926 research outputs found

    D.H. Lawrence, La Volpe, traduzione e cura di Stefania Michelucci, edizione bilingue

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    It is the bilingual and critical edition of D.H. Lawrence's The Fox in the series, Elsinore, Collana di Classici Inglesi, edited and translated by Stefania Michelucci The volume consists of a long introduction to the text, pp 11-37, of a biographical article on the author and his work (l'autore e l'opera), pp. 39-45), of a note to the text (pp. 47-48) (English and Italian, page to page, pp. 49-227) of explicatory notes (pp. 229-243) and of a biographical section (pp. 245-252)

    Ricordo di Stefania Rossi Minutelli

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    The author commemorates Stefania Rossi Minutelli – librarian at the Marciana National Library from 1971 to 2005, who died on october 10th, 2008 – remembering her professional career and her role within the Italian Library Association.L'autore ricorda con affetto e stima professionale Stefania Rossi Minutelli – bibliotecaria marciana dal 1971 al 2005, scomparsa nell'ottobre 2008 – ripercorrendo il tratto di strada fatto insieme all'interno dell'Associazione Italiana Biblioteche e del mondo bibliotecario italiano

    Tricyclic Pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6- tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

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    A series of analogues of 8-chloro-1-(2′,4′-dichlorophenyl)-AT- piperidin-1-yl-1,4,5,6-tetrahydrobenzo-[6,7]cyclohepta[1,2-c] pyrazole-3-carboxamide 4a (NESS 0327) (Ruiu, S.; Pinna, G. A.; Marchese, G.; Mussinu, J. M.; Saba, P.; Tambaro, S.; Casti, P.; Vargiu, R.; Pani, L. Synthesis and Characterization of NESS 0327: A Novel Putative Antagonist of CB 1 Cannabinoid Receptor. J. Pharmacol. Exp. Ther. 2003, 306, 363-370) was synthesized and evaluated for their affinity to cannabinoid receptors. Depending on the chemical modification of the lead structure that was chosen, compounds 4b, 4c, 4i, 4l, and 4m still proved to be potent binders of the CB1 receptor. Moreover, several analogues (4c, 4d, 4e, and 4m) demonstrated superior CB2 receptor binding affinities compared to the parent ligand. Compounds 4b, 4c, 4i, and 4l displayed the most promising pharmacological profiles, having the highest selectivity for CB1 receptors with Ki(CB2) to Ki(CB1) ratios of 11 250, 2000, 3330 and 4625, respectively. Compound 4c increased the intestinal propulsion in mice and antagonized the effect induced by the CB 1 receptor agonist WIN 55,212-2. Finally, molecular modeling studies were carried out on a set of tricyclic pyrazoles (2a-4a) and on rimonabant 1 (SR141716A), indicating that high CB1 receptors affinities were consistent for the tricyclic derivatives, both with a nonplanar geometry of the tricyclic cores and with a precise orientation of the substituent (chlorine) on this ring system. © 2005 American Chemical Society

    Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study

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    The prevalence of hypovitaminosis D is increasing worldwide. Vitamin D deficiency is supposed to play a role in sleep disturbances, but the complex relationships between hypovitaminosis D and pediatric obstructive sleep apnea syndrome (OSAS) are still incompletely understood. This study was aimed to retrospectively investigate the vitamin D status and significant clinical, laboratory, and instrumental variables in a cohort of pediatric patients with OSAS and to assess the possible relationship between serum vitamin D levels and OSAS severity. We consecutively enrolled all children aged 2–14 years admitted to our Pediatric Clinic from 1 July 2018 to 30 November 2020 for sleep-disordered breathing. Each patient underwent standard overnight in-hospital polygraphic evaluation, measurement of serum 25-hydroxyvitamin D (25(OH)D) levels, and clinical and laboratory investigation. A total of 127 children with OSAS were included. The 25(OH)D levels and BMI of OSAS patients were compared with those of an age-matched control group: the serum 25(OH)D levels were significantly lower in OSAS patients than in controls (22.4 vs. 25.5 ng/mL; p-value = 0.009), whereas no differences in the BMI percentile were found between the two groups. The mean value of 25(OH)D was not significantly lower (20.9 ng/mL) in the severe OSAS group compared with the mild (23.0 ng/mL) and moderate (23.3 ng/mL) OSAS groups (p-value = 0.28). Our findings indicate a relationship between vitamin D status and OSAS in children and suggest that severe cases of OSAS have lower vitamin D levels. Future, more extensive prospective studies are needed to confirm such preliminary findings

    The Global Art Gallery Report with Richard Taittinger, Magnus Resch, Stefania Bortolami, and James Fuentes

