118,477 research outputs found
La philosophie de Roza Egipcíaca, une esclave affranchie dans le Brésil du XVIIIe siècle
No full textLorsque l\u27on considère la pensée de Roza Egipcíaca, auteure mystique brésilienne du XVIIIe siècle, comme une philosophie, une telle caractérisation est, du point de vue de l\u27épistémologie du Nord Global, au mieux une extrapolation analogique. L\u27objectif de cet article est de montrer comment l\u27exposition de cette pensée remet précisément en question l\u27autolégitimation de la tradition - dans le cas de Roza Egipcíaca, les modèles théologiques de maintien du pouvoir colonial et, dans le cas du commentaire de son texte proposé ici, les modèles canoniques de l\u27histoire de la philosophie. Par cette approche, il s\u27agit de montrer comment la complexité de sa situation est exemplaire des impasses auxquelles la pensée en contexte colonial doit faire face.Lorsque l\u27on considère la pensée de Roza Egipcíaca, auteur mystique brésilien du XVIIIe siècle, comme une philosophie, une telle caractérisation est, du point de vue de l\u27épistémologie du Nord Global, au mieux une extrapolation analogique. L\u27objectif de cet article est de montrer comment l\u27exposition de cette pensée remet précisément en question l\u27autolégitimation de la tradition - dans le cas de Roza Egipcíaca, les modèles théologiques de maintien du pouvoir colonial et, dans le cas du commentaire de son texte proposé ici, les modèles canoniques de l\u27histoire de la philosophie. Par cette approche, il s\u27agit de montrer comment la complexité de sa situation est exemplaire des impasses auxquelles la pensée en contexte colonial doit faire face
Processing of UV-induced DNA damage in human skin cells
No full textIt was the aim of the experimental work presented in this thesis to identify -in
mammalian cells- the lesions responsible for UV-induced biological effects, such as cell-killing, to study the relation between the removal of lesions and the occurrence of repair synthesis of DNA ("unscheduled DNA synthesis") and to investigate the possible role and practical significance of photoreactivation in human
Gledališki eksperiment na Slovenskem (1966–1986) in njegovi odmevi v mladinski dramatiki – Andrej Rozman Roza
No full textIn Slovenian (youth) literature, three authors who have worked in the field of drama and/or theatre stand out – namely, Svetlana Makarovič, academically trained actress (Sapramiška), Milan Jesih (Four Plays for Children, adaptations of Andersen’s fairy tales The Emperor’s New Clothes and The Ugly Duckling) and Andrej Rozman Roza. The paper will focus on the latter, who was strongly influenced by the theatre experiment in Slovenia, especially during the formative period of his studies of the Slovenian language (1974–1978). Andrej Rozman Roza (1956) started performing and/or publishing plays in the period 1981– 1990 (Inspector Schwake, 1986; collection of texts Ana Monró Theatre, 1991, etc.). He is known in literary history as a youth poet and is included in Slovenian language curricula (1998, 2011, 2018). However, the definition of a systemic author is more appropriate for him (I. Even Zohar, M. Dović) since of the six functions in the literary system (author, institution, market, repertoire, book, reader) he holds at least three roles (author, “institution”, book [living book], etc.). This paper focuses on adaptations of classics of Slovenian (Cankar, Levstik, Linhart, Prešeren, etc.) or world literature that – regardless of literary genre or type – have become crossover literature in the process of literary reception, especially in picture-book editions (e.g., A Midsummer Night’s Dream which has the international fairy tale type number ATU 899A [Pyramus and Thisbe]). According to B. Kümmerling-Meibauer’s definition of crossover classics or authorship, Rozman is a crossover author. In addition, according to L. Hutcheon’s theory, adaptations are an important part of Rozman’s work and contribute to the updating of classics and modern classics. The paper