1,720,958 research outputs found
Studio del ruolo del sistema serotoninergico in un modello acuto murino di Morbo di Crohn
No full textSodium channel blockers: a patent review (2010 - 2014)
No full textAbnormal activity of voltage-gated sodium channels (VGSCs) is related to several pathological processes, including cardiac arrhythmias, epilepsy, cancer, neurodegenerative diseases, spasticity, chronic and neuropathic pain. As such VGSCs are considered important therapeutic targets
Study of role of serotonergic system in a murine model of acute Crohn's disease model
No full textIl Morbo di Crohn (CD) è una delle forme più importante di Inflammatory Bowel Disease, caratterizzata dall’infiammazione della parete intestinale, con massiccia infiltrazione di macrofagi e linfociti. Questa patologia provoca non solo importanti manifestazione a livello intestinale ed è un fattore di rischio per il cancro colonrettale, ma presenta anche manifestazioni sistemiche, come osteoporosi , diabete di tipo II, trombosi ed ulcerazioni a livello epidermico . L'incidenza di CD è aumentata negli ultimi 10 anni, ed in particolare è fortemente incrementata nei centri urbani.
La serotonina (5-HT) è uno dei più importanti neurotrasmettitori del tratto gastrointestinale, e la sua azione è modulata da un gran numero di recettori (5 - HTRs: 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT7) . Diversi autori hanno dimostrato il ruolo fondamentale svolto dalla 5-HT nello sviluppo di questo tipo di patologia e la presenza di diversi 5-HTR sulla superficie di tutte le cellule del sistema immunitario.
Scopo della nostra ricerca è quello di indagare il ruolo svolto dai 5-HTRs in un modello murino di CD acuta, realizzata con acido solfonico 2,4,6-trinitrobenzene (TNBS), attraverso la somministrazione di un antagonista del recettore 5-HT1A (WAY100135 ) ed un agonista del recettore 5-HT1A (8-OH DPAT∙HBr), nella prima parte del nostro studio, e attraverso la somministrazione di un antagonista del recettore 5- HT2 (Ketanserina), antagonista 5-HT3 (Ondansetron), antagonista 5-HT4 (GR125487) ed antagonista 5-HT7 (SB269970), nella seconda parte.
Nella prima parte del nostro studio, abbiamo dimostrato che agonisti del recettore 5-HT1A svolgono un ruolo protettivo, mentre, l'antagonismo del recettore 5-HT1A provoca un peggioramento del quadro clinico. Nella seconda parte del nostro studio abbiamo dimostrato il ruolo protettivo svolto dagli antagonisti 5-HT2 e 5-HT4, il ruolo marginale svolto dal recettore 5-HT7 e l’effetto aggravante causatato dalla somministrazione di antagonisti del recettore 5-HT3.
Tutti gli esperimenti sono stati eseguiti in conformità con principi guida nella cura e l'uso degli animali (DL117/92).Crohn’s Disease (CD) is one of the more important form of Inflammatory Bowel Disease, characterized by inflammation of intestinal wall, with a massive infiltration of macrophage and lymphocytes. This pathology causes not only important intestinal manifestation and a risk factor for colonrectal cancer, but also systemic effect, like osteoporosis, type II diabetes, thrombosis and skin ulceration . The incidence of CD is increase in the last 10 years, and in particular is strongly increase in the urban center.
Serotonin (5-HT) in one of the most important neurotransmitter of gastrointestinal tract, and its action is modulated by a large number of receptor (5-HTRs: 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT7). Many author have demonstrated the fundamental role of 5-HT in the development of this kind of pathology and the presence of 5-HTRs on the surface of all cell of immune system.
Aim of our study is to investigate the role of 5-HTRs in a murine model of acute CD, realized using 2,4,6–trinitrobenzene sulphonic acid (TNBS), through the administration of a 5-HT1A receptor antagonist (WAY100135) and 5-HT1A receptor agonist (8-OH DPAT∙HBr) in the first part of our study, and through the administration of 5-HT2 antagonist (Ketanserin), 5-HT3 antagonist (Ondansetron), 5-HT4 antagonist (GR125487) and 5-HT7 antagonist (SB269970).
In first part of our study, we have demonstrated that agonist of 5-HT1A receptor plays a protective role; by other hand, the antagonism of 5-HT1A receptor causes a clinical worsening. In second part of our study we demonstrate the protective role played by antagonist of 5-HT2 and 5-HT4 receptors, the marginal role played by 5-HT7 receptor antagonist and impaired effect caused by the administration of 5-HT3 receptor antagonist.
