygen-dependent fashion, albeit site-specificities appear to differ markedly from that of RSNOs
H-RADIC: una solución de tolerancia a fallos para clústeres virtuales en ambientes multi-nube
No full textEven though the cloud platform promises to be reliable, several availability incidents prove that it is not. How can we be sure that a parallel application finishes it´s execution even if a site is affected by a failure? This paper presents H-RADIC, an approach based on RADIC architecture, that executes parallel applications protected by RADIC in at least 3 different virtual clusters or sites. The execution state of each site is saved periodically in another site and it is recovered in case of failure. The paper details the configuration of the architecture and the experiment´s results using 3 clusters running NAS parallel applications protected with DMTCP, a very well-known distributed multi-threaded checkpoint tool. Our experiments show that by adding a cluster protector it will be possible to implement the next level in the hierarchy, where the first level in the RADIC hierarchy works as an observer at a site level. In adition, the experiments showed that the protection implementation is out of the critical path of the application and it depends on the utilized resources.Aunque las plataformas en la nube parecen ser muy confiables, varios incidentes de disponibilidad han podemos asegurarnos que una aplicación paralela termina su ejecución cuando el sitio en la nube ha sido afectado por una falla? Este articulo presenta HRADIC, un enfoque basado en la arquitectura RADIC, esta ejecuta aplicaciones paralelas en al menos 3 diferentes sitios o clústeres virtuales, todos protegidos por RADIC, donde el estado de la ejecución de cada sitio es guardado periódicamente en otro de los sitios y de ahí es recuperado en el caso de una falla. El articulo detalla la configuración de la arquitectura y los resultados de los experimentos usando 3 clústeres ejecutando aplicaciones NAS en paralelo, protegidas con DMTCP (una herramienta para realizar múltiples checkpoints). Nuestros experimentos muestran que al agregar un protector del clúster es posible implementar un nivel más en la jerarquía de RADIC, donde el primer nivel funciona como observador. Los experimentos muestran que la implementación de este protector esta fuera del camino critico de la ampliación y depende solamente de la utilización de recursos.Facultad de Informátic
Unimpaired phase-sensitive amplification by vector four-wave mixing near the zero-dispersion frequency
No full textPhase-sensitive amplification (PSA), which is produced by degenerate four-wave mixing (FWM) in a randomly-birefringent fiber, has the potential to improve the performance of optical communication systems. Scalar FWM, which is driven by parallel pumps, is impaired by the generation of pump-pump and pump-signal harmonics, which limit the level, and modify the phase sensitivity, of the signal gain. In contrast, vector FWM, which is driven by perpendicular pumps, is not impaired by the generation of harmonics. Vector FWM produces PSA with the classical properties of a one-mode squeezing transformation. © 2007 Optical Society of America
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Efficiency and competition in the investment banking industry
No full textQuesta tesi tratta sostanzialmente tre temi principali, inerenti l’efficienza e la competizione nell’ambito dell’investment bank, ognuno dei quali costituisce un capitolo della stessa. Il primo dei temi (Cap.2) ripercorre e recensisce la letteratura sull’argomento investment banking e fornisce una indicazione sulle tendenze più recenti nell’industria. Il secondo tema (Cap.3) analizza costo e guadagno di efficienza relativamente al caso di un investment banks per i paesi del G7 (Canada, Francia, Germania, Italia, Giappone, Gran Bretagna e Stati uniti d’America) e la Svizzera prima della recente crisi finanziaria.
Si è adottata la metodologia proposta da Coelli et al. (1999) per adattare (o aggiustare) il costo stimato e gli scores del guadagno di efficienza alle influenze dei fattori ambientali inclusi i “key banks’ risks”, i fattori specifici del sistema bancario e di quello industriale e le condizioni macroeconomiche.
I risultati a nostra disposizione ci suggeriscono che non tenere in considerazione i fattori ambientali può far spostare notevolmente gli scores registrati per i guadagni di efficienza dell’investment bannks. In particolare, il considerare i fattori di rischio bancario, (incluse liquidità ed esposizione al rischio) è stato molto importante per poter fissare accuratamente il guadagno di efficienza: vale a dire che i valori calcolati per il guadagno di efficienza sarebbero stati notevolmente sottostimati se non si fosse tenuto conto del rischio preso dalla banca. I dati ottenuti ci suggeriscono anche un altro fatto molto interessante, che la scala (o grandezza) influisce su entrambe i fattori; il costo e il guadano di profitto, sebbene ciò non implichi che mercati più concentrati siano per questo più efficienti.
Per ultimo (Cap.4) si è cercato di investigare la relazione esistente tra potere di mercato ed efficienza e di esplorare le caratteristiche di condizioni competitive nell’investment banking mondiale.
Al fine di condurre le analisi delle condizioni di competitività dei diversi paesi e del livello di efficienza regionale, abbiamo utilizzato inizialmente l’approccio delle frontiere stocastiche per creare il modello del costo efficienza e in un secondo momento abbiamo investigato l’indice di Lerner sul potere del monopolio per testare il grado di potere di mercato nell’industria dell’investment banking.