presents the collection Brvi čez morje (The Footbridge Across the Sea), which contains thirteen plays, three of which are folktale texts – Janko and Metka (Hansel and Gretel) [ATU 327], Obuti maček (Puss in Boots) [ATU 545B], Vžigalnik (The Tinderbox) [ATU 562] – and one which is a fairy tale, Kekec [ATU 1137]). Intertextually, they refer to folktale types.V slovenski (mladinski) književnosti izstopajo trije avtorji, ki so se ukvarjali z dramatiko in/ali gledališčem: to so Svetlana Makarovič, diplomirana igralka (npr. Sapramiška), Milan Jesih (Štiri igre za otroke, priredbe Andersenovih pravljic Cesarjeva nova oblačila in Grdi raček) in Andrej Rozman Roza. Prispevek bo obravnaval slednjega, na katerega je izrazito vplival gledališki eksperiment na Slovenskem, posebej v času študija slovenščine (1974–1978). Andrej Rozman Roza (roj. 1955) je začel nastopati in/ali objavljati dramska besedila v obdobju 1981–1990 (Inspektor Schwake, 1986; besedila v zborniku Gledališče Ane Monró: od Talija do Torija, 1991 idr.). V literarni zgodovini je znan kot mladinski pesnik, uvrščen je v učne načrte za slovenščino (1998, 2011, 2018), a je zanj primernejša oznaka sistemskega avtorja (I. Even Zohar, M. Dović), saj ima od šestih funkcij v literarnem sistemu (avtor, ustanova, trg, repertoar, knjiga, bralci) najmanj tri vloge (avtor, »ustanova«, knjiga [živa knjiga] idr.). Prispevek se osredotoča na priredbe klasične slovenske (Cankar, Levstik, Linhart, Prešeren itd.) ali svetovne književnosti, ne glede na literarno zvrst ali vrsto, ki je v procesu literarne recepcije postala večnaslovniška (angl. »crossover«), posebej v slikaniški izdaji (npr. Sen kresne noči, ki ima mednarodno številko pravljičnega tipa ATU 899A [Piram in Tizba]). Glede na opredelitev klasične oz. večnaslovniške književnosti (B. Kümmerling-Meibauer) je Rozman večnaslovniški avtor in po teoriji L. Hutcheon so adaptacije pomemben del njegovega opusa, ki prispeva k posodabljanju klasike in sodobne klasike. V prispevku bo predstavljena Rozmanova zbirka Brvi čez morje, v kateri je trinajst dramskih besedil, od tega so tri besedila ljudske pravljice (Janko in Metka [ATU 327], Obuti maček [ATU 545B], Vžigalnik [ATU 562], eno pa avtorska/literarna pravljica (Kekec [ATU 1137]), ki se medbesedilno navezujejo na pravljične tipe
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Inhibition of NETs-associated ARG1 enhances the efficacy of anti-cancer immunotherapeutic approaches
No full textNonostante gli straordinari risultati ottenuti dall'immunoterapia nel trattamento dei tumori, la sua efficacia risulta limitata a pochi pazienti. Tra i meccanismi responsabili di questa parziale efficacia gioca un ruolo chiave il microambiente tumorale (TME). Con le sue caratteristiche immunosoppressive, il TME è oggi oggetto di un’intensa ricerca, volta a identificare, caratterizzare e colpire le funzioni che lo regolano. Tra i componenti chiave del TME, annoveriamo le cellule mieloidi che, corrotte dalle cellule tumorali, intervengono nello spegnimento della risposta anti-tumorale attraverso svariati meccanismi. Tra questi, la degradazione di L-arginina nell'ambiente extracellulare da parte dell'arginasi 1 (ARG1) rappresenta un noto meccanismo immunosoppressorio. Sebbene siano stati fatti enormi sforzi per lo sviluppo di inibitori chimici efficaci contro l’ARG1, le differenze nella biologia di ARG1 tra uomo e modelli murini limita, ad oggi, l’efficacia della sua inibizione nella pratica clinica. Nel nostro studio, dimostriamo che ARG1 è presente nei neutrophil extracellular traps (NETs) rilasciati dalle cellule polimorfonucleate (PMNs) stimolate. Nei NETs ARG1 viene tagliata dalla catepsina S (CTSS), originando frammenti di diverso peso molecolare con attività enzimatica. Come conseguenza, il risultato netto della funzione di ARG1 risulta aumentato a pH fisiologico. In pazienti con tumore pancreatico abbiamo evidenziato che tale meccanismo è presente in cellule mieloidi periferiche ed infiltranti il tumore. Abbiamo altresì dimostrato che l’attività di