All the experiments were performed in accordance with Guiding Principles in the Care and Use of Animals (DL117/92)
Study of role of serotonergic system in a murine model of acute Crohn's disease model
No full textIl Morbo di Crohn (CD) è una delle forme più importante di Inflammatory Bowel Disease, caratterizzata dall’infiammazione della parete intestinale, con massiccia infiltrazione di macrofagi e linfociti. Questa patologia provoca non solo importanti manifestazione a livello intestinale ed è un fattore di rischio per il cancro colonrettale, ma presenta anche manifestazioni sistemiche, come osteoporosi , diabete di tipo II, trombosi ed ulcerazioni a livello epidermico . L'incidenza di CD è aumentata negli ultimi 10 anni, ed in particolare è fortemente incrementata nei centri urbani.
La serotonina (5-HT) è uno dei più importanti neurotrasmettitori del tratto gastrointestinale, e la sua azione è modulata da un gran numero di recettori (5 - HTRs: 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT7) . Diversi autori hanno dimostrato il ruolo fondamentale svolto dalla 5-HT nello sviluppo di questo tipo di patologia e la presenza di diversi 5-HTR sulla superficie di tutte le cellule del sistema immunitario.
Scopo della nostra ricerca è quello di indagare il ruolo svolto dai 5-HTRs in un modello murino di CD acuta, realizzata con acido solfonico 2,4,6-trinitrobenzene (TNBS), attraverso la somministrazione di un antagonista del recettore 5-HT1A (WAY100135 ) ed un agonista del recettore 5-HT1A (8-OH DPAT∙HBr), nella prima parte del nostro studio, e attraverso la somministrazione di un antagonista del recettore 5- HT2 (Ketanserina), antagonista 5-HT3 (Ondansetron), antagonista 5-HT4 (GR125487) ed antagonista 5-HT7 (SB269970), nella seconda parte.
Nella prima parte del nostro studio, abbiamo dimostrato che agonisti del recettore 5-HT1A svolgono un ruolo protettivo, mentre, l'antagonismo del recettore 5-HT1A provoca un peggioramento del quadro clinico. Nella seconda parte del nostro studio abbiamo dimostrato il ruolo protettivo svolto dagli antagonisti 5-HT2 e 5-HT4, il ruolo marginale svolto dal recettore 5-HT7 e l’effetto aggravante causatato dalla somministrazione di antagonisti del recettore 5-HT3.
Tutti gli esperimenti sono stati eseguiti in conformità con principi guida nella cura e l'uso degli animali (DL117/92).Crohn’s Disease (CD) is one of the more important form of Inflammatory Bowel Disease, characterized by inflammation of intestinal wall, with a massive infiltration of macrophage and lymphocytes. This pathology causes not only important intestinal manifestation and a risk factor for colonrectal cancer, but also systemic effect, like osteoporosis, type II diabetes, thrombosis and skin ulceration . The incidence of CD is increase in the last 10 years, and in particular is strongly increase in the urban center.
Serotonin (5-HT) in one of the most important neurotransmitter of gastrointestinal tract, and its action is modulated by a large number of receptor (5-HTRs: 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT7). Many author have demonstrated the fundamental role of 5-HT in the development of this kind of pathology and the presence of 5-HTRs on the surface of all cell of immune system.
Aim of our study is to investigate the role of 5-HTRs in a murine model of acute CD, realized using 2,4,6–trinitrobenzene sulphonic acid (TNBS), through the administration of a 5-HT1A receptor antagonist (WAY100135) and 5-HT1A receptor agonist (8-OH DPAT∙HBr) in the first part of our study, and through the administration of 5-HT2 antagonist (Ketanserin), 5-HT3 antagonist (Ondansetron), 5-HT4 antagonist (GR125487) and 5-HT7 antagonist (SB269970).
In first part of our study, we have demonstrated that agonist of 5-HT1A receptor plays a protective role; by other hand, the antagonism of 5-HT1A receptor causes a clinical worsening. In second part of our study we demonstrate the protective role played by antagonist of 5-HT2 and 5-HT4 receptors, the marginal role played by 5-HT7 receptor antagonist and impaired effect caused by the administration of 5-HT3 receptor antagonist.
All the experiments were performed in accordance with Guiding Principles in the Care and Use of Animals (DL117/92)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Role of 5-HT in intestinal ischemia-reperfusion: suppression of inflammatory events by 5-HT1A blockade in mice
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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