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    Moderator: Magnus Resch Book Author and Art Entrepreneur Panelists: Stefania Bortolami, Gallery Owner James Fuentes, Gallery Owner Richard Taittinger, Gallery Owner The Global Art Gallery Report is the first and the most wide-ranging report on today\u27s commercial art galleries. Published by Phaidon, it is the first insight of its kind, presenting a detailed and comprehensive portrait of today\u27s gallery scene. In a panel discussion, Magnus Resch will discuss his findings with gallerists Jeffrey Deitch, Stefania Bortolami and James Fuentes. Panelists will shine a light on the future of the art gallery. Founded in 1969, the Sotheby’s Institute of Art is the first and foremost graduate school for the study of art and its markets. With more than 6,000 alumni working internationally in art fairs, galleries, museums, auction houses, and nonprofits, the Institute’s alumni are shaping the future of the art industry. Past guest speakers at the Institute have included artists, such as: Ulay and Jaša, Dan Graham, Alexandre Singh, Glenn Ligon, Sanford Biggers, Carolee Schneemann, Dara Birnbaum, Alfredo Jaar, Ahmed Alsoudani; and art industry experts from Sotheby’s, Art Basel, Paddle8, Auctionata, Armory Show, Artsy, Whitney Museum, Swiss Institute, MoMA, and others.https://digitalcommons.sia.edu/speaker/1007/thumbnail.jp

    A Human Rights Approach to Environmental Health

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    This chapter explores the interface between health and the environment through the human rights prism, focusing on the environmental dimension of the right to health and on the now widely recognized right to a healthy, safe and clean environment. To this end, the chapter intends to offers a comprehensive analysis of the relevant provisions contained in human rights treaties and the obligations stemming therefrom. The review of these legal sources is completed by a critical assessment of the case law produced by regional human rights bodies and their evolutive interpretation of individual rights and corresponding State obligations in this field, with a special focus on the case law of the European Court of Human Rights. The aim of this legal analysis is to evaluate the added value of a human rights approach to environmental health litigation, with a view to best achieving the overarching goal of public health protection from environmental harm. The author highlights that human rights can be used in court as effective tools to protect public health against the adverse effects of environmental degradation and severe pollution. She also stresses that the potential of human rights bodies in the field of environmental health is yet fully unexpressed, but further positive developments towards the protection of collective and intergenerational rights related to the environment and human health can be achieved thanks to the dynamic and evolutive approach adopted by these bodies and through the virtuous circle created by judicial cross-fertilization

    A Multitude of Women: The Challenges of the Contemporary Italian Novel

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    A Multitude of Women looks at the ways in which both Italian literary tradition and external influences have assisted Italian women writers in rethinking the theoretical and aesthetic ties between author, text, and readership in the construction of the novel. Stefania Lucamante discusses the valuable contributions that Italian women writers have made to the contemporary novel and illustrates the relevance of the novelistic examples set by their predecessors. She addresses various discursive communities, reading works by Di Lascia, Ferrante, Vinci, and others with reference to intertextuality and the theories of Elsa Morante and Simone de Beauvoir. This study identifies a positive deviation from literary and ideological orthodoxy, a deviation that helps give meaning to the Italian novel and to transform the traditional notion of the canon in Italian literature. Lucamante argues that this is partly due to the merits of women writers and their ability to eschew obsolete patterns in narrative while favoring forms that are more attuned to the ever-changing needs of society. She shows that contemporary novels by women authors mirror a shift from previous trends in which the need for female emancipation interfered with the actual literary and aesthetic significance of the novel. A Multitude of Women offers a new epistemology of the novel and will appeal to those interested in women's writing, readership, Italian studies, and literary studies in general

    Stefania Poznanska (1923-2010) : a teacher, nursing tutor

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    Stefania Poznańska, PhD, was one of five managers of the school, which informal name was Cracow School of Nurses. The School was founded on 5 November 1911 under the name of School of Professional Nursing, also called the "old Cracow school". Its successor i.e. the University School of Nurses and Health Carers later Hygienists was opened on 10 December 1925. The abovementioned term also refers to the following nursing schools: University School of Nursing and Midwifery (1946-1951), Public School of Nursing and Midwifery (1949-1951), Public School Of Nursing (1950-1964), Public Medical School of Nursing (1964-1971), Department of Nursing of the Medical Vocational College No 1 (1971-1981), and Anna Rydlówna Department of Nursing of the Medical Vocational College No 1 (1982-2001). The school was localised in Cracow, 25 Kopernika St. until 1975, and then was moved to a new location - 12 Michałowskiego St. The aim of the study was the recollection of Stefania Poznańska, PhD, a nurse, teacher, tutor of nursing, author of multiple research studies and publications, a person dedicated to the development of modern nursing, and last but not least, a great fiend. The study material is based on a review of personal notes and archive materials gathered by the Institute of Nursing and Midwifery, Faculty of Health Sciences, Medical Collage, Jagiellonian University in Cracow. Also, personal recollections of multiple encounters with Stefania Poznańska were taken into account. A biography-historical method as well as the review of documents were applied by the authors. A significant contribution of Stefania Poznańska to the development of modern nursing must be emphasized. This contribution included her work for the Programme Committee in Cracow for nursing education curriculum at university level as well as specific detailed programs regarding nursing history and ethical issues in nursing care, and the publication of a series of articles on new concept for teaching nursing profession. Stefania Poznańska was a person open to another human being
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