ARG1 può essere neutralizzata, in vitro, da un nuovo anticorpo monoclonale specifico per ARG1 umana, mentre classici inibitori risultano inefficaci. L’efficacia dell’anticorpo anti-ARG1 è stata inoltre valutata in vivo su omogenati di tumore pancreatico umano e in modelli murini. In tal senso, l’anticorpo si è dimostrato in grado di aumentare l’efficacia di terapie basate su checkpoint inhibitors e trasferimento adottivo di cellule T antitumorali.Despite the progress in the field of the cancer immunotherapy, the immunosuppressive tumor microenvironment (TME) remains a huge problem-to-besolved nowadays. Among other key components, infiltrated myeloid cells in the TME can suppress anti-tumor immunity exploiting various mechanisms. L-arginine degradation from the extracellular milieu by arginase 1 (ARG1) is a notorious immunosuppressive mechanism. Although, huge effort has been made for the development of effective chemical inhibitors against ARG1, differences in ARG1 biology among species could restrain the successful translation of experimental model results in the clinical practice. In our study, we have demonstrated that ARG1 is present in neutrophil extracellular traps (NETs) released by stimulated polymorphonuclear cells (PMNs), where it is cleaved by the cysteine protease cathepsin S (CTSS). This cleavage generated two truncated forms of lower molecular weight and unleashed ARG1 enzymatic activity at physiological pH. Subsequently, ARG1 enhanced activity resulted in the arrest of T lymphocytes proliferation. We have developed a neutralizing monoclonal antibody against ARG1, which efficiently blocked ARG1 activity, while the commercially available ARG1 inhibitors were unable to restore T cells proliferation when the cleaved forms were present. In patients with pancreatic ductal adenocarcinoma (PDAC), neutrophils and CD14+ARG1+ cells released NETs-related ARG1 endowed with increased activity, due to CTSS cleavage, and administration of the ARG1 neutralizing antibody blocked its inhibitory function. ARG1 blockade in combination with immune checkpoint inhibitors (ICI) in ex vivo PDAC tumors enhanced the efficacy of immunotherapy through increased activation of T lymphocytes, while combinatory treatment of tumor-bearing humanized mice with adoptive cell therapy (ACT) and ARG1 neutralizing antibody increased T cells infiltration in the tumor tissues and attenuated tumor growth
MULTIPLIKASI TUNAS NANAS (Ananas comosus (L.) Merr.) cv. QUEEN MENGGUNAKAN KINETIN DAN NAA SECARA IN VITRO
No full textMULTIPLIKASI TUNAS NANAS (Ananas comosus (L.) Merr.)
cv. QUEEN MENGGUNAKAN KINETIN DAN NAA
SECARA IN VITRO
Vera Silfa Roza ( 11780223633 )
Di bawah bimbingan Rosmaina dan Rita Elfianis
INTISARI
Nanas (Ananas comosus (L) merr.) merupakan salah satu tanaman
holtikultura yang banyak diminati masyarakat. Kendala dalam perbanyakan nanas
saat ini adalah keterbatasan jumlah bibit yang banyak dan seragam. Penelitian ini
bertujuan untuk mengetahui konsentrasi kinetin terbaik pada media MS0 + 1.0
NAA terhadap perbanyakan tunas nanas. Penelitian ini disusun menggunakan
Rancangan Acak Lengkap (RAL) yang terdiri atas 5 perlakuan P0 = kontrol
(MS0), P1 = 0.5 ppm Kinetin+1.0 ppm NAA, P2 = 1.0 ppm Kinetin+1.0 ppm
NAA, P3 = 1.5 Kinetin+1.0 ppm NAA, P4 = 2.0 ppm Kinetin+1.0 ppm NAA.
Masing-masing perlakuan diulang sebanyak 10 kali sehingga terdapat 50 satuan
percobaan. Hasil penelitian menunjukkan penambahan Kinetin bepengaruh nyata
terhadap waktu muncul tunas, jumlah tunas, waktu muncul akar dan jumlah akar.
Pemberian kinetin 0.5-2.0 ppm menghasilkan rata-rata 3.10-5.52 tunas/eksplan
selama 8 MST. Penambahan 1.5 ppm Kinetin+1.0 ppm NAA merupakan
perlakuan terbaik yang mampu menginduksi jumlah tunas terbanyak (5-8
tunas/eksplan), waktu muncul tunas yang relative cepat yaitu 1.5 MST dan
menghasilkan jumlah akar yang ideal yaitu 3.37 akar/eksplan.
Kata Kunci : in vitro, media MS, perbanyakan, subkultur, ZP
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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