Per comprendere più a fondo gli schemi di competizione in tale industria abbiamo utilizzato i modelli proposti da Panzer e Rosse per il calcolo del grado di competizione nell’investment banking mondiale. Da ultimo, per investigare la relazione esistente tra potere di mercato ed efficienza abbiamo applicato un test di casualità. I dati utilizzati sono stati quelli provenienti dal bilancio, dalle dichiarazioni di reddito e dai report annuali per i 15 paesi presi in esame nel periodo 2001-2008. Le analisi effettuate evidenziano il fatto che i mercati mondiali dell’investment banking hanno iniziato ad essere progressivamente più concentrati e con un costo efficienza minore. Comunque questo non è stato il caso di tutti i paesi. Inoltre, L’investment bank sembra aver ridotto i loro costi marginali più velocemente della caduta dei prezzi e questo ha condotto ad un aumento nell’indice di Lerner che suggerisce quindi un più elevato potere di mercato. I risultati provenienti dalle statistiche di H, ci portano a conclusioni analoghe, indicando l’esistenza di oligopoli in conflitto nel mercato. Le evidenze di una relazione tra potere di mercato ed efficienza non è immediata, e altri fattori (tra cui gli incentivi al rischio, il contesto e la struttura delle regole etc) potrebbero influenzare sia la grandezza che la direzione di tale relazione e quindi potrebbero essere presi in considerazione per gli sviluppi futuri della ricerca su questa tematica.This thesis consists of three substantive essays on investment bank efficiency and competition, each constituting a separate chapter. The first essay (Chapter 2) reviews the literature on investment banking and provides indication on the recent trends in the industry.
The second essay (Chapter 3) analyses cost and profit efficiency for a sample of investment banks for the G7 countries (Canada, France, Germany, Italy, Japan, UK and US) and Switzerland prior to the recent financial crisis. We follow Coelli et al. (1999)’s methodology to adjust the estimated cost and profit efficiency scores for environmental influences including key banks’ risks, bank and industry specific factors and macroeconomic conditions. Our evidence suggests that failing to account for environmental factors can considerably bias the efficiency scores for investment banks. Specifically, bank-risk taking factors (including liquidity and capital risk exposures) are found particularly important to accurately assess profit efficiency: i.e. profit efficiency estimates are consistently underestimated without accounting for bank risk-taking. Interestingly, our evidence suggests that size matters for both cost and profit efficiency, however this does not imply that more concentrated markets are more efficient.
The final essay (Chapter 4) investigates the relationship between market power and efficiency, and explores characteristics of competitive conditions in worldwide investment banking. In order to conduct analysis of the countries competitive conditions and regional efficiency level, first we use stochastic frontier approach to model cost efficiency, and second we investigates Lerner index of monopoly power to test the degree of the market power in the investment banking industry. To further comprehend competition pattern in the industry we use Panzar and Rosse model to assess the degree of competition in worldwide investment banking. Lastly, to investigate the relationship between market power and efficiency, we apply a causality test. Data used was obtained from balance sheet, income statement and annual reports data for the 15 countries over 2001-2008 periods. The analysis highlights the fact that the investment banking markets worldwide are becoming progressively more concentrated and less cost efficient. However this is not the case for all the countries. Further, investment banks seem to have reduced their marginal costs faster than price falls and this led to an increase in the Lerner index thus suggesting greater market power. Results from H: Statistics lead to similar conclusions, hence indicating existence of colluding oligopoly in the market. The findings on the relationship between market power and efficiency is not straightforward and that other factors (such as among others, risk incentives, regulatory framework and contestability) may influence both the magnitude and the direction of the relationship and therefore should be accounted for in future research in this area
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Combination of searches for invisible decays of the Higgs boson using 139 fb-1 of proton-proton collision data at & RADIC;s=13 TeV collected with the ATLAS experiment
No full textMany extensions of the Standard Model predict the production of dark matter particles at the LHC. Sufficiently light dark matter particles may be produced in decays of the Higgs boson that would appear invisible to the detector. This Letter presents a statistical combination of searches for H & RARR; invisible decays where multiple production modes of the Standard Model Higgs boson are considered. These searches are performed with the ATLAS detector using 139 fb-1 of proton-proton collisions at a centre-of-mass energy of & RADIC;s = 13 TeV at the LHC. In combination with the results at & RADIC;s = 7 TeV and 8 TeV, an upper limit on the H & RARR; invisible branching ratio of 0.107 (0.077) at the 95% confidence level is observed (expected). These results are also interpreted in the context of models where the 125 GeV Higgs boson acts as a portal to dark matter, and limits are set on the scattering cross-section of weakly interacting massive particles and nucleons. & COPY; 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons .org /licenses /by /4 .0/). Funded by SCOAP3
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